JP2003520856A5 - - Google Patents

Download PDF

Info

Publication number
JP2003520856A5
JP2003520856A5 JP2001555061A JP2001555061A JP2003520856A5 JP 2003520856 A5 JP2003520856 A5 JP 2003520856A5 JP 2001555061 A JP2001555061 A JP 2001555061A JP 2001555061 A JP2001555061 A JP 2001555061A JP 2003520856 A5 JP2003520856 A5 JP 2003520856A5
Authority
JP
Japan
Prior art keywords
substituted
compound according
alkyl
compound
heterocycle
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2001555061A
Other languages
English (en)
Japanese (ja)
Other versions
JP4931314B2 (ja
JP2003520856A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2001/002740 external-priority patent/WO2001055119A2/en
Publication of JP2003520856A publication Critical patent/JP2003520856A/ja
Publication of JP2003520856A5 publication Critical patent/JP2003520856A5/ja
Application granted granted Critical
Publication of JP4931314B2 publication Critical patent/JP4931314B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

JP2001555061A 2000-01-25 2001-01-25 性腺刺激ホルモン放出ホルモンレセプタアンタゴニストおよびそれに関連した方法 Expired - Lifetime JP4931314B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US17793300P 2000-01-25 2000-01-25
US60/177,933 2000-01-25
US23968300P 2000-10-11 2000-10-11
US60/239,683 2000-10-11
PCT/US2001/002740 WO2001055119A2 (en) 2000-01-25 2001-01-25 Gonadotropin-releasing hormone receptor antagonists and methods relating thereto

Publications (3)

Publication Number Publication Date
JP2003520856A JP2003520856A (ja) 2003-07-08
JP2003520856A5 true JP2003520856A5 (enExample) 2008-03-13
JP4931314B2 JP4931314B2 (ja) 2012-05-16

Family

ID=26873790

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2001555061A Expired - Lifetime JP4931314B2 (ja) 2000-01-25 2001-01-25 性腺刺激ホルモン放出ホルモンレセプタアンタゴニストおよびそれに関連した方法

Country Status (14)

Country Link
US (4) US6608197B2 (enExample)
EP (1) EP1255738B1 (enExample)
JP (1) JP4931314B2 (enExample)
KR (1) KR100814269B1 (enExample)
AT (1) ATE548357T1 (enExample)
AU (1) AU767585B2 (enExample)
CA (1) CA2398018C (enExample)
CY (1) CY1112815T1 (enExample)
DK (1) DK1255738T3 (enExample)
ES (1) ES2383954T3 (enExample)
MX (1) MXPA02006848A (enExample)
NO (1) NO20023525D0 (enExample)
PT (1) PT1255738E (enExample)
WO (1) WO2001055119A2 (enExample)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1255738T3 (da) * 2000-01-25 2012-06-25 Neurocrine Biosciences Inc Gonadotropin-frigivende hormonreceptor-antagonister og fremgangsmåder relateret dertil
SE0100567D0 (sv) * 2001-02-20 2001-02-20 Astrazeneca Ab Compounds
MXPA04000985A (es) * 2001-08-02 2005-02-17 Neurocrine Biosciences Inc Piridin-4-onas sustituidas y su uso como antagonistas del receptor de hormona de liberacion de gonadotropina.
US6750350B2 (en) 2001-08-02 2004-06-15 Neurocrine Biosciences, Inc. Gonadotropin-releasing hormone receptor antagonists and methods relating thereto
EP1495768A4 (en) * 2002-04-12 2007-12-05 Takeda Pharmaceutical MEANS FOR THE PREVENTION / TREATMENT OF HITZEWALLUNGEN
ATE557007T1 (de) * 2003-07-07 2012-05-15 Neurocrine Biosciences Inc Arylpyrimidine geeignet zur behandlung von sexualhormonbedingten zuständen wie endometriose, prostatakrebs und dergleichen
DE602004020638D1 (de) * 2003-07-07 2009-05-28 Neurocrine Biosciences Inc Pyrimidin-2,4-dion-derivate als gonadotropin freisetzende hormon-rezeptor-antagonisten
WO2005007165A1 (en) * 2003-07-07 2005-01-27 Neurocrine Biosciences, Inc. Pyrimidine-2, 4-dione derivatives as gonadotropin-releasing hormone receptor antagonists
MXPA06001601A (es) 2003-08-13 2006-08-25 Takeda Pharmaceutical Derivados de 4-pirimidona y su uso como inhibidores de dipeptidilpeptidasa.
CN102127057A (zh) * 2004-03-15 2011-07-20 武田药品工业株式会社 二肽基肽酶抑制剂
US20080262005A1 (en) * 2004-05-14 2008-10-23 Neurocrine Biosciences, Inc. Uracil-Type Gonadotropin-Releasing Hormone Receptor Antagonists and Methods Related Thereto
EP1655288A1 (en) * 2004-11-05 2006-05-10 Institut Pasteur Aryl pyrimidyl compounds, pharmaceutical compositions comprising them, their use as antimicrobial agents
SI1942898T2 (sl) 2005-09-14 2014-08-29 Takeda Pharmaceutical Company Limited Dipeptidil-peptidazni inhibitorji za zdravljenje diabetesa
EP1924567B1 (en) * 2005-09-16 2012-08-22 Takeda Pharmaceutical Company Limited Process for the preparation of pyrimidinedione derivatives
WO2007122634A2 (en) * 2006-04-24 2007-11-01 Jubilant Biosys Limited Pyrimidinediones as tyrosine kinase inhibitors
TW200838536A (en) 2006-11-29 2008-10-01 Takeda Pharmaceutical Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor
AR065948A1 (es) 2007-04-06 2009-07-15 Neurocrine Biosciences Inc Antagonistas del receptor de la hormona liberadora de gonadotropina y procedimientos relacionados con los mismos
CL2008000986A1 (es) 2007-04-06 2008-10-17 Neurocrine Biosciences Inc COMPUESTO DERIVADO DE HETEROCICLOS DE NITROGENO, AGONISTAS DEL RECEPTOR GnRH; COMPOSICION FARMACEUTICA QUE COMPRENDE A DICHO COMPUESTO; Y USO PARA TRATAR UNA AFECCION RELACIONADA CON LAS HORMONAS SEXUALES, ENDOMETRIOSIS, DISMENORREA, ENFERMEDAD DE OV
CA2682400A1 (en) * 2007-04-18 2008-11-06 Kissei Pharmaceutical Co., Ltd. Fused heterocyclic derivative, pharmaceutical composition comprising the derivative, and use of the composition for medical purposes
EP2147922B1 (en) * 2007-04-18 2017-08-02 Kissei Pharmaceutical Co., Ltd. Fused heterocyclic derivative, pharmaceutical composition comprising the derivative, and use of the composition for medical purposes
WO2009062087A1 (en) * 2007-11-07 2009-05-14 Neurocrine Biosciences, Inc. Processes for the preparation of uracil derivatives
DE102008030091B4 (de) * 2008-06-25 2011-03-03 Resprotect Gmbh Uracilderivate und deren Verwendung
CA2736970A1 (en) * 2008-09-12 2010-03-18 Biolipox Ab Pyrimidinone derivatives for use as medicaments
US9034850B2 (en) 2009-11-20 2015-05-19 Sk Chemicals Co., Ltd. Gonadotropin releasing hormone receptor antagonist, preparation method thereof and pharmaceutical composition comprising the same
TW201130854A (en) 2009-12-22 2011-09-16 Bayer Schering Pharma Ag Pyridinone derivatives and pharmaceutical compositions thereof
WO2012175514A1 (en) 2011-06-21 2012-12-27 Bayer Intellectual Property Gmbh Pyridinone derivatives and pharmaceutical compositions thereof
CA2906894A1 (en) 2013-03-15 2014-09-18 Abbvie Inc. Compositions comprising elagolix for use in treating pain associated with endometriosis
US20200113901A1 (en) * 2017-03-31 2020-04-16 Epizyme, Inc. Methods of using ehmt2 inhibitors
EP3612181A4 (en) 2017-04-21 2021-01-06 Epizyme, Inc. Combination therapies with ehmt2 inhibitors
MX2020001877A (es) 2017-08-18 2020-09-14 Abbvie Inc Formulaciones farmacéuticas para tratar la endometriosis, los fibromas uterinos, el síndrome de ovario poliquístico o la adenomiosis.
WO2019036712A1 (en) 2017-08-18 2019-02-21 Abbvie Inc. PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT OF ENDOMETRIOSIS, UTERINE FIBROIDS, POLYKYSTIC OVARY SYNDROME OR ADENOMYOSIS
TW201912157A (zh) 2017-08-18 2019-04-01 美商艾伯維有限公司 治療子宮內膜異位症、子宮纖維瘤、多囊性卵巢症候群及子宮腺肌症之固體醫藥調配物
CN112261942A (zh) 2018-04-19 2021-01-22 艾伯维公司 治疗重度月经出血的方法
IL280135B2 (en) 2018-07-23 2024-06-01 Abbvie Inc Elagolix sodium compositions and processes
MX2021008457A (es) 2019-01-15 2021-10-01 Lupin Inc Composiciones de tipo elagolix deuterado y métodos.
CN111333586A (zh) * 2020-02-19 2020-06-26 诚达药业股份有限公司 一种含有6-甲基尿嘧啶结构化合物的制备方法
CN111333587B (zh) * 2020-04-11 2023-04-07 东莞市东阳光新药研发有限公司 取代的嘧啶-2,4(1h,3h)-二酮衍生物及其用途
CN113527213B (zh) * 2020-04-20 2023-01-03 上海英诺富成生物科技有限公司 促性激素释放激素受体拮抗剂及其用途
FI4122926T3 (fi) * 2021-04-14 2025-07-23 Shionogi & Co Triatsiinijohdannaisia, joilla on viruksien replikaatiota estävää aktiivisuutta, ja niitä käsittävä lääkekoostumus

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2631625B1 (fr) * 1988-05-17 1992-10-16 Synthelabo Derives de phenyl-6 piperazinylalkyl-3 1h,3h-pyrimidinedione-2,4, leur preparation et leur application en therapeutique
US5140029A (en) 1989-01-09 1992-08-18 Janssen Pharmaceutica N.V. 2-aminopyrimidinone derivatives
US5476855A (en) * 1993-11-02 1995-12-19 Mahmoud H. el Kouni Enzyme inhibitors, their synthesis and methods for use
UY23948A1 (es) * 1995-02-08 2001-10-25 Takeda Chemical Industries Ltd Derivados de anillos condensados de tiofeno su producción y uso.
EP0828731A1 (en) 1995-06-01 1998-03-18 Takeda Chemical Industries, Ltd. TRICYCLIC DIAZEPINES USEFUL AS GnRH RECEPTOR ANTAGONISTS
ATE201016T1 (de) * 1995-06-09 2001-05-15 Hoffmann La Roche Pyrimidindion-, pyrimidintrion-, triazindion- derivate als alpha-1-adrenergische rezeptorantagonisten
US5859014A (en) 1995-06-09 1999-01-12 Syntex (U.S.A.) Inc. Pyrimidinedione, pyrimidinetrione, triazinedione and tetrahydroquinazolinedione derivatives as α1 -adrenergic receptor antagonists
CN1063446C (zh) 1995-10-19 2001-03-21 武田药品工业株式会社 作为促性腺激素释放激素拮抗剂的噻吩并吡啶衍生物
AU7333496A (en) 1995-10-19 1997-05-07 Takeda Chemical Industries Ltd. Quinoline derivatives as gnrh antagonists
US5780437A (en) 1995-12-14 1998-07-14 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
EA000992B1 (ru) 1995-12-14 2000-08-28 Мерк Энд Ко., Инк. Антагонисты гормона, высвобождающего гонадотропин
HUP9902121A3 (en) 1995-12-14 2001-05-28 Merck & Co Inc Indole derivatives as antagonists of gonadotropin releasing hormone and pharmaceutical compositions containing them
US5849764A (en) 1995-12-14 1998-12-15 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
CA2240115A1 (en) 1995-12-14 1997-06-19 Wallace T. Ashton Antagonists of gonadotropin releasing hormone
US6197975B1 (en) 1995-12-14 2001-03-06 Merck & Co. , Inc. Antagonists of gonadotropin releasing hormone
JPH09286786A (ja) * 1996-04-18 1997-11-04 Nippon Paper Ind Co Ltd ピリミジン誘導体及びその抗腫瘍剤としての用途
JP2000511532A (ja) 1996-05-20 2000-09-05 メルク エンド カンパニー インコーポレーテッド 性腺刺激ホルモン放出ホルモンのアンタゴニスト
CA2254768A1 (en) 1996-05-20 1997-11-27 Jinlong Jiang Antagonists of gonadotropin releasing hormone
EP0918522A4 (en) 1996-05-20 1999-08-18 Merck & Co Inc GONADOLIBERIN ANTAGONISTS
WO1997044041A1 (en) 1996-05-20 1997-11-27 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
JP2002502422A (ja) 1997-06-05 2002-01-22 メルク エンド カンパニー インコーポレーテッド ゴナドトロピン放出ホルモンの拮抗薬
CA2291829A1 (en) 1997-06-05 1998-12-10 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
AU729752B2 (en) 1997-06-05 2001-02-08 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
JP2002502427A (ja) 1997-06-05 2002-01-22 メルク エンド カンパニー インコーポレーテッド ゴナドトロピン放出ホルモンの拮抗薬
US6313301B1 (en) 1997-08-13 2001-11-06 Takeda Chemical Industries, Ltd. Thienopyridine derivatives, their intermediates and production thereof
AU1687199A (en) 1997-12-26 1999-07-19 Takeda Chemical Industries Ltd. Nitrogen-containing heterocyclic compounds, their production and use
WO1999051232A1 (en) 1998-04-02 1999-10-14 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
WO2000029386A1 (en) * 1998-11-12 2000-05-25 Merck & Co., Inc. Pyrimidinedione derivatives useful as alpha 1a adrenoceptor antagonists
MXPA01011634A (es) 1999-05-14 2002-07-30 Neurocrine Biosciences Inc Imidazo- y pirrolo [1,2-a]pirimid-4-onas como antagonistas receptores de la hormona liberadora de gonadotropina.
AU771740B2 (en) * 1999-05-19 2004-04-01 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl uracils as anticoagulative agents
ES1043085Y (es) * 1999-06-03 2001-02-01 Nueva Ceramica Arb Sa Teja planoconvexa
CA2386942A1 (en) 1999-10-15 2001-04-26 Neurocrine Biosciences, Inc. Gonadotropin-releasing hormone receptor antagonists and methods relating thereto
DK1255738T3 (da) * 2000-01-25 2012-06-25 Neurocrine Biosciences Inc Gonadotropin-frigivende hormonreceptor-antagonister og fremgangsmåder relateret dertil
ATE557007T1 (de) * 2003-07-07 2012-05-15 Neurocrine Biosciences Inc Arylpyrimidine geeignet zur behandlung von sexualhormonbedingten zuständen wie endometriose, prostatakrebs und dergleichen
DE602004020638D1 (de) * 2003-07-07 2009-05-28 Neurocrine Biosciences Inc Pyrimidin-2,4-dion-derivate als gonadotropin freisetzende hormon-rezeptor-antagonisten
WO2005007165A1 (en) * 2003-07-07 2005-01-27 Neurocrine Biosciences, Inc. Pyrimidine-2, 4-dione derivatives as gonadotropin-releasing hormone receptor antagonists

Similar Documents

Publication Publication Date Title
JP2003520856A5 (enExample)
JP2003512379A5 (enExample)
CN104854098B (zh) 作为ep4拮抗剂的苯并咪唑衍生物
AU676210B2 (en) Benzo-fused lactams promote release of growth hormone
US20030134861A1 (en) Transmucosal phosphodiesterase inhibitors for the treatment of erectile dysfunction
CA2398018A1 (en) Gonadotropin-releasing hormone receptor antagonists and methods relating thereto
JP2005506338A5 (enExample)
JP2002543197A (ja) プロゲステロン受容体アゴニストとしてのシアノピロール
CN106573897A (zh) 作为mIDH1抑制剂的苯并咪唑‑2‑胺
JP2001526218A5 (enExample)
JP2004501930A5 (enExample)
CA2205384A1 (en) Dihydropyrimidines and uses thereof
JP2002540102A (ja) ｃＧＭＰホスホジエステラーゼの縮合ピリドピリダジン阻害剤
JP2002516858A (ja) Ｈｉｖインテグラーゼ阻害薬
JP2009510128A5 (enExample)
JP2003503449A5 (enExample)
JP2011231118A (ja) マトリックスメタロプロテイナーゼの阻害剤
JP2004525183A5 (enExample)
CN108602820A (zh) 杂-1,5,6,7-四氢-4h-吲哚-4-酮类化合物
JP2004525184A5 (enExample)
JP2005511594A5 (enExample)
JP2002506864A5 (enExample)
JP2002524460A5 (enExample)
WO2004029064A8 (en) (+)-trans-isomers of (1-phosphonomethoxy-2-alkylcyclopropyl) methyl nucleoside derivatives, process for the preparation of stereoisomers thereof, and use of antiviral agents thereof
TW200306817A (en) Pharmaceutical composition for treating or preventing virus infectious diseases