JP4717210B2 - 男性の勃起機能障害の処置のための５−ヘテロシクリルピラゾロ［４，３−ｄ］ピリミジン−７−オン - Google Patents

男性の勃起機能障害の処置のための５−ヘテロシクリルピラゾロ［４，３−ｄ］ピリミジン−７−オン Download PDF

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JP4717210B2
JP4717210B2 JP2000568846A JP2000568846A JP4717210B2 JP 4717210 B2 JP4717210 B2 JP 4717210B2 JP 2000568846 A JP2000568846 A JP 2000568846A JP 2000568846 A JP2000568846 A JP 2000568846A JP 4717210 B2 JP4717210 B2 JP 4717210B2
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alkyl
hydrogen
alkoxy
hydroxy
fluorinated
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Japanese (ja)
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JP2002524460A (ja
JP2002524460A5 (enExample
Inventor
スイ，ジフア
グアン，ジフア
マシーラグ，マーク・ジエイ
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オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2000568846A 1998-09-04 1999-09-02 男性の勃起機能障害の処置のための５−ヘテロシクリルピラゾロ［４，３−ｄ］ピリミジン−７−オン Expired - Fee Related JP4717210B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9926898P 1998-09-04 1998-09-04
US60/099,268 1998-09-04
PCT/US1999/020240 WO2000014088A1 (en) 1998-09-04 1999-09-02 5-heterocyclyl pyrazolo[4,3-d]pyrimidin-7-ones for the treatment of male erectile dysfunction

Publications (3)

Publication Number Publication Date
JP2002524460A JP2002524460A (ja) 2002-08-06
JP2002524460A5 JP2002524460A5 (enExample) 2006-11-02
JP4717210B2 true JP4717210B2 (ja) 2011-07-06

Family

ID=22274049

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000568846A Expired - Fee Related JP4717210B2 (ja) 1998-09-04 1999-09-02 男性の勃起機能障害の処置のための５−ヘテロシクリルピラゾロ［４，３−ｄ］ピリミジン−７−オン

Country Status (11)

Country Link
US (1) US6077841A (enExample)
EP (1) EP1109814B1 (enExample)
JP (1) JP4717210B2 (enExample)
AT (1) ATE264861T1 (enExample)
AU (1) AU5704199A (enExample)
CA (1) CA2342830C (enExample)
DE (1) DE69916627T2 (enExample)
DK (1) DK1109814T3 (enExample)
ES (1) ES2220109T3 (enExample)
PT (1) PT1109814E (enExample)
WO (1) WO2000014088A1 (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6403597B1 (en) 1997-10-28 2002-06-11 Vivus, Inc. Administration of phosphodiesterase inhibitors for the treatment of premature ejaculation
US6548490B1 (en) 1997-10-28 2003-04-15 Vivus, Inc. Transmucosal administration of phosphodiesterase inhibitors for the treatment of erectile dysfunction
UA67802C2 (uk) * 1998-10-23 2004-07-15 Пфайзер Рісьоч Енд Дівелепмент Компані, Н.В./С.А. Фармацевтична композиція з контрольованим вивільненням інгібітора цгмф фде-5 (варіанти), спосіб її одержання та спосіб лікування еректильної дисфункції
GB9828340D0 (en) * 1998-12-22 1999-02-17 Novartis Ag Organic compounds
AU5925500A (en) * 1999-07-09 2001-01-30 Picower Institute For Medical Research, The Pyrazolopyrimidinone derivatives conjugated to thiophene moieties or benzo [fused] 5-membered heterocycles for erectile dysfunction
KR100377782B1 (ko) * 2000-06-23 2003-03-29 동아제약 주식회사 발기부전 치료에 효과를 갖는 피라졸로피리미디논화합물의 제조방법
IT1318673B1 (it) * 2000-08-08 2003-08-27 Nicox Sa Farmaci per le disfunzioni sessuali.
US6503894B1 (en) 2000-08-30 2003-01-07 Unimed Pharmaceuticals, Inc. Pharmaceutical composition and method for treating hypogonadism
KR100435514B1 (ko) * 2002-03-22 2004-06-10 한미약품 주식회사 실데나필 젖산염의 속효제형
US7141669B2 (en) 2003-04-23 2006-11-28 Pfizer Inc. Cannabiniod receptor ligands and uses thereof
WO2005028480A2 (en) * 2003-09-03 2005-03-31 Neurogen Corporation 5-aryl-pyrazolo[4,3-d]pyrimidines, pyridines, and pyrazines and related compounds
CA2624788C (en) 2005-10-12 2011-04-19 Unimed Pharmaceuticals, Llc Improved testosterone gel and method of use
CN101891747B (zh) * 2010-07-02 2012-04-25 张南 抑制5型磷酸二酯酶的化合物及制备方法
WO2017168174A1 (en) 2016-04-02 2017-10-05 N4 Pharma Uk Limited New pharmaceutical forms of sildenafil
CN111606909B (zh) * 2020-06-09 2022-12-20 浙江大学 吡唑并嘧啶类化合物及其药物组合物及制备方法和应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4666908A (en) * 1985-04-05 1987-05-19 Warner-Lambert Company 5-Substituted pyrazolo[4,3-d]pyrimidine-7-ones and methods of use
US5250534A (en) * 1990-06-20 1993-10-05 Pfizer Inc. Pyrazolopyrimidinone antianginal agents
US5294612A (en) * 1992-03-30 1994-03-15 Sterling Winthrop Inc. 6-heterocyclyl pyrazolo [3,4-d]pyrimidin-4-ones and compositions and method of use thereof
GB9311920D0 (en) * 1993-06-09 1993-07-28 Pfizer Ltd Therapeutic agents
GB9315017D0 (en) * 1993-07-20 1993-09-01 Glaxo Lab Sa Chemical compounds
GB9423910D0 (en) * 1994-11-26 1995-01-11 Pfizer Ltd Therapeutic agents
GB9423911D0 (en) * 1994-11-26 1995-01-11 Pfizer Ltd Therapeutic agents
GB9612514D0 (en) * 1996-06-14 1996-08-14 Pfizer Ltd Novel process

Also Published As

Publication number Publication date
JP2002524460A (ja) 2002-08-06
EP1109814B1 (en) 2004-04-21
CA2342830C (en) 2008-11-25
ATE264861T1 (de) 2004-05-15
EP1109814A1 (en) 2001-06-27
DE69916627D1 (de) 2004-05-27
CA2342830A1 (en) 2000-03-16
DK1109814T3 (da) 2004-08-02
ES2220109T3 (es) 2004-12-01
AU5704199A (en) 2000-03-27
PT1109814E (pt) 2004-08-31
US6077841A (en) 2000-06-20
DE69916627T2 (de) 2005-07-28
WO2000014088A1 (en) 2000-03-16

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