JP2010507593A5 - - Google Patents
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- Publication number
- JP2010507593A5 JP2010507593A5 JP2009533595A JP2009533595A JP2010507593A5 JP 2010507593 A5 JP2010507593 A5 JP 2010507593A5 JP 2009533595 A JP2009533595 A JP 2009533595A JP 2009533595 A JP2009533595 A JP 2009533595A JP 2010507593 A5 JP2010507593 A5 JP 2010507593A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- compound according
- pharmaceutical composition
- compound
- erectile dysfunction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 9
- 239000008194 pharmaceutical composition Substances 0.000 claims 7
- 239000000203 mixture Substances 0.000 claims 5
- 208000010228 Erectile Dysfunction Diseases 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 201000001881 impotence Diseases 0.000 claims 4
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 claims 3
- 208000004403 Prostatic Hyperplasia Diseases 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 206010064911 Pulmonary arterial hypertension Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 claims 1
- 101100189582 Dictyostelium discoideum pdeD gene Proteins 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- 101150098694 PDE5A gene Proteins 0.000 claims 1
- 102100029175 cGMP-specific 3',5'-cyclic phosphodiesterase Human genes 0.000 claims 1
- 229910052805 deuterium Inorganic materials 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 230000000155 isotopic effect Effects 0.000 claims 1
- 230000000144 pharmacologic effect Effects 0.000 claims 1
- 210000001147 pulmonary artery Anatomy 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US85323406P | 2006-10-20 | 2006-10-20 | |
| PCT/US2007/082157 WO2008070313A2 (en) | 2006-10-20 | 2007-10-22 | 3-(dihydro-1h-pyrazolo [4,3-d] pyrimidin-5-yl)-4-propoxybenzenesulfonamide derivatives and methods of use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010507593A JP2010507593A (ja) | 2010-03-11 |
| JP2010507593A5 true JP2010507593A5 (enExample) | 2010-12-16 |
Family
ID=39492926
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009533595A Pending JP2010507593A (ja) | 2006-10-20 | 2007-10-22 | ３−（ジヒドロ−１Ｈ−ピラゾロ［４，３−ｄ］ピリミジン−５−イル）−４−プロポキシベンゼンスルホンアミド誘導体および使用方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US8552008B2 (enExample) |
| EP (1) | EP2089392A4 (enExample) |
| JP (1) | JP2010507593A (enExample) |
| KR (1) | KR20090091138A (enExample) |
| CN (1) | CN101528747A (enExample) |
| AU (1) | AU2007329728A1 (enExample) |
| CA (1) | CA2664940A1 (enExample) |
| MX (1) | MX2009003941A (enExample) |
| WO (1) | WO2008070313A2 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090197899A1 (en) * | 2006-10-20 | 2009-08-06 | Concert Pharmaceuticals Inc. | 3-(Dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-propoxybenzenesulfonamide Derivatives and Methods of Use |
| US20090270425A1 (en) * | 2006-10-20 | 2009-10-29 | Concert Pharmaceuticals Inc. | 3-(dihydro-1h-pyrazolo[4,3-d]pyrimidin-5-yl)-4-propoxybenzenesulfonamide derivatives and methods of use |
| KR101071877B1 (ko) * | 2009-02-18 | 2011-10-10 | 동아제약주식회사 | 유데나필 산부가염, 그의 제조방법 및 이를 포함하는 약학적 조성물 |
| WO2018049214A1 (en) | 2016-09-09 | 2018-03-15 | Incyte Corporation | Pyrazolopyridine derivatives as hpk1 modulators and uses thereof for the treatment of cancer |
| EP3510032B1 (en) | 2016-09-09 | 2022-07-06 | Incyte Corporation | Pyrazolopyridine derivatives as hpk1 modulators and uses thereof for the treatment of cancer |
| WO2018049152A1 (en) | 2016-09-09 | 2018-03-15 | Incyte Corporation | Pyrazolopyrimidine derivatives as hpk1 modulators and uses thereof for the treatment of cancer |
| WO2018152220A1 (en) | 2017-02-15 | 2018-08-23 | Incyte Corporation | Pyrazolopyridine compounds and uses thereof |
| WO2019051199A1 (en) | 2017-09-08 | 2019-03-14 | Incyte Corporation | 6-CYANO-INDAZOLE COMPOUNDS AS HEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) MODULATORS |
| US10745388B2 (en) | 2018-02-20 | 2020-08-18 | Incyte Corporation | Indazole compounds and uses thereof |
| KR20200133747A (ko) | 2018-02-20 | 2020-11-30 | 인사이트 코포레이션 | 암을 치료하기 위한 hpk1 억제제로서의 n-(페닐)-2-(페닐)피리미딘-4-카복스아미드 유도체 및 관련 화합물 |
| WO2019164847A1 (en) | 2018-02-20 | 2019-08-29 | Incyte Corporation | Indazole compounds and uses thereof |
| US11299473B2 (en) | 2018-04-13 | 2022-04-12 | Incyte Corporation | Benzimidazole and indole compounds and uses thereof |
| US10899755B2 (en) | 2018-08-08 | 2021-01-26 | Incyte Corporation | Benzothiazole compounds and uses thereof |
| EP3856348B1 (en) | 2018-09-25 | 2024-01-03 | Incyte Corporation | Pyrazolo[4,3-d]pyrimidine compounds as alk2 and/or fgfr modulators |
| JP2022543155A (ja) | 2019-08-06 | 2022-10-07 | インサイト・コーポレイション | Ｈｐｋ１阻害剤の固体形態 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6221335B1 (en) * | 1994-03-25 | 2001-04-24 | Isotechnika, Inc. | Method of using deuterated calcium channel blockers |
| KR100353014B1 (ko) * | 1998-11-11 | 2002-09-18 | 동아제약 주식회사 | 발기부전 치료에 효과를 갖는 피라졸로피리미디논 화합물 |
| US6440710B1 (en) * | 1998-12-10 | 2002-08-27 | The Scripps Research Institute | Antibody-catalyzed deuteration, tritiation, dedeuteration or detritiation of carbonyl compounds |
| ES2193921T3 (es) * | 1999-12-03 | 2003-11-16 | Pfizer Prod Inc | Compuestos de sulfamoilheteroaril-pirazol como agentes antinflamatorios/analgesicos. |
| TW200413273A (en) * | 2002-11-15 | 2004-08-01 | Wako Pure Chem Ind Ltd | Heavy hydrogenation method of heterocyclic rings |
| BRPI0615972A2 (pt) | 2005-07-29 | 2011-05-31 | Concert Pharmaceuticals Inc | composto isolado, mistura, composição, item de manufatura, uso de um composto, método para determinar a concentração do composto em uma amostra biológica, kit de diagnóstico e método para avaliar a estabilidade metabólica de um composto |
| US7598273B2 (en) * | 2005-10-06 | 2009-10-06 | Auspex Pharmaceuticals, Inc | Inhibitors of the gastric H+, K+-ATPase with enhanced therapeutic properties |
| US7750168B2 (en) * | 2006-02-10 | 2010-07-06 | Sigma-Aldrich Co. | Stabilized deuteroborane-tetrahydrofuran complex |
| MX2009002398A (es) * | 2006-09-05 | 2009-03-16 | Schering Corp | Combinaciones farmaceuticas para manejo de lipidos y en el tratamiento de aterosclerosis y estatosis hepatica. |
| US20080280927A1 (en) | 2006-10-20 | 2008-11-13 | Concert Pharmaceuticals Inc. | 3-(dihydro-1h-pyrazolo[4,3-d]pyrimidin-5-yl)-4-propoxybenzenesulfonamide derivatives and methods of use |
| US20090270425A1 (en) | 2006-10-20 | 2009-10-29 | Concert Pharmaceuticals Inc. | 3-(dihydro-1h-pyrazolo[4,3-d]pyrimidin-5-yl)-4-propoxybenzenesulfonamide derivatives and methods of use |
| US20090197899A1 (en) | 2006-10-20 | 2009-08-06 | Concert Pharmaceuticals Inc. | 3-(Dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-propoxybenzenesulfonamide Derivatives and Methods of Use |
-
2007
- 2007-10-22 US US11/876,754 patent/US8552008B2/en not_active Expired - Fee Related
- 2007-10-22 MX MX2009003941A patent/MX2009003941A/es not_active Application Discontinuation
- 2007-10-22 EP EP07871209A patent/EP2089392A4/en not_active Withdrawn
- 2007-10-22 CA CA002664940A patent/CA2664940A1/en not_active Abandoned
- 2007-10-22 AU AU2007329728A patent/AU2007329728A1/en not_active Abandoned
- 2007-10-22 WO PCT/US2007/082157 patent/WO2008070313A2/en not_active Ceased
- 2007-10-22 JP JP2009533595A patent/JP2010507593A/ja active Pending
- 2007-10-22 CN CNA2007800390918A patent/CN101528747A/zh active Pending
- 2007-10-22 KR KR1020097010321A patent/KR20090091138A/ko not_active Ceased
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