JP2010507593A5 - - Google Patents
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- Publication number
- JP2010507593A5 JP2010507593A5 JP2009533595A JP2009533595A JP2010507593A5 JP 2010507593 A5 JP2010507593 A5 JP 2010507593A5 JP 2009533595 A JP2009533595 A JP 2009533595A JP 2009533595 A JP2009533595 A JP 2009533595A JP 2010507593 A5 JP2010507593 A5 JP 2010507593A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- compound according
- pharmaceutical composition
- compound
- erectile dysfunction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 9
- 239000008194 pharmaceutical composition Substances 0.000 claims 7
- 239000000203 mixture Substances 0.000 claims 5
- 208000010228 Erectile Dysfunction Diseases 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 201000001881 impotence Diseases 0.000 claims 4
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 claims 3
- 208000004403 Prostatic Hyperplasia Diseases 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 206010064911 Pulmonary arterial hypertension Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 claims 1
- 101100189582 Dictyostelium discoideum pdeD gene Proteins 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- 101150098694 PDE5A gene Proteins 0.000 claims 1
- 102100029175 cGMP-specific 3',5'-cyclic phosphodiesterase Human genes 0.000 claims 1
- 229910052805 deuterium Inorganic materials 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 230000000155 isotopic effect Effects 0.000 claims 1
- 230000000144 pharmacologic effect Effects 0.000 claims 1
- 210000001147 pulmonary artery Anatomy 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US85323406P | 2006-10-20 | 2006-10-20 | |
| PCT/US2007/082157 WO2008070313A2 (en) | 2006-10-20 | 2007-10-22 | 3-(dihydro-1h-pyrazolo [4,3-d] pyrimidin-5-yl)-4-propoxybenzenesulfonamide derivatives and methods of use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010507593A JP2010507593A (ja) | 2010-03-11 |
| JP2010507593A5 true JP2010507593A5 (enExample) | 2010-12-16 |
Family
ID=39492926
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009533595A Pending JP2010507593A (ja) | 2006-10-20 | 2007-10-22 | ３−（ジヒドロ−１Ｈ−ピラゾロ［４，３−ｄ］ピリミジン−５−イル）−４−プロポキシベンゼンスルホンアミド誘導体および使用方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US8552008B2 (enExample) |
| EP (1) | EP2089392A4 (enExample) |
| JP (1) | JP2010507593A (enExample) |
| KR (1) | KR20090091138A (enExample) |
| CN (1) | CN101528747A (enExample) |
| AU (1) | AU2007329728A1 (enExample) |
| CA (1) | CA2664940A1 (enExample) |
| MX (1) | MX2009003941A (enExample) |
| WO (1) | WO2008070313A2 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090270425A1 (en) * | 2006-10-20 | 2009-10-29 | Concert Pharmaceuticals Inc. | 3-(dihydro-1h-pyrazolo[4,3-d]pyrimidin-5-yl)-4-propoxybenzenesulfonamide derivatives and methods of use |
| US20090197899A1 (en) * | 2006-10-20 | 2009-08-06 | Concert Pharmaceuticals Inc. | 3-(Dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-propoxybenzenesulfonamide Derivatives and Methods of Use |
| KR101071877B1 (ko) * | 2009-02-18 | 2011-10-10 | 동아제약주식회사 | 유데나필 산부가염, 그의 제조방법 및 이를 포함하는 약학적 조성물 |
| US20180072718A1 (en) | 2016-09-09 | 2018-03-15 | Incyte Corporation | Pyrazolopyridine compounds and uses thereof |
| IL292977A (en) | 2016-09-09 | 2022-07-01 | Incyte Corp | Pyrazolopyridine derivatives as modulators of hpk1 and their use in cancer therapy |
| AR109595A1 (es) | 2016-09-09 | 2018-12-26 | Incyte Corp | Compuestos de pirazolopirimidina y usos de estos como inhibidores de hpk1 |
| WO2018152220A1 (en) | 2017-02-15 | 2018-08-23 | Incyte Corporation | Pyrazolopyridine compounds and uses thereof |
| US10722495B2 (en) | 2017-09-08 | 2020-07-28 | Incyte Corporation | Cyanoindazole compounds and uses thereof |
| US10752635B2 (en) | 2018-02-20 | 2020-08-25 | Incyte Corporation | Indazole compounds and uses thereof |
| US10745388B2 (en) | 2018-02-20 | 2020-08-18 | Incyte Corporation | Indazole compounds and uses thereof |
| JP7526673B2 (ja) | 2018-02-20 | 2024-08-01 | インサイト・コーポレイション | がんを治療するためのｈｐｋ１阻害剤としてのｎ－（フェニル）－２－（フェニル）ピリミジン－４－カルボキサミド誘導体及び関連化合物 |
| US11299473B2 (en) | 2018-04-13 | 2022-04-12 | Incyte Corporation | Benzimidazole and indole compounds and uses thereof |
| US10899755B2 (en) | 2018-08-08 | 2021-01-26 | Incyte Corporation | Benzothiazole compounds and uses thereof |
| ES2973117T3 (es) | 2018-09-25 | 2024-06-18 | Incyte Corp | Compuestos de pirazolo[4,3-d]pirimidina como moduladores de ALK2 y/o FGFR |
| KR20220059480A (ko) | 2019-08-06 | 2022-05-10 | 인사이트 코포레이션 | 고체 형태의 hpk1 억제제 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6221335B1 (en) * | 1994-03-25 | 2001-04-24 | Isotechnika, Inc. | Method of using deuterated calcium channel blockers |
| KR100353014B1 (ko) * | 1998-11-11 | 2002-09-18 | 동아제약 주식회사 | 발기부전 치료에 효과를 갖는 피라졸로피리미디논 화합물 |
| US6440710B1 (en) * | 1998-12-10 | 2002-08-27 | The Scripps Research Institute | Antibody-catalyzed deuteration, tritiation, dedeuteration or detritiation of carbonyl compounds |
| DK1104760T3 (da) * | 1999-12-03 | 2003-06-30 | Pfizer Prod Inc | Sulfamoylheteroarylpyrazolforbindelser som anti-inflammatoriske/analgetiske midler |
| TW200413273A (en) * | 2002-11-15 | 2004-08-01 | Wako Pure Chem Ind Ltd | Heavy hydrogenation method of heterocyclic rings |
| JP2009502961A (ja) | 2005-07-29 | 2009-01-29 | コンサート ファーマシューティカルズ インコーポレイテッド | 新規な医薬組成物 |
| US7598273B2 (en) * | 2005-10-06 | 2009-10-06 | Auspex Pharmaceuticals, Inc | Inhibitors of the gastric H+, K+-ATPase with enhanced therapeutic properties |
| US7750168B2 (en) * | 2006-02-10 | 2010-07-06 | Sigma-Aldrich Co. | Stabilized deuteroborane-tetrahydrofuran complex |
| US20080103122A1 (en) * | 2006-09-05 | 2008-05-01 | Schering Corporation | Pharmaceutical combinations for lipid management and in the treatment of atherosclerosis and hepatic steatosis |
| US20090270425A1 (en) * | 2006-10-20 | 2009-10-29 | Concert Pharmaceuticals Inc. | 3-(dihydro-1h-pyrazolo[4,3-d]pyrimidin-5-yl)-4-propoxybenzenesulfonamide derivatives and methods of use |
| US20080280927A1 (en) | 2006-10-20 | 2008-11-13 | Concert Pharmaceuticals Inc. | 3-(dihydro-1h-pyrazolo[4,3-d]pyrimidin-5-yl)-4-propoxybenzenesulfonamide derivatives and methods of use |
| US20090197899A1 (en) * | 2006-10-20 | 2009-08-06 | Concert Pharmaceuticals Inc. | 3-(Dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-propoxybenzenesulfonamide Derivatives and Methods of Use |
-
2007
- 2007-10-22 WO PCT/US2007/082157 patent/WO2008070313A2/en not_active Ceased
- 2007-10-22 US US11/876,754 patent/US8552008B2/en not_active Expired - Fee Related
- 2007-10-22 EP EP07871209A patent/EP2089392A4/en not_active Withdrawn
- 2007-10-22 MX MX2009003941A patent/MX2009003941A/es not_active Application Discontinuation
- 2007-10-22 CA CA002664940A patent/CA2664940A1/en not_active Abandoned
- 2007-10-22 JP JP2009533595A patent/JP2010507593A/ja active Pending
- 2007-10-22 AU AU2007329728A patent/AU2007329728A1/en not_active Abandoned
- 2007-10-22 KR KR1020097010321A patent/KR20090091138A/ko not_active Ceased
- 2007-10-22 CN CNA2007800390918A patent/CN101528747A/zh active Pending
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