JP2006502134A5 - - Google Patents
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- Publication number
- JP2006502134A5 JP2006502134A5 JP2004527914A JP2004527914A JP2006502134A5 JP 2006502134 A5 JP2006502134 A5 JP 2006502134A5 JP 2004527914 A JP2004527914 A JP 2004527914A JP 2004527914 A JP2004527914 A JP 2004527914A JP 2006502134 A5 JP2006502134 A5 JP 2006502134A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- oxadiazol
- ylmethyl
- piperidin
- benzonitrile
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000000217 alkyl group Chemical group 0.000 claims 111
- JFDZBHWFFUWGJE-UHFFFAOYSA-N benzonitrile Substances N#CC1=CC=CC=C1 JFDZBHWFFUWGJE-UHFFFAOYSA-N 0.000 claims 44
- -1 3- (2,3-dimethoxyphenyl) -5- [1- (phenylmethyl) -2-pyrrolidinyl] -1,2,4-oxadiazole Chemical compound 0.000 claims 21
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 15
- 201000010099 disease Diseases 0.000 claims 12
- 125000004429 atom Chemical group 0.000 claims 9
- 229910052799 carbon Inorganic materials 0.000 claims 9
- 229910052757 nitrogen Inorganic materials 0.000 claims 9
- 229910052760 oxygen Inorganic materials 0.000 claims 9
- 229910052717 sulfur Inorganic materials 0.000 claims 9
- 150000001875 compounds Chemical class 0.000 claims 8
- 102000012777 Metabotropic Glutamate 5 Receptor Human genes 0.000 claims 7
- 108010065028 Metabotropic Glutamate 5 Receptor Proteins 0.000 claims 7
- 229910052739 hydrogen Inorganic materials 0.000 claims 7
- 239000001257 hydrogen Substances 0.000 claims 7
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 7
- 230000001404 mediated effect Effects 0.000 claims 7
- 125000002877 alkyl aryl group Chemical group 0.000 claims 6
- 125000001475 halogen functional group Chemical group 0.000 claims 6
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 6
- 125000004043 oxo group Chemical group O=* 0.000 claims 5
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- JRSWALOPXPBCPG-UHFFFAOYSA-N 3-(3-methylphenyl)-5-[1-(pyridin-2-ylmethyl)piperidin-2-yl]-1,2,4-oxadiazole Chemical compound CC1=CC=CC(C=2N=C(ON=2)C2N(CCCC2)CC=2N=CC=CC=2)=C1 JRSWALOPXPBCPG-UHFFFAOYSA-N 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 2
- 208000019901 Anxiety disease Diseases 0.000 claims 2
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 2
- 206010019196 Head injury Diseases 0.000 claims 2
- 208000013016 Hypoglycemia Diseases 0.000 claims 2
- 208000002193 Pain Diseases 0.000 claims 2
- 208000018737 Parkinson disease Diseases 0.000 claims 2
- 208000027418 Wounds and injury Diseases 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000005213 alkyl heteroaryl group Chemical group 0.000 claims 2
- 125000000304 alkynyl group Chemical group 0.000 claims 2
- 230000036506 anxiety Effects 0.000 claims 2
- 230000006378 damage Effects 0.000 claims 2
- 206010015037 epilepsy Diseases 0.000 claims 2
- 230000002218 hypoglycaemic effect Effects 0.000 claims 2
- 208000014674 injury Diseases 0.000 claims 2
- 208000037906 ischaemic injury Diseases 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 208000004296 neuralgia Diseases 0.000 claims 2
- 230000004770 neurodegeneration Effects 0.000 claims 2
- 208000015122 neurodegenerative disease Diseases 0.000 claims 2
- 208000021722 neuropathic pain Diseases 0.000 claims 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
- SOQLQSYJDARMFJ-UHFFFAOYSA-N 2-[[2-[3-(3-cyanophenyl)-1,2,4-oxadiazol-5-yl]piperidin-1-yl]methyl]-1,3-thiazole-4-carbonitrile Chemical compound N#CC1=CSC(CN2C(CCCC2)C=2ON=C(N=2)C=2C=C(C=CC=2)C#N)=N1 SOQLQSYJDARMFJ-UHFFFAOYSA-N 0.000 claims 1
- CRHDBAIOECFMNV-UHFFFAOYSA-N 3-(3-chlorophenyl)-5-[1-(pyridin-2-ylmethyl)piperidin-2-yl]-1,2,4-oxadiazole Chemical compound ClC1=CC=CC(C=2N=C(ON=2)C2N(CCCC2)CC=2N=CC=CC=2)=C1 CRHDBAIOECFMNV-UHFFFAOYSA-N 0.000 claims 1
- JCQVILDTFNPCQD-UHFFFAOYSA-N 3-(3-ethylphenyl)-5-[1-(pyridin-2-ylmethyl)piperidin-2-yl]-1,2,4-oxadiazole Chemical compound CCC1=CC=CC(C=2N=C(ON=2)C2N(CCCC2)CC=2N=CC=CC=2)=C1 JCQVILDTFNPCQD-UHFFFAOYSA-N 0.000 claims 1
- KMCWHZPMGGCHIK-UHFFFAOYSA-N 3-(3-fluoro-5-imidazol-1-ylphenyl)-5-[1-(pyridin-2-ylmethyl)piperidin-2-yl]-1,2,4-oxadiazole Chemical compound C=1C(F)=CC(C=2N=C(ON=2)C2N(CCCC2)CC=2N=CC=CC=2)=CC=1N1C=CN=C1 KMCWHZPMGGCHIK-UHFFFAOYSA-N 0.000 claims 1
- UEUYNVNBEXGSOM-UHFFFAOYSA-N 3-(3-methoxyphenyl)-5-[1-(pyridin-2-ylmethyl)piperidin-2-yl]-1,2,4-oxadiazole Chemical compound COC1=CC=CC(C=2N=C(ON=2)C2N(CCCC2)CC=2N=CC=CC=2)=C1 UEUYNVNBEXGSOM-UHFFFAOYSA-N 0.000 claims 1
- MUWLZOUUKMVYEQ-UHFFFAOYSA-N 3-[3-(3-chlorophenyl)-1,2,4-oxadiazol-5-yl]-4-(1,3-thiazol-2-ylmethyl)morpholine Chemical compound ClC1=CC=CC(C=2N=C(ON=2)C2N(CCOC2)CC=2SC=CN=2)=C1 MUWLZOUUKMVYEQ-UHFFFAOYSA-N 0.000 claims 1
- GTZFPOKFRGLTNQ-AWEZNQCLSA-N 3-[5-[(2s)-1-(1,3-thiazol-2-ylmethyl)pyrrolidin-2-yl]-1,2,4-oxadiazol-3-yl]benzonitrile Chemical compound N#CC1=CC=CC(C=2N=C(ON=2)[C@H]2N(CCC2)CC=2SC=CN=2)=C1 GTZFPOKFRGLTNQ-AWEZNQCLSA-N 0.000 claims 1
- NFDNFXGXISIHBR-UHFFFAOYSA-N 3-[5-[1-(quinolin-2-ylmethyl)piperidin-2-yl]-1,2,4-oxadiazol-3-yl]benzonitrile Chemical compound N#CC1=CC=CC(C=2N=C(ON=2)C2N(CCCC2)CC=2N=C3C=CC=CC3=CC=2)=C1 NFDNFXGXISIHBR-UHFFFAOYSA-N 0.000 claims 1
- ZLJYWKHFOAZQKU-UHFFFAOYSA-N 3-methoxy-5-[3-[1-(pyridin-2-ylmethyl)piperidin-2-yl]-1,2,4-oxadiazol-5-yl]benzonitrile Chemical compound COC1=CC(C#N)=CC(C=2ON=C(N=2)C2N(CCCC2)CC=2N=CC=CC=2)=C1 ZLJYWKHFOAZQKU-UHFFFAOYSA-N 0.000 claims 1
- HSHDPJHECYAPOJ-UHFFFAOYSA-N 3-phenyl-5-[1-(pyridin-2-ylmethyl)piperidin-2-yl]-1,2,4-oxadiazole Chemical compound C=1C=CC=NC=1CN1CCCCC1C(ON=1)=NC=1C1=CC=CC=C1 HSHDPJHECYAPOJ-UHFFFAOYSA-N 0.000 claims 1
- MQNJRODJEBAUQQ-UHFFFAOYSA-N 5-(3-methoxyphenyl)-3-[1-(pyridin-2-ylmethyl)piperidin-2-yl]-1,2,4-oxadiazole Chemical compound COC1=CC=CC(C=2ON=C(N=2)C2N(CCCC2)CC=2N=CC=CC=2)=C1 MQNJRODJEBAUQQ-UHFFFAOYSA-N 0.000 claims 1
- JZALMAHWFNMKOZ-UHFFFAOYSA-N 5-(3-methylphenyl)-3-[1-(pyridin-2-ylmethyl)piperidin-2-yl]-1,2,4-oxadiazole Chemical compound CC1=CC=CC(C=2ON=C(N=2)C2N(CCCC2)CC=2N=CC=CC=2)=C1 JZALMAHWFNMKOZ-UHFFFAOYSA-N 0.000 claims 1
- SGVJZWFVMHFQJK-UHFFFAOYSA-N 5-[1-(pyridin-2-ylmethyl)piperidin-2-yl]-3-thiophen-2-yl-1,2,4-oxadiazole Chemical compound C=1C=CC=NC=1CN1CCCCC1C(ON=1)=NC=1C1=CC=CS1 SGVJZWFVMHFQJK-UHFFFAOYSA-N 0.000 claims 1
- DAGHUOKMGWCJLR-UHFFFAOYSA-N 6-[[2-[3-(3-cyanophenyl)-1,2,4-oxadiazol-5-yl]piperidin-1-yl]methyl]pyridine-3-carbonitrile Chemical compound N1=CC(C#N)=CC=C1CN1C(C=2ON=C(N=2)C=2C=C(C=CC=2)C#N)CCCC1 DAGHUOKMGWCJLR-UHFFFAOYSA-N 0.000 claims 1
- 206010065390 Inflammatory pain Diseases 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 208000019695 Migraine disease Diseases 0.000 claims 1
- 208000012902 Nervous system disease Diseases 0.000 claims 1
- 208000025966 Neurological disease Diseases 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 208000005298 acute pain Diseases 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 208000022371 chronic pain syndrome Diseases 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 206010027599 migraine Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 208000020016 psychiatric disease Diseases 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40203802P | 2002-08-09 | 2002-08-09 | |
| PCT/US2003/024915 WO2004014902A2 (en) | 2002-08-09 | 2003-08-08 | Compounds having an activity at metabotropic glutamate receptors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006502134A JP2006502134A (ja) | 2006-01-19 |
| JP2006502134A5 true JP2006502134A5 (enExample) | 2006-09-28 |
Family
ID=31715775
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004527914A Pending JP2006502134A (ja) | 2002-08-09 | 2003-08-08 | 代謝調節型グルタミン酸受容体において活性を有する化合物 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7074809B2 (enExample) |
| EP (1) | EP1581525A2 (enExample) |
| JP (1) | JP2006502134A (enExample) |
| AU (1) | AU2003264018A1 (enExample) |
| CA (1) | CA2495179A1 (enExample) |
| MX (1) | MXPA05001590A (enExample) |
| WO (1) | WO2004014902A2 (enExample) |
Families Citing this family (84)
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| US7585881B2 (en) * | 2004-02-18 | 2009-09-08 | Astrazeneca Ab | Additional heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists |
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| ES2346685T3 (es) * | 2005-01-14 | 2010-10-19 | F. Hoffmann-La Roche Ag | Deribados de tiazol-4-carboxamida como antagonistas de mglur5. |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3740434A (en) | 1966-12-23 | 1973-06-19 | American Cyanamid Co | Substituted nitroimidazolylthiadiazoles and oxadiazoles as antiprotozoal agents |
| IL31990A (en) | 1968-04-26 | 1974-05-16 | Chinoin Gyogyszer Es Vegyeszet | Pyridyl 1,2,4-oxadiazole derivatives,process for the preparation thereof and pharmaceutical compositions containing same |
| US3816426A (en) * | 1970-10-27 | 1974-06-11 | Abbott Lab | 1-(5-phenyl-4-oxo-2-oxazolin-2-yl)piperazines |
| US4022901A (en) | 1975-03-05 | 1977-05-10 | E. R. Squibb & Sons, Inc. | 3-Pyridinyl-5-isothiocyanophenyl oxadiazoles |
| JPS56127364A (en) * | 1980-03-01 | 1981-10-06 | Mitsui Toatsu Chem Inc | Novel piperazine compound, its preparation and utilization |
| JP3003148B2 (ja) | 1989-01-05 | 2000-01-24 | 藤沢薬品工業株式会社 | チアゾール化合物、その製造法およびそれを含有する医薬組成物 |
| IL96891A0 (en) * | 1990-01-17 | 1992-03-29 | Merck Sharp & Dohme | Indole-substituted five-membered heteroaromatic compounds,their preparation and pharmaceutical compositions containing them |
| AU678186B2 (en) * | 1992-10-23 | 1997-05-22 | Merck Sharp & Dohme Limited | Dopamine receptor subtype ligands |
| US6589969B1 (en) * | 1998-10-16 | 2003-07-08 | Ono Pharmaceutical Co., Ltd. | Carboxylic acid derivatives and drugs containing the same as the active ingredient |
| DE19858191A1 (de) | 1998-12-17 | 2000-06-21 | Aventis Cropscience Gmbh | 4-Haloalkyl-3-heterocyclylpyridine und 4-Haloalkyl-5-heterocyclyl-pyrimidine und ihre Verwendung als Repellentien |
| CO5170501A1 (es) | 1999-04-14 | 2002-06-27 | Novartis Ag | AZOLES SUSTITUIDOS UTILES PARA EL TRATAMIENTO DE ENFERMEDADES MEDIADAS POR TNFa eIL-1 Y ENFERMEDADES DEL METABOLISMO OSEO |
| ATE307129T1 (de) * | 1999-08-19 | 2005-11-15 | Nps Pharma Inc | Heteropolycyclische verbindungen und ihre verwendung als antagonisten von metabotropen glutamatrezeptoren |
| TWI283577B (en) * | 1999-10-11 | 2007-07-11 | Sod Conseils Rech Applic | Pharmaceutical composition of imidazole derivatives acting as modulators of sodium channels and the use thereof |
| US6800647B2 (en) * | 2000-05-26 | 2004-10-05 | Merck & Co., Inc. | 5-chloro-3-(4-methanesulfonylphenyl)-6'-methyl-[2,3]bipyridinyl in pure crystalline form and process for synthesis |
| WO2002024680A1 (en) * | 2000-09-21 | 2002-03-28 | Smithkline Beecham P.L.C. | Imidazole derivatives as raf kinase inhibitors |
| AU2479702A (en) | 2000-10-30 | 2002-05-15 | Janssen Pharmaceutica Nv | Tripeptidyl peptidase inhibitors |
| NZ525917A (en) | 2000-12-04 | 2005-11-25 | F | Phenylethenyl or phenylethinyl derivatives as glutamate receptor antagonists and their use in treating mGLuR5 receptor mediated disorders |
| GB0113233D0 (en) * | 2001-05-31 | 2001-07-25 | Glaxo Group Ltd | Chemical compounds |
| GB0115862D0 (en) | 2001-06-28 | 2001-08-22 | Smithkline Beecham Plc | Compounds |
| ES2240661T3 (es) * | 2001-07-05 | 2005-10-16 | Pfizer Products Inc. | Sulfonil-heteroaril-triazoles como agentes antiinflamatorios y analgesicos. |
| MXPA04000565A (es) | 2001-07-19 | 2005-06-17 | Cv Therapeutics Inc | Compuestos de piperazina sustituidos y su uso como inhibidores de oxidacion de acidos grasos. |
| AR036873A1 (es) * | 2001-09-07 | 2004-10-13 | Euro Celtique Sa | Piridinas aril sustituidas a, composiciones farmaceuticas y el uso de las mismas para la preparacion de un medicamento |
| US6864268B2 (en) * | 2002-02-27 | 2005-03-08 | Pfizer Inc. | β3 adrenergic receptor agonists |
-
2003
- 2003-08-08 AU AU2003264018A patent/AU2003264018A1/en not_active Abandoned
- 2003-08-08 JP JP2004527914A patent/JP2006502134A/ja active Pending
- 2003-08-08 CA CA002495179A patent/CA2495179A1/en not_active Abandoned
- 2003-08-08 EP EP03785076A patent/EP1581525A2/en not_active Withdrawn
- 2003-08-08 US US10/636,977 patent/US7074809B2/en not_active Expired - Fee Related
- 2003-08-08 WO PCT/US2003/024915 patent/WO2004014902A2/en not_active Ceased
- 2003-08-08 MX MXPA05001590A patent/MXPA05001590A/es unknown
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