JP2005534715A - カンナビノイドレセプタ配位子 - Google Patents

カンナビノイドレセプタ配位子 Download PDF

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JP2005534715A
JP2005534715A JP2004527741A JP2004527741A JP2005534715A JP 2005534715 A JP2005534715 A JP 2005534715A JP 2004527741 A JP2004527741 A JP 2004527741A JP 2004527741 A JP2004527741 A JP 2004527741A JP 2005534715 A JP2005534715 A JP 2005534715A
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JP2005534715A5 (enExample
Inventor
ジョセフ エー. コズロウスキー,
シー, ネン−ヤン
ブライアン ジェイ. ラビー,
ラジア ケー. リズビ,
バンダーペール ビー. シャンカー,
ジェームス エム. スピットラー,
リン トン,
ウォリン, ロナルド
マイケル ケー. ウォン,
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Merck Sharp and Dohme LLC
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Schering Corp
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Publication of JP2005534715A publication Critical patent/JP2005534715A/ja
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009544755A (ja) * 2006-07-28 2009-12-17 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Cb2受容体を変調する化合物

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001038322A1 (en) 1999-11-23 2001-05-31 Methylgene, Inc. Inhibitors of histone deacetylase
US7507767B2 (en) * 2001-02-08 2009-03-24 Schering Corporation Cannabinoid receptor ligands
KR20100107509A (ko) 2001-09-14 2010-10-05 9222-9129 퀘벡 인코포레이티드 히스톤 데아세틸라아제의 억제제
US6897220B2 (en) 2001-09-14 2005-05-24 Methylgene, Inc. Inhibitors of histone deacetylase
US7868204B2 (en) 2001-09-14 2011-01-11 Methylgene Inc. Inhibitors of histone deacetylase
HUP0401924A3 (en) * 2001-11-14 2009-07-28 Schering Corp Cannabinoid receptor ligands, their use and pharmaceutical compositions containing them
JP2005533809A (ja) * 2002-06-19 2005-11-10 シェーリング コーポレイション カンナビノイドレセプタアゴニスト
TW200413297A (en) 2002-11-25 2004-08-01 Schering Corp Cannabinoid receptor ligands
WO2004113320A1 (en) * 2003-05-20 2004-12-29 The University Of Tennessee Research Foundation Cannabinoid derivatives, methods of making, and use thereof
EP1663953A1 (en) * 2003-09-24 2006-06-07 Methylgene, Inc. Inhibitors of histone deacetylase
AU2004287849A1 (en) * 2003-10-30 2005-05-19 Merck Sharp & Dohme Corp. Aralkyl amines as cannabinoid receptor modulators
US7253204B2 (en) * 2004-03-26 2007-08-07 Methylgene Inc. Inhibitors of histone deacetylase
GB2431105A (en) * 2005-10-12 2007-04-18 Gw Pharma Ltd Cannabinoids for the treatment of pulmonary disorders
CN101466670B (zh) * 2006-04-07 2013-04-17 梅特希尔基因公司 组蛋白脱乙酰酶抑制剂
US7928123B2 (en) 2006-09-25 2011-04-19 Boehringer Ingelheim International Gmbh Compounds which modulate the CB2 receptor
CA2679185A1 (en) 2007-02-28 2008-09-04 Advinus Therapeutics Private Limited 2,2,2-tri-substituted acetamide derivatives as glucokinase activators, their process and pharmaceutical application
CN101668425A (zh) * 2007-03-02 2010-03-10 田纳西州立大学研究基金会 三芳基/杂芳族大麻素类和其应用
WO2009011850A2 (en) * 2007-07-16 2009-01-22 Abbott Laboratories Novel therapeutic compounds
CA2704684A1 (en) 2007-11-07 2009-05-14 Boehringer Ingelheim International Gmbh Compounds which modulate the cb2 receptor
WO2010005782A1 (en) 2008-07-10 2010-01-14 Boehringer Ingelheim International Gmbh Sulfone compounds which modulate the cb2 receptor
PE20110397A1 (es) 2008-09-25 2011-07-01 Boehringer Ingelheim Int Compuestos que modulan selectivamente el receptor cb2
CN102573480B (zh) 2009-06-09 2015-06-10 加利福尼亚资本权益有限责任公司 三嗪衍生物及其治疗应用
KR20120026612A (ko) 2009-06-09 2012-03-19 아브락시스 바이오사이언스, 엘엘씨 벤질 치환 트리아진 유도체와 이들의 치료적 용도
KR20120018224A (ko) 2009-06-09 2012-02-29 아브락시스 바이오사이언스, 엘엘씨 헷지호그 신호전달 억제제로서의 이소퀴놀린, 퀴놀린 및 퀴나졸린 유도체
US8299103B2 (en) 2009-06-15 2012-10-30 Boehringer Ingelheim International Gmbh Compounds which selectively modulate the CB2 receptor
WO2010147791A1 (en) 2009-06-16 2010-12-23 Boehringer Ingelheim International Gmbh Azetidine 2 -carboxamide derivatives which modulate the cb2 receptor
JP2013505295A (ja) 2009-09-22 2013-02-14 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Cb2受容体を選択的に調節する化合物
WO2011088015A1 (en) 2010-01-15 2011-07-21 Boehringer Ingelheim International Gmbh Compounds which modulate the cb2 receptor
EP2542539B1 (en) 2010-03-05 2014-02-26 Boehringer Ingelheim International GmbH Tetrazole compounds which selectively modulate the cb2 receptor
WO2012012307A1 (en) 2010-07-22 2012-01-26 Boehringer Ingelheim International Gmbh Sulfonyl compounds which modulate the cb2 rece
WO2012014127A1 (en) 2010-07-30 2012-02-02 Ranbaxy Laboratories Limited 5-lipoxygenase inhibitors
TW201329025A (zh) 2011-11-01 2013-07-16 Astex Therapeutics Ltd 醫藥化合物
CN104136021B (zh) 2012-03-14 2016-04-20 中国中化股份有限公司 取代二苯胺类化合物作为制备抗肿瘤药物的应用
TW201512171A (zh) 2013-04-19 2015-04-01 Pfizer Ltd 化學化合物
EP2803668A1 (en) 2013-05-17 2014-11-19 Boehringer Ingelheim International Gmbh Novel (cyano-dimethyl-methyl)-isoxazoles and -[1,3,4]thiadiazoles
US9636298B2 (en) 2014-01-17 2017-05-02 Methylgene Inc. Prodrugs of compounds that enhance antifungal activity and compositions of said prodrugs
JP6769963B2 (ja) 2014-08-29 2020-10-14 ティエエッセ ファルマ ソチエタ レスポンサビリタ リミタータ α−アミノ−β−カルボキシムコン酸セミアルデヒド脱炭酸酵素の阻害剤
CN112552200B (zh) * 2019-09-10 2024-03-12 烟台药物研究所 一种光学纯4-(1-氨基)乙基苯甲酸酯及其盐的制备方法

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0673014A (ja) * 1992-06-23 1994-03-15 Elf Sanofi 新規なピラゾール誘導体、それらを調製する方法、及びこれらを含有する薬学的組成物
JPH10508870A (ja) * 1995-02-15 1998-09-02 メルク フロスト カナダ インコーポレーテツド カンナビノイド受容体への親和性を有するインドール誘導体
JP2000514060A (ja) * 1996-07-01 2000-10-24 シェーリング コーポレイション ムスカリン様アンタゴニスト
JP2001508799A (ja) * 1997-01-21 2001-07-03 スミスクライン・ビーチャム・コーポレイション 新規カンナビノイド受容体モジュレータ
JP2003512326A (ja) * 1999-10-18 2003-04-02 ユニヴァーシティ オブ コネチカット カンナビノイド相似インドール誘導体
JP2005530797A (ja) * 2002-05-17 2005-10-13 サノフィ−アベンティス インドール誘導体およびcb2レセプターリガンドとしてのそれらの使用
JP2005533809A (ja) * 2002-06-19 2005-11-10 シェーリング コーポレイション カンナビノイドレセプタアゴニスト
JP2009024011A (ja) * 2001-02-08 2009-02-05 Schering Corp カンナビノイドレセプターリガンド

Family Cites Families (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3715375A (en) * 1970-09-17 1973-02-06 Merck & Co Inc New diphenyl sulfones
US4170648A (en) 1972-05-26 1979-10-09 Rohm And Haas Company Phosphonothioureide anthelmintics
DE3039208A1 (de) 1980-10-17 1982-05-13 Basf Ag, 6700 Ludwigshafen Neue sulfone, deren herstellung und verwendung
DE3118126A1 (de) 1981-05-07 1982-12-02 Bayer Ag, 5090 Leverkusen Sulfenamide zur verwendung in arzneimitteln
US4618363A (en) 1982-01-25 1986-10-21 Ciba-Geigy Corporation N-phenylsulfonyl-N'-triazinylureas
US4468389A (en) 1982-05-21 1984-08-28 Rohm And Haas Company Pesticidal N-sulfonyl phosphorodiamido(di)thioates
US4466965A (en) * 1982-07-26 1984-08-21 American Hospital Supply Corporation Phthalazine compounds, compositions and use
US4567184A (en) * 1982-12-01 1986-01-28 Usv Pharmaceutical Corporation Certain aryl or hetero-aryl derivatives of 1-hydroxy-pentane or 1-hydroxy-hexane which are useful for treating inflammation and allergies
NO174506B (no) 1984-10-30 1994-02-07 Usv Pharma Corp Analogifremgangsmaate ved fremstilling av terapeutisk aktive forbindelser
US4781866A (en) 1985-03-15 1988-11-01 Mcneilab, Inc. Process for producing amidine sulfonic acid intermediates for guanidines
US4678855A (en) 1985-10-09 1987-07-07 Merck & Co., Inc. Substituted benzenesulfonamides
HU201455B (en) 1986-03-31 1990-11-28 Rhone Poulenc Bv Synergetic compositions regulating the growth of plants
DE3788629T2 (de) 1986-03-31 1994-04-28 Rhone Poulenc Bv Neue malonsäurederivate und zusammensetzungen, die sie enthalten, zur verzögerung des pflanzenwachstums.
DE3634926A1 (de) 1986-10-14 1988-04-21 Bayer Ag Verfahren zur herstellung von o-aryl-n'-pyrimidin-2-yl-isoharnstoffen
DE3634927A1 (de) 1986-10-14 1988-04-21 Bayer Ag Verfahren zur herstellung von sulfonylisothioharnstoffen
US4851423A (en) 1986-12-10 1989-07-25 Schering Corporation Pharmaceutically active compounds
NZ232493A (en) 1989-02-14 1992-06-25 Toyama Chemical Co Ltd Aryl- or heterocyclyl-substituted 1,2-ethanediol derivatives and pharmaceutical compositions
US5064825A (en) 1989-06-01 1991-11-12 Merck & Co., Inc. Angiotensin ii antagonists
WO1991000858A1 (en) 1989-07-07 1991-01-24 Schering Corporation Pharmaceutically active compounds
IT1240676B (it) 1990-04-24 1993-12-17 Agrimont Spa Composizioni ad attivita' erbicida
NZ239846A (en) 1990-09-27 1994-11-25 Merck & Co Inc Sulphonamide derivatives and pharmaceutical compositions thereof
US5332820A (en) * 1991-05-20 1994-07-26 E. I. Du Pont De Nemours And Company Dibenzobicyclo(2.2.2) octane angiotensin II antagonists
CA2111957A1 (en) 1991-06-27 1993-01-07 Richard A. Glennon Sigma receptor ligands and the use thereof
US5506227A (en) 1992-04-13 1996-04-09 Merck Frosst Canada, Inc. Pyridine-substituted benzyl alcohols as leukotriene antagonists
JPH0672979A (ja) 1992-06-08 1994-03-15 Hiroyoshi Hidaka アミノベンジル誘導体
US5338753A (en) * 1992-07-14 1994-08-16 Sumner H. Burstein (3R,4R)-Δ6 -tetrahydrocannabinol-7-oic acids useful as antiinflammatory agents and analgesics
GB9218834D0 (en) 1992-09-05 1992-10-21 Procter & Gamble Nasal spray products
WO1995000491A1 (en) 1993-06-17 1995-01-05 Dunlena Pty Ltd. Arthropodicidal sulfonates
US5486525A (en) * 1993-12-16 1996-01-23 Abbott Laboratories Platelet activating factor antagonists: imidazopyridine indoles
FR2714057B1 (fr) * 1993-12-17 1996-03-08 Sanofi Elf Nouveaux dérivés du 3-pyrazolecarboxamide, procédé pour leur préparation et compositions pharmaceutiques les contenant.
ATE196896T1 (de) 1994-04-06 2000-10-15 Shionogi & Co Gamma-substituierte phenylessigsäurederivate, verfahren zu ihrer herstellung und sie enthaltendes bakterizid für die landwirtschaft
US5596106A (en) * 1994-07-15 1997-01-21 Eli Lilly And Company Cannabinoid receptor antagonists
IT1271266B (it) * 1994-12-14 1997-05-27 Valle Francesco Della Impiego terapeutico di ammidi di acidi mono e bicarbossilici con amminoalcoli,selettivamente attive sul recettore periferico dei cannabinoidi
NZ301265A (en) 1995-02-02 1998-12-23 Smithkline Beecham Plc Indole derivatives as 5ht receptor antagonists, preparation and pharmaceutical compositions thereof
US5700816A (en) 1995-06-12 1997-12-23 Isakson; Peter C. Treatment of inflammation and inflammation-related disorders with a combination of a cyclooxygenase-2 inhibitor and a leukotriene A4 hydrolase inhibitor
FR2735774B1 (fr) * 1995-06-21 1997-09-12 Sanofi Sa Utilisation de composes agonistes du recepteur cb2 humain pour la preparation de medicaments immunomodulateurs, nouveaux composes agonistes du recepteur cb2 et les compositions pharmaceutiques les contenant
JPH11510485A (ja) 1995-07-21 1999-09-14 ニィコメド・オーストリア・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 酵素のシクロオキシゲナーゼiiの阻害剤としてのベンゼンスルホンアミドの誘導体
DE19533644A1 (de) 1995-09-12 1997-03-13 Nycomed Arzneimittel Gmbh Neue Benzolsulfonamide
FR2742148B1 (fr) * 1995-12-08 1999-10-22 Sanofi Sa Nouveaux derives du pyrazole-3-carboxamide, procede pour leur preparation et compositions pharmaceutiques les contenant
AU1618697A (en) * 1996-02-06 1997-08-28 Japan Tobacco Inc. Novel compounds and pharmaceutical use thereof
SE9602646D0 (sv) 1996-07-04 1996-07-04 Astra Ab Pharmaceutically-useful compounds
JP2001500864A (ja) 1996-09-13 2001-01-23 メルク エンド カンパニー インコーポレーテッド トロンビン阻害物質
ATA16597A (de) 1997-02-03 1998-04-15 Nycomed Austria Gmbh Neue substituierte p-sulfonylaminobenzol- sulfonsäureamide
DE19740785A1 (de) 1997-02-21 1998-08-27 Bayer Ag Arylsulfonamide und Analoga
EP0979228A4 (en) * 1997-03-18 2000-05-03 Smithkline Beecham Corp CANNABINOID RECEPTOR AGONISTS
JP4438919B2 (ja) 1997-10-24 2010-03-24 日産化学工業株式会社 スルファモイル化合物並びに農園芸用殺菌剤
WO1999026612A1 (en) 1997-11-21 1999-06-03 Smithkline Beecham Corporation Novel cannabinoid receptor modulators
MY153569A (en) 1998-01-20 2015-02-27 Mitsubishi Tanabe Pharma Corp Inhibitors of ?4 mediated cell adhesion
NZ506435A (en) 1998-03-26 2002-08-28 Shionogi & Co 3-Indoly-2-hydroxy-4-oxo-2-butanoic acid useful as antiviral activity
CN1310621A (zh) 1998-07-28 2001-08-29 史密丝克莱恩比彻姆公司 取代的n-酰苯胺化合物和方法
WO2000056707A1 (en) 1999-03-24 2000-09-28 Sepracor, Inc. Diaryl thioethers, compositions and uses thereof
DE60038687T2 (de) 1999-09-14 2009-05-28 Shionogi & Co., Ltd. 2-imino-1,3-thiazin-derivate
EP2014285B1 (en) 1999-11-26 2010-05-05 Shionogi&Co., Ltd. NPYY5 antagonists
EP1242366A1 (en) 1999-12-15 2002-09-25 Axys Pharmaceuticals, Inc. Salicylamides as serine protease and factor xa inhibitors
EP1741713A3 (en) 1999-12-15 2009-09-09 Bristol-Myers Squibb Company Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists
ATE311366T1 (de) 2000-02-29 2005-12-15 Millennium Pharm Inc Benzamide und ähnliche inhibitoren vom faktor xa
CA2402414A1 (en) 2000-03-22 2001-09-27 Christopher Bayly Sulfur substituted aryldifluoromethylphosphonic acids as ptp-1b inhibitors
US7132567B2 (en) 2000-04-03 2006-11-07 Cerno Biosciences, Llc Generation of combinatorial synthetic libraries and screening for proadhesins and nonadhesins
CN1657523A (zh) 2000-04-28 2005-08-24 田边制药株式会社 环状化合物
AU2001258771A1 (en) 2000-05-19 2001-11-26 Takeda Chemical Industries Ltd. -secretase inhibitors
GB0028702D0 (en) 2000-11-24 2001-01-10 Novartis Ag Organic compounds
HUP0401924A3 (en) 2001-11-14 2009-07-28 Schering Corp Cannabinoid receptor ligands, their use and pharmaceutical compositions containing them

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0673014A (ja) * 1992-06-23 1994-03-15 Elf Sanofi 新規なピラゾール誘導体、それらを調製する方法、及びこれらを含有する薬学的組成物
JPH10508870A (ja) * 1995-02-15 1998-09-02 メルク フロスト カナダ インコーポレーテツド カンナビノイド受容体への親和性を有するインドール誘導体
JP2000514060A (ja) * 1996-07-01 2000-10-24 シェーリング コーポレイション ムスカリン様アンタゴニスト
JP2001508799A (ja) * 1997-01-21 2001-07-03 スミスクライン・ビーチャム・コーポレイション 新規カンナビノイド受容体モジュレータ
JP2003512326A (ja) * 1999-10-18 2003-04-02 ユニヴァーシティ オブ コネチカット カンナビノイド相似インドール誘導体
JP2009024011A (ja) * 2001-02-08 2009-02-05 Schering Corp カンナビノイドレセプターリガンド
JP4330341B2 (ja) * 2001-02-08 2009-09-16 シェーリング コーポレイション カンナビノイドレセプターリガンド
JP2005530797A (ja) * 2002-05-17 2005-10-13 サノフィ−アベンティス インドール誘導体およびcb2レセプターリガンドとしてのそれらの使用
JP2005533809A (ja) * 2002-06-19 2005-11-10 シェーリング コーポレイション カンナビノイドレセプタアゴニスト

Cited By (1)

* Cited by examiner, † Cited by third party
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JP2009544755A (ja) * 2006-07-28 2009-12-17 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Cb2受容体を変調する化合物

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AU2003257172A1 (en) 2004-02-25
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CA2494827A1 (en) 2004-02-19
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