PE20040754A1 - Ligandos de receptores canabinoides - Google Patents

Ligandos de receptores canabinoides

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Publication number
PE20040754A1
PE20040754A1 PE2003000774A PE2003000774A PE20040754A1 PE 20040754 A1 PE20040754 A1 PE 20040754A1 PE 2003000774 A PE2003000774 A PE 2003000774A PE 2003000774 A PE2003000774 A PE 2003000774A PE 20040754 A1 PE20040754 A1 PE 20040754A1
Authority
PE
Peru
Prior art keywords
alkyl
leagues
canabinoid
refers
canabinoid receptor
Prior art date
Application number
PE2003000774A
Other languages
English (en)
Spanish (es)
Inventor
Joseph A Kozlowski
Brian J Lavey
Razia K Rizvi
Bandarpalle B Shankar
Michael K Wong
James M Spitler
Ling Tong
Ronald L Wolin
Neng-Yang Shih
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of PE20040754A1 publication Critical patent/PE20040754A1/es

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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/70—Sulfur atoms
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Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101026205B1 (ko) 1999-11-23 2011-03-31 메틸진 인코포레이티드 히스톤 디아세틸라제의 억제제
US7507767B2 (en) * 2001-02-08 2009-03-24 Schering Corporation Cannabinoid receptor ligands
US6897220B2 (en) 2001-09-14 2005-05-24 Methylgene, Inc. Inhibitors of histone deacetylase
MXPA04002397A (es) 2001-09-14 2004-12-02 Methylgene Inc Inhibidores de histona deacetilasa.
US7868204B2 (en) 2001-09-14 2011-01-11 Methylgene Inc. Inhibitors of histone deacetylase
CN100567266C (zh) * 2001-11-14 2009-12-09 先灵公司 类大麻苷受体配体
DE60319714T2 (de) * 2002-06-19 2009-04-02 Schering Corp. Agonisten des cannabinoidrezeptors
DE60328033D1 (de) 2002-11-25 2009-07-30 Schering Corp Cannabinoid-rezeptorliganden
AU2004249669B2 (en) * 2003-05-20 2008-05-22 The University Of Tennessee Research Foundation Cannabinoid derivatives, methods of making, and use thereof
EP1663953A1 (en) * 2003-09-24 2006-06-07 Methylgene, Inc. Inhibitors of histone deacetylase
WO2005044785A1 (en) * 2003-10-30 2005-05-19 Merck & Co., Inc. Aralkyl amines as cannabinoid receptor modulators
US7253204B2 (en) 2004-03-26 2007-08-07 Methylgene Inc. Inhibitors of histone deacetylase
GB2431105A (en) 2005-10-12 2007-04-18 Gw Pharma Ltd Cannabinoids for the treatment of pulmonary disorders
CA2648804C (en) * 2006-04-07 2014-05-27 Methylgene Inc. Benzamide derivatives as inhibitors of histone deacetylase
EP2081905B1 (en) 2006-07-28 2012-09-12 Boehringer Ingelheim International GmbH Sulfonyl compounds which modulate the cb2 receptor
MX2009002888A (es) 2006-09-25 2009-03-31 Boehringer Ingelheim Int Compuestos que modulan el receptor cb2.
JP5491871B2 (ja) 2007-02-28 2014-05-14 アドビナス セラピュティックス プライベート リミテッド グルコキナーゼ活性化因子としての２，２，２−三置換アセトアミド誘導体、その方法及び薬学的応用
CA2679373A1 (en) * 2007-03-02 2008-09-12 The University Of Tennessee Research Foundation Tri-aryl/heteroaromatic cannabinoids and use thereof
US20090069288A1 (en) * 2007-07-16 2009-03-12 Breinlinger Eric C Novel therapeutic compounds
WO2009061652A1 (en) 2007-11-07 2009-05-14 Boehringer Ingelheim International Gmbh Compounds which modulate the cb2 receptor
EP2326629B1 (en) 2008-07-10 2013-10-02 Boehringer Ingelheim International GmbH Sulfone compounds which modulate the cb2 receptor
NZ591111A (en) 2008-09-25 2013-08-30 Boehringer Ingelheim Int Sulfonyl compounds which selectively modulate the cb2 receptor
CN102573480B (zh) 2009-06-09 2015-06-10 加利福尼亚资本权益有限责任公司 三嗪衍生物及其治疗应用
CA2765044A1 (en) 2009-06-09 2010-12-16 California Capital Equity, Llc Benzyl substituted triazine derivatives and their therapeutical applications
CN102573473B (zh) 2009-06-09 2015-05-27 加利福尼亚资本权益有限责任公司 用作hedgehog 信号转导抑制剂的异喹啉、喹啉和喹唑啉衍生物
US8299103B2 (en) 2009-06-15 2012-10-30 Boehringer Ingelheim International Gmbh Compounds which selectively modulate the CB2 receptor
US8383615B2 (en) 2009-06-16 2013-02-26 Boehringer Ingelheim International Gmbh Azetidine 2-carboxamide derivatives which modulate the CB2 receptor
EP2480544A1 (en) 2009-09-22 2012-08-01 Boehringer Ingelheim International GmbH Compounds which selectively modulate the cb2 receptor
EP2523936A1 (en) 2010-01-15 2012-11-21 Boehringer Ingelheim International GmbH Compounds which modulate the cb2 receptor
WO2011109324A1 (en) 2010-03-05 2011-09-09 Boehringer Ingelheim International Gmbh Tetrazole compounds which selectively modulate the cb2 receptor
JP5746764B2 (ja) 2010-07-22 2015-07-08 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃｂ２受容体を調節する化合物
WO2012014127A1 (en) 2010-07-30 2012-02-02 Ranbaxy Laboratories Limited 5-lipoxygenase inhibitors
TW201329025A (zh) 2011-11-01 2013-07-16 Astex Therapeutics Ltd 醫藥化合物
KR101599300B1 (ko) 2012-03-14 2016-03-03 시노켐 코포레이션 치환 디페닐아민 화합물 및 항종양제로서의 용도
TW201512171A (zh) 2013-04-19 2015-04-01 Pfizer Ltd 化學化合物
EP2803668A1 (en) 2013-05-17 2014-11-19 Boehringer Ingelheim International Gmbh Novel (cyano-dimethyl-methyl)-isoxazoles and -[1,3,4]thiadiazoles
US9636298B2 (en) 2014-01-17 2017-05-02 Methylgene Inc. Prodrugs of compounds that enhance antifungal activity and compositions of said prodrugs
BR112017003745A2 (pt) 2014-08-29 2017-12-05 Tes Pharma S R L inibidores de semialdeído descarboxilase de ácido alfa-amino-beta-carboximucônico
CN112552200B (zh) * 2019-09-10 2024-03-12 烟台药物研究所 一种光学纯4-(1-氨基)乙基苯甲酸酯及其盐的制备方法

Family Cites Families (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3715375A (en) * 1970-09-17 1973-02-06 Merck & Co Inc New diphenyl sulfones
US4170648A (en) 1972-05-26 1979-10-09 Rohm And Haas Company Phosphonothioureide anthelmintics
DE3039208A1 (de) 1980-10-17 1982-05-13 Basf Ag, 6700 Ludwigshafen Neue sulfone, deren herstellung und verwendung
DE3118126A1 (de) 1981-05-07 1982-12-02 Bayer Ag, 5090 Leverkusen Sulfenamide zur verwendung in arzneimitteln
US4618363A (en) 1982-01-25 1986-10-21 Ciba-Geigy Corporation N-phenylsulfonyl-N'-triazinylureas
US4468389A (en) 1982-05-21 1984-08-28 Rohm And Haas Company Pesticidal N-sulfonyl phosphorodiamido(di)thioates
US4466965A (en) 1982-07-26 1984-08-21 American Hospital Supply Corporation Phthalazine compounds, compositions and use
US4567184A (en) 1982-12-01 1986-01-28 Usv Pharmaceutical Corporation Certain aryl or hetero-aryl derivatives of 1-hydroxy-pentane or 1-hydroxy-hexane which are useful for treating inflammation and allergies
NZ213986A (en) 1984-10-30 1989-07-27 Usv Pharma Corp Heterocyclic or aromatic compounds, and pharmaceutical compositions containing such
US4781866A (en) 1985-03-15 1988-11-01 Mcneilab, Inc. Process for producing amidine sulfonic acid intermediates for guanidines
US4678855A (en) 1985-10-09 1987-07-07 Merck & Co., Inc. Substituted benzenesulfonamides
SK219487A3 (en) 1986-03-31 1996-02-07 Union Carbide Agricult Agent for retardation growth of plants
EP0262209B1 (en) 1986-03-31 1992-08-05 Rhone Poulenc Nederland B.V. Synergistic plant growth regulator compositions
DE3634927A1 (de) 1986-10-14 1988-04-21 Bayer Ag Verfahren zur herstellung von sulfonylisothioharnstoffen
DE3634926A1 (de) 1986-10-14 1988-04-21 Bayer Ag Verfahren zur herstellung von o-aryl-n'-pyrimidin-2-yl-isoharnstoffen
US4851423A (en) 1986-12-10 1989-07-25 Schering Corporation Pharmaceutically active compounds
NZ232493A (en) 1989-02-14 1992-06-25 Toyama Chemical Co Ltd Aryl- or heterocyclyl-substituted 1,2-ethanediol derivatives and pharmaceutical compositions
US5064825A (en) 1989-06-01 1991-11-12 Merck & Co., Inc. Angiotensin ii antagonists
WO1991000858A1 (en) 1989-07-07 1991-01-24 Schering Corporation Pharmaceutically active compounds
IT1240676B (it) 1990-04-24 1993-12-17 Agrimont Spa Composizioni ad attivita' erbicida
NZ239846A (en) 1990-09-27 1994-11-25 Merck & Co Inc Sulphonamide derivatives and pharmaceutical compositions thereof
US5332820A (en) 1991-05-20 1994-07-26 E. I. Du Pont De Nemours And Company Dibenzobicyclo(2.2.2) octane angiotensin II antagonists
EP0591426A4 (en) 1991-06-27 1996-08-21 Univ Virginia Commonwealth Sigma receptor ligands and the use thereof
US5506227A (en) 1992-04-13 1996-04-09 Merck Frosst Canada, Inc. Pyridine-substituted benzyl alcohols as leukotriene antagonists
JPH0672979A (ja) 1992-06-08 1994-03-15 Hiroyoshi Hidaka アミノベンジル誘導体
FR2692575B1 (fr) * 1992-06-23 1995-06-30 Sanofi Elf Nouveaux derives du pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant.
US5338753A (en) 1992-07-14 1994-08-16 Sumner H. Burstein (3R,4R)-Δ6 -tetrahydrocannabinol-7-oic acids useful as antiinflammatory agents and analgesics
GB9218834D0 (en) 1992-09-05 1992-10-21 Procter & Gamble Nasal spray products
WO1995000491A1 (en) 1993-06-17 1995-01-05 Dunlena Pty Ltd. Arthropodicidal sulfonates
US5486525A (en) 1993-12-16 1996-01-23 Abbott Laboratories Platelet activating factor antagonists: imidazopyridine indoles
FR2714057B1 (fr) 1993-12-17 1996-03-08 Sanofi Elf Nouveaux dérivés du 3-pyrazolecarboxamide, procédé pour leur préparation et compositions pharmaceutiques les contenant.
WO1995027693A1 (en) 1994-04-06 1995-10-19 Shionogi & Co., Ltd. α-SUBSTITUTED PHENYLACETIC ACID DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND AGRICULTURAL BACTERICIDE CONTAINING THE SAME
US5596106A (en) 1994-07-15 1997-01-21 Eli Lilly And Company Cannabinoid receptor antagonists
IT1271266B (it) 1994-12-14 1997-05-27 Valle Francesco Della Impiego terapeutico di ammidi di acidi mono e bicarbossilici con amminoalcoli,selettivamente attive sul recettore periferico dei cannabinoidi
CA2212061A1 (en) 1995-02-02 1996-08-08 Laramie Mary Gaster Indole derivatives as 5-ht receptor antagonist
US5532237A (en) * 1995-02-15 1996-07-02 Merck Frosst Canada, Inc. Indole derivatives with affinity for the cannabinoid receptor
US5700816A (en) 1995-06-12 1997-12-23 Isakson; Peter C. Treatment of inflammation and inflammation-related disorders with a combination of a cyclooxygenase-2 inhibitor and a leukotriene A4 hydrolase inhibitor
FR2735774B1 (fr) 1995-06-21 1997-09-12 Sanofi Sa Utilisation de composes agonistes du recepteur cb2 humain pour la preparation de medicaments immunomodulateurs, nouveaux composes agonistes du recepteur cb2 et les compositions pharmaceutiques les contenant
WO1997003953A1 (de) 1995-07-21 1997-02-06 Nycomed Austria Gmbh Derivate von benzosulfonamiden als hemmer des enzym cyclooxygenase ii
DE19533644A1 (de) 1995-09-12 1997-03-13 Nycomed Arzneimittel Gmbh Neue Benzolsulfonamide
FR2742148B1 (fr) 1995-12-08 1999-10-22 Sanofi Sa Nouveaux derives du pyrazole-3-carboxamide, procede pour leur preparation et compositions pharmaceutiques les contenant
WO1997029079A1 (en) 1996-02-06 1997-08-14 Japan Tobacco Inc. Novel compounds and pharmaceutical use thereof
AU717431B2 (en) * 1996-07-01 2000-03-23 Schering Corporation Muscarinic antagonists
SE9602646D0 (sv) 1996-07-04 1996-07-04 Astra Ab Pharmaceutically-useful compounds
EP0927035A4 (en) 1996-09-13 2002-11-13 Merck & Co Inc THROMBIN INHIBITORS
ES2213892T3 (es) 1997-01-21 2004-09-01 Smithkline Beecham Corporation Nuevos moduladores del receptor de canabinoides.
ATA16597A (de) 1997-02-03 1998-04-15 Nycomed Austria Gmbh Neue substituierte p-sulfonylaminobenzol- sulfonsäureamide
DE19740785A1 (de) 1997-02-21 1998-08-27 Bayer Ag Arylsulfonamide und Analoga
US5948777A (en) 1997-03-18 1999-09-07 Smithkline Beecham Corporation Cannabinoid receptor agonists
HU229840B1 (en) 1997-10-24 2014-09-29 Nissan Chemical Ind Ltd Sulfamoyl compounds and agricultural and horticultural fungicide compositions
WO1999026612A1 (en) 1997-11-21 1999-06-03 Smithkline Beecham Corporation Novel cannabinoid receptor modulators
MY153569A (en) 1998-01-20 2015-02-27 Mitsubishi Tanabe Pharma Corp Inhibitors of ?4 mediated cell adhesion
RU2217421C2 (ru) 1998-03-26 2003-11-27 Шионоги & Ко., Лтд. Производные индола, обладающие антивирусной активностью
JP2002521436A (ja) 1998-07-28 2002-07-16 スミスクライン・ビーチャム・コーポレイション 置換アニリド化合物および方法
AU3772800A (en) 1999-03-24 2000-10-09 Sepracor, Inc. Diaryl thioethers, compositions and uses thereof
WO2001019807A1 (en) 1999-09-14 2001-03-22 Shionogi & Co., Ltd. 2-imino-1,3-thiazine derivatives
DE60030303T2 (de) * 1999-10-18 2007-10-11 The University Of Connecticut, Farmington Cannabimimetische indolderivate
JP3910446B2 (ja) 1999-11-26 2007-04-25 塩野義製薬株式会社 Ｎｐｙｙ５拮抗剤
CA2394639A1 (en) 1999-12-15 2001-06-21 Danny Peter Claude Mcgee Salicylamides as serine protease and factor xa inhibitors
AU2092601A (en) 1999-12-15 2001-06-25 Bristol-Myers Squibb Company Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists
AU2001245353A1 (en) 2000-02-29 2001-09-12 Cor Therapeutics, Inc. Benzamides and related inhibitors of factor xa
CA2402414A1 (en) 2000-03-22 2001-09-27 Christopher Bayly Sulfur substituted aryldifluoromethylphosphonic acids as ptp-1b inhibitors
WO2001074762A2 (en) 2000-04-03 2001-10-11 Phycogen, Inc. Arylsulfates and their use as enhancers or inhibitors of bioadhesion to surfaces
CA2407231A1 (en) 2000-04-28 2002-10-23 Tanabe Seiyaku Co., Ltd. Cyclic compounds
KR20020097484A (ko) 2000-05-19 2002-12-31 다케다 야쿠힌 고교 가부시키가이샤 β-씨크리타아제 억제제
GB0028702D0 (en) 2000-11-24 2001-01-10 Novartis Ag Organic compounds
US7507767B2 (en) 2001-02-08 2009-03-24 Schering Corporation Cannabinoid receptor ligands
CN100567266C (zh) 2001-11-14 2009-12-09 先灵公司 类大麻苷受体配体
FR2839718B1 (fr) * 2002-05-17 2004-06-25 Sanofi Synthelabo Derives d'indole, leur procede de preparation et les compositions pharmaceutiques en contenant
DE60319714T2 (de) * 2002-06-19 2009-04-02 Schering Corp. Agonisten des cannabinoidrezeptors

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