AR040803A1 - Ligandos de receptores canabinoides, composiciones farmaceuticas, un proceso para su elaboracion y el uso de dichos compuestos, solos o combinados, para la preparacion de medicamentos - Google Patents
Ligandos de receptores canabinoides, composiciones farmaceuticas, un proceso para su elaboracion y el uso de dichos compuestos, solos o combinados, para la preparacion de medicamentosInfo
- Publication number
- AR040803A1 AR040803A1 AR20030102821A ARP030102821A AR040803A1 AR 040803 A1 AR040803 A1 AR 040803A1 AR 20030102821 A AR20030102821 A AR 20030102821A AR P030102821 A ARP030102821 A AR P030102821A AR 040803 A1 AR040803 A1 AR 040803A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- cycloalkyl
- disease
- group
- alkoxy
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 5
- 239000003814 drug Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 6
- 125000003118 aryl group Chemical group 0.000 abstract 4
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 4
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 3
- -1 alkenyl cycloalkyl Chemical group 0.000 abstract 3
- 125000001072 heteroaryl group Chemical group 0.000 abstract 3
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 3
- 201000009794 Idiopathic Pulmonary Fibrosis Diseases 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 208000036971 interstitial lung disease 2 Diseases 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- 239000000651 prodrug Substances 0.000 abstract 2
- 229940002612 prodrug Drugs 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000012453 solvate Substances 0.000 abstract 2
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 2
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 abstract 1
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 abstract 1
- 208000000884 Airway Obstruction Diseases 0.000 abstract 1
- 208000035285 Allergic Seasonal Rhinitis Diseases 0.000 abstract 1
- 208000023328 Basedow disease Diseases 0.000 abstract 1
- 201000006474 Brain Ischemia Diseases 0.000 abstract 1
- 206010008120 Cerebral ischaemia Diseases 0.000 abstract 1
- 208000011231 Crohn disease Diseases 0.000 abstract 1
- 206010012438 Dermatitis atopic Diseases 0.000 abstract 1
- 208000010412 Glaucoma Diseases 0.000 abstract 1
- 206010018364 Glomerulonephritis Diseases 0.000 abstract 1
- 208000024869 Goodpasture syndrome Diseases 0.000 abstract 1
- 208000009329 Graft vs Host Disease Diseases 0.000 abstract 1
- 208000015023 Graves' disease Diseases 0.000 abstract 1
- 208000030836 Hashimoto thyroiditis Diseases 0.000 abstract 1
- 206010020751 Hypersensitivity Diseases 0.000 abstract 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 abstract 1
- 208000019693 Lung disease Diseases 0.000 abstract 1
- 208000001132 Osteoporosis Diseases 0.000 abstract 1
- 201000004681 Psoriasis Diseases 0.000 abstract 1
- 206010063897 Renal ischaemia Diseases 0.000 abstract 1
- 208000004756 Respiratory Insufficiency Diseases 0.000 abstract 1
- 208000017442 Retinal disease Diseases 0.000 abstract 1
- 208000036284 Rhinitis seasonal Diseases 0.000 abstract 1
- 206010039710 Scleroderma Diseases 0.000 abstract 1
- 206010040047 Sepsis Diseases 0.000 abstract 1
- 208000006011 Stroke Diseases 0.000 abstract 1
- 208000031673 T-Cell Cutaneous Lymphoma Diseases 0.000 abstract 1
- 206010047115 Vasculitis Diseases 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 208000026935 allergic disease Diseases 0.000 abstract 1
- 201000010105 allergic rhinitis Diseases 0.000 abstract 1
- 230000007815 allergy Effects 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 201000008937 atopic dermatitis Diseases 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 206010006451 bronchitis Diseases 0.000 abstract 1
- 206010006475 bronchopulmonary dysplasia Diseases 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 206010008118 cerebral infarction Diseases 0.000 abstract 1
- 230000001684 chronic effect Effects 0.000 abstract 1
- 206010009887 colitis Diseases 0.000 abstract 1
- 208000029078 coronary artery disease Diseases 0.000 abstract 1
- 201000007241 cutaneous T cell lymphoma Diseases 0.000 abstract 1
- 125000000000 cycloalkoxy group Chemical group 0.000 abstract 1
- 125000006310 cycloalkyl amino group Chemical group 0.000 abstract 1
- 125000005112 cycloalkylalkoxy group Chemical group 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 208000024908 graft versus host disease Diseases 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 208000006454 hepatitis Diseases 0.000 abstract 1
- 231100000283 hepatitis Toxicity 0.000 abstract 1
- 125000004404 heteroalkyl group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 230000002519 immonomodulatory effect Effects 0.000 abstract 1
- 201000001441 melanoma Diseases 0.000 abstract 1
- 201000006417 multiple sclerosis Diseases 0.000 abstract 1
- 206010028417 myasthenia gravis Diseases 0.000 abstract 1
- 201000005962 mycosis fungoides Diseases 0.000 abstract 1
- 208000010125 myocardial infarction Diseases 0.000 abstract 1
- 201000008383 nephritis Diseases 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 208000025638 primary cutaneous T-cell non-Hodgkin lymphoma Diseases 0.000 abstract 1
- ILVXOBCQQYKLDS-UHFFFAOYSA-N pyridine N-oxide Chemical group [O-][N+]1=CC=CC=C1 ILVXOBCQQYKLDS-UHFFFAOYSA-N 0.000 abstract 1
- 201000004193 respiratory failure Diseases 0.000 abstract 1
- 230000002441 reversible effect Effects 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
- 201000000306 sarcoidosis Diseases 0.000 abstract 1
- 208000017022 seasonal allergic rhinitis Diseases 0.000 abstract 1
- 230000035939 shock Effects 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 208000011580 syndromic disease Diseases 0.000 abstract 1
- 201000000596 systemic lupus erythematosus Diseases 0.000 abstract 1
Classifications
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
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- C07C317/36—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring with the nitrogen atoms of the amino groups bound to hydrogen atoms or to carbon atoms
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- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
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- C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
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| DE60328033D1 (de) | 2002-11-25 | 2009-07-30 | Schering Corp | Cannabinoid-rezeptorliganden |
| AU2004249669B2 (en) * | 2003-05-20 | 2008-05-22 | The University Of Tennessee Research Foundation | Cannabinoid derivatives, methods of making, and use thereof |
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| WO2005044785A1 (en) * | 2003-10-30 | 2005-05-19 | Merck & Co., Inc. | Aralkyl amines as cannabinoid receptor modulators |
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| CA2679373A1 (en) * | 2007-03-02 | 2008-09-12 | The University Of Tennessee Research Foundation | Tri-aryl/heteroaromatic cannabinoids and use thereof |
| US20090069288A1 (en) * | 2007-07-16 | 2009-03-12 | Breinlinger Eric C | Novel therapeutic compounds |
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| HU229840B1 (en) | 1997-10-24 | 2014-09-29 | Nissan Chemical Ind Ltd | Sulfamoyl compounds and agricultural and horticultural fungicide compositions |
| WO1999026612A1 (en) | 1997-11-21 | 1999-06-03 | Smithkline Beecham Corporation | Novel cannabinoid receptor modulators |
| MY153569A (en) | 1998-01-20 | 2015-02-27 | Mitsubishi Tanabe Pharma Corp | Inhibitors of ?4 mediated cell adhesion |
| RU2217421C2 (ru) | 1998-03-26 | 2003-11-27 | Шионоги & Ко., Лтд. | Производные индола, обладающие антивирусной активностью |
| JP2002521436A (ja) | 1998-07-28 | 2002-07-16 | スミスクライン・ビーチャム・コーポレイション | 置換アニリド化合物および方法 |
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| DE60030303T2 (de) * | 1999-10-18 | 2007-10-11 | The University Of Connecticut, Farmington | Cannabimimetische indolderivate |
| JP3910446B2 (ja) | 1999-11-26 | 2007-04-25 | 塩野義製薬株式会社 | Npyy5拮抗剤 |
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| AU2092601A (en) | 1999-12-15 | 2001-06-25 | Bristol-Myers Squibb Company | Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists |
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| CA2402414A1 (en) | 2000-03-22 | 2001-09-27 | Christopher Bayly | Sulfur substituted aryldifluoromethylphosphonic acids as ptp-1b inhibitors |
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| KR20020097484A (ko) | 2000-05-19 | 2002-12-31 | 다케다 야쿠힌 고교 가부시키가이샤 | β-씨크리타아제 억제제 |
| GB0028702D0 (en) | 2000-11-24 | 2001-01-10 | Novartis Ag | Organic compounds |
| US7507767B2 (en) | 2001-02-08 | 2009-03-24 | Schering Corporation | Cannabinoid receptor ligands |
| CN100567266C (zh) | 2001-11-14 | 2009-12-09 | 先灵公司 | 类大麻苷受体配体 |
| FR2839718B1 (fr) * | 2002-05-17 | 2004-06-25 | Sanofi Synthelabo | Derives d'indole, leur procede de preparation et les compositions pharmaceutiques en contenant |
| DE60319714T2 (de) * | 2002-06-19 | 2009-04-02 | Schering Corp. | Agonisten des cannabinoidrezeptors |
-
2002
- 2002-08-07 US US10/214,897 patent/US7067539B2/en not_active Expired - Fee Related
-
2003
- 2003-08-05 MX MXPA05001433A patent/MXPA05001433A/es active IP Right Grant
- 2003-08-05 WO PCT/US2003/024398 patent/WO2004014825A1/en not_active Ceased
- 2003-08-05 PE PE2003000774A patent/PE20040754A1/es not_active Application Discontinuation
- 2003-08-05 CA CA002494827A patent/CA2494827A1/en not_active Abandoned
- 2003-08-05 AU AU2003257172A patent/AU2003257172A1/en not_active Abandoned
- 2003-08-05 JP JP2004527741A patent/JP2005534715A/ja active Pending
- 2003-08-05 EP EP03784905A patent/EP1539662A1/en not_active Withdrawn
- 2003-08-06 TW TW092121502A patent/TW200413298A/zh unknown
- 2003-08-06 AR AR20030102821A patent/AR040803A1/es unknown
-
2009
- 2009-11-04 JP JP2009253551A patent/JP2010024251A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| JP2005534715A (ja) | 2005-11-17 |
| JP2010024251A (ja) | 2010-02-04 |
| US7067539B2 (en) | 2006-06-27 |
| TW200413298A (en) | 2004-08-01 |
| MXPA05001433A (es) | 2005-06-06 |
| WO2004014825A1 (en) | 2004-02-19 |
| US20030232859A1 (en) | 2003-12-18 |
| AU2003257172A1 (en) | 2004-02-25 |
| CA2494827A1 (en) | 2004-02-19 |
| PE20040754A1 (es) | 2004-11-20 |
| EP1539662A1 (en) | 2005-06-15 |
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