EA200600333A1 - Производные индазола - Google Patents

Производные индазола

Info

Publication number
EA200600333A1
EA200600333A1 EA200600333A EA200600333A EA200600333A1 EA 200600333 A1 EA200600333 A1 EA 200600333A1 EA 200600333 A EA200600333 A EA 200600333A EA 200600333 A EA200600333 A EA 200600333A EA 200600333 A1 EA200600333 A1 EA 200600333A1
Authority
EA
Eurasian Patent Office
Prior art keywords
substituted
unsubstituted
heterocyclic group
hydrogen atom
ararkyl
Prior art date
Application number
EA200600333A
Other languages
English (en)
Other versions
EA010165B1 (ru
Inventor
Йосихиса Охта
Фумихико Канаи
Синдзи Нара
Ютака Канда
Хироси Умехара
Юкимаса Сиоцу
Томоки Наое
Хитоси Кийои
Кейко Кавасима
Хироми Андо
Мотоки Мияма
Original Assignee
Киова Хакко Когио Ко., Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Киова Хакко Когио Ко., Лтд. filed Critical Киова Хакко Когио Ко., Лтд.
Publication of EA200600333A1 publication Critical patent/EA200600333A1/ru
Publication of EA010165B1 publication Critical patent/EA010165B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Данное изобретение относится к соединению, представленному формулой (I)где Rозначает CONRR(где Rи Rмогут быть одинаковыми или разными и каждый означает атом водорода, замещенный или незамещенный низший алкил, замещенный или незамещенный арил, замещенный или незамещенный аралкил или замещенную или незамещенную гетероциклическую группу, или Rи Rобъединены вместе со смежным атомом азота с образованием замещенной или незамещенной гетероциклической группы) или тому подобное, Rозначает атом водорода, CONRR(где Rи Rмогут быть одинаковыми или разными и каждый означает атом водорода, замещенный или незамещенный низший алкил, замещенный или незамещенный арил, замещенный или незамещенный аралкил или замещенную или незамещенную гетероциклическую группу, или Rи Rобъединены вместе со смежным атомом азота с образованием замещенной или незамещенной гетероциклической группы), NRR(где Rи Rмогут быть одинаковыми или разными и каждый означает атом водорода, замещенный или незамещенный низший алкил, замещенный или незамещенный низший алканоил, замещенный или незамещенный ароил, замещенный или незамещенный гетероароил, замещенный или незамещенный аралкил, замещенный или незамещенный низший алкилсульфонил или замещенный или незамещенный низший арилсульфонил) или тому подобное.
EA200600333A 2003-07-30 2004-07-30 Производные индазола EA010165B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2003203508 2003-07-30
PCT/JP2004/011287 WO2005012257A1 (ja) 2003-07-30 2004-07-30 インダゾール誘導体

Publications (2)

Publication Number Publication Date
EA200600333A1 true EA200600333A1 (ru) 2006-06-30
EA010165B1 EA010165B1 (ru) 2008-06-30

Family

ID=34113614

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200600333A EA010165B1 (ru) 2003-07-30 2004-07-30 Производные индазола

Country Status (15)

Country Link
US (2) US7470717B2 (ru)
EP (1) EP1652842B1 (ru)
JP (1) JP4335212B2 (ru)
KR (1) KR20060119705A (ru)
CN (1) CN100390149C (ru)
AT (1) ATE553092T1 (ru)
AU (1) AU2004260756B2 (ru)
BR (1) BRPI0408876A (ru)
CA (1) CA2518950A1 (ru)
EA (1) EA010165B1 (ru)
ES (1) ES2384568T3 (ru)
MX (1) MXPA05011420A (ru)
NO (1) NO20055333L (ru)
WO (1) WO2005012257A1 (ru)
ZA (1) ZA200509952B (ru)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003076438A1 (en) 2002-03-13 2003-09-18 Janssen Pharmaceutica N.V. Piperazinyl-, piperidinyl- and morpholinyl-derivatives as novel inhibitors of histone deacetylase
DK1485354T3 (da) 2002-03-13 2008-09-01 Janssen Pharmaceutica Nv Sulfonylamino-derivater som nye inhibitorer af histandeacetylase
DK1485353T3 (da) 2002-03-13 2011-11-28 Janssen Pharmaceutica Nv Nye inhibitorer af histondeacetylase
KR20040090981A (ko) 2002-03-13 2004-10-27 얀센 파마슈티카 엔.브이. 신규한 히스톤 디아세틸라제 저해제로서의카보닐아미노-유도체
US7470717B2 (en) * 2003-07-30 2008-12-30 Kyowa Hakko Kogyo Co., Ltd. Indazole derivatives
EP1781639B1 (en) 2004-07-28 2012-01-25 Janssen Pharmaceutica NV Substituted indolyl alkyl amino derivatives as novel inhibitors of histone deacetylase
CA2596527C (en) 2005-01-27 2013-02-12 Kyowa Hakko Kogyo Co., Ltd. Igf-1r inhibitors
EP1878737A4 (en) * 2005-04-28 2010-08-04 Kyowa Hakko Kirin Co Ltd METHOD OF SYNTHESIZING INDAZOLE-3-YLMETHYLPHOSPHONIUM SALT
CA2605272C (en) 2005-05-18 2013-12-10 Janssen Pharmaceutica N.V. Substituted aminopropenyl piperidine or morpholine derivatives as novel inhibitors of histone deacetylase
EP1943232B1 (en) * 2005-10-27 2011-05-18 Janssen Pharmaceutica NV Squaric acid derivatives as inhibitors of histone deacetylase
WO2007082878A1 (en) 2006-01-19 2007-07-26 Janssen Pharmaceutica N.V. Aminophenyl derivatives as novel inhibitors of histone deacetylase
US8101616B2 (en) 2006-01-19 2012-01-24 Janssen Pharmaceutica N.V. Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase
EP1981875B1 (en) 2006-01-19 2014-04-16 Janssen Pharmaceutica N.V. Substituted indolyl-alkyl-amino-derivatives as inhibitors of histone deacetylase
AU2007206942B2 (en) 2006-01-19 2012-08-23 Janssen Pharmaceutica N.V. Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase
JPWO2008001885A1 (ja) 2006-06-30 2009-11-26 協和発酵キリン株式会社 Ａｂｌキナーゼ阻害剤
US20090209537A1 (en) * 2006-06-30 2009-08-20 Kyowa Hakko Kirin Co., Ltd. Aurora inhibitors
WO2008020606A1 (fr) * 2006-08-16 2008-02-21 Kyowa Hakko Kirin Co., Ltd. Agent anti-angiogénique
GB0619325D0 (en) 2006-09-30 2006-11-08 Univ Strathclyde New compounds
TW200901960A (en) 2007-03-05 2009-01-16 Kyowa Hakko Kogyo Kk Pharmaceutical composition
CA2680122A1 (en) 2007-03-05 2008-09-18 Kyowa Hakko Kirin Co., Ltd. Pharmaceutical composition
WO2008114812A1 (ja) * 2007-03-19 2008-09-25 Kyowa Hakko Kirin Co., Ltd. Jak阻害剤
US20090325964A1 (en) * 2008-05-23 2009-12-31 Wyeth Piperazine Metabotropic Glutamate Receptor 5 (MGLUR5) Negative Allosteric Modulators For Anxiety/Depression
CN103804382A (zh) * 2012-11-05 2014-05-21 韩文毅 一类治疗湿疹的化合物及其用途
CN103804306A (zh) * 2012-11-12 2014-05-21 韩文毅 一类治疗糖尿病的化合物及其用途
GB201511382D0 (en) 2015-06-29 2015-08-12 Imp Innovations Ltd Novel compounds and their use in therapy
MA42953A (fr) 2015-09-22 2018-08-01 Graybug Vision Inc Composés et compositions pour le traitement de troubles oculaires
JP7217022B2 (ja) 2017-03-23 2023-02-02 グレイバグ ビジョン インコーポレイテッド 眼障害の治療のための薬物及び組成物
MX2019013363A (es) 2017-05-10 2020-01-13 Graybug Vision Inc Microparticulas de liberacion extendida y suspensiones de las mismas para terapia medica.
WO2019051396A1 (en) * 2017-09-08 2019-03-14 President And Fellows Of Harvard College SMALL MOLECULE INHIBITORS OF EBOLA VIRUSES AND LASSA FEVER, AND METHODS OF USE THEREOF
MX2021000657A (es) * 2018-07-23 2021-05-12 Celgene Quanticel Res Inc Proceso para la preparacion de inhibidor de bromodominio.

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0232059A (ja) * 1988-07-18 1990-02-01 Kyowa Hakko Kogyo Co Ltd インダゾール誘導体
TWI262914B (en) * 1999-07-02 2006-10-01 Agouron Pharma Compounds and pharmaceutical compositions for inhibiting protein kinases
PE20010306A1 (es) * 1999-07-02 2001-03-29 Agouron Pharma Compuestos de indazol y composiciones farmaceuticas que los contienen utiles para la inhibicion de proteina kinasa
US6632815B2 (en) 1999-09-17 2003-10-14 Millennium Pharmaceuticals, Inc. Inhibitors of factor Xa
YU54202A (sh) 2000-01-18 2006-01-16 Agouron Pharmaceuticals Inc. Jedinjenja indazola, farmaceutske smeše i postupci za stimulisanje i inhibiranje ćelijske proliferacije
US7238853B2 (en) 2000-07-14 2007-07-03 Unicrop Ltd Molecular mechanisms for gene containment in plants
US20050009876A1 (en) 2000-07-31 2005-01-13 Bhagwat Shripad S. Indazole compounds, compositions thereof and methods of treatment therewith
US7211594B2 (en) 2000-07-31 2007-05-01 Signal Pharmaceuticals, Llc Indazole compounds and compositions thereof as JNK inhibitors and for the treatment of diseases associated therewith
US6897231B2 (en) 2000-07-31 2005-05-24 Signal Pharmaceuticals, Inc. Indazole derivatives as JNK inhibitors and compositions and methods related thereto
JP4535680B2 (ja) 2001-04-16 2010-09-01 エーザイ・アール・アンド・ディー・マネジメント株式会社 新規１ｈ−インダゾール化合物
TW200406385A (en) 2002-05-31 2004-05-01 Eisai Co Ltd Pyrazole compound and pharmaceutical composition containing the same
JPWO2004050088A1 (ja) * 2002-12-03 2006-03-30 協和醗酵工業株式会社 Ｊｎｋ阻害剤
US7470717B2 (en) * 2003-07-30 2008-12-30 Kyowa Hakko Kogyo Co., Ltd. Indazole derivatives

Also Published As

Publication number Publication date
CA2518950A1 (en) 2005-02-10
EP1652842A1 (en) 2006-05-03
AU2004260756B2 (en) 2010-03-25
KR20060119705A (ko) 2006-11-24
WO2005012257A1 (ja) 2005-02-10
CN1777590A (zh) 2006-05-24
EP1652842A4 (en) 2008-10-01
EP1652842B1 (en) 2012-04-11
NO20055333L (no) 2005-11-11
US20070117856A1 (en) 2007-05-24
US7919517B2 (en) 2011-04-05
MXPA05011420A (es) 2005-12-12
ZA200509952B (en) 2006-09-27
ATE553092T1 (de) 2012-04-15
ES2384568T3 (es) 2012-07-09
CN100390149C (zh) 2008-05-28
US20090082348A1 (en) 2009-03-26
JP4335212B2 (ja) 2009-09-30
BRPI0408876A (pt) 2006-04-11
US7470717B2 (en) 2008-12-30
AU2004260756A1 (en) 2005-02-10
EA010165B1 (ru) 2008-06-30
JPWO2005012257A1 (ja) 2006-09-14

Similar Documents

Publication Publication Date Title
NO20055333L (no) Indazolderivater
TW200722422A (en) Heterocyclic compound and organic electroluminescent device using the same
AP1902A (en) N-aryl-2-oxazolidinone-5-carboxamides and their derivatives and their use as antibacterials
NO20060219L (no) Forbindelser
DE60208364D1 (de) Chinolinderivate mit einer azolylgruppe und chinazolinderivate
ATE314383T1 (de) 2-amino-propanol derivate
FR15C0027I2 (fr) Derives de pyrazolinone
CY1112899T1 (el) Παραγωγα θειαδιαζολινης για τη θεραπεια του καρκινου
DE69813605D1 (de) Benzofuranderivate
DK1643984T3 (da) Anvendelse af parthenolidderivater som antileukæmiske og cytotoksske midler
GB0423405D0 (en) Organic compounds
EP1671957A4 (en) THIADIAZOLINDERIVATE
ATE449773T1 (de) Homomorpholinoxazolidinone als antibakterielle mittel
DK0601191T3 (da) Hidtil ukendt tetracyklisk forbindelse
BR0308935A (pt) Inibidor de fosfodiesterase iv contendo derivado de piridilacrilamida
DE60009032T2 (de) Benzolsulfonamid-derivate und ihre verwendung
ATE552003T1 (de) Chinoxalinderivate
DE60330038D1 (de) Neue alpha-ketoamidderivate und deren verwendung
DE60103732D1 (de) Pyrimidinderivate mit antitumor-wirkung
DE60211018D1 (de) Fungizide thiazolderivate
DE69915688D1 (de) Benzonaphtyridin-1,8 derivate
DE60230924D1 (de) 2-substituierte vitamin-d-derivate
TH59387B (th) อนุพันธ์ n-ไตรอะโซลอิลเมทธิล-พิเพอราซิน เป็น นิวโรไคนิน-รีเซปเตอร์แอนทาโกนิสท์

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

PD4A Registration of transfer of a eurasian patent in accordance with the succession in title
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU