EA200600333A1 - Производные индазола - Google Patents

Производные индазола

Info

Publication number
EA200600333A1
EA200600333A1 EA200600333A EA200600333A EA200600333A1 EA 200600333 A1 EA200600333 A1 EA 200600333A1 EA 200600333 A EA200600333 A EA 200600333A EA 200600333 A EA200600333 A EA 200600333A EA 200600333 A1 EA200600333 A1 EA 200600333A1
Authority
EA
Eurasian Patent Office
Prior art keywords
substituted
unsubstituted
heterocyclic group
hydrogen atom
ararkyl
Prior art date
Application number
EA200600333A
Other languages
English (en)
Other versions
EA010165B1 (ru
Inventor
Йосихиса Охта
Фумихико Канаи
Синдзи Нара
Ютака Канда
Хироси Умехара
Юкимаса Сиоцу
Томоки Наое
Хитоси Кийои
Кейко Кавасима
Хироми Андо
Мотоки Мияма
Original Assignee
Киова Хакко Когио Ко., Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Киова Хакко Когио Ко., Лтд. filed Critical Киова Хакко Когио Ко., Лтд.
Publication of EA200600333A1 publication Critical patent/EA200600333A1/ru
Publication of EA010165B1 publication Critical patent/EA010165B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Данное изобретение относится к соединению, представленному формулой (I)где Rозначает CONRR(где Rи Rмогут быть одинаковыми или разными и каждый означает атом водорода, замещенный или незамещенный низший алкил, замещенный или незамещенный арил, замещенный или незамещенный аралкил или замещенную или незамещенную гетероциклическую группу, или Rи Rобъединены вместе со смежным атомом азота с образованием замещенной или незамещенной гетероциклической группы) или тому подобное, Rозначает атом водорода, CONRR(где Rи Rмогут быть одинаковыми или разными и каждый означает атом водорода, замещенный или незамещенный низший алкил, замещенный или незамещенный арил, замещенный или незамещенный аралкил или замещенную или незамещенную гетероциклическую группу, или Rи Rобъединены вместе со смежным атомом азота с образованием замещенной или незамещенной гетероциклической группы), NRR(где Rи Rмогут быть одинаковыми или разными и каждый означает атом водорода, замещенный или незамещенный низший алкил, замещенный или незамещенный низший алканоил, замещенный или незамещенный ароил, замещенный или незамещенный гетероароил, замещенный или незамещенный аралкил, замещенный или незамещенный низший алкилсульфонил или замещенный или незамещенный низший арилсульфонил) или тому подобное.
EA200600333A 2003-07-30 2004-07-30 Производные индазола EA010165B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2003203508 2003-07-30
PCT/JP2004/011287 WO2005012257A1 (ja) 2003-07-30 2004-07-30 インダゾール誘導体

Publications (2)

Publication Number Publication Date
EA200600333A1 true EA200600333A1 (ru) 2006-06-30
EA010165B1 EA010165B1 (ru) 2008-06-30

Family

ID=34113614

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200600333A EA010165B1 (ru) 2003-07-30 2004-07-30 Производные индазола

Country Status (15)

Country Link
US (2) US7470717B2 (ru)
EP (1) EP1652842B1 (ru)
JP (1) JP4335212B2 (ru)
KR (1) KR20060119705A (ru)
CN (1) CN100390149C (ru)
AT (1) ATE553092T1 (ru)
AU (1) AU2004260756B2 (ru)
BR (1) BRPI0408876A (ru)
CA (1) CA2518950A1 (ru)
EA (1) EA010165B1 (ru)
ES (1) ES2384568T3 (ru)
MX (1) MXPA05011420A (ru)
NO (1) NO20055333L (ru)
WO (1) WO2005012257A1 (ru)
ZA (1) ZA200509952B (ru)

Families Citing this family (30)

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AU2003218735B2 (en) 2002-03-13 2009-03-12 Janssen Pharmaceutica N.V. Piperazinyl-, piperidinyl- and morpholinyl-derivatives as novel inhibitors of histone deacetylase
PL214279B1 (pl) 2002-03-13 2013-07-31 Janssen Pharmaceutica Nv Pochodna sulfonyloaminowa, sposób jej wytwarzania i zastosowanie oraz kompozycja farmaceutyczna i sposób jej wytwarzania
DK1485348T3 (da) 2002-03-13 2008-09-29 Janssen Pharmaceutica Nv Carbonylamino-derivater som nye inhibitorer af histandeacetylase
US7501417B2 (en) 2002-03-13 2009-03-10 Janssen Pharmaceutica, N.V. Aminocarbonyl-derivatives as novel inhibitors of histone deacetylase
ATE553092T1 (de) * 2003-07-30 2012-04-15 Kyowa Hakko Kirin Co Ltd Indazolderivate
KR101261305B1 (ko) 2004-07-28 2013-05-08 얀센 파마슈티카 엔.브이. 히스톤 디아세틸라제의 신규한 저해제로의 치환된 인돌릴알킬 아미노 유도체
JPWO2006080450A1 (ja) * 2005-01-27 2008-06-19 協和醗酵工業株式会社 Ｉｇｆ−１ｒ阻害剤
WO2006118257A1 (ja) * 2005-04-28 2006-11-09 Kyowa Hakko Kogyo Co., Ltd. インダゾール-3-イルメチルホスホニウム塩の製造法
DK1885710T3 (en) 2005-05-18 2015-11-23 Janssen Pharmaceutica Nv SUBSTITUTED AMINOPROPENYLPIPERIDINE OR MORPHOLINE DERIVATIVES AS UNKNOWN INHIBITORS OF HISTONDEACETYLASE
AU2006307918B2 (en) * 2005-10-27 2012-06-21 Janssen Pharmaceutica N.V. Squaric acid derivatives as inhibitors of histone deacetylase
AU2007206942B2 (en) 2006-01-19 2012-08-23 Janssen Pharmaceutica N.V. Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase
JP5137848B2 (ja) 2006-01-19 2013-02-06 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ヒストンデアセチラーゼのインヒビターとしてのピリジン及びピリミジン誘導体
JP5225104B2 (ja) 2006-01-19 2013-07-03 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 新しい、ヒストンデアセチラーゼのインヒビターとしてのアミノフェニル誘導体
AU2007206950B2 (en) 2006-01-19 2012-02-02 Janssen Pharmaceutica N.V. Substituted indolyl-alkyl-amino-derivatives as inhibitors of histone deacetylase
WO2008001886A1 (fr) 2006-06-30 2008-01-03 Kyowa Hakko Kirin Co., Ltd. Inhibiteur d'aurora
CN101484427A (zh) 2006-06-30 2009-07-15 协和发酵麒麟株式会社 Abl激酶抑制剂
JPWO2008020606A1 (ja) * 2006-08-16 2010-01-07 協和発酵キリン株式会社 血管新生阻害剤
GB0619325D0 (en) 2006-09-30 2006-11-08 Univ Strathclyde New compounds
WO2008108386A1 (ja) 2007-03-05 2008-09-12 Kyowa Hakko Kirin Co., Ltd. 医薬組成物
JPWO2008111441A1 (ja) 2007-03-05 2010-06-24 協和発酵キリン株式会社 医薬組成物
WO2008114812A1 (ja) * 2007-03-19 2008-09-25 Kyowa Hakko Kirin Co., Ltd. Jak阻害剤
US20090325964A1 (en) * 2008-05-23 2009-12-31 Wyeth Piperazine Metabotropic Glutamate Receptor 5 (MGLUR5) Negative Allosteric Modulators For Anxiety/Depression
CN103804382A (zh) * 2012-11-05 2014-05-21 韩文毅 一类治疗湿疹的化合物及其用途
CN103804306A (zh) * 2012-11-12 2014-05-21 韩文毅 一类治疗糖尿病的化合物及其用途
GB201511382D0 (en) 2015-06-29 2015-08-12 Imp Innovations Ltd Novel compounds and their use in therapy
KR20180058758A (ko) 2015-09-22 2018-06-01 그레이버그 비젼, 인크. 안구 장애의 치료를 위한 화합물 및 조성물
CN110662543A (zh) 2017-03-23 2020-01-07 灰色视觉公司 用于治疗眼部疾病的药物和组合物
WO2018209155A1 (en) 2017-05-10 2018-11-15 Graybug Vision, Inc. Extended release microparticles and suspensions thereof for medical therapy
US11629139B2 (en) 2017-09-08 2023-04-18 President And Fellows Of Harvard College Small molecule inhibitors of Ebola and Lassa fever viruses and methods of use
WO2020023438A2 (en) * 2018-07-23 2020-01-30 Celgene Quanticel Research, Inc. Process for the preparation of bromodomain inhibitor

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* Cited by examiner, † Cited by third party
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JPH0232059A (ja) * 1988-07-18 1990-02-01 Kyowa Hakko Kogyo Co Ltd インダゾール誘導体
TWI262914B (en) * 1999-07-02 2006-10-01 Agouron Pharma Compounds and pharmaceutical compositions for inhibiting protein kinases
PE20010306A1 (es) * 1999-07-02 2001-03-29 Agouron Pharma Compuestos de indazol y composiciones farmaceuticas que los contienen utiles para la inhibicion de proteina kinasa
US6632815B2 (en) * 1999-09-17 2003-10-14 Millennium Pharmaceuticals, Inc. Inhibitors of factor Xa
YU54202A (sh) * 2000-01-18 2006-01-16 Agouron Pharmaceuticals Inc. Jedinjenja indazola, farmaceutske smeše i postupci za stimulisanje i inhibiranje ćelijske proliferacije
US7238853B2 (en) * 2000-07-14 2007-07-03 Unicrop Ltd Molecular mechanisms for gene containment in plants
US20050009876A1 (en) * 2000-07-31 2005-01-13 Bhagwat Shripad S. Indazole compounds, compositions thereof and methods of treatment therewith
US7211594B2 (en) * 2000-07-31 2007-05-01 Signal Pharmaceuticals, Llc Indazole compounds and compositions thereof as JNK inhibitors and for the treatment of diseases associated therewith
US6897231B2 (en) * 2000-07-31 2005-05-24 Signal Pharmaceuticals, Inc. Indazole derivatives as JNK inhibitors and compositions and methods related thereto
JP4535680B2 (ja) * 2001-04-16 2010-09-01 エーザイ・アール・アンド・ディー・マネジメント株式会社 新規１ｈ−インダゾール化合物
WO2003101968A1 (fr) * 2002-05-31 2003-12-11 Eisai Co., Ltd. Compose de pyrazole et composition medicinale le contenant
EP1582211A1 (en) * 2002-12-03 2005-10-05 Kyowa Hakko Kogyo Co., Ltd. Jnk inhibitor
ATE553092T1 (de) * 2003-07-30 2012-04-15 Kyowa Hakko Kirin Co Ltd Indazolderivate

Also Published As

Publication number Publication date
CN100390149C (zh) 2008-05-28
JP4335212B2 (ja) 2009-09-30
AU2004260756A1 (en) 2005-02-10
US7470717B2 (en) 2008-12-30
CA2518950A1 (en) 2005-02-10
ZA200509952B (en) 2006-09-27
EP1652842B1 (en) 2012-04-11
JPWO2005012257A1 (ja) 2006-09-14
KR20060119705A (ko) 2006-11-24
US20090082348A1 (en) 2009-03-26
WO2005012257A1 (ja) 2005-02-10
AU2004260756B2 (en) 2010-03-25
EA010165B1 (ru) 2008-06-30
BRPI0408876A (pt) 2006-04-11
ES2384568T3 (es) 2012-07-09
US7919517B2 (en) 2011-04-05
US20070117856A1 (en) 2007-05-24
ATE553092T1 (de) 2012-04-15
CN1777590A (zh) 2006-05-24
NO20055333L (no) 2005-11-11
EP1652842A4 (en) 2008-10-01
MXPA05011420A (es) 2005-12-12
EP1652842A1 (en) 2006-05-03

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

PD4A Registration of transfer of a eurasian patent in accordance with the succession in title
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU