JP2005532986A5 - - Google Patents

Info

Publication number

JP2005532986A5

JP2005532986A5 JP2003539658A JP2003539658A JP2005532986A5 JP 2005532986 A5 JP2005532986 A5 JP 2005532986A5 JP 2003539658 A JP2003539658 A JP 2003539658A JP 2003539658 A JP2003539658 A JP 2003539658A JP 2005532986 A5 JP2005532986 A5 JP 2005532986A5

Authority

JP

Japan

Prior art keywords

formulation

water

anticancer

preparation

butanol

Prior art date

2002-11-01

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• DKGAVHZHDRPRBM-UHFFFAOYSA-N Tert-Butanol Chemical compound CC(C)(C)O DKGAVHZHDRPRBM-UHFFFAOYSA-N 0.000 claims 12
• DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 9
• 238000002360 preparation method Methods 0.000 claims 9
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 8
• 230000001093 anti-cancer Effects 0.000 claims 6
• 239000000203 mixture Substances 0.000 claims 6
• 239000002842 anticancer formulation Substances 0.000 claims 5
• 239000000945 filler Substances 0.000 claims 5
• 238000009472 formulation Methods 0.000 claims 5
• GUBGYTABKSRVRQ-QKKXKWKRSA-N lactose group Chemical group OC1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@@H](O)[C@H](O2)CO)[C@H](O1)CO GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims 5
• 206010005003 Bladder cancer Diseases 0.000 claims 3
• ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims 3
• UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 claims 3
• 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 3
• 239000008101 lactose Substances 0.000 claims 3
• 201000005112 urinary bladder cancer Diseases 0.000 claims 3
• 238000000034 method Methods 0.000 claims 2
• 206010028980 Neoplasm Diseases 0.000 claims 1
• 201000011510 cancer Diseases 0.000 claims 1
• 239000003795 chemical substances by application Substances 0.000 claims 1
• 239000012931 lyophilized formulation Substances 0.000 claims 1
• 238000012856 packing Methods 0.000 claims 1
• 230000000087 stabilizing effect Effects 0.000 claims 1
• ODLHGICHYURWBS-LKONHMLTSA-N trappsol cyclo Chemical compound CC(O)COC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)COCC(O)C)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1COCC(C)O ODLHGICHYURWBS-LKONHMLTSA-N 0.000 claims 1