JP4317452B2 - 膀胱癌の膀胱内処置用の医学的組成物 - Google Patents
膀胱癌の膀胱内処置用の医学的組成物 Download PDFInfo
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- JP4317452B2 JP4317452B2 JP2003539658A JP2003539658A JP4317452B2 JP 4317452 B2 JP4317452 B2 JP 4317452B2 JP 2003539658 A JP2003539658 A JP 2003539658A JP 2003539658 A JP2003539658 A JP 2003539658A JP 4317452 B2 JP4317452 B2 JP 4317452B2
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- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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| CA2653541C (en) | 2005-06-06 | 2014-12-23 | The University Of British Columbia | Polymer-based serum albumin substitute |
| JP2009526085A (ja) * | 2006-02-09 | 2009-07-16 | スペクトラム ファーマシューティカルズ インコーポレイテッド | Ｅｏ９およびプロピレングリコールの使用による膀胱癌の治療 |
| US20080114021A1 (en) * | 2006-11-09 | 2008-05-15 | University Of Maryland Baltimore | Use Of 5,6-Dimethylxanthenone-4-Acetic Acid as an Antimicrobial Agent |
| RU2354386C1 (ru) * | 2007-12-26 | 2009-05-10 | ГУ Московская городская онкологическая больница №62 Департамента здравоохранения г. Москвы | Способ профилактики рецидивов поверхностного рака мочевого пузыря |
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Family Cites Families (65)
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| AU565354B2 (en) | 1983-11-14 | 1987-09-10 | Bio-Mimetics Inc. | Bioadhesive compositions and methods of treatment therewith |
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| JPS60163621A (ja) | 1984-02-02 | 1985-08-26 | 村上 俊文 | 紙製便座カバ−の製造方法 |
| JPS60163821A (ja) | 1984-02-03 | 1985-08-26 | Tdk Corp | フエライト粒子を含む薬剤用担体 |
| JPS61189215A (ja) | 1985-02-18 | 1986-08-22 | Teijin Ltd | ５−フルオロ−２′−デオキシウリジンエステル類の油状医薬組成物 |
| WO1987006227A2 (en) * | 1986-04-17 | 1987-10-22 | Jouhar Akbar Jan | Indoloquinone compounds |
| US4871542A (en) * | 1987-04-30 | 1989-10-03 | Ferring Service Center, N.V. | Method and apparatus useful for delivering medicinal compositions into the bladder and urinary tract |
| EP0331635A3 (en) | 1988-02-29 | 1990-02-28 | The Board of Regents of the University of Texas System | Preparations for treating bladder cancer |
| EP0338679A3 (en) | 1988-03-24 | 1991-03-06 | Genentech, Inc. | Tumour necrosis factor in the treatment of bladder cancer |
| FR2629584B1 (fr) | 1988-03-31 | 1993-06-04 | France Etat Armement | Dispositif de stabilisation pour un projectile a faible moment d'inertie longitudinal tire a partir d'un tube raye |
| US5843156A (en) * | 1988-08-24 | 1998-12-01 | Endoluminal Therapeutics, Inc. | Local polymeric gel cellular therapy |
| US5744166A (en) * | 1989-02-25 | 1998-04-28 | Danbiosyst Uk Limited | Drug delivery compositions |
| PT93772A (pt) * | 1989-04-17 | 1991-01-08 | Searle & Co | Processo para a preparacao de composicoes para o tratamento de neoplasias, contendo um agente anti-neoplastico, por exemplo doxorubicina e um agente protector para reduzir os efeitos secundarios, por exemplo carbetimer |
| US5216011A (en) * | 1989-09-01 | 1993-06-01 | Bristol-Myers Squibb Co. | Stable solutions of mitomycin c |
| US5237466A (en) | 1989-11-02 | 1993-08-17 | International Business Machines Corporation | Method and apparatus for programmably controlling spindle synchronization and phase among disk drives in a storage subsystem |
| FI84874C (fi) | 1989-11-02 | 1992-02-10 | Valio Meijerien | Foerfarande foer inkapsling av biologiskt aktiva aemnen, enligt metoden framstaelld kapsel, dess anvaendning och foder innehaollande den. |
| US5292516A (en) * | 1990-05-01 | 1994-03-08 | Mediventures, Inc. | Body cavity drug delivery with thermoreversible gels containing polyoxyalkylene copolymers |
| US5346703A (en) * | 1990-08-07 | 1994-09-13 | Mediventures, Inc. | Body cavity drug delivery with thermo-irreversible polyoxyalkylene and ionic polysaccharide gels |
| IT1250421B (it) | 1991-05-30 | 1995-04-07 | Recordati Chem Pharm | Composizione farmaceutica a rilascio controllato con proprieta' bio-adesive. |
| US5550110A (en) | 1992-04-22 | 1996-08-27 | Warner-Lambert Company | Endothelin Antagonists II |
| JP3598049B2 (ja) | 1992-09-18 | 2004-12-08 | 山之内製薬株式会社 | ハイドロゲル徐放性製剤 |
| US5744155A (en) * | 1993-08-13 | 1998-04-28 | Friedman; Doron | Bioadhesive emulsion preparations for enhanced drug delivery |
| EP0995447A1 (en) | 1993-09-09 | 2000-04-26 | Takeda Chemical Industries, Ltd. | Formulation comprising antibacterial substance and antiulcer substance |
| CA2135151A1 (en) | 1993-11-08 | 1995-05-09 | Mitsuhiro Wakimasu | Cyclic hexapeptides, their production and use |
| US5405622A (en) * | 1993-12-22 | 1995-04-11 | Vernice; Joseph | Gamma radiation resistant lubricating gel |
| TW438601B (en) * | 1994-05-18 | 2001-06-07 | Janssen Pharmaceutica Nv | New mucoadhesive emulsion compositions and a process for the preparation thereof |
| US5811416A (en) | 1994-06-06 | 1998-09-22 | Board Of Regents The University Of Texas System | Endothelin antagonist and/or endothelin synthase inhibitor in combination with a progestin, an estrogen, a cyclooxygenase inhibitor, or a nitric acid donor or substrate |
| US5612359A (en) | 1994-08-26 | 1997-03-18 | Bristol-Myers Squibb Company | Substituted biphenyl isoxazole sulfonamides |
| EP2301562B1 (en) | 1994-12-12 | 2013-04-17 | Omeros Corporation | Irrigation solution and method for inhibition of pain, inflammation and spasm |
| US5749845A (en) * | 1995-01-25 | 1998-05-12 | Iotek, Inc. | Delivering an agent to an organ |
| WO1997023456A1 (en) | 1995-12-21 | 1997-07-03 | British Technology Group Ltd. | Indoloquinone derivatives as bioreductive agents |
| US5985312A (en) * | 1996-01-26 | 1999-11-16 | Brown University Research Foundation | Methods and compositions for enhancing the bioadhesive properties of polymers |
| JP2000509014A (ja) * | 1996-03-11 | 2000-07-18 | フォーカル，インコーポレイテッド | 放射性核種および放射性医薬品のポリマー送達 |
| US5955096A (en) * | 1996-06-25 | 1999-09-21 | Brown University Research Foundation | Methods and compositions for enhancing the bioadhesive properties of polymers using organic excipients |
| US6251861B1 (en) | 1996-06-27 | 2001-06-26 | Takeda Chemical Industries, Ltd. | Treatment of cerebral infarction using cyclic hexapeptides |
| JP2967734B2 (ja) * | 1996-10-18 | 1999-10-25 | 日本電気株式会社 | 薄膜の形成方法 |
| EP0971641A4 (en) * | 1997-04-03 | 2003-08-13 | Point Biomedical Corp | SYSTEM FOR THE ADMINISTRATION OF AN INTRAVESICAL MEDICINAL PRODUCT |
| US5854382A (en) * | 1997-08-18 | 1998-12-29 | Meadox Medicals, Inc. | Bioresorbable compositions for implantable prostheses |
| AU9082698A (en) * | 1997-09-08 | 1999-03-29 | Theramark Limited | Treatment of inflammatory conditions |
| US6156744A (en) | 1998-03-19 | 2000-12-05 | Cancer Research Campaign Tech (London) | DT-diaphorase directed anti-tumor agents |
| EP0950418A2 (en) | 1998-04-14 | 1999-10-20 | Takeda Chemical Industries, Ltd. | Composition for preventing or treating ischemic disease |
| US6171610B1 (en) * | 1998-04-24 | 2001-01-09 | University Of Massachusetts | Guided development and support of hydrogel-cell compositions |
| KR20010043322A (ko) | 1998-05-05 | 2001-05-25 | 아스트라제네카 악티에볼라그 | 미코박테리아성 억제제 |
| IL124957A0 (en) | 1998-06-16 | 1999-01-26 | Univ Ben Gurion | Active ingredient delivery systems and devices based on porous matrices |
| US6087396A (en) * | 1998-10-05 | 2000-07-11 | Situs Corporation | Oxybutynin formulations and method of use |
| GB9827034D0 (en) | 1998-12-10 | 1999-02-03 | Univ Manchester | Delivery formulation |
| JP2000256182A (ja) | 1999-03-03 | 2000-09-19 | Kazuhiro Morimoto | 抗菌製剤 |
| WO2000067023A1 (en) | 1999-04-29 | 2000-11-09 | Coley Pharmaceutical Gmbh | Screening for immunostimulatory dna functional modifyers |
| US7566452B1 (en) | 1999-05-04 | 2009-07-28 | New York University | Cancer treatment with endothelin receptor antagonists |
| US6545048B1 (en) | 1999-06-29 | 2003-04-08 | California Institute Of Technology | Compositions and methods of treating cancer using compositions comprising an inhibitor or endothelin receptor activity |
| WO2001091736A2 (en) | 2000-05-31 | 2001-12-06 | Warner-Lambert Company | Combinations of an endothelin receptor antagonist and an antiepileptic compound having pain alleviating properties or analgesic |
| MXPA03004832A (es) | 2000-12-01 | 2004-05-04 | Guilford Pharm Inc | Compuestos y sus usos. |
| WO2002049630A2 (en) | 2000-12-21 | 2002-06-27 | Bristol-Myers Squibb Company | Method for preventing or treating pain by administering an endothelin antagonist |
| WO2003009805A2 (en) | 2001-07-23 | 2003-02-06 | Brigham And Women's Hospital, Inc. | Analgesic methods using endothelin receptor ligands |
| ATE493126T1 (de) | 2001-11-01 | 2011-01-15 | Spectrum Pharmaceuticals Inc | Medizinische zusammensetzungen zur intravesikalen behandlung von blasenkrebs |
| US7973064B2 (en) | 2001-11-27 | 2011-07-05 | The Board Of Trustees Of The University Of Illinois | Method and composition for potentiating an opiate analgesic |
| JP5184738B2 (ja) | 2002-05-03 | 2013-04-17 | ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト | 修飾第ｖｉｉ因子の安定化された固体組成物 |
| US20040009918A1 (en) | 2002-05-03 | 2004-01-15 | Hanne Nedergaard | Stabilised solid compositions of modified factor VII |
| JP2006508086A (ja) | 2002-10-24 | 2006-03-09 | ザ ボード オブ トラスティーズ オブ ザ ユニバーシティ オブ イリノイ | 固形腫瘍を予防および治療するための方法および組成物 |
| HRP20140338T1 (hr) | 2005-07-25 | 2014-06-20 | Emergent Product Development Seattle, Llc | Smanjenje broja b-stanica upotrebom molekula koje se specifiäśno vežu na cd37 i cd20 |
| JP2009526085A (ja) | 2006-02-09 | 2009-07-16 | スペクトラム ファーマシューティカルズ インコーポレイテッド | Ｅｏ９およびプロピレングリコールの使用による膀胱癌の治療 |
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