JP2005532398A5 - - Google Patents
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- Publication number
- JP2005532398A5 JP2005532398A5 JP2004519909A JP2004519909A JP2005532398A5 JP 2005532398 A5 JP2005532398 A5 JP 2005532398A5 JP 2004519909 A JP2004519909 A JP 2004519909A JP 2004519909 A JP2004519909 A JP 2004519909A JP 2005532398 A5 JP2005532398 A5 JP 2005532398A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- hydroxytyrosol
- weight ratio
- oleuropein
- water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- JUUBCHWRXWPFFH-UHFFFAOYSA-N Hydroxytyrosol Chemical compound OCCC1=CC=C(O)C(O)=C1 JUUBCHWRXWPFFH-UHFFFAOYSA-N 0.000 claims 38
- 238000000034 method Methods 0.000 claims 23
- 239000000203 mixture Substances 0.000 claims 22
- 235000003248 hydroxytyrosol Nutrition 0.000 claims 19
- 229940095066 hydroxytyrosol Drugs 0.000 claims 19
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 19
- RFWGABANNQMHMZ-UHFFFAOYSA-N 8-acetoxy-7-acetyl-6,7,7a,8-tetrahydro-5H-benzo[g][1,3]dioxolo[4',5':4,5]benzo[1,2,3-de]quinoline Natural products CC=C1C(CC(=O)OCCC=2C=C(O)C(O)=CC=2)C(C(=O)OC)=COC1OC1OC(CO)C(O)C(O)C1O RFWGABANNQMHMZ-UHFFFAOYSA-N 0.000 claims 11
- HKVGJQVJNQRJPO-UHFFFAOYSA-N Demethyloleuropein Natural products O1C=C(C(O)=O)C(CC(=O)OCCC=2C=C(O)C(O)=CC=2)C(=CC)C1OC1OC(CO)C(O)C(O)C1O HKVGJQVJNQRJPO-UHFFFAOYSA-N 0.000 claims 11
- RFWGABANNQMHMZ-HYYSZPHDSA-N Oleuropein Chemical compound O([C@@H]1OC=C([C@H](C1=CC)CC(=O)OCCC=1C=C(O)C(O)=CC=1)C(=O)OC)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O RFWGABANNQMHMZ-HYYSZPHDSA-N 0.000 claims 11
- 235000011576 oleuropein Nutrition 0.000 claims 11
- RFWGABANNQMHMZ-CARRXEGNSA-N oleuropein Natural products COC(=O)C1=CO[C@@H](O[C@H]2O[C@@H](CO)[C@H](O)[C@@H](O)[C@@H]2O)C(=CC)[C@H]1CC(=O)OCCc3ccc(O)c(O)c3 RFWGABANNQMHMZ-CARRXEGNSA-N 0.000 claims 11
- 241000196324 Embryophyta Species 0.000 claims 8
- 239000003814 drug Substances 0.000 claims 6
- 229940124597 therapeutic agent Drugs 0.000 claims 6
- 239000002253 acid Substances 0.000 claims 5
- 238000011534 incubation Methods 0.000 claims 5
- YCCILVSKPBXVIP-UHFFFAOYSA-N 2-(4-hydroxyphenyl)ethanol Chemical compound OCCC1=CC=C(O)C=C1 YCCILVSKPBXVIP-UHFFFAOYSA-N 0.000 claims 4
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical group CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims 3
- 240000007817 Olea europaea Species 0.000 claims 3
- 230000002411 adverse Effects 0.000 claims 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 3
- 230000000694 effects Effects 0.000 claims 3
- 230000005855 radiation Effects 0.000 claims 3
- DBLDQZASZZMNSL-QMMMGPOBSA-N L-tyrosinol Natural products OC[C@@H](N)CC1=CC=C(O)C=C1 DBLDQZASZZMNSL-QMMMGPOBSA-N 0.000 claims 2
- 241000207836 Olea <angiosperm> Species 0.000 claims 2
- 239000003960 organic solvent Substances 0.000 claims 2
- 150000008442 polyphenolic compounds Chemical class 0.000 claims 2
- 235000013824 polyphenols Nutrition 0.000 claims 2
- 235000004330 tyrosol Nutrition 0.000 claims 2
- 239000002775 capsule Substances 0.000 claims 1
- 238000004587 chromatography analysis Methods 0.000 claims 1
- 239000007972 injectable composition Substances 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 239000006187 pill Substances 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 238000000746 purification Methods 0.000 claims 1
- 239000003826 tablet Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/190,043 US7713569B2 (en) | 2000-09-01 | 2002-07-05 | Hydroxytyrosol-rich composition from olive vegetation water and method of use thereof |
| PCT/US2003/021111 WO2004005228A1 (en) | 2002-07-05 | 2003-07-03 | An hydroxytyrosol-rich composition from olive vegetation water and method of use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005532398A JP2005532398A (ja) | 2005-10-27 |
| JP2005532398A5 true JP2005532398A5 (https=) | 2006-09-07 |
Family
ID=30114043
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004519909A Pending JP2005532398A (ja) | 2002-07-05 | 2003-07-03 | オリーブ植物水由来のヒドロキシチロソール富化組成物およびその使用方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US7713569B2 (https=) |
| EP (1) | EP1523465B1 (https=) |
| JP (1) | JP2005532398A (https=) |
| KR (1) | KR20050025588A (https=) |
| CN (1) | CN1665764B (https=) |
| AU (1) | AU2003249719B2 (https=) |
| CA (1) | CA2491613C (https=) |
| ES (1) | ES2873449T3 (https=) |
| WO (1) | WO2004005228A1 (https=) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9072753B1 (en) * | 2000-04-03 | 2015-07-07 | Amy C. Brown | Gargle method to reduce the duration of common cold symptoms |
| JP3820218B2 (ja) * | 2000-09-01 | 2006-09-13 | クレアグリ, インコーポレイテッド | 植物水からヒドロキシチロソール富化組成物を得る方法 |
| US7713569B2 (en) | 2000-09-01 | 2010-05-11 | Creagri, Inc. | Hydroxytyrosol-rich composition from olive vegetation water and method of use thereof |
| CA2474798C (en) * | 2002-02-13 | 2012-12-04 | Creagri, Inc. | Method and composition for treatment of inflammation and aids-associated neurological disorders |
| US7468355B2 (en) * | 2002-05-22 | 2008-12-23 | H2Rc Corporation | Methods for inhibiting cancer and scar formation |
| ITMI20041627A1 (it) | 2004-08-06 | 2004-11-06 | Lachifarma S R L Lab Chimi Co | Processo per il recupero di tirosolo idrossitirosolo e altri componenti fenolici da acque di vegetazione e metodo di ossidazione catalitica di tirosolo a idrossitirosolo |
| US20200319198A1 (en) * | 2004-08-09 | 2020-10-08 | Kathleen Matt | Olive compositions and methods for treating inflammatory conditions |
| WO2006020588A1 (en) * | 2004-08-09 | 2006-02-23 | Creagri, Inc. | Olive compositions and methods for treating inflammatory conditions |
| JP4832445B2 (ja) * | 2004-11-16 | 2011-12-07 | ディーエスエム アイピー アセッツ ビー.ブイ. | 筋回復のための抗酸化化合物の使用 |
| US9789149B2 (en) * | 2005-07-19 | 2017-10-17 | Creagri, Inc. | Vegetation water composition for treatment of inflammatory skin conditions |
| PT103326A (pt) * | 2005-07-27 | 2007-01-31 | Inst De Biolog Ex E Tecnologic | Método para obtenção de um concentrado natural rico em hidroxitirosol a partir de resíduos da produção de azeite utilizando tecnologias limpas |
| EP2040696B1 (en) * | 2006-07-14 | 2017-01-25 | DSM IP Assets B.V. | Compositions and use thereof for the treatment, co-treatment or prevention of inflammatory disorders |
| EP2068901B1 (en) * | 2006-10-05 | 2018-11-21 | DSM IP Assets B.V. | Use of hydroxytyrosol to reduce the amount of lactic acid in plasma |
| JP5175481B2 (ja) * | 2006-10-23 | 2013-04-03 | エーザイフード・ケミカル株式会社 | 軟骨再生促進剤 |
| EP1938698A1 (en) * | 2006-12-06 | 2008-07-02 | DSMIP Assets B.V. | Novel powders based on vegetation water from olive oil production |
| EP2049458B1 (en) | 2007-01-26 | 2013-12-25 | Probelte Pharma, S.A. | Process for the production of hydroxytyrosol containing extract from olives and solids containing residues of olive oil extraction |
| US8968811B2 (en) | 2007-01-26 | 2015-03-03 | Probelte Pharma, S.A. | Hydroxytrosol containing extract obtained from olives and solids containing residues of olive oil extraction |
| EP1982707A1 (en) * | 2007-04-18 | 2008-10-22 | DSMIP Assets B.V. | Use of hydroxytyrosol as anti-aging agent |
| EP1982603A1 (en) * | 2007-04-18 | 2008-10-22 | DSMIP Assets B.V. | Novel use of hydroxytyrosol and olive extracts/concentrates containing it |
| KR20100015595A (ko) * | 2007-04-18 | 2010-02-12 | 디에스엠 아이피 어셋츠 비.브이. | 하이드록시타이로솔 및 이를 함유하는 올리브 추출물/농축물의 신규한 용도 |
| ES2311401B1 (es) * | 2007-05-22 | 2009-12-22 | Ges-Biolives, S.L. | Procedimiento para la obtencion de extractos con alto contenido en hidroxitirosol a partir de productos derivados de la oliva. |
| KR20100051663A (ko) | 2007-08-21 | 2010-05-17 | 디에스엠 아이피 어셋츠 비.브이. | 고체 함량이 감소된 올리브 쥬스 추출물의 제조 방법 |
| US20110111087A1 (en) * | 2007-08-29 | 2011-05-12 | Roberto Crea | Food and beverage supplement |
| JP2009227616A (ja) * | 2008-03-24 | 2009-10-08 | Toin Gakuen | オレウロペイン及び/又はヒドロキシチロソールを有効成分として含有する骨形成促進剤 |
| US20110111086A1 (en) * | 2009-11-11 | 2011-05-12 | Lusk Lance T | Method of Improving Flavor Stability In Fermented Beverages |
| NZ600912A (en) * | 2009-12-01 | 2014-05-30 | Seprox Biotech S L | Topical use of hydroxytyrosol and derivatives for the prevention of hiv infection |
| US8465939B2 (en) * | 2010-03-02 | 2013-06-18 | Nox Technologies, Inc. | Aging-related circulating particle-associated lipoprotein B oxidase (apoBNOX) and inhibitors thereof |
| IT1400373B1 (it) * | 2010-06-03 | 2013-05-31 | Mazzotta | Preparazione di un estratto ricco di polifenoli e di una frazione solida da acque di vegetazione delle olive e suo uso farmaceutico, cosmetico e alimentare. |
| MY175348A (en) | 2011-02-11 | 2020-06-22 | Crea Roberto | Treatment of elaeis fruit products with antioxidants |
| ITMI20110941A1 (it) | 2011-05-25 | 2012-11-26 | Phenofarm S R L | Processo di produzione di un fito-estratto da acque di vegetazione esanse olearie |
| DE102013203753A1 (de) * | 2013-03-05 | 2014-09-11 | Wacker Chemie Ag | Verfahren zur Herstellung von Hydroxytyrosol |
| FR3018686B1 (fr) | 2014-03-24 | 2017-05-19 | Pierre Fabre Dermo Cosmetique | Utilisation cosmetique d'un extrait de margines d'olivier pour redensifier le cheveu |
| US10532022B2 (en) * | 2014-07-21 | 2020-01-14 | The United States Of America, As Represented By The Secretary Of Agriculture | Whole stablized olive mill process water, production thereof and uses thereof |
| CN106610409A (zh) * | 2015-10-23 | 2017-05-03 | 杭州师范大学 | 一种壳聚糖填充微型基质固相分散方法 |
| JP6381076B2 (ja) | 2015-12-01 | 2018-08-29 | 小豆島ヘルシーランド株式会社 | 紫外線遮断剤および化粧料 |
| CN105997703B (zh) * | 2016-07-05 | 2019-11-12 | 上海相宜本草化妆品股份有限公司 | 橄榄叶提取物以及包含该提取物的化妆品 |
| JP7079551B2 (ja) | 2016-10-04 | 2022-06-02 | ニュートラマックス ラボラトリーズ,インコーポレイテッド | ヒドロキシチロソールおよびボスウェリン酸を有する組成物 |
| CN108314607A (zh) * | 2018-05-08 | 2018-07-24 | 广西大学 | 一种高纯度固体羟基酪醇的纯化方法 |
| DE102021111719A1 (de) * | 2021-05-05 | 2022-11-10 | Henkel Ag & Co. Kgaa | Erhalt der Haarstruktur gegenüber Umwelteinflüssen umfassend ein Phenol und multivalente Ionen |
| CN113277931A (zh) * | 2021-06-04 | 2021-08-20 | 陕西富恒生物科技有限公司 | 一种从油橄榄果中提取羟基酪醇的方法 |
| CN116253605B (zh) * | 2022-12-30 | 2025-09-26 | 山东农业大学 | 一种橄榄果渣多酚提取物-羟基酪醇作为生物源氮肥增效剂的应用 |
| MA61008A1 (fr) * | 2023-06-12 | 2024-12-31 | Hind Mikdame | Valorisation des marjines dans la fabrication des savons solides,mous et liquides et des produits cosmetiques. |
| WO2025145263A1 (es) * | 2024-01-04 | 2025-07-10 | Quimica Mavar S.A. | Composición extracto polifenólico y acuoso derivado de alpechin como bioestimulante y agente protectivo para plantas |
| US20250275535A1 (en) * | 2024-03-01 | 2025-09-04 | Veos Pharmaceuticals, S.L. | Olive tree biomass extract |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4370274A (en) | 1980-12-23 | 1983-01-25 | Fps Development Partnership | Olive oil recovery |
| US4452744A (en) | 1980-12-23 | 1984-06-05 | Fps Development Partnership | Olive oil recovery |
| US4522119A (en) | 1980-12-23 | 1985-06-11 | Fps Development Partnership | Olive oil recovery |
| DE3720408A1 (de) | 1987-06-19 | 1988-12-29 | Peter Dr Hussmann | Verfahren und vorrichtung zur umweltschonenden beseitigung des bei der olivenpressung anfallenden abwassers |
| ES2006904A6 (es) | 1988-04-15 | 1989-05-16 | Jimenez Rodriguez Jose Luis | Procedimiento de obtencion de aceite a partir del orujo. |
| AU670742B2 (en) | 1991-03-21 | 1996-08-01 | Parfums Christian Dior | Novel derivative of caffeic acid, oraposide, cosmetic or pharmaceutical, particularly dermatological, composition containing it |
| IT1262967B (it) | 1992-07-31 | 1996-07-23 | Inn Tec Srl | Macchina e procedimento per la produzione di olio di oliva senza frangitura dei noccioli. |
| JPH07223940A (ja) * | 1994-02-14 | 1995-08-22 | Pola Chem Ind Inc | 活性酸素消去剤及びこれを含有する組成物 |
| JP3499616B2 (ja) | 1994-10-20 | 2004-02-23 | 一丸ファルコス株式会社 | ヒドロキシチロソール、メラニン生成抑制剤又は過酸化脂質生成抑制剤への応用 |
| WO1996014064A1 (en) * | 1994-11-07 | 1996-05-17 | Strecker, Robert, B. | Method and composition for antiviral therapy |
| IT1278025B1 (it) | 1995-02-21 | 1997-11-17 | Tecnologie 2000 S R L | Separatore centrifugo orizzontale, in particolare per la pruduzione di olio, con estrazione accelerata della fase liquida. |
| IT1276576B1 (it) | 1995-05-10 | 1997-11-03 | Tecnologie 2000 S R L | Snocciolatore a lame per la preparazione di pasta di olive e apparato mobile per la produzione non industriale di olio. |
| WO1997021434A1 (en) | 1995-12-11 | 1997-06-19 | Inholtra, Inc. | Dietary regimen of nutritional supplements for relief of symptoms of arthritis |
| WO1997028089A1 (en) | 1996-01-31 | 1997-08-07 | Dianellos Georgoudis | Method of extraction of olive paste from vegetable water and its use as a foodstuff |
| EP0811678A1 (fr) | 1996-06-08 | 1997-12-10 | Societe Des Produits Nestle S.A. | Extraction d'antioxydants |
| US5998641A (en) * | 1997-01-31 | 1999-12-07 | Unilever Patent Holdings | Debittering of olive oil |
| US5714150A (en) | 1997-01-08 | 1998-02-03 | Nachman; Leslie | Method for producing extract of olive leaves |
| HUP0101529A3 (en) | 1998-04-14 | 2002-08-28 | Unilever Nv | Fortification of a vegetable fat with antioxidants |
| US6165475A (en) * | 1998-07-23 | 2000-12-26 | Creagri, Inc. | Water-soluble extract from olives |
| US6936287B1 (en) * | 1998-07-23 | 2005-08-30 | Creagri, Inc. | Water-soluble extract from olives |
| WO2000004794A1 (en) * | 1998-07-23 | 2000-02-03 | Creagri, Inc. | Water-soluble extract from olives |
| EP1139797A2 (en) * | 1998-12-22 | 2001-10-10 | Unilever N.V. | Food compositions fortified with anti-oxidants |
| US6220267B1 (en) * | 1999-01-27 | 2001-04-24 | Ceramatec, Inc. | Apparatus and method for controllably delivering fluid to a second fluid stream |
| US6242491B1 (en) * | 1999-06-25 | 2001-06-05 | Rima Kaddurah-Daouk | Use of creatine or creatine compounds for skin preservation |
| JP4025546B2 (ja) * | 1999-10-14 | 2007-12-19 | 日清オイリオグループ株式会社 | 美肌剤、皮膚の抗老化剤、美白剤および皮膚外用剤 |
| US6358542B2 (en) * | 1999-12-20 | 2002-03-19 | Usana, Inc. | Antioxidant compositions extracted from olives and olive by-products |
| US6437004B1 (en) | 2000-04-06 | 2002-08-20 | Nicholas V. Perricone | Treatment of skin damage using olive oil polyphenols |
| US6440465B1 (en) * | 2000-05-01 | 2002-08-27 | Bioderm, Inc. | Topical composition for the treatment of psoriasis and related skin disorders |
| JP3820218B2 (ja) * | 2000-09-01 | 2006-09-13 | クレアグリ, インコーポレイテッド | 植物水からヒドロキシチロソール富化組成物を得る方法 |
| US7713569B2 (en) | 2000-09-01 | 2010-05-11 | Creagri, Inc. | Hydroxytyrosol-rich composition from olive vegetation water and method of use thereof |
| PT1369407E (pt) * | 2001-02-15 | 2009-01-22 | Consejo Superior Investigacion | Processo de obtenção de hidroxitirosol purificado a partir de produtos e subprodutos derivados da oliveira |
| JP4587200B2 (ja) * | 2001-10-09 | 2010-11-24 | 株式会社ファンケル | グルタチオン増強用組成物 |
| US6906100B2 (en) * | 2002-02-08 | 2005-06-14 | Lavipharm S.A. | Compounds and compositions derived from olives and methods of the use thereof |
| CA2474798C (en) * | 2002-02-13 | 2012-12-04 | Creagri, Inc. | Method and composition for treatment of inflammation and aids-associated neurological disorders |
| US20050103711A1 (en) * | 2003-11-18 | 2005-05-19 | Wayne Emmons | Isolation of oleuropein aglycon from olive vegetation water |
| US9789149B2 (en) * | 2005-07-19 | 2017-10-17 | Creagri, Inc. | Vegetation water composition for treatment of inflammatory skin conditions |
-
2002
- 2002-07-05 US US10/190,043 patent/US7713569B2/en not_active Expired - Lifetime
-
2003
- 2003-07-03 EP EP03763237.9A patent/EP1523465B1/en not_active Expired - Lifetime
- 2003-07-03 CA CA2491613A patent/CA2491613C/en not_active Expired - Fee Related
- 2003-07-03 JP JP2004519909A patent/JP2005532398A/ja active Pending
- 2003-07-03 ES ES03763237T patent/ES2873449T3/es not_active Expired - Lifetime
- 2003-07-03 WO PCT/US2003/021111 patent/WO2004005228A1/en not_active Ceased
- 2003-07-03 AU AU2003249719A patent/AU2003249719B2/en not_active Ceased
- 2003-07-03 KR KR1020057000208A patent/KR20050025588A/ko not_active Ceased
- 2003-07-03 CN CN038159864A patent/CN1665764B/zh not_active Expired - Fee Related
-
2010
- 2010-05-10 US US12/776,812 patent/US20100216874A1/en not_active Abandoned
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