JP2005525178A - 化合物を蒸発させるための方法および装置 - Google Patents
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Abstract
Description
高出力シルバニア(登録商標)フラッシュバルブは、その高分子コーティングが損なわれていない状態で、重量を測り、ニコチンのガラスビン内に配置された。液体ニコチンを高分子コーティング中に1時間吸収させておき、ティッシュで拭き取ることにより、余分な液体を除去した。アルゴン雰囲気下でガラスビン内に一晩中バルブを平衡状態にしておいた。その後、ガラスビンを開放して、アルゴンをバルブ上に45分間流した。再度重量を測ったら、高分子コーティング中に全体で24.6mgのニコチンが溶けていた。バルブは、8mLのガラスビン内に閉じ込められ、AAAバッテリの端子両端間のリード線と接触させることにより点火された。目に見えるエアゾールがガラスビン内に形成され、このエアゾールを壁上で再び凝結させておいた。凝縮液を高性能な液体クロマトグラフィで分析すると、この凝縮液が1.3mgの純粋なニコチンから成ることが分かった。
300〜400Jのエネルギを生成できる高出力フラッシュキューブ(GEまたはシルバニア)を陽極酸化されたアルミニウムチューブ内に挿入した。薬剤を含有する有機溶液中にフラッシュキューブ/チューブアセンブリを浸漬して直ぐに除去した。アセンブリを真空チャンバ内に30分間配置することにより、残った溶媒をアセンブリから蒸発させた。これにより、アルミニウムチューブの外面上にコーティングされた薬剤の膜が残った。フラッシュバルブアセンブリを、2つの1.5Vバッテリおよび銅ワイヤを使用するスイッチに対して電気的に接続し、その後、シールされたガラスビン内に封じ込めた。フラッシュバルブとバッテリとの間でスイッチを少しの間だけONすることにより、フラッシュバルブの点火を行なった。点火後、ガラスビンを30分間閉じたままにしておき、これにより、揮発された薬剤の粒子をガラスビンの内面上で凝固させて凝縮(液化)させた。エアゾールの分析では、5mLのアセトニトリルを用いてガラスビンを濯ぐとともに、有機溶液のサンプルを高性能液体クロマトグラフィ装置内に注入した。高速熱電対を用いて測定すると、アルミニウムチューブが50ミリ秒後に600℃まで加熱された。すなわち、12000°/sの加熱速度を示した。
Claims (36)
- コーティングされた薬剤物質を急速に加熱して蒸発させるための装置であって、
可燃性部材および燃焼反応生成物を完全に収容するための内部領域を取り囲む内面と、外面とを有する基体と、
前記基体の前記内部領域の内側にシール状態で封入される可燃性部材と、
前記可燃性部材の酸化を起こすために前記可燃性部材に接続されたスパーク点火器または抵抗点火器と、
前記可燃性部材の点火時に蒸発される薬剤を含有する、前記基体の外面上にコーティングされた薬剤と、
を含む装置。 - 前記可燃性部材がバルブ内にシール状態で封入されている、請求項1に記載の装置。
- 前記バルブがガラスによって形成されている、請求項2に記載の装置。
- 前記バルブが前記基体の内面および外面を構成している、請求項3に記載の装置。
- 前記基体が金属製である、請求項1に記載の装置。
- 前記基体がステンレススチールまたはアルミニウムによって形成されている、請求項5に記載の装置。
- 前記基体の内面が光を吸収する、請求項1に記載の装置。
- 前記基体が、ガラスバルブまたは高分子コーティング剤を取り囲むシースを含む、請求項3に記載の装置。
- 前記可燃性部材が燃焼時にガスを消費する、請求項1に記載の装置。
- 前記可燃性部材が可燃性金属を含む、請求項9に記載の装置。
- 前記可燃性部材が、マグネシウム、ジルコニウム、あるいは、アルミニウムを含む、請求項10に記載の装置。
- シールされたバルブ上に前記基体がコーティングされている、請求項2に記載の装置。
- 前記基体の外面の周囲に、薬剤の蒸発後に薬剤の吸入を容易にするためのハウジングを更に含む、請求項1に記載の装置。
- 前記ハウジングが、薬剤の蒸発後に薬剤の経口吸入を容易にするマウスピースを含む、請求項13に記載の装置。
- 前記ハウジングが、薬剤の蒸発後に薬剤の経鼻吸入を容易にする鼻アタッチメントを含む、請求項13に記載の装置。
- 薬剤を蒸発させるための装置であって、
内部領域を取り囲む内面と、外面とを有する基体と、
前記基体の前記内部領域の内側に収容される可燃性部材と、
前記可燃性部材に接続されるとともに、前記可燃性部材の燃焼を起こすためのスパーク点火器または抵抗点火器と、
前記基体の外面に付着されるとともに、前記可燃性部材の点火時に蒸発される薬剤と、
を含む装置。 - シールされたバルブ内に前記可燃性部材が収容されている、請求項16に記載の装置。
- 前記基体が金属製である、請求項16に記載の装置。
- 前記バルブがガラスによって形成されている、請求項17に記載の装置。
- 前記バルブが前記基体の内面および外面を構成している、請求項17に記載の装置。
- 前記基体がステンレススチールまたはアルミニウムによって形成されている、請求項18に記載の装置。
- 前記基体の内面が陽極酸化されている、請求項21に記載の装置。
- 前記基体が、バルブまたは高分子コーティング剤を取り囲むシースを含む、請求項17に記載の装置。
- 前記可燃性部材が燃焼時にガスを消費する、請求項16に記載の装置。
- 前記可燃性部材が可燃性金属を含む、請求項16に記載の装置。
- 前記可燃性部材が、マグネシウム、ジルコニウム、あるいは、アルミニウムを含む、請求項25に記載の装置。
- 前記基体の外面を取り囲むハウジングであって、薬剤の蒸発後に薬剤の吸入を容易にするハウジングを更に含む、請求項16に記載の装置。
- 前記ハウジングが、薬剤の蒸発後に薬剤の経口吸入を容易にするマウスピースを含む、請求項27に記載の装置。
- 前記点火器が前記基体を点火するための電源を含むとともに、装置が2つの部分に分離可能であり、そのうちの第1の部分が電源を収容し、第2の部分が、前記基体と、前記可燃性部材と、前記薬剤とを収容する、請求項28に記載の装置。
- 薬剤をエアゾール化するための方法であって、
内部領域を取り囲む内面と外面とを有する基体を設けるステップと、
前記基体の外面に少なくとも1つの薬剤をコーティングするステップと、
前記基体の前記内部領域に可燃性フィラメントを配置するステップと、
前記内部領域でスパーク加熱または抵抗加熱により前記可燃性フィラメントを点火することにより、前記基体の外面を加熱して、この外面にコーティングされている薬剤を蒸発させるステップと、
を含む方法。 - 記基体の前記内部領域に可燃性フィラメントを配置する前記ステップが、シールされたバルブ内に前記可燃性フィラメントを封入するとともに、シールされた前記バルブを前記基体の前記内部領域に配置することを含む、請求項30に記載の方法。
- 基体を形成する前記ステップが、ステンレススチールまたはアルミニウムから前記基体を形成することを含む、請求項31に記載の方法。
- 基体を設ける前記ステップが、前記基体の外面を陽極酸化することを含む、請求項32に記載の方法。
- 前記基体の前記内部領域に可燃性フィラメントを配置する前記ステップが、マグネシウム、ジルコニウム、または、アルミニウムを含む可燃性フィラメントを設けることを含む、請求項33に記載の方法。
- 薬剤の蒸発後に薬剤のエアゾール化を容易にするハウジング内に前記基体を封入するステップを更に備える、請求項31に記載の方法。
- 薬剤を蒸発させるための装置であって、
内部領域を取り囲む面を有する基体と、
前記基体の前記内部領域内に収められた可燃性部材と、
前記可燃性部材に接続され、前記可燃性部材の燃焼を起こすための点火器と、
前記基体中に吸収される薬剤であって、前記可燃性部材の点火時に蒸発される薬剤と、
を含む装置。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/146,086 US7458374B2 (en) | 2002-05-13 | 2002-05-13 | Method and apparatus for vaporizing a compound |
PCT/US2003/014983 WO2003095012A1 (en) | 2002-05-13 | 2003-05-13 | Method and apparatus for vaporizing a compound |
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JP2005525178A true JP2005525178A (ja) | 2005-08-25 |
JP4426439B2 JP4426439B2 (ja) | 2010-03-03 |
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JP2004503091A Expired - Fee Related JP4426439B2 (ja) | 2002-05-13 | 2003-05-13 | 化合物を蒸発させるための方法および装置 |
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US (2) | US7458374B2 (ja) |
EP (3) | EP1506031B1 (ja) |
JP (1) | JP4426439B2 (ja) |
CN (2) | CN100540080C (ja) |
AT (1) | ATE425784T1 (ja) |
CA (1) | CA2485721C (ja) |
CY (1) | CY1118820T1 (ja) |
DE (1) | DE60326713D1 (ja) |
DK (1) | DK2052753T3 (ja) |
ES (2) | ES2623467T3 (ja) |
HK (3) | HK1081888A1 (ja) |
IL (1) | IL165161A0 (ja) |
MX (1) | MXPA04011279A (ja) |
PT (1) | PT2052753T (ja) |
SI (1) | SI2052753T1 (ja) |
WO (1) | WO2003095012A1 (ja) |
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- 2003-05-13 DK DK09002094.2T patent/DK2052753T3/en active
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- 2003-05-13 JP JP2004503091A patent/JP4426439B2/ja not_active Expired - Fee Related
- 2003-05-13 WO PCT/US2003/014983 patent/WO2003095012A1/en active Application Filing
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2004
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2006
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2008
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2009
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2017
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ES2323418T3 (es) | 2009-07-15 |
WO2003095012B1 (en) | 2004-03-04 |
CN1662272A (zh) | 2005-08-31 |
WO2003095012A1 (en) | 2003-11-20 |
AU2003239441A1 (en) | 2003-11-11 |
EP1506031A1 (en) | 2005-02-16 |
EP2052753A1 (en) | 2009-04-29 |
HK1129077A1 (zh) | 2009-11-20 |
EP1506031B1 (en) | 2009-03-18 |
EP2052753B1 (en) | 2017-01-25 |
US20090071477A1 (en) | 2009-03-19 |
SI2052753T1 (sl) | 2017-05-31 |
MXPA04011279A (es) | 2005-02-17 |
US20030209240A1 (en) | 2003-11-13 |
PT2052753T (pt) | 2017-04-11 |
EP3207954A1 (en) | 2017-08-23 |
ES2623467T3 (es) | 2017-07-11 |
CY1118820T1 (el) | 2018-01-10 |
CA2485721A1 (en) | 2003-11-20 |
US7987846B2 (en) | 2011-08-02 |
CN100540080C (zh) | 2009-09-16 |
DK2052753T3 (en) | 2017-04-24 |
JP4426439B2 (ja) | 2010-03-03 |
HK1243014A1 (zh) | 2018-07-06 |
US7458374B2 (en) | 2008-12-02 |
ATE425784T1 (de) | 2009-04-15 |
IL165161A0 (en) | 2005-12-18 |
CA2485721C (en) | 2011-07-26 |
CN101623528B (zh) | 2012-03-07 |
HK1081888A1 (en) | 2006-05-26 |
CN101623528A (zh) | 2010-01-13 |
DE60326713D1 (de) | 2009-04-30 |
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