CR20210437A - 5-metoxi-n, n-dimetiltriptamina (5-meo-dmt) para tratamiento de la depresión - Google Patents

5-metoxi-n, n-dimetiltriptamina (5-meo-dmt) para tratamiento de la depresión

Info

Publication number
CR20210437A
CR20210437A CR20210437A CR20210437A CR20210437A CR 20210437 A CR20210437 A CR 20210437A CR 20210437 A CR20210437 A CR 20210437A CR 20210437 A CR20210437 A CR 20210437A CR 20210437 A CR20210437 A CR 20210437A
Authority
CR
Costa Rica
Prior art keywords
disorder
dimethyltryptamine
dmt
meo
methoxy
Prior art date
Application number
CR20210437A
Other languages
English (en)
Inventor
Theis Terwey
Original Assignee
Gh Res Ireland Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gh Res Ireland Limited filed Critical Gh Res Ireland Limited
Publication of CR20210437A publication Critical patent/CR20210437A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Se proporcionan composiciones para su uso en el tratamiento de un paciente que padece un trastorno mental en particular trastorno depresivo mayor, trastorno depresivo persistente, trastorno de ansiedad, trastorno de estrés postraumático, trastorno dismórfico corporal, trastorno obsesivo compulsivo, trastorno alimentario y abuso de sustancias psicoactivas. Se proporcionan además regímenes de dosificación para tratar estos trastornos.
CR20210437A 2019-02-22 2020-02-24 5-metoxi-n, n-dimetiltriptamina (5-meo-dmt) para tratamiento de la depresión CR20210437A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP19158774 2019-02-22
PCT/EP2020/054803 WO2020169850A1 (en) 2019-02-22 2020-02-24 5-methoxy-n,n-dimethyltryptamine (5-meo-dmt) for treating depression

Publications (1)

Publication Number Publication Date
CR20210437A true CR20210437A (es) 2021-11-02

Family

ID=65529503

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20210437A CR20210437A (es) 2019-02-22 2020-02-24 5-metoxi-n, n-dimetiltriptamina (5-meo-dmt) para tratamiento de la depresión

Country Status (31)

Country Link
US (2) US20220071958A1 (es)
EP (3) EP3927337B8 (es)
JP (1) JP2022521337A (es)
KR (1) KR20210154966A (es)
CN (1) CN114555078A (es)
AU (1) AU2020225410A1 (es)
BR (1) BR112021016153A2 (es)
CA (1) CA3130406A1 (es)
CL (1) CL2021002174A1 (es)
CO (1) CO2021010882A2 (es)
CR (1) CR20210437A (es)
DK (1) DK3927337T3 (es)
DO (1) DOP2021000176A (es)
EA (1) EA202192318A1 (es)
EC (1) ECSP21060868A (es)
ES (1) ES2984438T3 (es)
FI (1) FI3927337T3 (es)
HR (1) HRP20240532T1 (es)
HU (1) HUE066828T2 (es)
IL (1) IL285537A (es)
LT (1) LT3927337T (es)
MA (1) MA55021B1 (es)
MD (1) MD3927337T2 (es)
MX (1) MX2021009941A (es)
NI (1) NI202100080A (es)
PE (1) PE20220015A1 (es)
PL (1) PL3927337T3 (es)
PT (1) PT3927337T (es)
RS (1) RS65706B1 (es)
SI (1) SI3927337T1 (es)
WO (1) WO2020169850A1 (es)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT3927337T (pt) 2019-02-22 2024-05-17 Gh Res Ireland Limited 5-metoxi-n,n-dimetiltriptamina (5-meo-dmt) para o tratamento da depressão major
GB201907871D0 (en) 2019-06-03 2019-07-17 Small Pharma Ltd Therapeutic compositions
EP3753923A1 (en) * 2019-06-19 2020-12-23 GH Research Limited Recrystallisation of 5-methoxy-n,n-dimethyltryptamine (5-meo-dmt) in methyl tert.-butyl ether (mtbe) without adding an anti-solvent
PT3844147T (pt) 2019-11-07 2022-07-04 Small Pharma Ltd Compostos
EP3868364A1 (en) 2020-02-24 2021-08-25 GH Research Limited Aerosol comprising 5-methoxy-n,n-dimethyltryptamine
IL312785A (en) 2020-05-19 2024-07-01 Cybin Irl Ltd Denatured Tryptamine Derivatives and Methods of Use
US12042564B2 (en) 2020-06-02 2024-07-23 Cybin Uk Ltd Therapeutic solid dosage forms
US11773062B2 (en) 2021-03-22 2023-10-03 Small Pharma Ltd Deuterated compounds
KR20230024378A (ko) 2020-06-12 2023-02-20 벡클리 싸이테크 리미티드 5-메톡시-n, n-디메틸트립타민의 벤조에이트 염을 포함하는 조성물
WO2022031566A1 (en) * 2020-08-05 2022-02-10 Universitatsspital Basel Intravenous dmt administration method for dmt-assisted psychotherapy
CA3186359A1 (en) 2020-08-18 2022-02-24 Cybin Irl Limited Phenethylamine derivatives, compositions, and methods of use
US11406619B2 (en) 2020-08-28 2022-08-09 Small Pharma Ltd Injectable formulations
IL298129B1 (en) * 2020-08-28 2024-07-01 Cybin Uk Ltd An injectable formulation containing the fumarate salt of dimethyltryptamine or deuterium-containing dimethyltryptamine
AU2021354006A1 (en) * 2020-10-02 2023-03-02 Cybin Irl Limited Methods for delivery of psychedelic medications by inhalation and systems for performing the methods
CN112138028A (zh) * 2020-10-10 2020-12-29 南京中医药大学 蟾蜍色胺类物质在制备抗抑郁药物中的应用
WO2022082058A1 (en) * 2020-10-16 2022-04-21 Eleusis Therapeutics Us, Inc. Method of treatment by tryptamine alkaloids
EP4255421A1 (en) * 2020-12-01 2023-10-11 Small Pharma Ltd Inhalable formulations
US11660289B2 (en) 2020-12-01 2023-05-30 Small Pharma Ltd. Deuterated or partially deuterated N,N-dimethyltryptamine compounds
CA3113414A1 (en) * 2021-03-29 2022-09-29 Mind Cure Health Inc. Psychedelics protocol computer systems and methods
US20230136824A1 (en) 2021-04-26 2023-05-04 ATAI Life Sciences AG N-n-dimethyltryptamine (dmt) and dmt analog compositions, methods of making, and methods of use thereof
AU2022267240A1 (en) 2021-04-26 2023-11-23 Atai Therapeutics, Inc. Novel n,n-dimethyltryptamine compositions and methods
WO2022235927A1 (en) * 2021-05-05 2022-11-10 Gilgamesh Pharmaceuticals, Inc. Novel tryptamines and methods of treating mood disorders
KR20240019152A (ko) 2021-06-09 2024-02-14 아타이 테라퓨틱스, 인크. 신규 전구약물 및 디메틸트립타민의 접합체
US11697638B2 (en) 2021-09-08 2023-07-11 Small Pharma Ltd 5-methoxy-N,N-dimethyltryptamine crystalline forms
EP4159201A1 (en) * 2021-09-30 2023-04-05 Biomind Labs Inc Encapsulated microparticles and nanoparticles of dimethyltriptamines
IL312859A (en) * 2021-11-18 2024-07-01 Cybin Uk Ltd Injectable and inhaled formulations
US12012381B2 (en) 2021-12-30 2024-06-18 Atai Therapeutics, Inc. Dimethyltryptamine analogues as nitric oxide delivery drugs
US20230202978A1 (en) 2022-03-04 2023-06-29 Reset Pharmaceuticals, Inc. Co-crystal or salt
WO2023186837A1 (en) 2022-03-27 2023-10-05 GH Research Ireland Limited Treatment of postnatal depression
WO2023186835A1 (en) 2022-03-27 2023-10-05 GH Research Ireland Limited Treatment of mental disorders
RS65585B1 (sr) 2022-03-27 2024-06-28 Gh Res Ireland Limited Kristalna so 5-meo-dmt hidrobromid
GB202212116D0 (en) 2022-08-19 2022-10-05 Beckley Psytech Ltd Pharmaceutically acceptable salts and Compositions thereof
WO2024160390A1 (en) 2023-01-30 2024-08-08 GH Research Ireland Limited 5-methoxy-n,n-dimethyltryptamine for the treatment of postpartum depression
WO2024160392A1 (en) 2023-01-30 2024-08-08 GH Research Ireland Limited 5-meo-dmt for use in the treatment of postpartum depression

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DE19803376C1 (de) 1998-01-29 1999-10-14 Markus Storz Inhalator zur Erzeugung von aroma- und/oder wirkstoffhaltigen Dämpfen aus Pflanzenmaterial und/oder Flüssigkeiten
US7458374B2 (en) 2002-05-13 2008-12-02 Alexza Pharmaceuticals, Inc. Method and apparatus for vaporizing a compound
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CN103816150A (zh) * 2014-03-14 2014-05-28 兰州理工大学 山蚂蝗生物碱单体成分的用途
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EP3713568A1 (en) * 2017-10-26 2020-09-30 Consejo Superior de Investigaciones Cientificas (CSIC) Combination product for the treatment of neurological and/or psychiatric disorders
PT3927337T (pt) 2019-02-22 2024-05-17 Gh Res Ireland Limited 5-metoxi-n,n-dimetiltriptamina (5-meo-dmt) para o tratamento da depressão major

Also Published As

Publication number Publication date
CL2021002174A1 (es) 2022-01-28
HUE066828T2 (hu) 2024-09-28
CO2021010882A2 (es) 2022-01-17
US20220071958A1 (en) 2022-03-10
PT3927337T (pt) 2024-05-17
EP4353314A2 (en) 2024-04-17
WO2020169850A1 (en) 2020-08-27
HRP20240532T1 (hr) 2024-07-19
NI202100080A (es) 2021-12-06
PE20220015A1 (es) 2022-01-11
EP3927337A1 (en) 2021-12-29
PL3927337T3 (pl) 2024-07-29
MX2021009941A (es) 2021-12-10
ECSP21060868A (es) 2021-11-30
IL285537A (en) 2021-09-30
EP4349407A3 (en) 2024-07-03
FI3927337T3 (fi) 2024-05-08
US20240307350A1 (en) 2024-09-19
EP3927337B1 (en) 2024-02-14
ES2984438T3 (es) 2024-10-29
LT3927337T (lt) 2024-07-10
JP2022521337A (ja) 2022-04-06
CA3130406A1 (en) 2020-08-27
EP4353314A3 (en) 2024-07-03
BR112021016153A2 (pt) 2021-10-05
MD3927337T2 (ro) 2024-08-31
CN114555078A (zh) 2022-05-27
DOP2021000176A (es) 2021-11-21
EP3927337B8 (en) 2024-03-20
EA202192318A1 (ru) 2021-12-21
SI3927337T1 (sl) 2024-07-31
MA55021A (fr) 2021-12-29
DK3927337T3 (da) 2024-04-22
KR20210154966A (ko) 2021-12-21
AU2020225410A1 (en) 2021-08-19
EP4349407A2 (en) 2024-04-10
MA55021B1 (fr) 2024-05-31
RS65706B1 (sr) 2024-08-30

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