JP2005522542A5 - - Google Patents
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- Publication number
- JP2005522542A5 JP2005522542A5 JP2003584135A JP2003584135A JP2005522542A5 JP 2005522542 A5 JP2005522542 A5 JP 2005522542A5 JP 2003584135 A JP2003584135 A JP 2003584135A JP 2003584135 A JP2003584135 A JP 2003584135A JP 2005522542 A5 JP2005522542 A5 JP 2005522542A5
- Authority
- JP
- Japan
- Prior art keywords
- emulsifier
- polymer dispersion
- weight
- range
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003995 emulsifying agent Substances 0.000 claims description 21
- JIGUQPWFLRLWPJ-UHFFFAOYSA-N Ethyl acrylate Chemical compound CCOC(=O)C=C JIGUQPWFLRLWPJ-UHFFFAOYSA-N 0.000 claims description 12
- 239000000178 monomer Substances 0.000 claims description 12
- PNJWIWWMYCMZRO-UHFFFAOYSA-N pent‐4‐en‐2‐one Natural products CC(=O)CC=C PNJWIWWMYCMZRO-UHFFFAOYSA-N 0.000 claims description 12
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 claims description 8
- 229920000642 polymer Polymers 0.000 claims description 6
- 239000011248 coating agent Substances 0.000 claims description 4
- 238000000576 coating method Methods 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 4
- 239000006185 dispersion Substances 0.000 claims description 3
- 239000003814 drug Substances 0.000 claims description 3
- 229940079593 drug Drugs 0.000 claims description 3
- 238000009472 formulation Methods 0.000 claims description 3
- 239000004815 dispersion polymer Substances 0.000 claims 14
- 229910052739 hydrogen Inorganic materials 0.000 claims 9
- 239000001257 hydrogen Substances 0.000 claims 9
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 8
- 238000006116 polymerization reaction Methods 0.000 claims 6
- 125000004432 carbon atom Chemical group C* 0.000 claims 5
- 239000002831 pharmacologic agent Substances 0.000 claims 5
- 238000002360 preparation method Methods 0.000 claims 5
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 4
- 239000011324 bead Substances 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 230000000379 polymerizing effect Effects 0.000 claims 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- 239000007888 film coating Substances 0.000 claims 2
- 238000009501 film coating Methods 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- IUBSYMUCCVWXPE-UHFFFAOYSA-N metoprolol Chemical group COCCC1=CC=C(OCC(O)CNC(C)C)C=C1 IUBSYMUCCVWXPE-UHFFFAOYSA-N 0.000 claims 2
- 239000000825 pharmaceutical preparation Substances 0.000 claims 2
- 239000004094 surface-active agent Substances 0.000 claims 2
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims 1
- 208000024172 Cardiovascular disease Diseases 0.000 claims 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical group OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims 1
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims 1
- 208000018522 Gastrointestinal disease Diseases 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 claims 1
- 239000000048 adrenergic agonist Substances 0.000 claims 1
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims 1
- 239000003405 delayed action preparation Substances 0.000 claims 1
- 208000010643 digestive system disease Diseases 0.000 claims 1
- 208000018685 gastrointestinal system disease Diseases 0.000 claims 1
- 229960002237 metoprolol Drugs 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 claims 1
- 229940095064 tartrate Drugs 0.000 claims 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims 1
- 102100026735 Coagulation factor VIII Human genes 0.000 description 5
- 101000911390 Homo sapiens Coagulation factor VIII Proteins 0.000 description 5
- WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 description 5
- 244000309464 bull Species 0.000 description 3
- 229920001577 copolymer Polymers 0.000 description 3
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 2
- 238000005054 agglomeration Methods 0.000 description 2
- 230000002776 aggregation Effects 0.000 description 2
- 239000008101 lactose Substances 0.000 description 2
- 239000004816 latex Substances 0.000 description 2
- 229920000126 latex Polymers 0.000 description 2
- 239000000839 emulsion Substances 0.000 description 1
- 238000007720 emulsion polymerization reaction Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 239000003094 microcapsule Substances 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0201110A SE0201110D0 (sv) | 2002-04-12 | 2002-04-12 | New film coating |
| PCT/GB2003/001531 WO2003087180A2 (en) | 2002-04-12 | 2003-04-09 | New film coating |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005522542A JP2005522542A (ja) | 2005-07-28 |
| JP2005522542A5 true JP2005522542A5 (enExample) | 2009-01-29 |
Family
ID=20287566
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003584135A Pending JP2005522542A (ja) | 2002-04-12 | 2003-04-09 | 新規フィルム・コーティング |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20050256255A1 (enExample) |
| EP (1) | EP1497345A2 (enExample) |
| JP (1) | JP2005522542A (enExample) |
| KR (1) | KR20040107501A (enExample) |
| CN (1) | CN100467503C (enExample) |
| AU (1) | AU2003217070B2 (enExample) |
| BR (1) | BR0308892A (enExample) |
| CA (1) | CA2481139A1 (enExample) |
| DE (1) | DE20320377U1 (enExample) |
| IL (1) | IL164372A0 (enExample) |
| MX (1) | MXPA04009766A (enExample) |
| NO (1) | NO20044926L (enExample) |
| NZ (1) | NZ535750A (enExample) |
| SE (1) | SE0201110D0 (enExample) |
| WO (1) | WO2003087180A2 (enExample) |
| ZA (1) | ZA200407669B (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0100200D0 (sv) * | 2001-01-24 | 2001-01-24 | Astrazeneca Ab | New film coating |
| EP1355633B1 (en) * | 2001-12-19 | 2005-01-19 | AstraZeneca AB | NEW FILM COATING containing an ethyl acrylate/methyl methacrylate copolymer and polyvinyl acetate |
| SE0202353D0 (sv) * | 2002-08-01 | 2002-08-01 | Astrazeneca Ab | New film coating |
| US8414926B1 (en) | 2006-09-12 | 2013-04-09 | University Of South Florida | Nanoparticles with covalently bound surfactant for drug delivery |
| US8268356B2 (en) * | 2007-11-16 | 2012-09-18 | Asahi Kasei Chemicals Corporation | Aqueous film coating solution, film coated granule and tablet using the same |
| DK3043778T3 (da) * | 2013-09-13 | 2017-11-27 | Bayer Pharma AG | Farmaceutiske sammensætninger, der indeholder refametinib |
| CN103626913A (zh) * | 2013-11-14 | 2014-03-12 | 悦康药业集团安徽天然制药有限公司 | 一种甲基丙烯酸-丙烯酸乙酯共聚物水分散体肠溶型材料及其制备方法 |
| CN104758937B (zh) * | 2014-01-02 | 2019-05-21 | 石药集团中奇制药技术（石家庄）有限公司 | 一种美托洛尔缓释微丸制剂 |
| PL3166599T3 (pl) * | 2014-07-09 | 2025-09-22 | Sun Pharmaceutical Industries Ltd | Postać dawkowania w formie kapsułek zawierających bursztynian metoprololu |
| CN114699448A (zh) * | 2022-03-21 | 2022-07-05 | 广东省惠州市中药厂有限公司 | 糖衣片剂及其制备方法 |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL233559A (enExample) * | 1957-11-25 | |||
| US3234039A (en) * | 1961-01-16 | 1966-02-08 | Dow Chemical Co | Transparent latex finish system for exterior wood |
| DE1570223A1 (de) * | 1965-08-31 | 1970-07-09 | Aschaffenburger Zellstoffwerke | Verfahren zur Herstellung von Acryl- bzw. Methacrylpolymerisatfolien |
| GB1263148A (en) * | 1968-04-03 | 1972-02-09 | Toray Industries | Antistatic copolymers and their use in the treatment of synthetic fibers |
| US3944513A (en) * | 1969-04-29 | 1976-03-16 | Rohm And Haas Company | Purification of polymer dispersions with adsorbent carbon particles |
| DE2031871C3 (de) * | 1970-06-27 | 1974-06-27 | Roehm Gmbh, 6100 Darmstadt | Überzugsmasse für Arzneiformen |
| US4056497A (en) * | 1972-05-15 | 1977-11-01 | Hoechst Aktiengesellschaft | Acrylic ester copolymers capable of being cross-linked |
| DE2228515B1 (de) * | 1972-06-12 | 1974-02-14 | Röhm GmbH, 6100 Darmstadt | Verfahren zur herstellung von polyacrylatdispersionen |
| US3890292A (en) * | 1973-05-23 | 1975-06-17 | Daubert Chemical Co | Adhesive compositions and tapes |
| NL160278C (nl) * | 1975-09-25 | 1979-10-15 | Synres Internationaal Nv | Werkwijze voor het bereiden van waterige emulsies van additiepolymeren. |
| DE2651048A1 (de) * | 1976-11-09 | 1978-05-18 | Hoechst Ag | Kunststoffdispersion mit hoher nasshaftung und verfahren zu ihrer herstellung |
| JPS5525165A (en) * | 1978-08-12 | 1980-02-22 | Hitachi Electronics | Pulse information transmission in telemeter |
| JPS597687B2 (ja) * | 1979-09-20 | 1984-02-20 | 日東電工株式会社 | 医薬部材 |
| GB8521494D0 (en) * | 1985-08-29 | 1985-10-02 | Zyma Sa | Controlled release tablet |
| US4616074A (en) * | 1985-10-01 | 1986-10-07 | Alco Chemical Corporation | Acrylic-methylene succinic ester emulsion copolymers for thickening aqueous systems |
| SE455836B (sv) * | 1985-10-11 | 1988-08-15 | Haessle Ab | Beredning med kontrollerad frisettning innehallande ett salt av metoprolol samt metod for framstellning av denna beredning |
| JPH0832730B2 (ja) * | 1986-08-25 | 1996-03-29 | ライオン株式会社 | 超微粒子化ポリマ−ラテツクスの製造方法 |
| GB8724763D0 (en) * | 1987-10-22 | 1987-11-25 | Aps Research Ltd | Sustained-release formulations |
| JPH01113322A (ja) * | 1987-10-23 | 1989-05-02 | Tomoaki Fukuda | アクリル系エマルジョンおよびこれを用いたｐＨ非依存性遅延放出型製剤 |
| US5085866A (en) * | 1988-12-02 | 1992-02-04 | Southern Research Institute | Method of producing zero-order controlled-released devices |
| US5292522A (en) * | 1989-06-20 | 1994-03-08 | Rohm Gmbh | Aqueous film coating agent for solid medicaments |
| CA2053005A1 (en) * | 1990-10-10 | 1992-04-11 | Achim Gopferich | Emulsifier-free emulsion polymers |
| US5260068A (en) * | 1992-05-04 | 1993-11-09 | Anda Sr Pharmaceuticals Inc. | Multiparticulate pulsatile drug delivery system |
| JP3094118B2 (ja) * | 1992-10-06 | 2000-10-03 | ジェイエスアール株式会社 | コーティング用水分散体 |
| US5376384A (en) * | 1992-12-23 | 1994-12-27 | Kinaform Technology, Inc. | Delayed, sustained-release pharmaceutical preparation |
| JP3405756B2 (ja) * | 1993-04-20 | 2003-05-12 | 共和薬品工業株式会社 | マイクロカプセルの皮膜材料 |
| DE9414066U1 (de) * | 1994-08-31 | 1994-11-03 | Röhm GmbH & Co. KG, 64293 Darmstadt | Überzugs- und Bindemittel für Arzneiformen sowie damit hergestellte Arzneiform |
| US5626655A (en) * | 1995-07-11 | 1997-05-06 | Hewlett-Packard Company | Use of co-surfactants to adjust properties of ink-jet inks |
| US5721313A (en) * | 1995-11-02 | 1998-02-24 | Rhone-Poulenc Inc. | Crosslinked polymer composition |
| US5939578A (en) * | 1996-06-21 | 1999-08-17 | Tong-Ho Lin | Vasomolol: an ultra short-acting and vasodilatory vanilloid type β.sub. - adrenoceptor antagonist |
| SE0100200D0 (sv) * | 2001-01-24 | 2001-01-24 | Astrazeneca Ab | New film coating |
| US6646046B2 (en) * | 2001-12-06 | 2003-11-11 | Permachel | Aqueous pressure-sensitive adhesive composition, production method therefor and pressure-sensitive adhesive tape using the composition |
| EP1355633B1 (en) * | 2001-12-19 | 2005-01-19 | AstraZeneca AB | NEW FILM COATING containing an ethyl acrylate/methyl methacrylate copolymer and polyvinyl acetate |
| SE0202353D0 (sv) * | 2002-08-01 | 2002-08-01 | Astrazeneca Ab | New film coating |
-
2002
- 2002-04-12 SE SE0201110A patent/SE0201110D0/xx unknown
-
2003
- 2003-04-09 BR BR0308892-8A patent/BR0308892A/pt not_active IP Right Cessation
- 2003-04-09 US US10/511,115 patent/US20050256255A1/en not_active Abandoned
- 2003-04-09 MX MXPA04009766A patent/MXPA04009766A/es active IP Right Grant
- 2003-04-09 JP JP2003584135A patent/JP2005522542A/ja active Pending
- 2003-04-09 CA CA002481139A patent/CA2481139A1/en not_active Abandoned
- 2003-04-09 WO PCT/GB2003/001531 patent/WO2003087180A2/en not_active Ceased
- 2003-04-09 KR KR10-2004-7016214A patent/KR20040107501A/ko not_active Ceased
- 2003-04-09 EP EP03712458A patent/EP1497345A2/en not_active Withdrawn
- 2003-04-09 AU AU2003217070A patent/AU2003217070B2/en not_active Ceased
- 2003-04-09 CN CNB038132001A patent/CN100467503C/zh not_active Expired - Fee Related
- 2003-04-09 DE DE20320377U patent/DE20320377U1/de not_active Expired - Lifetime
- 2003-04-09 NZ NZ535750A patent/NZ535750A/xx unknown
-
2004
- 2004-09-22 ZA ZA200407669A patent/ZA200407669B/en unknown
- 2004-10-03 IL IL16437204A patent/IL164372A0/xx unknown
- 2004-11-11 NO NO20044926A patent/NO20044926L/no not_active Application Discontinuation
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