CN114699448A - 糖衣片剂及其制备方法 - Google Patents
糖衣片剂及其制备方法 Download PDFInfo
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- CN114699448A CN114699448A CN202210278783.4A CN202210278783A CN114699448A CN 114699448 A CN114699448 A CN 114699448A CN 202210278783 A CN202210278783 A CN 202210278783A CN 114699448 A CN114699448 A CN 114699448A
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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Abstract
本发明涉及一种糖衣片剂,包括片胚和包裹片胚的糖衣。片胚是由药粒进行定型压片操作得到,药粒由以下重量份数的组分组成:苍耳子30~40份、野菊花10~15份、鹅不食草20~22份、无籽刺梨10~15份、明日叶10~15份、墨旱莲20~22份、白芍10~15份、微晶纤维素6~8份、硬脂酸镁2~3份、柠檬酸钠1~5份及扑尔敏0.05~0.1份。糖衣由以下重量份数的组分组成:聚乙二醇丙烯酸酯5~10份、三甘醇二丙烯酸酯5~10份、低聚异麦芽糖5~15份、乳糖2~5份、甜菊糖0.2~3份、赤藓糖醇0.5~1份、甘露糖醇0.5~1份,木糖醇5~10份。本发明还涉及该糖衣片剂的制备方法。
Description
技术领域
本发明涉及鼻炎药物领域,特别是涉及用于治疗慢性鼻炎的糖衣片剂及其制备方法。
背景技术
鼻舒适片具有清热消炎、通窍之功效,用于治疗慢性鼻炎引起的喷嚏、流涕、鼻塞、头痛、过敏性鼻炎、慢性鼻窦炎。目前,鼻舒适片中的有效成分可与常规辅助剂和/或赋型剂混合来制备成各种药物剂型(如胶囊剂、片剂、颗粒剂、糖衣丸剂、溶液剂等药物剂型)。其中,常用赋型剂包括:填料和增容剂(如淀粉,微晶纤维等)、粘合剂(如羧甲基纤维素,聚乙烯吡咯烷酮等)、致湿剂(如甘油)、崩解剂(如碳酸钙等)、吸收剂(如高岭土等)、润滑剂(如滑石粉等)。药用赋型剂可以是固体、半固体、液体等各种形态。
申请人在申请号为CN202010124485.0的发明专利中公开了一种鼻舒适片,该鼻舒适片包括如下质量份的中药组分:苍耳子300~400份、野菊花120~160份、鹅不食草200~220份、白芷100~120份、防风100~120份、墨旱莲200~220份、白芍130~160份、胆南星60~80份、甘草65~85份、蒺藜200~220份及扑尔敏0.1~0.5份,该鼻舒适片是通过干膏粉进行整粒操作及压片操作得到,该鼻舒适片使用时需要将鼻舒适片及水放入至所述蒸馏器内进行蒸馏操作得到药液蒸气,药液蒸气再通过引流柱进入鼻孔,使用时程序较为繁琐。若口服该鼻舒适片,由于鼻舒适片存在中药的苦味和不良气味,导致患者口服时体验不佳。
与其它药物剂型的形态相比,糖衣片剂具有食用方便,运输便利,产品货架期较长等优点,因此基于申请号为CN202010124485.0的发明专利,申请人将鼻舒适片改进为糖衣片剂,食用简便,使用方便。该糖衣片剂的医用疗效和鼻舒适片相当,并且该糖衣片剂的口感独特、并且本身具有一定营养价值与促进健康作用。
发明内容
为实现上述目的,本发明采用如下技术方案:一种糖衣片剂,包括片胚和包裹片胚的糖衣。
其中,片胚是由药粒进行定型压片操作得到的,药粒由以下重量份数的组分组成:苍耳子30~40份、野菊花10~15份、鹅不食草20~22份、无籽刺梨10~15份、明日叶10~15份、墨旱莲20~22份、白芍10~15份、微晶纤维素6~8份、硬脂酸镁2~3份、柠檬酸钠1~5份及扑尔敏0.05~0.1份。
其中,糖衣由以下重量份数的组分组成:聚乙二醇丙烯酸酯5~10份、三甘醇二丙烯酸酯5~10份、低聚异麦芽糖5~15份、乳糖2~5份、甜菊糖0.2~3份、赤藓糖醇0.5~1份、甘露糖醇0.5~1份,木糖醇5~10份。
另一发明,本发明还提供制备所述糖衣片剂的方法,包括如下步骤:
步骤一,将苍耳子、野菊花、鹅不食草、无籽刺梨、明日叶、墨旱莲、白芍分别清洗干净后混合得到混合物,然后将混合物破碎成小块,加去离子水0~0.3倍,匀浆2~3min后将混合物置于真空环境中进行冷冻干燥12~24h;
步骤二,将步骤一得到的混合物的冻干粉粉碎精磨过80~120目筛,制成药粉;
步骤三,将药粉置于提取溶剂中浸泡不少于24h后进行煎煮操作,得到提取液,向提取液中加入微晶纤维素、硬脂酸镁、柠檬酸钠份及扑尔敏,并混合均匀得到药液,优选的,提取溶剂为水和乙醇按体积比1~2:1配置而成;
步骤四,对药液进行减压干燥操作,得到预干膏;
步骤五,对所述预干膏进行粉碎研磨操作,得到药粒,然后对所述药粒进行整粒操作及压片操作,得到片胚;
步骤六,通过在片胚的表面喷雾糖衣液的同时进行干燥,从而在片胚表明形成包裹片胚的糖衣,糖衣液是将聚乙二醇丙烯酸酯、三甘醇二丙烯酸酯、低聚异麦芽糖、乳糖、甜菊糖、赤藓糖醇、甘露糖醇和木糖醇溶于溶剂中制成的,本发明中记载的糖衣液的溶剂只要是通常糖衣液中使用的溶剂则无特别限定。例如可以举出水、乙醇、异丙醇等低级醇、丙酮或它们的混合物。这些溶剂中,通常优选使用水。糖衣液的粘度只要是可以利用制造糖衣所用装置进行喷雾的范围即可,还可以调整溶剂的配合量使得其粘度通常为3~1000cp、优选为5~700cp、更优选为10~400cp。
相比于现有技术,本发明提供的技术方案至少存在以下有益效果:
1.本发明提供的糖衣片剂具有清热消炎、通窍之功效,可应用于治疗慢性鼻炎引起的喷嚏、流涕、鼻塞、头痛、过敏性鼻炎、慢性鼻窦炎,该糖衣片剂通过口服使用,因此使用更方便;
2.由于糖衣片剂是患者用口服吞下,因为在保证糖衣片剂的医用疗效的情况下,根据糖衣片剂的使用特点,该糖衣片剂需要同时满足以下要求:①片胚在保证医用疗效的情况下必须具备一定的硬度,从而提高该糖衣片剂的理化性质稳定、贮存性能;②片胚在保证医用疗效的情况下需要尽可能抑制该片胚的苦味和会产生口腔不适感的异味;③糖衣需要具有充分硬度,并且糖衣需要具有低吸湿性、防臭性、崩解性优异,从而保证该糖衣片剂的存储稳定性和提高该糖衣片剂的口服口感;④糖衣的甜味需要中和或掩盖片胚的苦味和异味,使得患者咀嚼该糖衣片剂时不会产生味觉不适,从而方便该糖衣片剂的口服。本发明对于片胚和糖衣的组分、组分配比进行了改进从而使得该糖衣片剂同时满足上述要求;
3.制备片胚的药粒中同时含有微晶纤维素、硬脂酸镁和柠檬酸钠,从而使得药粒经过整粒操作及压片操作能够显著提高片胚的硬度,并且有效提升了该糖衣片剂的存储有效期;制备片胚的药粒中同时含有苍耳子、野菊花、鹅不食草、无籽刺梨、明日叶、墨旱莲、白芍和扑尔敏,该组合在保证糖衣片剂的疗效的情况下,同时显著降低了糖衣片剂作为口服药物对人体肝脏的负担和副作用;
4.本发明在制备糖衣片剂的糖衣时采用能够同时进行糖衣液的喷雾工序和干燥工序的连续包衣法,可以在不需要复杂工序的情况下,短时间地制造低透氧性、低吸湿性、防臭性、崩解性优异的糖衣。另外,本发明提供的糖衣片剂的制备方法能够形成薄的糖衣,因此大大有助于糖衣液使用量的减少;
5.本发明中应用于制备糖衣的糖衣液中,提供甜味的组分选择是基于片胚的组分,即糖衣液中提供甜味的组分(包括低聚异麦芽糖、乳糖、甜菊糖、赤藓糖醇、甘露糖醇和木糖醇)的组合能有效中和或掩盖片胚的苦味和异味,并且该组分的组合能在营养成分、口感风味和保健方面都有较好的协同作用;
6.本发明能采用连续包衣法是基于糖衣液中以特定比例添加了聚乙二醇丙烯酸酯和三甘醇二丙烯酸酯,通过聚乙二醇丙烯酸酯和三甘醇二丙烯酸酯的组合使得糖衣具备低吸湿性、防臭性及良好的崩解性;
7.本发明提供的糖衣片剂具有清热消炎、通窍之功效的同时,由于片胚的药粒中同时含有苍耳子、野菊花、鹅不食草、无籽刺梨、明日叶、墨旱莲、白芍,上述组分的组合使得片胚具有营养互补的作用,上述组分含有丰富的维生素和微量元素有助于人体维持正常机能,提高机体免疫能力,抗疲劳等功效,且极大的抑制了片胚的苦味和异味,使得糖衣片剂口感清甜独特,非常适宜于现代人群食用;
8.本发明制备的糖衣片剂易于保存、方便携带与运输、食用简便,并通过咀嚼作用促进片胚中的有效成分在片剂中崩解成细小颗粒,有利于有效成分在体内的吸收,提高了这些有效成分的生物利用度。
具体实施方式
应当理解,此处所描述的具体实施例仅仅用以解释本发明,并不用于限定本发明。
本发明中所记载的糖衣片剂的糖衣层具有防止氧、水、难闻成分透过的功能,因此低透氧性、低吸湿性、防臭性优异,显著提高了该糖衣片剂的存储稳定性。
本发明中记载的连续包衣法是在片胚表面通过重复数次糖衣液的喷雾和干燥而制造糖衣。连续包衣法中,需要将喷雾的糖衣液迅速、均匀地扩展在片胚的表面,因此需要稀释糖衣液降低粘度,但降低糖衣液粘度容易导致糖衣层具有致密性不充分,制备的糖衣的低透氧性、低吸湿性、防臭性差的问题。而本发明使用的糖衣液以特定比例添加了聚乙二醇丙烯酸酯和三甘醇二丙烯酸酯从而克服了糖衣液降低粘度后产生的问题,本发明使用的糖衣液以特定比例添加了聚乙二醇丙烯酸酯和三甘醇二丙烯酸酯从使得制备的糖衣的吸湿率在温湿度25℃-85%的24小时后的条件下为1.0%以下,在温湿度40℃-75%的30日后的条件下为4.0%以下,并且糖衣的硬度达到100N以上,糖衣的崩解度为12分钟以内。
制备糖衣时喷雾的糖衣液的液滴径优选为0.1~1000μm、喷雾量可以根据片胚的大小或量进行调整使得涉及片胚的整个表面。另外,糖衣液的温度优选为10~80℃。给气温度和风量优选按照制品温度达到10~60℃进行调节。如此获得的糖衣片剂的糖衣层薄、具有充分的硬度、且低吸湿性、防臭性及崩解性也优异。
本发明的糖衣液中除了上述各成分之外,还可以根据需要配合作为药品添加物允许、且可口服的各种任意成分。作为这种添加剂,例如可以举出包衣剂、着色剂和光泽化剂等。作为包衣剂,例如可以举出羟丙基纤维素、羟丙基甲基纤维素2910、羟丙基甲基纤维素2208、甲基纤维素、聚乙烯醇、聚乙烯吡咯烷酮、结晶纤维素、阿拉伯胶粉末、精制虫胶、支链淀粉、沉降碳酸钙、滑石粉、磷酸氢钙、轻质硅酸酐、含水二氧化硅、氧化钛、磷酸二氢钠、氢化油、单硬脂酸甘油酯及聚乙二醇单硬脂酸酯等。着色剂例如可以举出各种食用色素、焦油色素及三氧化二铁等。光泽化剂例如可以举出巴西棕榈蜡或蜜蜡等。
另外,本发明的糖衣液的粘度通常为3~1000cp、优选为5~700cp、更优选为10~400cp。使用这种范围粘度的糖衣液时,即便在利用连续包衣法制造糖衣片剂时,也容易形成均匀的糖衣层。
另外,本发明提供的糖衣片剂的片胚中除了上述组分之外,还可以根据需要配合可口服给药的各种任意成分。作为这种可口服给药的各种任意添加物例如可以举出赋形剂、粘合剂、崩解剂、光滑剂等。赋形剂可以举出乳糖、蔗糖、甘露醇、轻质硅酸酐、磷酸氢钙及玉米淀粉等。粘合剂可以举出甲基纤维素、羟丙基纤维素、羟丙基甲基纤维素、明胶、聚乙烯吡咯烷酮及支链淀粉等。崩解剂可以举出羧甲纤维素钙、低取代度羟丙基纤维素、交联聚维酮及交联羧甲纤维素钠等。光滑剂可以举出硬脂酸钙及滑石粉等。
另外,本发明的提供的糖衣片剂除了使用本发明糖衣液形成的1层或多层糖衣之外,还可以具有由其他包衣液形成的1层或多层包覆层。予以说明,本说明书中,将使用本发明的糖衣液形成的层记载为“糖衣”、将该糖衣层及使用本发明糖衣液以外的包衣液形成的层一并记载为“包覆层”。
包覆层可以根据其功能分为防水层、底涂层、中涂层、上涂层及抛光层等多个层等。防水层为用于防止糖衣工序中水分向片胚的移动而实施。另外,底涂层为用于规整糖衣片剂外形而实施,该底涂层的好坏会影响到糖衣片剂的外观、强度的好坏。另外,中涂层为用于平滑糖衣片剂表面而实施、上涂层为着色用于提高糖衣片剂的识别性或商品价值而实施、抛光层为用于赋予糖衣片剂光泽而实施。本发明的糖衣片剂没有必要具有具备上述功能的全部包覆层,优选含有具有底涂层功能的包覆层,糖衣片剂的糖衣可以作为具有底涂层功能的包覆层优选使用。
实施例1
本实施例提供一种糖衣片剂,包括片胚和包裹片胚的糖衣。
其中,片胚是由药粒进行定型压片操作得到的,药粒由以下重量份数的组分组成:苍耳子30份、野菊花10份、鹅不食草20份、无籽刺梨10份、明日叶10份、墨旱莲20份、白芍10份、微晶纤维素6份、硬脂酸镁2份、柠檬酸钠1份及扑尔敏0.05份。
其中,糖衣由以下重量份数的组分组成:聚乙二醇丙烯酸酯5份、三甘醇二丙烯酸酯5份、低聚异麦芽糖5份、乳糖2份、甜菊糖0.2份、赤藓糖醇0.5份、甘露糖醇0.5份,木糖醇5份。
本实施例提供的糖衣片剂的制备方法包括如下步骤:
步骤一,将苍耳子、野菊花、鹅不食草、无籽刺梨、明日叶、墨旱莲、白芍分别清洗干净后混合得到混合物,然后将混合物破碎成小块,加去离子水0~0.3倍,匀浆2~3min后将混合物置于真空环境中进行冷冻干燥12~24h;
步骤二,将步骤一得到的混合物的冻干粉粉碎精磨过80~120目筛,制成药粉;
步骤三,将药粉置于提取溶剂中浸泡不少于24h后进行煎煮操作,得到提取液,向提取液中加入微晶纤维素、硬脂酸镁、柠檬酸钠份及扑尔敏,并混合均匀得到药液;
步骤四,对药液进行减压干燥操作,得到预干膏;
步骤五,对所述预干膏进行粉碎研磨操作,得到药粒,然后对所述药粒进行整粒操作及压片操作,得到片胚;
步骤六,将聚乙二醇丙烯酸酯、三甘醇二丙烯酸酯、低聚异麦芽糖、乳糖、甜菊糖、赤藓糖醇、甘露糖醇和木糖醇溶于纯水中制成糖衣液,利用包衣机在片胚表面喷雾糖衣液、同时进行干燥,获得糖衣片剂。
实施例2
本实施例提供一种糖衣片剂,包括片胚和包裹片胚的糖衣。该糖衣片剂的制备方法和实施例1提供的糖衣片剂的制备方法相同。
其中,片胚是由药粒进行定型压片操作得到的,药粒由以下重量份数的组分组成:苍耳子40份、野菊花15份、鹅不食草22份、无籽刺梨15份、明日叶15份、墨旱莲22份、白芍15份、微晶纤维素8份、硬脂酸镁2~3份、柠檬酸钠5份及扑尔敏0.1份。
其中,糖衣由以下重量份数的组分组成:聚乙二醇丙烯酸酯10份、三甘醇二丙烯酸酯10份、低聚异麦芽糖15份、乳糖5份、甜菊糖3份、赤藓糖醇1份、甘露糖醇1份,木糖醇10份。
实施例3
本实施例提供一种糖衣片剂,包括片胚和包裹片胚的糖衣。该糖衣片剂的制备方法和实施例1提供的糖衣片剂的制备方法相同。
其中,片胚是由药粒进行定型压片操作得到的,药粒由以下重量份数的组分组成:苍耳子35份、野菊花12份、鹅不食草21份、无籽刺梨14份、明日叶12份、墨旱莲21份、白芍12份、微晶纤维素7份、硬脂酸镁2.5份、柠檬酸钠3份及扑尔敏0.08份。
其中,糖衣由以下重量份数的组分组成:聚乙二醇丙烯酸酯7份、三甘醇二丙烯酸酯8份、低聚异麦芽糖10份、乳糖4份、甜菊糖1份、赤藓糖醇0.7份、甘露糖醇0.6份,木糖醇6份。
比较例1
本实施例提供一种糖衣片剂,包括片胚和包裹片胚的糖衣。该糖衣片剂和实施例1提供的糖衣片剂的区别仅仅在于:糖衣中不含有聚乙二醇丙烯酸酯和三甘醇二丙烯酸酯。
比较例2
本实施例提供一种糖衣片剂,包括片胚和包裹片胚的糖衣。该糖衣片剂和实施例1提供的糖衣片剂的区别仅仅在于:糖衣中不含有聚乙二醇丙烯酸酯。
比较例3
本实施例提供一种糖衣片剂,包括片胚和包裹片胚的糖衣。该糖衣片剂和实施例1提供的糖衣片剂的区别仅仅在于:糖衣中不含有三甘醇二丙烯酸酯。
<吸湿性的评价>
测定将实施例1~3、比较例1~3获得的糖衣片剂在25℃-84.3%条件下静置1小时、2小时、3小时及24小时后的质量,与开始时的质量相比,测定吸湿量,计算吸湿率(%)。
吸湿率(%)=(各小时保管后的糖衣片剂质量-开始时的糖衣片剂质量)/开始时的糖衣片剂质量×100
结果为,实施例1~3的糖衣片剂即便在上述条件下静置24小时,吸湿率也低达0.1%。比较例1和比较例2的糖衣片剂在静置3小时时,吸湿率达到0.4%,在静置24小时时增加至接近2.0%。另外,比较例3的糖衣制剂在静置24小时时,吸湿率增加至0.5%左右。
由以上可知,当使用本发明的糖衣液时,即便是利用在喷雾糖衣液的同时进行干燥的包衣方法制造糖衣片剂时,也可获得低吸湿性优异的糖衣片剂。
<物性的评价>
测定实施例1~3、比较例1~3获得的糖衣片剂的硬度及崩解度。硬度为取20片利用片剂硬度计对每1片测定片剂硬度、计算平均值。结果示于表1。
表1
实施例1 | 实施例2 | 实施例3 | 比较例1 | 比较例2 | 比较例3 | |
硬度(N) | 120.2 | 126.8 | 120.4 | 71.6 | 112.7 | 87.5 |
崩解度(min) | 11.4 | 10.8 | 11.1 | 32.1 | 21.5 | 28.6 |
实施例1~3的糖衣片剂具有充分的硬度、且崩解性也优异。另一方面,比较例1和比较例3的糖衣片剂的硬度及崩解性均不充分。比较例2的糖衣片剂剂虽然具有高硬度,但崩解性不充分。
由以上可知,本发明的糖衣片剂具有充分的硬度、且崩解性也优异。
<气味的评价>
对实施例1~3、比较例1~3获得的糖衣片剂的气味进行评价。将糖衣片剂放入透明玻璃瓶进行密封后,对在60℃的条件下保存3日、1周及2周时的气味的发生。结果为:实施例1~3的糖衣片剂即便经过2周的保存期间,也完全感觉不到来自片胚的不愉快气味。另一方面,比较例1的糖衣片剂在3天后感到来自片胚的不愉快气味,在1周后强烈地感觉到不愉快气味。比较例2和比较例3的糖衣片剂在经过2周的保存期间微弱地感到片胚来源的不愉快气味,特别是随着保存延长,不愉快气味加强。
由以上可知,本发明的糖衣片剂的防臭性更为优异。
由以上可知,本发明的糖衣片剂的糖衣虽然薄,但具有充分硬度、且低吸湿性、防臭性优异。
以上所述实施例的各技术特征可以进行任意的组合,为使描述简洁,未对上述实施例中的各个技术特征所有可能的组合都进行描述,然而,只要这些技术特征的组合不存在矛盾,都应当认为是本说明书记载的范围。
以上所述实施例仅表达了本发明的几种实施方式,其描述较为具体和详细,但并不能因此而理解为对发明专利范围的限制。应当指出的是,对于本领域的普通技术人员来说,在不脱离本发明构思的前提下,还可以做出若干变形和改进,这些都属于本发明的保护范围。因此,本发明专利的保护范围应以所附权利要求为准。
Claims (4)
1.一种糖衣片剂,包括片胚和包裹片胚的糖衣,其特征在于,
所述片胚是由药粒进行定型压片操作得到,所述药粒由以下重量份数的组分组成:苍耳子30~40份、野菊花10~15份、鹅不食草20~22份、无籽刺梨10~15份、明日叶10~15份、墨旱莲20~22份、白芍10~15份、微晶纤维素6~8份、硬脂酸镁2~3份、柠檬酸钠1~5份及扑尔敏0.05~0.1份;所述糖衣由以下重量份数的组分组成:聚乙二醇丙烯酸酯5~10份、三甘醇二丙烯酸酯5~10份、低聚异麦芽糖5~15份、乳糖2~5份、甜菊糖0.2~3份、赤藓糖醇0.5~1份、甘露糖醇0.5~1份,木糖醇5~10份。
2.一种制备权利要求1所述的糖衣片剂的方法,其特征在于,包括如下步骤:
步骤一,将所述苍耳子、野菊花、鹅不食草、无籽刺梨、明日叶、墨旱莲、白芍分别清洗干净后混合得到混合物,然后将所述混合物破碎成小块,加去离子水0~0.3倍,匀浆2~3min后将所述混合物置于真空环境中进行冷冻干燥12~24h;
步骤二,将所述混合物的冻干粉粉碎精磨过80~120目筛,制成药粉;
步骤三,将所述药粉置于提取溶剂中浸泡不少于24h后进行煎煮操作,得到提取液,向所述提取液中加入所述微晶纤维素、硬脂酸镁、柠檬酸钠份及扑尔敏,并混合均匀得到药液;
步骤四,对所述药液进行减压干燥操作,得到预干膏;
步骤五,对所述预干膏进行粉碎研磨操作,得到所述药粒,然后对所述药粒进行整粒操作及压片操作,得到所述片胚;
步骤六,通过在所述片胚的表面喷雾糖衣液的同时进行干燥,从而在所述片胚表明形成包裹片胚的糖衣,所述糖衣液是将所述聚乙二醇丙烯酸酯、三甘醇二丙烯酸酯、低聚异麦芽糖、乳糖、甜菊糖、赤藓糖醇、甘露糖醇和木糖醇溶于溶剂中制成的。
3.根据权利要求2所述的方法,其特征在于,所述提取溶剂为水和乙醇按体积比1~2:1配置而成。
4.根据权利要求2的方法,其特征在于,所述溶剂为水、乙醇、异丙醇等低级醇、丙酮或它们的混合物。
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