JP2005517380A5 - - Google Patents
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- JP2005517380A5 JP2005517380A5 JP2002519606A JP2002519606A JP2005517380A5 JP 2005517380 A5 JP2005517380 A5 JP 2005517380A5 JP 2002519606 A JP2002519606 A JP 2002519606A JP 2002519606 A JP2002519606 A JP 2002519606A JP 2005517380 A5 JP2005517380 A5 JP 2005517380A5
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- amino acid
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- 125000000539 amino acid group Chemical group 0.000 description 110
- 102000037865 fusion proteins Human genes 0.000 description 63
- 108020001507 fusion proteins Proteins 0.000 description 63
- 239000002245 particle Substances 0.000 description 59
- 230000002163 immunogen Effects 0.000 description 50
- 210000004899 c-terminal region Anatomy 0.000 description 41
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 description 41
- 108090000765 processed proteins & peptides Proteins 0.000 description 30
- 108090000623 proteins and genes Proteins 0.000 description 30
- 239000002054 inoculum Substances 0.000 description 26
- 229960005486 vaccine Drugs 0.000 description 26
- 241001465754 Metazoa Species 0.000 description 24
- 235000018102 proteins Nutrition 0.000 description 24
- 102000004169 proteins and genes Human genes 0.000 description 24
- 108020004707 nucleic acids Proteins 0.000 description 19
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- 230000000295 complement effect Effects 0.000 description 6
- 208000002672 hepatitis B Diseases 0.000 description 6
- 230000001939 inductive effect Effects 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- KZMAWJRXKGLWGS-UHFFFAOYSA-N 2-chloro-n-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]-n-(3-methoxypropyl)acetamide Chemical compound S1C(N(C(=O)CCl)CCCOC)=NC(C=2C=CC(OC)=CC=2)=C1 KZMAWJRXKGLWGS-UHFFFAOYSA-N 0.000 description 5
- 238000010521 absorption reaction Methods 0.000 description 5
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- 241000607142 Salmonella Species 0.000 description 4
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- 239000002671 adjuvant Substances 0.000 description 4
- 235000018417 cysteine Nutrition 0.000 description 4
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 4
- 235000014113 dietary fatty acids Nutrition 0.000 description 4
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- 125000001433 C-terminal amino-acid group Chemical group 0.000 description 3
- 241000588724 Escherichia coli Species 0.000 description 3
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 3
- 241000235058 Komagataella pastoris Species 0.000 description 3
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 description 3
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- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 3
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 3
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- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 3
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- 125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 3
- YYGNTYWPHWGJRM-UHFFFAOYSA-N (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C YYGNTYWPHWGJRM-UHFFFAOYSA-N 0.000 description 2
- 241000193987 Streptococcus sobrinus Species 0.000 description 2
- BHEOSNUKNHRBNM-UHFFFAOYSA-N Tetramethylsqualene Natural products CC(=C)C(C)CCC(=C)C(C)CCC(C)=CCCC=C(C)CCC(C)C(=C)CCC(C)C(C)=C BHEOSNUKNHRBNM-UHFFFAOYSA-N 0.000 description 2
- 108010015780 Viral Core Proteins Proteins 0.000 description 2
- 239000003085 diluting agent Substances 0.000 description 2
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N dodecahydrosqualene Natural products CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 2
- 239000003995 emulsifying agent Substances 0.000 description 2
- 230000001747 exhibiting effect Effects 0.000 description 2
- 241000737598 recombinant Hepatitis B virus Species 0.000 description 2
- 229940031439 squalene Drugs 0.000 description 2
- TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 description 2
- 230000003612 virological effect Effects 0.000 description 2
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 description 1
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 1
- RYELXWKWBUDRKN-UMMCILCDSA-N 2-amino-9-[(2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-oxo-3h-purine-8-sulfonic acid Chemical class OS(=O)(=O)C1=NC=2C(=O)NC(N)=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O RYELXWKWBUDRKN-UMMCILCDSA-N 0.000 description 1
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 1
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 1
- 108010042708 Acetylmuramyl-Alanyl-Isoglutamine Proteins 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 101710132601 Capsid protein Proteins 0.000 description 1
- 241000223936 Cryptosporidium parvum Species 0.000 description 1
- 241001115402 Ebolavirus Species 0.000 description 1
- 241000224431 Entamoeba Species 0.000 description 1
- 241000224432 Entamoeba histolytica Species 0.000 description 1
- 241000710198 Foot-and-mouth disease virus Species 0.000 description 1
- 241000606768 Haemophilus influenzae Species 0.000 description 1
- 241000588655 Moraxella catarrhalis Species 0.000 description 1
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 1
- 239000005642 Oleic acid Substances 0.000 description 1
- 241000223960 Plasmodium falciparum Species 0.000 description 1
- 241000223810 Plasmodium vivax Species 0.000 description 1
- 241000223830 Plasmodium yoelii Species 0.000 description 1
- 241000605862 Porphyromonas gingivalis Species 0.000 description 1
- 241000293871 Salmonella enterica subsp. enterica serovar Typhi Species 0.000 description 1
- 241000242677 Schistosoma japonicum Species 0.000 description 1
- 241000242680 Schistosoma mansoni Species 0.000 description 1
- 241000607762 Shigella flexneri Species 0.000 description 1
- 241000580858 Simian-Human immunodeficiency virus Species 0.000 description 1
- 201000005010 Streptococcus pneumonia Diseases 0.000 description 1
- 241000193998 Streptococcus pneumoniae Species 0.000 description 1
- 241000223104 Trypanosoma Species 0.000 description 1
- 241000607479 Yersinia pestis Species 0.000 description 1
- 125000003295 alanine group Chemical group N[C@@H](C)C(=O)* 0.000 description 1
- 229940037003 alum Drugs 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 150000001413 amino acids Chemical group 0.000 description 1
- 230000002238 attenuated effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 159000000007 calcium salts Chemical class 0.000 description 1
- 230000001268 conjugating effect Effects 0.000 description 1
- 229940007078 entamoeba histolytica Drugs 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 229940047650 haemophilus influenzae Drugs 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
- 239000000893 inhibin Substances 0.000 description 1
- ZPNFWUPYTFPOJU-LPYSRVMUSA-N iniprol Chemical compound C([C@H]1C(=O)NCC(=O)NCC(=O)N[C@H]2CSSC[C@H]3C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](C(N[C@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC=4C=CC=CC=4)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC=4C=CC=CC=4)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC2=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]2N(CCC2)C(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N2[C@@H](CCC2)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N2[C@@H](CCC2)C(=O)N3)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@H](C(=O)N1)C(C)C)[C@@H](C)O)[C@@H](C)CC)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 ZPNFWUPYTFPOJU-LPYSRVMUSA-N 0.000 description 1
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
- 229940035032 monophosphoryl lipid a Drugs 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- 229920001542 oligosaccharide Polymers 0.000 description 1
- 150000002482 oligosaccharides Chemical class 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 150000003384 small molecules Chemical group 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 241000712461 unidentified influenza virus Species 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22584300P | 2000-08-16 | 2000-08-16 | |
| US22686700P | 2000-08-22 | 2000-08-22 | |
| US09/930,915 US20030138769A1 (en) | 2000-08-16 | 2001-08-15 | Immunogenic HBc chimer particles having enhanced stability |
| PCT/US2001/041759 WO2002014478A2 (en) | 2000-08-16 | 2001-08-16 | IMMUNOGENIC HBc CHIMER PARTICLES HAVING ENHANCED STABILITY |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012088679A Division JP2012139237A (ja) | 2000-08-16 | 2012-04-09 | 安定性が強化された免疫原性ＨＢｃキメラ粒子 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005517380A JP2005517380A (ja) | 2005-06-16 |
| JP2005517380A5 true JP2005517380A5 (https=) | 2008-10-02 |
Family
ID=27397530
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002519606A Pending JP2005517380A (ja) | 2000-08-16 | 2001-08-16 | 安定性が強化された免疫原性ＨＢｃキメラ粒子 |
| JP2012088679A Pending JP2012139237A (ja) | 2000-08-16 | 2012-04-09 | 安定性が強化された免疫原性ＨＢｃキメラ粒子 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012088679A Pending JP2012139237A (ja) | 2000-08-16 | 2012-04-09 | 安定性が強化された免疫原性ＨＢｃキメラ粒子 |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US20030138769A1 (https=) |
| EP (1) | EP1333857A4 (https=) |
| JP (2) | JP2005517380A (https=) |
| KR (1) | KR20030084887A (https=) |
| AP (1) | AP2003002752A0 (https=) |
| AU (2) | AU8545201A (https=) |
| BR (1) | BR0113307A (https=) |
| CA (1) | CA2420037A1 (https=) |
| EA (1) | EA006207B1 (https=) |
| MX (1) | MXPA03001338A (https=) |
| OA (1) | OA12366A (https=) |
| WO (1) | WO2002014478A2 (https=) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6942866B2 (en) | 2000-08-16 | 2005-09-13 | Apovia, Inc. | Malaria immunogen and vaccine |
| US7022830B2 (en) * | 2000-08-17 | 2006-04-04 | Tripep Ab | Hepatitis C virus codon optimized non-structural NS3/4A fusion gene |
| US7094409B2 (en) | 2001-01-19 | 2006-08-22 | Cytos Biotechnology Ag | Antigen arrays for treatment of allergic eosinophilic diseases |
| US7128911B2 (en) | 2001-01-19 | 2006-10-31 | Cytos Biotechnology Ag | Antigen arrays for treatment of bone disease |
| WO2003102165A2 (en) * | 2002-02-21 | 2003-12-11 | Apovia, Inc. | IMMUNOGENIC HBc CHIMER PARTICLES STABILIZED WITH AN N-TERMINAL CYSTEINE |
| US7361352B2 (en) | 2001-08-15 | 2008-04-22 | Acambis, Inc. | Influenza immunogen and vaccine |
| DE60234375D1 (de) | 2001-09-14 | 2009-12-24 | Cytos Biotechnology Ag | VERPACKUNG VON IMMUNSTIMULIERENDEM CpG IN VIRUSÄHNLICHEN PARTIKELN: HERSTELLUNGSVERFAHREN UND VERWENDUNG |
| MXPA04002644A (es) | 2001-10-05 | 2004-07-08 | Cytos Biotechnology Ag | Conjugados que portan un peptido de angiotensina y usos de los mismos. |
| US7115266B2 (en) | 2001-10-05 | 2006-10-03 | Cytos Biotechnology Ag | Angiotensin peptide-carrier conjugates and uses thereof |
| AT410666B (de) * | 2001-12-11 | 2003-06-25 | Intercell Biomedizinische Forschungs & Entwicklungs Gmbh | Nukleinsäure bindende peptide und die verwendung derartiger peptide in pharmazeutischen präparaten |
| US7351413B2 (en) * | 2002-02-21 | 2008-04-01 | Lorantis, Limited | Stabilized HBc chimer particles as immunogens for chronic hepatitis |
| CA2487849A1 (en) | 2002-07-18 | 2004-01-29 | Cytos Biotechnology Ag | Hapten-carrier conjugates comprising virus like particles and uses thereof |
| EP2338510A1 (en) | 2002-07-19 | 2011-06-29 | Novartis Pharma AG | Vaccine compositions containing amyloid beta1-6 antigen arrays |
| AU2003300841B2 (en) * | 2002-12-10 | 2008-03-20 | Lorantis Ltd. | Stabilized immunogenic HBc chimer particles |
| AU2004224761A1 (en) | 2003-03-26 | 2004-10-07 | Cytos Biotechnology Ag | HIV-peptide-carrier-conjugates |
| US7537767B2 (en) | 2003-03-26 | 2009-05-26 | Cytis Biotechnology Ag | Melan-A- carrier conjugates |
| US7144712B2 (en) | 2003-07-30 | 2006-12-05 | Vaccine Research Institute Of San Diego | Human hepatitis B virus core proteins as vaccine platforms and methods of use thereof |
| EP1651258B1 (en) * | 2003-07-30 | 2014-03-19 | Vaccine Research Institute of San Diego | Hepatitis virus core proteins as vaccine platforms and methods of use thereof |
| US7320795B2 (en) * | 2003-07-30 | 2008-01-22 | Vaccine Research Institute Of San Diego | Rodent hepatitis B virus core proteins as vaccine platforms and methods of use thereof |
| US7408075B1 (en) * | 2005-03-23 | 2008-08-05 | The United States Of America As Represented By The Department Of Health And Human Services | Synthesis of phosphocholine ester derivatives and conjugates thereof |
| US20070160628A1 (en) * | 2005-08-31 | 2007-07-12 | Birkett Ashley J | Stabilized virus-like particles and epitope display systems |
| AU2007297801A1 (en) | 2006-07-14 | 2008-03-27 | Sanofi Pasteur Biologics Co. | Construction of recombinant virus vaccines by direct transposon-mediated insertion of foreign immunologic determinants into vector virus proteins |
| EP1897887A1 (de) * | 2006-09-08 | 2008-03-12 | Universitätsklinikum Freiburg | Split-Core-Partikel für die Präsentation von Fremdmolekülen, insbesondere für Impfstoffanwendungen und Verfahren zu deren Herstellung |
| EP2069483A4 (en) * | 2006-09-29 | 2010-10-27 | Sanofi Pasteur Biologics Co | RECOMBINANT RHINOVIRAL VECTORS |
| US8652486B2 (en) | 2006-09-29 | 2014-02-18 | Sanofi Pasteur Biologics, Llc | Neutralizing immunogen (NimIV) of rhinovirus and its use for vaccine applications |
| PL1920781T3 (pl) * | 2006-11-10 | 2015-06-30 | Glycotope Gmbh | Kompozycje zawierające core-1-dodatnie mikroorganizmy i ich zastosowanie w leczeniu lub profilaktyce nowotworów |
| KR100861923B1 (ko) * | 2006-12-07 | 2008-10-09 | 메디칸(주) | 바이러스 항원 발현 재조합 벡터로 형질전환된 곤충세포를 이용한 ａ형 간염 바이러스 항원의 제조방법 |
| US8071561B2 (en) * | 2007-08-16 | 2011-12-06 | Chrontech Pharma Ab | Immunogen platform |
| ITUD20080055A1 (it) * | 2008-03-13 | 2009-09-14 | Transactiva S R L | Procedimento per la produzione di una proteina umana in pianta, in particolare un enzima lisosomiale umano ricombinante in endosperma di cereali |
| US10485879B2 (en) | 2008-04-15 | 2019-11-26 | Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, National Institutes Of Health | Plasma cell cytokine vehicle containing fusion proteins for targeted introduction of siRNA into cells and tissues |
| BRPI0922561A2 (pt) | 2008-12-09 | 2020-08-11 | Pfizer Vaccines Llc | vacina de peptídeo de ch3 da ige. |
| JP2013500326A (ja) | 2009-07-30 | 2013-01-07 | ファイザー バクシーンズ エルエルシー | 抗原性タウペプチドおよびその使用 |
| WO2011027257A2 (en) | 2009-09-03 | 2011-03-10 | Pfizer Vaccines Llc | Pcsk9 vaccine |
| EP2575868A1 (en) | 2010-06-07 | 2013-04-10 | Pfizer Vaccines LLC | Ige ch3 peptide vaccine |
| US20120328605A1 (en) * | 2010-10-27 | 2012-12-27 | Daniel Larocque | Compositions and uses |
| US10238747B2 (en) * | 2010-12-13 | 2019-03-26 | Cel-Sci, Corp | Method for inducing an immune response against avian, swine, spanish, H1N1, H5N9 influenza viruses and formulations thereof |
| EA032364B1 (ru) | 2011-02-11 | 2019-05-31 | Дзе Трастиз Оф Дзе Юниверсити Оф Пенсильвания | Молекула нуклеиновой кислоты, кодирующая коровый белок вируса гепатита в, и вакцина, содержащая указанную молекулу |
| WO2012131504A1 (en) | 2011-03-02 | 2012-10-04 | Pfizer Inc. | Pcsk9 vaccine |
| US9446120B2 (en) | 2011-04-15 | 2016-09-20 | Osaka University | DNA vaccine |
| WO2012162564A1 (en) | 2011-05-25 | 2012-11-29 | Cel-Sci Corporation | Method for inducing an immune response and formulations thereof |
| US9486507B2 (en) * | 2011-06-10 | 2016-11-08 | Biogen Ma Inc. | Pro-coagulant compounds and methods of use thereof |
| US20130164217A1 (en) * | 2011-12-21 | 2013-06-27 | Meso Scale Technologies, Llc | Method of diagnosing, preventing and/or treating dementia & related disorders |
| JP6422022B2 (ja) | 2012-08-31 | 2018-11-14 | 国立大学法人大阪大学 | Ｖｅｇｆ及び／又はアンギオポエチン−２の特異的エピトープを含むｄｎａワクチン |
| WO2015123291A1 (en) | 2014-02-11 | 2015-08-20 | The Usa, As Represented By The Secretary, Dept. Of Health And Human Services | Pcsk9 vaccine and methods of using the same |
| CN111925423B (zh) * | 2014-11-07 | 2022-08-19 | 普莱柯生物工程股份有限公司 | 一种抗o型口蹄疫的疫苗组合物及其制备方法和应用 |
| SG11201911430PA (en) | 2017-07-04 | 2020-01-30 | Curevac Ag | Novel nucleic acid molecules |
| US20220233568A1 (en) | 2017-10-19 | 2022-07-28 | Curevac Ag | Novel artificial nucleic acid molecules |
| JP7366057B2 (ja) | 2018-04-19 | 2023-10-20 | チェックメイト ファーマシューティカルズ， インコーポレイテッド | 合成ｒｉｇ－ｉ様受容体アゴニスト |
| TW202039534A (zh) | 2018-12-14 | 2020-11-01 | 美商美國禮來大藥廠 | KRAS變體mRNA分子 |
| JP7707161B2 (ja) | 2019-10-23 | 2025-07-14 | チェックメイト ファーマシューティカルズ， インコーポレイテッド | 合成ｒｉｇ－ｉ様受容体アゴニスト |
| CN113943075A (zh) * | 2020-07-15 | 2022-01-18 | 湖南怡田美农业科技有限公司 | 一种剑麻皂素提取后的污染处理方法 |
| JP2025519107A (ja) * | 2022-05-23 | 2025-06-24 | バクスディグム カンパニー，リミティド | ウイルスヌクレオカプシドを用いた結晶性タンパク質ベースの標的タンパク質融合自己組織化ナノ粒子製造プラットフォーム |
| WO2023229330A1 (ko) * | 2022-05-23 | 2023-11-30 | 주식회사 백스다임 | 바이러스 뉴클레오캡시드를 이용한 오량체형 독소 단백질 기반 목적 단백질 융합 오량체 제조 플랫폼 |
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2001
- 2001-08-15 US US09/930,915 patent/US20030138769A1/en not_active Abandoned
- 2001-08-16 AU AU8545201A patent/AU8545201A/xx active Pending
- 2001-08-16 BR BR0113307-1A patent/BR0113307A/pt not_active IP Right Cessation
- 2001-08-16 AP APAP/P/2003/002752A patent/AP2003002752A0/en unknown
- 2001-08-16 EA EA200300270A patent/EA006207B1/ru not_active IP Right Cessation
- 2001-08-16 OA OA1200300045A patent/OA12366A/en unknown
- 2001-08-16 JP JP2002519606A patent/JP2005517380A/ja active Pending
- 2001-08-16 EP EP01964615A patent/EP1333857A4/en not_active Withdrawn
- 2001-08-16 WO PCT/US2001/041759 patent/WO2002014478A2/en not_active Ceased
- 2001-08-16 MX MXPA03001338A patent/MXPA03001338A/es not_active Application Discontinuation
- 2001-08-16 CA CA002420037A patent/CA2420037A1/en not_active Abandoned
- 2001-08-16 AU AU2001285452A patent/AU2001285452B2/en not_active Ceased
- 2001-08-16 KR KR10-2003-7002259A patent/KR20030084887A/ko not_active Ceased
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2004
- 2004-03-22 US US10/805,913 patent/US20040156864A1/en not_active Abandoned
- 2004-03-22 US US10/806,006 patent/US20040152876A1/en not_active Abandoned
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2012
- 2012-04-09 JP JP2012088679A patent/JP2012139237A/ja active Pending
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