JP2005515966A - 鎮痛薬としての使用のための６−ヒドロキシ−オキシモルホンの経口投与 - Google Patents

鎮痛薬としての使用のための６−ヒドロキシ−オキシモルホンの経口投与 Download PDF

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JP2005515966A
JP2005515966A JP2003510043A JP2003510043A JP2005515966A JP 2005515966 A JP2005515966 A JP 2005515966A JP 2003510043 A JP2003510043 A JP 2003510043A JP 2003510043 A JP2003510043 A JP 2003510043A JP 2005515966 A JP2005515966 A JP 2005515966A
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Prior art keywords
hydroxyoxymorphone
pharmaceutical composition
oxymorphone
analgesia
amount sufficient
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JP2003510043A
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JP2005515966A5 (enExample
Inventor
フアイ−フン カオ，
リチャード スミス−カーリス，
トロイ マコール，
デイビッド リー，
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エンドー ファーマシューティカルズ， インコーポレイティド
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Application filed by エンドー ファーマシューティカルズ， インコーポレイティド filed Critical エンドー ファーマシューティカルズ， インコーポレイティド
Publication of JP2005515966A publication Critical patent/JP2005515966A/ja
Publication of JP2005515966A5 publication Critical patent/JP2005515966A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biophysics (AREA)
  • Organic Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Dental Preparations (AREA)
JP2003510043A 2001-07-06 2002-07-03 鎮痛薬としての使用のための６−ヒドロキシ−オキシモルホンの経口投与 Pending JP2005515966A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US30335701P 2001-07-06 2001-07-06
US32943201P 2001-10-15 2001-10-15
US32944501P 2001-10-15 2001-10-15
US32944401P 2001-10-15 2001-10-15
PCT/US2002/021400 WO2003004032A1 (en) 2001-07-06 2002-07-03 Oral administration of 6-hydroxy-oxymorphone for use as an analgesic

Publications (2)

Publication Number Publication Date
JP2005515966A true JP2005515966A (ja) 2005-06-02
JP2005515966A5 JP2005515966A5 (enExample) 2006-01-05

Family

ID=27501826

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2003510043A Pending JP2005515966A (ja) 2001-07-06 2002-07-03 鎮痛薬としての使用のための６−ヒドロキシ−オキシモルホンの経口投与
JP2003510041A Expired - Fee Related JP4440635B2 (ja) 2001-07-06 2002-07-03 オキシモルホン放出制御性処方物
JP2003510042A Pending JP2005520778A (ja) 2001-07-06 2002-07-03 鎮痛薬として使用するための６−ヒドロキシ−オキシモルホンの非経口投与
JP2009044920A Pending JP2009114209A (ja) 2001-07-06 2009-02-26 オキシモルホン放出制御性処方物

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2003510041A Expired - Fee Related JP4440635B2 (ja) 2001-07-06 2002-07-03 オキシモルホン放出制御性処方物
JP2003510042A Pending JP2005520778A (ja) 2001-07-06 2002-07-03 鎮痛薬として使用するための６−ヒドロキシ−オキシモルホンの非経口投与
JP2009044920A Pending JP2009114209A (ja) 2001-07-06 2009-02-26 オキシモルホン放出制御性処方物

Country Status (13)

Country Link
US (13) US20030130297A1 (enExample)
EP (4) EP2311460A1 (enExample)
JP (4) JP2005515966A (enExample)
KR (1) KR20030034171A (enExample)
CN (3) CN1268338C (enExample)
AT (1) ATE359077T1 (enExample)
AU (3) AU2002316582B2 (enExample)
BR (1) BR0205721A (enExample)
CA (3) CA2452872A1 (enExample)
DE (1) DE60219478T2 (enExample)
ES (1) ES2284888T3 (enExample)
NO (1) NO20031018L (enExample)
WO (3) WO2003004030A1 (enExample)

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CN1551770A (zh) 2004-12-01
AU2002318211B2 (en) 2007-07-12
WO2003004032A1 (en) 2003-01-16
US9820982B2 (en) 2017-11-21
JP2005520778A (ja) 2005-07-14
AU2002320309B2 (en) 2007-07-12
US20160136152A1 (en) 2016-05-19
US20210008063A1 (en) 2021-01-14
NO20031018D0 (no) 2003-03-05
US20080262013A1 (en) 2008-10-23
WO2003004031A1 (en) 2003-01-16
US20070098792A1 (en) 2007-05-03
JP2004536832A (ja) 2004-12-09
CN1268338C (zh) 2006-08-09
JP4440635B2 (ja) 2010-03-24
US20180338967A1 (en) 2018-11-29
WO2003004030A1 (en) 2003-01-16
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US8309122B2 (en) 2012-11-13
DE60219478T2 (de) 2008-01-03
CA2452871C (en) 2011-10-04
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US20070098793A1 (en) 2007-05-03
AU2002316582B2 (en) 2007-03-15
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US20040214849A1 (en) 2004-10-28
US20150011577A1 (en) 2015-01-08
CN1538846A (zh) 2004-10-20
KR20030034171A (ko) 2003-05-01
ATE359077T1 (de) 2007-05-15
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US20030130297A1 (en) 2003-07-10
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