JP4440635B2 - オキシモルホン放出制御性処方物 - Google Patents
オキシモルホン放出制御性処方物 Download PDFInfo
- Publication number
- JP4440635B2 JP4440635B2 JP2003510041A JP2003510041A JP4440635B2 JP 4440635 B2 JP4440635 B2 JP 4440635B2 JP 2003510041 A JP2003510041 A JP 2003510041A JP 2003510041 A JP2003510041 A JP 2003510041A JP 4440635 B2 JP4440635 B2 JP 4440635B2
- Authority
- JP
- Japan
- Prior art keywords
- oxymorphone
- hours
- controlled release
- treatment
- release
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Description
疼痛は、最も頻繁に報告される症状であり、臨床医が直面する一般的な臨床的問題である。近年の多くの報告によると、アメリカ合衆国において数百万人の人が、重篤な疼痛に罹患しており、彼らは、慢性的に治療中であるかまたは不適切に処置されている。オピオイドの鎮痛特性の臨床的有用性は、数世紀にわたって認識されており、モルヒネおよびその誘導体は、種々の臨床的疼痛状態を鎮痛するために、数十年にわたって広範に用いられてきた。
本発明は、放出制御性の薬学的錠剤を投与することによって、疼痛を軽減するための方法を提供し、この錠剤は、オキシモルホンを含有し、このオキシモルホンは、投与後少なくとも12時間の間、少なくとも予め決定した最小血漿中レベルを生じ、かつこの錠剤は、この期間にわたって、持続した疼痛の軽減を生じる。
本発明は、少なくとも12時間以上にわたって少なくとも最小値のオキシモルホンおよび/または6−OHオキシモルホンの血漿中レベルを生じさせることによって、薬学的組成物の単回用量を使用して、12〜24時間、疼痛を軽減するための方法を提供する。本明細書中で使用される場合、用語「6−OHオキシモルホン」および「6−ヒドロキシオキシモルホン」は、相互交換可能であり、6位にてオキシモルホンにおいて見出されるカルボキシ部分を置き換えたアルコール(ヒドロキシ)部分を有するオキシモルホンのアナログをいう。
浸透性ポンプは、内部コンパートメントを規定し、かつこのシェルを通過する出口を有する、シェルを含む。この内部コンパートメントは、活性な薬学的成分を含む。一般に、この活性な薬学的成分は、賦形剤または他の組成物(例えば、ポリアルキレン)と混合される。このシェルは、一般に、少なくとも部分的に、ポンプが使用される環境の液体(通常、胃酸)に対して浸透性である材料(例えば、酢酸セルロース)から作製される。一旦、摂取されると、液体がポンプのシェル通って拡散する場合、このポンプは作動する。液体は組成物を溶解し、飽和状態を生じさせる。より多くの液体がポンプ中に拡散すると、薬物を含有する飽和溶液が、出口を通ってポンプから排出される。これは、活性成分(本発明の場合、オキシモルホン)のほぼ一定の放出を生じさせる。
この実施形態において、オキシモルホンまたはオキシモルホン塩を含むコアは、水不溶性材料を含む放出制御性フィルムでコーティングされる。このフィルムは、コア上に水不溶性材料の水性分散物をスプレーすることによって、適用され得る。適切な水不溶性材料は、アルキルセルロース、アクリル酸ポリマー、ワックス(ワックス単独または脂肪性アルコールとの混合物中のワックス)、シェラックおよびゼインを含む。アルキルセルロールおよびアクリル酸ポリマーの水性分散物は、好ましくは、可塑剤(例えば、クエン酸トリエチル、フタル酸ジブチル、プロピレングリコール、およびポリエチレングリコール)を含む。このフィルムコートは、水溶性材料(例えば、ポリビニルピロリドン(PVP)またはヒドロキシプロピルメチルセルロース(HPMC))を含み得る。
オキシモルホンおよび6−ヒドロキシオキシモルホンの適切な血漿レベルが達成され、かつ十分な時間維持され、12〜24時間の間、患者に疼痛の免荷を提供することが、本発明において重要である。適切な血漿レベルを達成し、維持するために好ましい組成物は、放出制御性マトリックスである。この実施形態において、このオキシモルホンまたはオキシモルホン塩は、親水性材料(ゲル化剤)を含む放出制御性送達系において分散され、これは、胃腸液に曝されると、制御された速度でオキシモルホンを放出するゲルマトリックスを形成する。このような親水性材料としては、ガム、セルロースエーテル、アクリル酸樹脂、およびタンパク質送達材料が挙げられる。適切なセルロースエーテルとしては、ヒドロキシアルキルセルロースおよびカルボキシアルキルセルロース、特に、ヒドロキシエチルセルロース(HEC)、ヒドロキシプロピルセルロース(HPC)、HPMC、およびカルボキシメチルセルロース(CMC)が挙げられる。適切なアクリル酸樹脂としては、アクリル酸、メタクリル酸、メチルアクリレートおよびメチルメタクリレートのポリマーおよびコポリマーが挙げられる。適切なガムとしては、ヘテロポリサッカライドガムおよびホモポリサッカライドガム(例えば、キサンタンガム、トラガカントゴム、アラビアゴム、カラヤゴム、アルギナート、寒天、ガーゴム、ヒドロキシプロピルガーゴム、カラゲーナン、およびローカストマメゴム(locust bean gum))が挙げられる。
2つの放出制御性送達システムは、キサンタンガム、イナゴマメガム、硫酸カルシウム無水物、およびデキストロースを、高速混合/造粒機で三分間、乾燥混合することによって調製される。スラリーは、エチルセルロースをアルコールと混合することによって調製される。チョッパー/インペラーを作動させる間、スラリーを、乾燥混合された混合物に添加し、そしてさらに3分間粒状化する。次いで、約10重量%未満のLOD(乾燥減少(loss on drying))まで乾燥する。次いで、顆粒は、20メッシュの篩を使用して粉砕される。成分の相対的な量は、以下の表に列挙される。
20mgの錠剤の2つのバッチを、放出制御性送達系の処方物1を使用して、上記されるように調製した。1つのバッチを、比較的速い放出制御性を提供するために処方し、もう1つのバッチを、比較的遅い放出制御性を提供するために処方した。錠剤の組成を、以下の表に示す。
3つの臨床的研究を実施し、オキシモルホンのバイオアベイラビリティー(吸収の速度および程度)を評価した。研究1は、絶食患者における、(実施例2および3の)放出制御性(CR)オキシモルホン錠剤および経口オキシモルホン溶液の相対吸収速度を取り扱った。研究2は、摂食患者における、(実施例2および3の)CRオキシモルホン錠剤および経口オキシモルホン溶液の相対吸収速度を取り扱った。研究3は、摂食患者および絶食患者における、(実施例4の)CRオキシモルホン錠剤および経口オキシモルホン溶液の相対吸収速度を取り扱った。
以下の薬物動態的方法パラメーターを、血漿オキシモルホン濃度−時間データから計算した:
AUC(0−t) 時間0〜時間最後の定量可能な濃度(Ct)までの薬物濃度−時間曲線の下の面積。線形台形和を使用して計算される。
AUC(0−inf) 時間0〜無限大までの薬物濃度−時間曲線の下の面積。AUC(0−inf)=AUC(0−t)+Ct/Kel、ここで、Kelは終末排除速度定数である。
AUC(0−24) 時間0〜24時間までの薬物濃度−時間曲線の下の部分面積。
Cmax 最大実測薬物濃度。
Tmax 最大薬物濃度が観測される時刻。
Kel LN(濃度)時間曲線の終末直線部分の直線回帰に基づく、排除速度定数。
健常ボランティアに、10時間の絶食後、240mlの水と一緒に摂取させて20mgのCRオキシモルホンの単一経口用量を与えた。被験体に、実施例2の錠剤(処置1A)または実施例3の錠剤(処置1B)を与えた。さらに、被験体に、180mlのリンゴジュース中の単一経口用量の10mg/10ml オキシモルホン溶液を与え、続いて、60mlの水を与えた(処置1C)。経口投薬した溶液を使用して、即時放出(IR)用量を模倣した。
健常なボランティアに、摂食状態で、240mlの水と一緒に摂取させて20mgのCRオキシモルホンの単一経口用量を与えた。被験体に、実施例2の錠剤(処置2A)または実施例3の錠剤(処置2B)を与えた。さらに、被験体に、180mlのリンゴジュース中の単一経口用量の10mg/10ml オキシモルホン溶液を与え、続いて、60mlの水を与えた(処置2C)。経口投薬した溶液を使用して、即時放出(IR)用量を模倣した。
本研究は、単一機関の、オープンラベルの、分析的に盲目的な、ランダム化した、フォーウェイクロスオーバーの設計を有した。以下に記載されるように、処置3Aおよび処置3Cに対してランダム化した被験体は、一晩の10時間の断食の後の、飢餓状態であった。以下に記載されるように、処置3Bおよび処置3Dに対してランダム化した被験体は、高脂質の朝食を摂っており(投与の10分前に完了していた)、満腹の状態であった。4回の用量の投与の間に14日間の洗い流しの間隔を設けた。被験体を、各々の研究期間の間、診療所に拘束した。処置3Aおよび処置3Bを受けるように割り当てられた被験体を、48時間の手順の後の3日目に、診療所から開放し、そして処置3Cおよび処置3Dを受けるように割り当てられた被験体を、36時間の手順の後の2日目に、診療所から開放した。各々の研究期間の1日目に、これらの被験体は、4つの処置のうちの1つを与えた:
(処置3Aおよび処置3B)
実施例3からのオキシモルホンの放出制御性の20mg錠剤。処置3Aに対するランダム化された被験体に、10時間の断食期間の後に、240mlの水と組み合わせた、単回の経口用量の20mgオキシモルホンの放出制御性錠剤を与えた。処置3Bに対するランダム化した被験体に、標準化された高脂質の食料を摂った10分後に、240mlの水と組み合わせた、単回の経口用量の20mgオキシモルホンの放出制御性錠剤を与えた。
オキシモルホンHCl溶液、USP、1.5mg/ml 10mlバイアル。処置3Cに対するランダム化された被験体に、10時間の断食期間の後に、240mlの水と組み合わせた、単回の経口用量の10mg(6.7ml)オキシモルホン溶液を与えた。処置3Dに対するランダム化した被験体に、標準化された高脂質の食料を摂った10分後に、240mlの水と組み合わせた、単回の経口用量の10mg(6.7ml)オキシモルホン溶液を与えた。
単回用量条件下および複数回用量(一定状態)条件下での放出制御性オキシモルホン錠剤および即時放出性オキシモルホン錠剤の、バイオアベイラビリティーおよび薬理動態を比較するための研究を行った。放出制御性の研究のために、健常なボランティアに、1日目の朝に単回用量の20mg放出制御性オシキモルホン錠剤を投与した。3日目の朝に開始して、9日目の朝の投薬まで、ボランティアに20mg放出制御性オキシモルホン錠剤を12時間毎に投与した。即時放出性研究のために、健常なボランティアに、単回の10mg用量の即時放出性オキシモルホン錠剤を1日目の朝に投与した。3日目の朝に、さらに10mgの即時放出性錠剤を、9日目の最初の2用量まで6時間毎に投与した。
本研究の目的は、絶食条件および餌を与える条件の両方において、オキシモルホン即時放出(4×10mg)と比較したオキシモルホン放出制御(40mg)由来のオキシモルホンの相対バイオアベイラビリティーを評価し、放出制御性処方物由来のオキシモルホンであるオキシモルホンCR、および即時放出性処方物由来のオキシモルホンであるオキシモルホンIRのバイオアベイラビリティーに対する物の影響を決定することである。
Claims (12)
- 放出制御マトリックスおよびオキシモルホンを含む、放出制御性オキシモルホン処方物であって、ここで、該放出制御マトリックスは、イナゴマメガム、キサンタンガムおよびデキストロースを含む、放出制御性オキシモルホン処方物。
- 前記キサンタンガムと前記イナゴマメガムとが1:1の比率で存在する、請求項1に記載の放出制御性オキシモルホン処方物。
- 前記放出制御性マトリックスは、30重量%のイナゴマメガム、30重量%のキサンタンガム、および40重量%のデキストロースからなる、請求項1に記載の放出制御性オキシモルホン処方物。
- 硫酸カルシウム無水物およびエチルセルロースをさらに含む、請求項1に記載の放出制御性オキシモルホン処方物。
- 前記放出制御性マトリックスは、25重量%のイナゴマメガム、25重量%のキサンタンガム、35重量%のデキストロース、10重量%の硫酸カルシウム無水物、および5重量%のエチルセルロースからなる、請求項4に記載の放出制御性オキシモルホン処方物。
- 前記処方物は、5mg〜80mgのオキシモルホンを含む、請求項1〜5のいずれか1項に記載の放出制御性オキシモルホン処方物。
- 請求項1〜6のいずれか1項に記載の放出制御性オキシモルホン処方物を含む、8時間にわたり患者における疼痛を制御するための組成物。
- 前記組成物が、5mgのオキシモルホンを含む、請求項7に記載の組成物。
- 前記組成物が、10mgのオキシモルホンを含む、請求項7に記載の組成物。
- 前記組成物が、20mgのオキシモルホンを含む、請求項7に記載の組成物。
- 前記組成物が、40mgのオキシモルホンを含む、請求項7に記載の組成物。
- 前記組成物が、80mgのオキシモルホンを含む、請求項7に記載の組成物。
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US30335701P | 2001-07-06 | 2001-07-06 | |
US32943201P | 2001-10-15 | 2001-10-15 | |
US32944501P | 2001-10-15 | 2001-10-15 | |
US32944401P | 2001-10-15 | 2001-10-15 | |
PCT/US2002/021396 WO2003004030A1 (en) | 2001-07-06 | 2002-07-03 | Oxymorphone controlled release formulations |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2009044920A Division JP2009114209A (ja) | 2001-07-06 | 2009-02-26 | オキシモルホン放出制御性処方物 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2004536832A JP2004536832A (ja) | 2004-12-09 |
JP4440635B2 true JP4440635B2 (ja) | 2010-03-24 |
Family
ID=27501826
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2003510041A Expired - Fee Related JP4440635B2 (ja) | 2001-07-06 | 2002-07-03 | オキシモルホン放出制御性処方物 |
JP2003510042A Pending JP2005520778A (ja) | 2001-07-06 | 2002-07-03 | 鎮痛薬として使用するための6−ヒドロキシ−オキシモルホンの非経口投与 |
JP2003510043A Pending JP2005515966A (ja) | 2001-07-06 | 2002-07-03 | 鎮痛薬としての使用のための6−ヒドロキシ−オキシモルホンの経口投与 |
JP2009044920A Pending JP2009114209A (ja) | 2001-07-06 | 2009-02-26 | オキシモルホン放出制御性処方物 |
Family Applications After (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2003510042A Pending JP2005520778A (ja) | 2001-07-06 | 2002-07-03 | 鎮痛薬として使用するための6−ヒドロキシ−オキシモルホンの非経口投与 |
JP2003510043A Pending JP2005515966A (ja) | 2001-07-06 | 2002-07-03 | 鎮痛薬としての使用のための6−ヒドロキシ−オキシモルホンの経口投与 |
JP2009044920A Pending JP2009114209A (ja) | 2001-07-06 | 2009-02-26 | オキシモルホン放出制御性処方物 |
Country Status (13)
Country | Link |
---|---|
US (13) | US20040214849A1 (ja) |
EP (4) | EP1406630A1 (ja) |
JP (4) | JP4440635B2 (ja) |
KR (1) | KR20030034171A (ja) |
CN (3) | CN1610551A (ja) |
AT (1) | ATE359077T1 (ja) |
AU (3) | AU2002318211B2 (ja) |
BR (1) | BR0205721A (ja) |
CA (3) | CA2452871C (ja) |
DE (1) | DE60219478T2 (ja) |
ES (1) | ES2284888T3 (ja) |
NO (1) | NO20031018L (ja) |
WO (3) | WO2003004032A1 (ja) |
Families Citing this family (65)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5478577A (en) * | 1993-11-23 | 1995-12-26 | Euroceltique, S.A. | Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level |
UA81224C2 (uk) | 2001-05-02 | 2007-12-25 | Euro Celtic S A | Дозована форма оксикодону та її застосування |
US20110104214A1 (en) | 2004-04-15 | 2011-05-05 | Purdue Pharma L.P. | Once-a-day oxycodone formulations |
US8329216B2 (en) | 2001-07-06 | 2012-12-11 | Endo Pharmaceuticals Inc. | Oxymorphone controlled release formulations |
ATE376832T1 (de) * | 2001-07-06 | 2007-11-15 | Penwest Pharmaceuticals Co | Verzögert freisetzende formulierungen von oxymorphon |
EP1406630A1 (en) | 2001-07-06 | 2004-04-14 | Endo Pharmaceuticals Inc. | Parenteral administration of 6-hydroxy-oxymorphone for use as an analgesic |
US20030091635A1 (en) * | 2001-09-26 | 2003-05-15 | Baichwal Anand R. | Opioid formulations having reduced potential for abuse |
US7776314B2 (en) | 2002-06-17 | 2010-08-17 | Grunenthal Gmbh | Abuse-proofed dosage system |
PT1551372T (pt) | 2002-09-20 | 2018-07-23 | Alpharma Pharmaceuticals Llc | Subunidade de sequestração e composições e métodos relacionados |
DE10336400A1 (de) | 2003-08-06 | 2005-03-24 | Grünenthal GmbH | Gegen Missbrauch gesicherte Darreichungsform |
DE102005005446A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Bruchfeste Darreichungsformen mit retardierter Freisetzung |
US20070048228A1 (en) | 2003-08-06 | 2007-03-01 | Elisabeth Arkenau-Maric | Abuse-proofed dosage form |
DE10361596A1 (de) | 2003-12-24 | 2005-09-29 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
AU2005227303A1 (en) * | 2004-03-22 | 2005-10-06 | E.I. Dupont De Nemours And Company | Orthoester-protected polyols for low VOC coatings |
DE102004032049A1 (de) | 2004-07-01 | 2006-01-19 | Grünenthal GmbH | Gegen Missbrauch gesicherte, orale Darreichungsform |
DE102005005449A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
US8394812B2 (en) | 2005-08-24 | 2013-03-12 | Penwest Pharmaceuticals Co. | Sustained release formulations of nalbuphine |
US8497258B2 (en) | 2005-11-12 | 2013-07-30 | The Regents Of The University Of California | Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract |
US20070212414A1 (en) * | 2006-03-08 | 2007-09-13 | Penwest Pharmaceuticals Co. | Ethanol-resistant sustained release formulations |
US20080119501A1 (en) * | 2006-04-28 | 2008-05-22 | Hein William A | Immediate release oxymorphone compositions and methods of using same |
EP2526932B1 (en) | 2006-06-19 | 2017-06-07 | Alpharma Pharmaceuticals LLC | Pharmaceutical composition |
EP2097069A1 (en) * | 2006-10-10 | 2009-09-09 | Penwest Pharmaceuticals Co. | Robust sustained release formulations of oxymorphone |
US20080085305A1 (en) * | 2006-10-10 | 2008-04-10 | Penwest Pharmaceuticals Co. | Robust sustained release formulations of oxymorphone |
MX2009003770A (es) * | 2006-10-10 | 2009-07-22 | Penwest Pharmaceuticals Co | Formulaciones de oximorfona robustas, de liberacion sostenida y metodos para su uso. |
US20080085303A1 (en) * | 2006-10-10 | 2008-04-10 | Penwest Pharmaceuticals Co. | Robust sustained release formulations of oxymorphone and methods of use thereof |
MX2009003771A (es) * | 2006-10-10 | 2009-07-22 | Penwest Pharmaceuticals Co | Formulaciones robustas de liberacion sostenida. |
GB0624880D0 (en) * | 2006-12-14 | 2007-01-24 | Johnson Matthey Plc | Improved method for making analgesics |
DE102007011485A1 (de) * | 2007-03-07 | 2008-09-11 | Grünenthal GmbH | Darreichungsform mit erschwertem Missbrauch |
US20080318993A1 (en) * | 2007-06-21 | 2008-12-25 | Endo Pharmaceuticals, Inc. | Method of Treating Pain Utilizing Controlled Release Oxymorphone Pharmaceutical Compositions and Instruction on Dosing for Hepatic Impairment |
US20090124650A1 (en) * | 2007-06-21 | 2009-05-14 | Endo Pharmaceuticals, Inc. | Method of Treating Pain Utilizing Controlled Release Oxymorphone Pharmaceutical Compositions and Instructions on Effects of Alcohol |
US20080318994A1 (en) | 2007-06-21 | 2008-12-25 | Endo Pharmaceuticals, Inc. | Method of Treating Pain Utilizing Controlled Release Oxymorphone Pharmaceutical Compositions and Instruction on Dosing for Renal Impairment |
PL2187873T3 (pl) | 2007-08-13 | 2019-01-31 | Abuse Deterrent Pharmaceutical Llc | Leki odporne na nadużywanie, metoda stosowania i metoda wytwarzania |
US8623418B2 (en) | 2007-12-17 | 2014-01-07 | Alpharma Pharmaceuticals Llc | Pharmaceutical composition |
AU2009207796B2 (en) | 2008-01-25 | 2014-03-27 | Grunenthal Gmbh | Pharmaceutical dosage form |
BRPI0912014A2 (pt) | 2008-05-09 | 2019-03-06 | Grünenthal GmbH | processo para a preparação de uma formulação em pó intermediária e uma forma de dosagem sólida final sob uso de uma etapa de congelamento por atomização |
US20120065221A1 (en) * | 2009-02-26 | 2012-03-15 | Theraquest Biosciences, Inc. | Extended Release Oral Pharmaceutical Compositions of 3-Hydroxy-N-Methylmorphinan and Method of Use |
US20110097401A1 (en) | 2009-06-12 | 2011-04-28 | Meritage Pharma, Inc. | Methods for treating gastrointestinal disorders |
RU2015138422A (ru) | 2009-07-22 | 2018-12-25 | Грюненталь Гмбх | Стабильная при окислении, прочная на излом лекарственная форма |
CA2765971C (en) * | 2009-07-22 | 2017-08-22 | Gruenenthal Gmbh | Hot-melt extruded controlled release dosage form |
DE102009060332B4 (de) * | 2009-12-23 | 2017-04-06 | Telefónica O2 Germany GmbH & Co. OHG | Verfahren und Vorrichtung zum Bereitstellen eines Telekommunikationsdienstes |
PL2611426T3 (pl) | 2010-09-02 | 2014-09-30 | Gruenenthal Gmbh | Postać dawkowania zawierająca nieorganiczne sole, odporna na zgniatanie |
WO2012028318A1 (en) | 2010-09-02 | 2012-03-08 | Grünenthal GmbH | Tamper resistant dosage form comprising an anionic polymer |
US10201502B2 (en) | 2011-07-29 | 2019-02-12 | Gruenenthal Gmbh | Tamper-resistant tablet providing immediate drug release |
EP2736497B1 (en) | 2011-07-29 | 2017-08-23 | Grünenthal GmbH | Tamper-resistant tablet providing immediate drug release |
US20130225697A1 (en) | 2012-02-28 | 2013-08-29 | Grunenthal Gmbh | Tamper-resistant dosage form comprising pharmacologically active compound and anionic polymer |
MX362357B (es) | 2012-04-18 | 2019-01-14 | Gruenenthal Gmbh | Forma de dosificacion farmaceutica resistente a la adulteracion y resistente a la liberacion inmediata de la dosis. |
US10064945B2 (en) | 2012-05-11 | 2018-09-04 | Gruenenthal Gmbh | Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc |
BR112015000320B1 (pt) | 2012-07-12 | 2023-03-07 | SpecGx LLC | Composições farmacêuticas dissuasivas de abuso e seu processo de preparação |
US11571390B2 (en) | 2013-03-15 | 2023-02-07 | Othemo Life Sciences, Inc. | Abuse deterrent compositions and methods of use |
WO2014191397A1 (en) | 2013-05-29 | 2014-12-04 | Grünenthal GmbH | Tamper-resistant dosage form containing one or more particles |
AR096439A1 (es) | 2013-05-29 | 2015-12-30 | Gruenenthal Gmbh | Forma de dosificación resistente al uso indebido que contiene una o más partículas |
EA032465B1 (ru) | 2013-07-12 | 2019-05-31 | Грюненталь Гмбх | Защищенная от применения не по назначению пероральная фармацевтическая лекарственная форма, содержащая этиленвинилацетатный полимер, и способ ее изготовления |
BR112016002079A2 (pt) | 2013-08-02 | 2017-09-05 | Johnson Matthey Plc | Processo para preparação de um aditivo ácido de oximorfona, solução aquosa de aditivo ácido de oximorfona, aditivo ácido de oximorfona sólido, e, alcaloide de oximorfona sólido |
CN105934241B (zh) | 2013-11-26 | 2020-06-05 | 格吕伦塔尔有限公司 | 通过低温研磨制备粉末状药物组合物 |
US9062063B1 (en) | 2014-03-21 | 2015-06-23 | Johnson Matthey Public Limited Company | Forms of oxymorphone hydrochloride |
JP2017518980A (ja) | 2014-05-12 | 2017-07-13 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | タペンタドールを含む、改変防止即時放出カプセル製剤 |
WO2015181059A1 (en) | 2014-05-26 | 2015-12-03 | Grünenthal GmbH | Multiparticles safeguarded against ethanolic dose-dumping |
US10729685B2 (en) | 2014-09-15 | 2020-08-04 | Ohemo Life Sciences Inc. | Orally administrable compositions and methods of deterring abuse by intranasal administration |
US9918979B2 (en) | 2015-01-29 | 2018-03-20 | Johnson Matthey Public Limited Company | Process of preparing low ABUK oxymorphone hydrochloride |
EP3285745A1 (en) | 2015-04-24 | 2018-02-28 | Grünenthal GmbH | Tamper-resistant dosage form with immediate release and resistance against solvent extraction |
EP3346991A1 (en) | 2015-09-10 | 2018-07-18 | Grünenthal GmbH | Protecting oral overdose with abuse deterrent immediate release formulations |
US9861629B1 (en) | 2015-10-07 | 2018-01-09 | Banner Life Sciences Llc | Opioid abuse deterrent dosage forms |
US10335405B1 (en) | 2016-05-04 | 2019-07-02 | Patheon Softgels, Inc. | Non-burst releasing pharmaceutical composition |
US10335375B2 (en) | 2017-05-30 | 2019-07-02 | Patheon Softgels, Inc. | Anti-overingestion abuse deterrent compositions |
ES2862209T3 (es) * | 2017-07-20 | 2021-10-07 | Intas Pharmaceuticals Ltd | Composiciones orales sólidas de liberación prolongada no pulsátil que contienen betahistina |
Family Cites Families (217)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US458349A (en) * | 1891-08-25 | Hose-coupling | ||
US591431A (en) * | 1897-10-12 | Coupling for traps and pipes | ||
US2806033A (en) | 1955-08-03 | 1957-09-10 | Lewenstein | Morphine derivative |
DE1517480A1 (de) | 1962-11-16 | 1969-05-22 | Permutit Co Ltd | Vorrichtung zum Regenerieren von Ionenaustauschern,insbesondere fuer die Wasserenthaertung |
US3400197A (en) * | 1965-01-26 | 1968-09-03 | Robins Co Inc A H | Compressible sustained release pharmaceutical tablet lipid-colloidal silica gel matrix fragment granules |
US3456049A (en) * | 1965-05-25 | 1969-07-15 | Ciba Geigy Corp | Gradual-release tablet |
IL26896A (en) | 1966-01-19 | 1970-11-30 | Endo Lab | 14 - Hydroxynormorphinins and 14 - Hydroxynormorphinones |
US3558768A (en) * | 1969-12-19 | 1971-01-26 | Sterling Drug Inc | Sustained release pharmaceutical compositions |
US3879555A (en) * | 1970-11-16 | 1975-04-22 | Bristol Myers Co | Method of treating drug addicts |
US3845770A (en) | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
US3980766A (en) * | 1973-08-13 | 1976-09-14 | West Laboratories, Inc. | Orally administered drug composition for therapy in the treatment of narcotic drug addiction |
US3966940A (en) * | 1973-11-09 | 1976-06-29 | Bristol-Myers Company | Analgetic compositions |
DE2530563C2 (de) * | 1975-07-09 | 1986-07-24 | Bayer Ag, 5090 Leverkusen | Analgetische Arzneimittel mit vermindertem Mißbrauchspotential |
US4140755A (en) * | 1976-02-13 | 1979-02-20 | Hoffmann-La Roche Inc. | Sustained release tablet formulations |
JPS5936110B2 (ja) * | 1976-11-01 | 1984-09-01 | 株式会社日立製作所 | 二重点火式点火装置 |
US4303691A (en) * | 1977-11-09 | 1981-12-01 | Anderson, Clayton & Co. | Proteinaceous food product |
NO793297L (no) | 1978-10-19 | 1980-04-22 | Mallinckrodt Inc | Fremgangsmaate til fremstilling av oksymorfon |
US4248858A (en) * | 1979-08-09 | 1981-02-03 | American Home Products Corporation | Sustained release pharmaceutical compositions |
US4309405A (en) * | 1979-08-09 | 1982-01-05 | American Home Products Corporation | Sustained release pharmaceutical compositions |
US4252786A (en) * | 1979-11-16 | 1981-02-24 | E. R. Squibb & Sons, Inc. | Controlled release tablet |
US4457933A (en) * | 1980-01-24 | 1984-07-03 | Bristol-Myers Company | Prevention of analgesic abuse |
US4489080A (en) * | 1981-06-26 | 1984-12-18 | The Upjohn Company | Process for analgesic treatment |
US4366159A (en) * | 1981-09-08 | 1982-12-28 | Michael Richard Magruder | Nalbuphine-narcotic analgesic composition and method of producing analgesia |
US4415547A (en) * | 1982-06-14 | 1983-11-15 | Sterling Drug Inc. | Sustained-release pharmaceutical tablet and process for preparation thereof |
US4587249A (en) * | 1982-07-22 | 1986-05-06 | Analgesic Associates | Analgesic and anti-inflammatory compositions comprising caffeine and methods of using same |
US4656177A (en) * | 1982-07-22 | 1987-04-07 | Analgesic Associates | Analgesic and anti-inflammatory compositions comprising caffeine and methods of using same |
WO1984000488A1 (en) | 1982-07-22 | 1984-02-16 | Richardson Vicks Inc | Improved analgesic and anti-inflammatory compositions comprising caffeine and methods of using same |
US4486436A (en) | 1982-07-22 | 1984-12-04 | Analgesic Associates | Analgesic and anti-inflammatory compositions comprising caffeine and methods of using same |
US4777174A (en) | 1982-07-22 | 1988-10-11 | Analgesic Associates | Analgesic and anti-inflammatory compositions comprising caffeine and methods of using same |
US4464376A (en) * | 1982-07-22 | 1984-08-07 | Richardson-Vicks, Inc. | Analgesic and anti-inflammatory compositions comprising caffeine and methods of using same |
US4461759A (en) * | 1983-01-03 | 1984-07-24 | Verex Laboratories, Inc. | Constant release rate solid oral dosage formulations of veropamil |
US4522804A (en) * | 1983-01-03 | 1985-06-11 | Verex Laboratories, Inc. | Constant release rate solid oral dosage formulations of propranolol |
US4521402A (en) * | 1983-01-03 | 1985-06-04 | Verex Laboratories, Inc. | Constant release rate solid oral dosage formulations of hydrazine |
US4521401A (en) * | 1983-01-03 | 1985-06-04 | Verex Laboratories, Inc. | Constant release rate solid oral dosage formulations of quinidine |
US4567183A (en) | 1983-03-11 | 1986-01-28 | Analgesic Associates | Analgesic and anti-inflammatory compositions comprising xanthines and methods of using same |
US4479956A (en) | 1983-04-26 | 1984-10-30 | Analgeic Associates | Analgesic compositions comprising propiram and methods of using same |
US4558051A (en) | 1983-10-11 | 1985-12-10 | Richardson-Vicks, Inc. | Analgesic and anti-inflammatory compositions comprising xanthines and methods of using same |
JPS60100516A (ja) * | 1983-11-04 | 1985-06-04 | Takeda Chem Ind Ltd | 徐放型マイクロカプセルの製造法 |
GB8332556D0 (en) * | 1983-12-06 | 1984-01-11 | Reckitt & Colmann Prod Ltd | Analgesic compositions |
JPS6124516A (ja) * | 1984-07-12 | 1986-02-03 | Fujisawa Pharmaceut Co Ltd | 持続性錠剤 |
US4610870A (en) * | 1984-10-05 | 1986-09-09 | E. R. Squibb & Sons, Inc. | Controlled release formulation |
GB8430346D0 (en) * | 1984-11-30 | 1985-01-09 | Reckitt & Colmann Prod Ltd | Analgesic compositions |
US4599114A (en) * | 1985-02-11 | 1986-07-08 | Atkinson George K | Treatment of titanium dioxide and other pigments to improve dispersibility |
US4569937A (en) * | 1985-02-11 | 1986-02-11 | E. I. Du Pont De Nemours And Company | Analgesic mixture of oxycodone and ibuprofen |
GB8514665D0 (en) * | 1985-06-11 | 1985-07-10 | Eroceltique Sa | Oral pharmaceutical composition |
GB2176999B (en) | 1985-06-22 | 1989-07-12 | Stanley Stewart Davis | Sustained release medicament |
GB8521350D0 (en) * | 1985-08-28 | 1985-10-02 | Euro Celtique Sa | Analgesic composition |
GB8601204D0 (en) * | 1986-01-18 | 1986-02-19 | Boots Co Plc | Therapeutic agents |
IE63321B1 (en) * | 1986-02-03 | 1995-04-05 | Elan Corp Plc | Drug delivery system |
IT1191674B (it) * | 1986-03-07 | 1988-03-23 | Eurand Spa | Formulazioni per la preparazione di farmaci a rilascio prolungato adatte alla somministrazione per via orale |
SE8601624D0 (sv) * | 1986-04-11 | 1986-04-11 | Haessle Ab | New pharmaceutical preparations |
US4795642A (en) * | 1986-05-01 | 1989-01-03 | Pharmacaps, Inc. | Gelatin-encapsulated controlled-release composition |
US4861598A (en) | 1986-07-18 | 1989-08-29 | Euroceltique, S.A. | Controlled release bases for pharmaceuticals |
US4859461A (en) * | 1986-07-30 | 1989-08-22 | Fisons Corporation | Coatable ion exchange resins |
GB8626098D0 (en) * | 1986-10-31 | 1986-12-03 | Euro Celtique Sa | Controlled release hydromorphone composition |
US4968508A (en) * | 1987-02-27 | 1990-11-06 | Eli Lilly And Company | Sustained release matrix |
GB8705083D0 (en) * | 1987-03-04 | 1987-04-08 | Euro Celtique Sa | Spheroids |
FR2618073B1 (fr) * | 1987-07-16 | 1990-09-07 | Pf Medicament | Comprimes de type a matrice hydrophile a base de salbutamol et leur procede de preparation |
US4792452A (en) * | 1987-07-28 | 1988-12-20 | E. R. Squibb & Sons, Inc. | Controlled release formulation |
US4994276A (en) | 1988-09-19 | 1991-02-19 | Edward Mendell Co., Inc. | Directly compressible sustained release excipient |
SE8703881D0 (sv) * | 1987-10-08 | 1987-10-08 | Haessle Ab | New pharmaceutical preparation |
GB8723896D0 (en) * | 1987-10-12 | 1987-11-18 | Aps Research Ltd | Controlled-release formulation |
GB8728294D0 (en) * | 1987-12-03 | 1988-01-06 | Reckitt & Colmann Prod Ltd | Treatment compositions |
US5096714A (en) * | 1988-06-28 | 1992-03-17 | Hauser-Kuhrts, Inc. | Prolonged release drug tablet formulations |
DE3822095A1 (de) | 1988-06-30 | 1990-01-04 | Klinge Co Chem Pharm Fab | Neue arzneimittelformulierung sowie verfahren zu deren herstellung |
GB8820353D0 (en) * | 1988-08-26 | 1988-09-28 | Staniforth J N | Controlled release tablet |
US5135757A (en) * | 1988-09-19 | 1992-08-04 | Edward Mendell Co., Inc. | Compressible sustained release solid dosage forms |
US5128143A (en) * | 1988-09-19 | 1992-07-07 | Edward Mendell Co., Inc. | Sustained release excipient and tablet formulation |
US5169639A (en) | 1988-09-19 | 1992-12-08 | Edward Mendell Co., Inc. | Controlled release verapamil tablets |
US5236714A (en) * | 1988-11-01 | 1993-08-17 | Alza Corporation | Abusable substance dosage form having reduced abuse potential |
US5202128A (en) * | 1989-01-06 | 1993-04-13 | F. H. Faulding & Co. Limited | Sustained release pharmaceutical composition |
GB8903328D0 (en) * | 1989-02-14 | 1989-04-05 | Ethical Pharma Ltd | Nifedipine-containing pharmaceutical compositions and process for the preparation thereof |
US5126145A (en) * | 1989-04-13 | 1992-06-30 | Upsher Smith Laboratories Inc | Controlled release tablet containing water soluble medicament |
US4990535A (en) * | 1989-05-03 | 1991-02-05 | Schering Corporation | Pharmaceutical composition comprising loratadine, ibuprofen and pseudoephedrine |
GB8926612D0 (en) | 1989-11-24 | 1990-01-17 | Erba Farmitalia | Pharmaceutical compositions |
US5126147A (en) * | 1990-02-08 | 1992-06-30 | Biosearch, Inc. | Sustained release dosage form |
JP2572673B2 (ja) | 1990-07-25 | 1997-01-16 | エスエス製薬株式会社 | 徐放性錠剤 |
SE9003903D0 (sv) * | 1990-12-07 | 1990-12-07 | Astra Ab | New pharmaceutical formulations |
US5431922A (en) | 1991-03-05 | 1995-07-11 | Bristol-Myers Squibb Company | Method for administration of buspirone |
US5286497A (en) | 1991-05-20 | 1994-02-15 | Carderm Capital L.P. | Diltiazem formulation |
US5215758A (en) * | 1991-09-11 | 1993-06-01 | Euroceltique, S.A. | Controlled release matrix suppository for pharmaceuticals |
US5226331A (en) * | 1991-10-03 | 1993-07-13 | General Electric Company | Apparatus and method for measuring the particle number rate and the velocity distribution of a sprayed stream |
US5169638A (en) * | 1991-10-23 | 1992-12-08 | E. R. Squibb & Sons, Inc. | Buoyant controlled release powder formulation |
US5266331A (en) * | 1991-11-27 | 1993-11-30 | Euroceltique, S.A. | Controlled release oxycodone compositions |
US5958459A (en) | 1991-12-24 | 1999-09-28 | Purdue Pharma L.P. | Opioid formulations having extended controlled released |
US5580578A (en) * | 1992-01-27 | 1996-12-03 | Euro-Celtique, S.A. | Controlled release formulations coated with aqueous dispersions of acrylic polymers |
US5968551A (en) | 1991-12-24 | 1999-10-19 | Purdue Pharma L.P. | Orally administrable opioid formulations having extended duration of effect |
US5681585A (en) | 1991-12-24 | 1997-10-28 | Euro-Celtique, S.A. | Stabilized controlled release substrate having a coating derived from an aqueous dispersion of hydrophobic polymer |
US5478577A (en) | 1993-11-23 | 1995-12-26 | Euroceltique, S.A. | Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level |
GB9202464D0 (en) * | 1992-02-05 | 1992-03-18 | Danbiosyst Uk | Composition for nasal administration |
WO1993017673A1 (en) | 1992-03-03 | 1993-09-16 | Top Gold Pty., Limited | Sustained release analgesics |
DE4227385A1 (de) * | 1992-08-19 | 1994-02-24 | Kali Chemie Pharma Gmbh | Pankreatinmikropellets |
US5512578A (en) * | 1992-09-21 | 1996-04-30 | Albert Einstein College Of Medicine Of Yeshiva University, A Division Of Yeshiva University | Method of simultaneously enhancing analgesic potency and attenuating dependence liability caused by exogenous and endogenous opiod agonists |
USRE36547E (en) | 1992-09-21 | 2000-02-01 | Albert Einstein College Of Medicine Of Yeshiva University | Method of simultaneously enhancing analgesic potency and attenuating dependence liability caused by exogenous and endogenous opioid agonists |
US5330761A (en) * | 1993-01-29 | 1994-07-19 | Edward Mendell Co. Inc. | Bioadhesive tablet for non-systemic use products |
IL110014A (en) * | 1993-07-01 | 1999-11-30 | Euro Celtique Sa | Solid controlled-release oral dosage forms of opioid analgesics |
US5773025A (en) | 1993-09-09 | 1998-06-30 | Edward Mendell Co., Inc. | Sustained release heterodisperse hydrogel systems--amorphous drugs |
US5662933A (en) * | 1993-09-09 | 1997-09-02 | Edward Mendell Co., Inc. | Controlled release formulation (albuterol) |
US5455046A (en) | 1993-09-09 | 1995-10-03 | Edward Mendell Co., Inc. | Sustained release heterodisperse hydrogel systems for insoluble drugs |
US5399358A (en) * | 1993-11-12 | 1995-03-21 | Edward Mendell Co., Inc. | Sustained release formulations for 24 hour release of metroprolol |
KR100354702B1 (ko) | 1993-11-23 | 2002-12-28 | 유로-셀티크 소시에떼 아노뉨 | 약학조성물의제조방법및서방형조성물 |
GB9401894D0 (en) * | 1994-02-01 | 1994-03-30 | Rhone Poulenc Rorer Ltd | New compositions of matter |
US5543434A (en) | 1994-02-25 | 1996-08-06 | Weg; Stuart L. | Nasal administration of ketamine to manage pain |
US5399359A (en) * | 1994-03-04 | 1995-03-21 | Edward Mendell Co., Inc. | Controlled release oxybutynin formulations |
JP3279318B2 (ja) | 1994-04-25 | 2002-04-30 | ペンウェスト ファーマシューティカルズ カンパニー | 持続放出性賦形剤 |
US5399362A (en) * | 1994-04-25 | 1995-03-21 | Edward Mendell Co., Inc. | Once-a-day metoprolol oral dosage form |
US5958458A (en) * | 1994-06-15 | 1999-09-28 | Dumex-Alpharma A/S | Pharmaceutical multiple unit particulate formulation in the form of coated cores |
US5633000A (en) | 1994-06-23 | 1997-05-27 | Axxia Technologies | Subcutaneous implant |
US5914131A (en) | 1994-07-07 | 1999-06-22 | Alza Corporation | Hydromorphone therapy |
US5556837A (en) | 1994-08-01 | 1996-09-17 | Regeneron Pharmaceuticals Inc. | Methods for treating addictive disorders |
US5965161A (en) * | 1994-11-04 | 1999-10-12 | Euro-Celtique, S.A. | Extruded multi-particulates |
GB9426407D0 (en) | 1994-12-30 | 1995-03-01 | Sandoz Ltd | Improvements in or relating to organic compounds |
US5948438A (en) | 1995-01-09 | 1999-09-07 | Edward Mendell Co., Inc. | Pharmaceutical formulations having improved disintegration and/or absorptivity |
FR2729857B1 (fr) * | 1995-01-27 | 1997-04-04 | Rhone Poulenc Chimie | Compositions pharmaceutiques sous forme de comprimes a liberation prolongee a base de granules en polysaccharides de haut poids moleculaire |
US5686107A (en) * | 1995-01-30 | 1997-11-11 | Fmc Corporation | Chewable pharmaceutical tablets |
US5612053A (en) * | 1995-04-07 | 1997-03-18 | Edward Mendell Co., Inc. | Controlled release insufflation carrier for medicaments |
US5567754A (en) | 1995-08-23 | 1996-10-22 | Kerr-Mcgee Corporation | Pigments with improved dispersibility in thermoplastic resins |
CA2230690C (en) | 1995-08-30 | 2008-12-23 | Stuart L. Weg | Administration of ketamine to manage pain and to reduce drug dependency |
AU2068797A (en) * | 1996-01-29 | 1997-08-20 | Edward Mendell Co. Inc. | Sustained release excipient |
US6245351B1 (en) * | 1996-03-07 | 2001-06-12 | Takeda Chemical Industries, Ltd. | Controlled-release composition |
JP3134187B2 (ja) | 1996-03-07 | 2001-02-13 | 武田薬品工業株式会社 | 放出制御組成物 |
US6103258A (en) * | 1996-04-12 | 2000-08-15 | Simon; David Lew | Salts and bases of the 17-(Cyclopropylmethyl)-4,5 alpha-epoxy-6-Methylenemorphinan-3,14 diol molecule for optimizing dopamine homeostasis during administration of opioid analgesics |
CA2461157C (en) | 1996-04-18 | 2007-08-28 | Penwest Pharmaceutical Co. | Sustained release heterodisperse hydrogel systems - amorphous drugs |
AU3581397A (en) | 1996-06-28 | 1998-01-21 | Knoll Pharmaceutical Company | Slow release pharmaceutical compositions and methods of making same |
CA2231195C (en) * | 1996-07-08 | 2003-01-21 | Edward Mendell Co., Inc. | Sustained release matrix for high-dose insoluble drugs |
US6248789B1 (en) * | 1996-08-29 | 2001-06-19 | Stuart L. Weg | Administration of ketamine to manage pain and to reduce drug dependency |
US5891474A (en) * | 1997-01-29 | 1999-04-06 | Poli Industria Chimica, S.P.A. | Time-specific controlled release dosage formulations and method of preparing same |
DE19710008A1 (de) | 1997-03-12 | 1998-09-17 | Basf Ag | Feste, mindestens zweiphasige Zubereitungsformen eines Opioid-Analgeticums mit verzögerter Freisetzung |
DE69831335T3 (de) * | 1997-06-06 | 2015-01-15 | Depomed, Inc. | Im magen verweilende orale dosierungsformen von wasserlöslichen arzneistoffen mit kontrollierter freisetzung |
WO1999001111A1 (en) | 1997-07-02 | 1999-01-14 | Euro-Celtique, S.A. | Stabilized sustained release tramadol formulations |
US6391336B1 (en) * | 1997-09-22 | 2002-05-21 | Royer Biomedical, Inc. | Inorganic-polymer complexes for the controlled release of compounds including medicinals |
CA2305183C (en) | 1997-10-03 | 2008-09-23 | The Governors Of The University Of Alberta | Postsurgical treatment with dichloroacetate |
US5904937A (en) | 1997-10-03 | 1999-05-18 | Fmc Corporation | Taste masked pharmaceutical compositions |
US6056977A (en) | 1997-10-15 | 2000-05-02 | Edward Mendell Co., Inc. | Once-a-day controlled release sulfonylurea formulation |
US6193991B1 (en) * | 1997-10-29 | 2001-02-27 | Atul J. Shukla | Biodegradable delivery systems of biologically active substances |
US6102358A (en) * | 1997-11-03 | 2000-08-15 | Mcleary; Joseph Butler | Counterpoise and mounting clamp for a musical drum |
DK1041987T3 (da) | 1997-12-22 | 2006-08-21 | Euro Celtique Sa | Oral farmaceutisk doseringsform omfattende en kombination af en opioid-agonist og naltrexon |
HUP0100310A3 (en) | 1997-12-22 | 2002-11-28 | Euro Celtique Sa | A method of preventing abuse of opioid dosage forms |
US6375957B1 (en) * | 1997-12-22 | 2002-04-23 | Euro-Celtique, S.A. | Opioid agonist/opioid antagonist/acetaminophen combinations |
US6245357B1 (en) * | 1998-03-06 | 2001-06-12 | Alza Corporation | Extended release dosage form |
US6143325A (en) | 1998-06-05 | 2000-11-07 | Bristol-Myers Squibb Company | Nefazodone dosage form |
KR20000011247A (ko) * | 1998-07-23 | 2000-02-25 | 김윤 | 다당류를이용한대장선택성약물전달조성물및약학제제 |
GB9816723D0 (en) | 1998-08-01 | 1998-09-30 | Boots Co Plc | Therapeutic agents |
US6806294B2 (en) * | 1998-10-15 | 2004-10-19 | Euro-Celtique S.A. | Opioid analgesic |
DE29818454U1 (de) | 1998-10-15 | 1999-01-14 | Euro Celtique Sa | Opioid-Analgetikum |
CN100444830C (zh) * | 1998-11-02 | 2008-12-24 | 伊兰公司,Plc | 多颗粒改进释放组合物 |
US6242001B1 (en) * | 1998-11-30 | 2001-06-05 | Mcneil-Ppc, Inc. | Method for producing dispersible sterol and stanol compounds |
EP1005863A1 (en) | 1998-12-04 | 2000-06-07 | Synthelabo | Controlled-release dosage forms comprising a short acting hypnotic or a salt thereof |
FR2787715B1 (fr) | 1998-12-23 | 2002-05-10 | Synthelabo | Composition pharmaceutique comprenant un compose hypnotique ou un de ses sels pharmaceutiquement acceptables |
PE20001396A1 (es) * | 1999-01-18 | 2000-12-23 | Gruenenthal Chemie | Formulaciones medicamentosas retardadas que contienen una combinacion de un opioide o una sal fisiologicamente tolerables del mismo, un o-agonista |
US6166211A (en) * | 1999-03-19 | 2000-12-26 | Endo Pharmaceuticals, Inc. | Sequential benzylic oxidations of the naloxone ring system |
US20030170181A1 (en) | 1999-04-06 | 2003-09-11 | Midha Kamal K. | Method for preventing abuse of methylphenidate |
US6306425B1 (en) | 1999-04-09 | 2001-10-23 | Southern Research Institute | Injectable naltrexone microsphere compositions and their use in reducing consumption of heroin and alcohol |
CN100382782C (zh) | 1999-04-13 | 2008-04-23 | 比彻姆药品(Pte)有限公司 | 一种释放改良型药用制剂 |
EP1064937A1 (en) | 1999-06-28 | 2001-01-03 | Sanofi-Synthelabo | Timed dual release dosage forms comprising a short acting hypnotic or a salt thereof |
US20030118641A1 (en) * | 2000-07-27 | 2003-06-26 | Roxane Laboratories, Inc. | Abuse-resistant sustained-release opioid formulation |
CA2379987A1 (en) | 1999-07-29 | 2001-02-08 | Roxane Laboratories, Inc. | Opioid sustained-released formulation |
KR100345214B1 (ko) | 1999-08-17 | 2002-07-25 | 이강춘 | 생체적합성 고분자가 수식된 펩타이드의 비점막 전달 |
NZ517997A (en) | 1999-08-27 | 2002-11-26 | Southern Res Inst | Injectable, slow release partial opioid agonist or antagonist compositions and their use |
US6436977B1 (en) | 1999-09-29 | 2002-08-20 | Pfizer Inc. | Dosing regimens for lasofoxifene |
ES2304980T3 (es) | 1999-09-30 | 2008-11-01 | Penwest Pharmaceuticals Co. | Sistemas de matriz de liberacion sostenida para farmacos altamente solubles. |
KR101216270B1 (ko) | 1999-10-29 | 2012-12-31 | 유로-셀티크 소시에떼 아노뉨 | 서방성 하이드로코돈 제형 |
KR100523127B1 (ko) | 1999-12-23 | 2005-10-20 | 화이자 프로덕츠 인코포레이티드 | 하이드로겔계 약물 투여 형태 |
WO2001052813A1 (en) | 2000-01-19 | 2001-07-26 | Pharmaceutical Discovery Corporation | Multi-spike release formulation for drug delivery |
RS50407B (sr) | 2000-02-08 | 2009-12-31 | Euro-Celtique S.A., | Oralne formulacije opijatnog agonista otporne na mehaničke,termičke i/ili hemijske promene fizičkih osobina doznog oblika |
US6716449B2 (en) * | 2000-02-08 | 2004-04-06 | Euro-Celtique S.A. | Controlled-release compositions containing opioid agonist and antagonist |
AU782523B2 (en) | 2000-07-13 | 2005-08-04 | Euro-Celtique S.A. | Salts and bases of 17-(cyclopropylmethyl)-4,5 alpha-epoxy-6-methylenemorphinan-3,14 diol for optimizing dopamine homeostasis during administration of opioid analgesics |
US20020032581A1 (en) * | 2000-07-17 | 2002-03-14 | Reitberg Donald P. | Single-patient drug trials used with accumulated database: risk of habituation |
US6296842B1 (en) | 2000-08-10 | 2001-10-02 | Alkermes Controlled Therapeutics, Inc. | Process for the preparation of polymer-based sustained release compositions |
AU2001286518A1 (en) | 2000-08-15 | 2002-02-25 | University Of Kentucky Research Foundation | Programmable multi-dose intranasal drug delivery device |
KR20030059803A (ko) | 2000-10-03 | 2003-07-10 | 펜웨스트 파마슈티칼스 컴퍼니 | 다수의 약학적 활성 물질을 다양한 방출 속도로 전달하는시스템 |
US20020187192A1 (en) | 2001-04-30 | 2002-12-12 | Yatindra Joshi | Pharmaceutical composition which reduces or eliminates drug abuse potential |
ES2361148T3 (es) | 2001-05-11 | 2011-06-14 | Endo Pharmaceuticals Inc. | Forma de dosificación de opioides de liberación controlada resistente al abuso. |
DE60216078T2 (de) * | 2001-05-11 | 2007-07-05 | Endo Pharmaceuticals Inc. | Opioid enthaltende arzneiform gegen missbrauch |
WO2002094172A2 (en) | 2001-05-22 | 2002-11-28 | Euro-Celtique | Compartmentalized dosage form |
US20030064122A1 (en) * | 2001-05-23 | 2003-04-03 | Endo Pharmaceuticals, Inc. | Abuse resistant pharmaceutical composition containing capsaicin |
EP1406630A1 (en) * | 2001-07-06 | 2004-04-14 | Endo Pharmaceuticals Inc. | Parenteral administration of 6-hydroxy-oxymorphone for use as an analgesic |
US8329216B2 (en) * | 2001-07-06 | 2012-12-11 | Endo Pharmaceuticals Inc. | Oxymorphone controlled release formulations |
ATE376832T1 (de) | 2001-07-06 | 2007-11-15 | Penwest Pharmaceuticals Co | Verzögert freisetzende formulierungen von oxymorphon |
CA2454328C (en) | 2001-07-18 | 2008-03-18 | Christopher D. Breder | Pharmaceutical combinations of oxycodone and naloxone |
MXPA04001210A (es) * | 2001-08-06 | 2004-07-08 | Euro Celtique Sa | Formulaciones de agonista opioide con antagonista liberable y aislado. |
DE20220917U1 (de) | 2001-08-06 | 2004-08-19 | Euro-Celtique S.A. | Zusammensetzungen zur Verhinderung des Missbrauchs von Opioiden |
WO2003015531A2 (en) | 2001-08-06 | 2003-02-27 | Thomas Gruber | Pharmaceutical formulation containing dye |
DE20220910U1 (de) | 2001-08-06 | 2004-08-05 | Euro-Celtique S.A. | Zusammensetzungen zur Verhinderung des Missbrauchs von Opioiden |
US20030068375A1 (en) * | 2001-08-06 | 2003-04-10 | Curtis Wright | Pharmaceutical formulation containing gelling agent |
US7332182B2 (en) * | 2001-08-06 | 2008-02-19 | Purdue Pharma L.P. | Pharmaceutical formulation containing opioid agonist, opioid antagonist and irritant |
WO2003013433A2 (en) | 2001-08-06 | 2003-02-20 | Euro-Celtique S.A. | Sequestered antagonist formulations |
US7144587B2 (en) * | 2001-08-06 | 2006-12-05 | Euro-Celtique S.A. | Pharmaceutical formulation containing opioid agonist, opioid antagonist and bittering agent |
US7842307B2 (en) * | 2001-08-06 | 2010-11-30 | Purdue Pharma L.P. | Pharmaceutical formulation containing opioid agonist, opioid antagonist and gelling agent |
US7157103B2 (en) * | 2001-08-06 | 2007-01-02 | Euro-Celtique S.A. | Pharmaceutical formulation containing irritant |
US7141250B2 (en) * | 2001-08-06 | 2006-11-28 | Euro-Celtique S.A. | Pharmaceutical formulation containing bittering agent |
US20030044458A1 (en) | 2001-08-06 | 2003-03-06 | Curtis Wright | Oral dosage form comprising a therapeutic agent and an adverse-effect agent |
US20030049272A1 (en) * | 2001-08-30 | 2003-03-13 | Yatindra Joshi | Pharmaceutical composition which produces irritation |
US20030059397A1 (en) * | 2001-09-17 | 2003-03-27 | Lyn Hughes | Dosage forms |
US20030068276A1 (en) | 2001-09-17 | 2003-04-10 | Lyn Hughes | Dosage forms |
US20030091635A1 (en) * | 2001-09-26 | 2003-05-15 | Baichwal Anand R. | Opioid formulations having reduced potential for abuse |
US20030125347A1 (en) * | 2001-11-02 | 2003-07-03 | Elan Corporation Plc | Pharmaceutical composition |
US20030158264A1 (en) | 2002-02-20 | 2003-08-21 | Ramachandran Radhakrishnan | Orally administrable pharmaceutical formulation comprising ephedrine hydrochloride and process for preparing the same |
ES2314223T3 (es) | 2002-02-27 | 2009-03-16 | Ab Science | Utilizacion de inhibidores de la tirosina quinasa para el tratamiento de trastornos por uso de sustancias. |
AU2003220551A1 (en) | 2002-03-26 | 2003-10-13 | Euro-Celtique S.A. | Sustained-release gel coated compositions |
US7524515B2 (en) * | 2003-01-10 | 2009-04-28 | Mutual Pharmaceuticals, Inc. | Pharmaceutical safety dosage forms |
JP2008520744A (ja) * | 2004-11-19 | 2008-06-19 | ザ・レジェンツ・オブ・ザ・ユニバーシティ・オブ・カリフォルニア | 抗炎症性ピラゾロピリミジン |
US20060228413A1 (en) | 2005-02-28 | 2006-10-12 | Penwest Pharmaceuticals Co. | Controlled release venlafaxine formulations |
US20090155357A1 (en) | 2005-08-01 | 2009-06-18 | Alpharma Inc. | Alcohol Resistant Pharmaceutical Formulations |
PL2402005T3 (pl) | 2005-08-24 | 2021-11-22 | Endo Pharmaceuticals Inc. | Formulacje nalbufiny o przedłużonym uwalnianiu |
PL116330U1 (en) | 2005-10-31 | 2007-04-02 | Alza Corp | Method for the reduction of alcohol provoked rapid increase in the released dose of the orally administered opioide with prolonged liberation |
US20070184115A1 (en) | 2005-12-30 | 2007-08-09 | Biovail Laboratories International S.R.L. | Modified release formulations of tramadol and uses thereof |
US20070212414A1 (en) | 2006-03-08 | 2007-09-13 | Penwest Pharmaceuticals Co. | Ethanol-resistant sustained release formulations |
US20080119501A1 (en) * | 2006-04-28 | 2008-05-22 | Hein William A | Immediate release oxymorphone compositions and methods of using same |
US20080085303A1 (en) * | 2006-10-10 | 2008-04-10 | Penwest Pharmaceuticals Co. | Robust sustained release formulations of oxymorphone and methods of use thereof |
EP2097069A1 (en) | 2006-10-10 | 2009-09-09 | Penwest Pharmaceuticals Co. | Robust sustained release formulations of oxymorphone |
US20080085305A1 (en) * | 2006-10-10 | 2008-04-10 | Penwest Pharmaceuticals Co. | Robust sustained release formulations of oxymorphone |
MX2009003771A (es) | 2006-10-10 | 2009-07-22 | Penwest Pharmaceuticals Co | Formulaciones robustas de liberacion sostenida. |
US20080085304A1 (en) * | 2006-10-10 | 2008-04-10 | Penwest Pharmaceuticals Co. | Robust sustained release formulations |
MX2009003770A (es) | 2006-10-10 | 2009-07-22 | Penwest Pharmaceuticals Co | Formulaciones de oximorfona robustas, de liberacion sostenida y metodos para su uso. |
US20080318994A1 (en) | 2007-06-21 | 2008-12-25 | Endo Pharmaceuticals, Inc. | Method of Treating Pain Utilizing Controlled Release Oxymorphone Pharmaceutical Compositions and Instruction on Dosing for Renal Impairment |
US20080318993A1 (en) | 2007-06-21 | 2008-12-25 | Endo Pharmaceuticals, Inc. | Method of Treating Pain Utilizing Controlled Release Oxymorphone Pharmaceutical Compositions and Instruction on Dosing for Hepatic Impairment |
-
2002
- 2002-07-03 EP EP02748086A patent/EP1406630A1/en not_active Withdrawn
- 2002-07-03 US US10/189,653 patent/US20040214849A1/en not_active Abandoned
- 2002-07-03 AU AU2002318211A patent/AU2002318211B2/en not_active Ceased
- 2002-07-03 AU AU2002320309A patent/AU2002320309B2/en not_active Ceased
- 2002-07-03 EP EP02749821A patent/EP1404333A1/en not_active Ceased
- 2002-07-03 BR BR0205721-2A patent/BR0205721A/pt not_active Application Discontinuation
- 2002-07-03 AT AT02746895T patent/ATE359077T1/de not_active IP Right Cessation
- 2002-07-03 EP EP02746895A patent/EP1414458B1/en not_active Expired - Lifetime
- 2002-07-03 CA CA2452871A patent/CA2452871C/en not_active Expired - Fee Related
- 2002-07-03 CN CNA028153243A patent/CN1610551A/zh active Pending
- 2002-07-03 CA CA002452872A patent/CA2452872A1/en not_active Abandoned
- 2002-07-03 EP EP10162749A patent/EP2311460A1/en not_active Withdrawn
- 2002-07-03 AU AU2002316582A patent/AU2002316582B2/en not_active Ceased
- 2002-07-03 US US10/189,897 patent/US20030130297A1/en not_active Abandoned
- 2002-07-03 CN CNA028172361A patent/CN1551770A/zh active Pending
- 2002-07-03 KR KR10-2003-7003330A patent/KR20030034171A/ko active Search and Examination
- 2002-07-03 WO PCT/US2002/021400 patent/WO2003004032A1/en active IP Right Grant
- 2002-07-03 CA CA002452874A patent/CA2452874A1/en not_active Abandoned
- 2002-07-03 ES ES02746895T patent/ES2284888T3/es not_active Expired - Lifetime
- 2002-07-03 WO PCT/US2002/021398 patent/WO2003004031A1/en active IP Right Grant
- 2002-07-03 US US10/190,192 patent/US9820982B2/en not_active Expired - Lifetime
- 2002-07-03 DE DE60219478T patent/DE60219478T2/de not_active Expired - Lifetime
- 2002-07-03 JP JP2003510041A patent/JP4440635B2/ja not_active Expired - Fee Related
- 2002-07-03 CN CNB02815276XA patent/CN1268338C/zh not_active Expired - Fee Related
- 2002-07-03 WO PCT/US2002/021396 patent/WO2003004030A1/en active IP Right Grant
- 2002-07-03 JP JP2003510042A patent/JP2005520778A/ja active Pending
- 2002-07-03 JP JP2003510043A patent/JP2005515966A/ja active Pending
-
2003
- 2003-03-05 NO NO20031018A patent/NO20031018L/no not_active Application Discontinuation
-
2006
- 2006-06-22 US US11/425,966 patent/US20070098792A1/en not_active Abandoned
- 2006-06-23 US US11/426,170 patent/US20070098793A1/en not_active Abandoned
-
2007
- 2007-02-28 US US11/680,432 patent/US8309122B2/en active Active
-
2008
- 2008-07-03 US US12/167,859 patent/US20080262013A1/en not_active Abandoned
-
2009
- 2009-02-26 JP JP2009044920A patent/JP2009114209A/ja active Pending
- 2009-04-17 US US12/426,112 patent/US20090192183A1/en not_active Abandoned
-
2013
- 2013-06-03 US US13/908,328 patent/US20140134250A1/en not_active Abandoned
-
2014
- 2014-09-22 US US14/492,701 patent/US20150011577A1/en not_active Abandoned
-
2015
- 2015-07-14 US US14/798,619 patent/US20160136152A1/en not_active Abandoned
-
2018
- 2018-07-30 US US16/049,390 patent/US20180338967A1/en not_active Abandoned
-
2020
- 2020-09-28 US US17/035,453 patent/US20210008063A1/en not_active Abandoned
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP4440635B2 (ja) | オキシモルホン放出制御性処方物 | |
US8329216B2 (en) | Oxymorphone controlled release formulations | |
US7276250B2 (en) | Sustained release formulations of oxymorphone | |
AU2002320309A1 (en) | Oxymorphone controlled release formulations | |
JP2832248B2 (ja) | メトプロロールまたはメトプロロール塩の徐放性調剤とその製造方法 | |
US20220313688A1 (en) | Method of treating pain utilizing controlled release oxymorphone pharmaceutical compositions and instruction on dosing for renal impairment | |
US20090124650A1 (en) | Method of Treating Pain Utilizing Controlled Release Oxymorphone Pharmaceutical Compositions and Instructions on Effects of Alcohol | |
US20080318993A1 (en) | Method of Treating Pain Utilizing Controlled Release Oxymorphone Pharmaceutical Compositions and Instruction on Dosing for Hepatic Impairment | |
ZA200301807B (en) | Oxymorphone controlled release formulations. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20050629 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20080903 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20081202 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20081209 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20081225 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20090108 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20090202 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20090209 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20090226 |
|
A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20090407 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20090806 |
|
A911 | Transfer to examiner for re-examination before appeal (zenchi) |
Free format text: JAPANESE INTERMEDIATE CODE: A911 Effective date: 20091110 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20091211 |
|
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20100107 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20130115 Year of fee payment: 3 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 4440635 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
LAPS | Cancellation because of no payment of annual fees |