US20030130297A1 - Oral administration of 6-hydroxy-oxymorphone for use as an analgesic - Google Patents
Oral administration of 6-hydroxy-oxymorphone for use as an analgesic Download PDFInfo
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- US20030130297A1 US20030130297A1 US10/189,897 US18989702A US2003130297A1 US 20030130297 A1 US20030130297 A1 US 20030130297A1 US 18989702 A US18989702 A US 18989702A US 2003130297 A1 US2003130297 A1 US 2003130297A1
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- oxymorphone
- hydroxy
- hydroxy oxymorphone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
Abstract
In a method of treating pain, a patient is administered a pharmaceutical composition of 6-hydroxy oxymorphone in amount sufficient to induce analgesia. In one embodiment, the pharmaceutical composition is administered orally. Any known or later developed method of oral delivery may be used. To achieve the desired analgesic effect, blood plasma levels of 6-hydroxy oxymorphone are raised to at least approximately 0.2 ng/mL. Most preferably blood plasma levels of 6-hydroxy oxymorphone range at least 0.3 ng/mL during treatment. Administration of compositions containing 6-hydroxy oxymorphone, and one or more carriers, diluents, and excipients in an amount sufficient to induce analgesia is also contemplated.
Description
- This application relates to provisional patent application serial Nos. 60/329,445 filed Oct. 15, 2001, .60/329,432 filed Oct. 15, 2001, 60/303,357 filed Jul. 6, 2001, and 60/329,444 filed Oct. 15, 2001.
- 1. Field of Invention
- The invention relates to methods for alleviating pain. More particularly, the invention relates to methods for alleviating pain by administering 6-hydroxy oxymorphone. Most particularly, the invention relates to methods of inducing analgesia by increasing blood plasma levels of 6-hydroxy oxymorphone through oral administration of a pharmaceutical composition containing 6-hydroxy oxymorphone.
- 2. Summary of the Invention
- The present invention provides methods of treating pain by administering a pharmaceutical composition comprising 6-hydroxy oxymorphone in an amount sufficient to induce analgesia. In one embodiment, the pharmaceutical composition is administered orally. Any known or later developed method of oral delivery may be used. To achieve the desired analgesic effect, blood plasma levels of 6-hydroxy oxymorphone are raised to at least about 0.2 ng/mL. Most preferably blood plasma levels of 6-hydroxy oxymorphone of at least about 0.3 ng/mL during treatment. Methods for administering compositions comprising 6-hydroxy oxymorphone, and one or more carriers, diluents, and excipients in an amount sufficient to induce analgesia are also provided.
- FIG. 1 is a pharmacokinetic profile for 6-hydroxy oxymorphone with PID scores.
- FIG. 2 is a pharmacokinetic profile for oxymorphone with PID scores.
- FIG. 3 is a pharmacokinetic profile for 6-hydroxy oxymorphone with categorical pain scores.
- FIG. 4 is a pharmacokinetic profile for oxymorphone with categorical pain scores.
- The methods described herein provide for the administration of a pharmaceutical composition containing 6-hydroxy oxymorphone as an active ingredient. In a preferred embodiment the preferred composition comprises 6-hydroxy oxymorphone alone (excepting, of course, carriers, diluents, and other excipients). In other preferred embodiments, 6-hydroxy oxymorphone may be combined with other opioids or other pharmaceutical agents. For example, another preferred embodiment provides compositions comprising both 6-hydroxy oxymorphone and its parent, oxymorphone.
- In two separate studies, blood plasma levels and indications of pain relief were recorded over a 12 hour period after. FIGS.1-4 show graphical representation of the data combining the two studies such that the effect of blood plasma levels of oxymorphone and its metabolite, 6-hydroxy oxymorphone on pain can be evaluated.
- The administration of oxymorphone yields blood plasma levels of oxymorphone and all of its metabolites, 6-hydroxy oxymorphone. Oxymorphone levels peak within 2 hours, fall slightly, and plateau. Interestingly, the level spikes again at 4-6 hours from administration. After this time, oxymorphone levels again drop and eventually fall to levels near the earlier plateau.
- Like oxymorphone, 6-hydroxy oxymorphone blood plasma levels peak within 2 hours after administration. After the initial peak, however, a more or less steady decline in the 6-hydroxy oxymorphones plasma levels is observed.
- Comparing these levels to the pain profiles, a correlation between the 6-hydroxy oxymorphone blood plasma levels and pain relief can be seen. The pain levels nearly mirror the 6-hydroxy oxymorphone levels, with substantial rises in relief near the spikes associated with 6-hydroxy oxymorphone blood levels. Thus, pain relief can be achieved through administration of 6-hydroxy oxymorphone alone.
- In addition to the pharmacokinetic studies, binding studies have been conducted to compare the binding affinity of 6-hydroxy oxymorphone to that of oxymorphone. The results are reported in TABLE 1. These results clearly indicate that 6-hydroxy oxymorphone has great binding affinity for the δ, κ, and μ receptor cites, comparable to the binding affinity of its parent. The inventors believe that by virtue of this binding affinity, 6-hydroxy oxymorphone has similar analgesic effects to its parent, oxymorphone.
TABLE 1 ASSAY REPORT 6-HYDROXY OXYMORPHONE OXYMORPHONE 10 nm 10 μm 10 nm 10 μm 1.0 E−8 1.0 E−5 1.0 E−8 1.0 E−5 Opiate, Delta 1 −4.12% 90.48% −18.26% 89.03% Opiate, Delta 2 7.19% 55.45% 7.76% 72.74% (Human Recombinant) Opiate, Kappa 2.45% 62.47% 10.35% 89.41% (Human Recombinant Opiate, Mu 63.16% 99.91% 85.42% 100.39% (Human Recombinant) - Accordingly, methods of administering the metabolite, 6-hydroxy oxymorphone, directly have been developed. It is believed that the β isomer has greater efficacy in the treatment of pain, but this disclosure is not limited to use of that isomer alone. Pharmaceutical compositions containing either 6-α-hydroxy oxymorphone, 6-β-hydroxy oxymorphone, or mixtures thereof can be used in the invention.
- Formulation as a suspension, syrup, or other liquid, tablet, capsule, liquid-filled gel cap, or other solid or semi-solid means may be used. The composition may alternately be in the form of a time release formulation, including timed, suspended and extended release formulations. Regardless of the formulation, an amount of 6-hydroxy oxymorphone sufficient to induce analgesia will be supplied to the patient. Blood plasma levels of 6-hydroxy oxymorphone must be raised to levels sufficient to induce the desired level of analgesia.
- The amount administered will be dependent upon normal criteria such as patient weight, intensity of pain, and other factors. Based on the pharmacokinetic studies, blood plasma levels around at least 0.2 ng/mL will provide some analgesia. The upper plasma level limit will be ultimately established by safety concerns. Over-dosing of any opioid, including 6-hydroxy oxymorphone, may lead to respiratory failure and other undesirable side effects and can even result in death. Preferably, the blood plasma level of 6-hydroxy oxymorphone will be raised to at least 0.3 ng/mL. Subsequent doses may be required to maintain these blood levels.
- The preferred administration is of 6-hydroxy oxymorphone with appropriate carriers and excipients as will be readily apparent to those skilled in the art. The resulting blood plasma in these preferred administrations will therefore be substantially free of oxymorphone.
- The above description encompasses some preferred embodiments of the invention. The disclosure is merely illustrative in nature and is not intended to limit the following claims.
Claims (8)
1. A method of treating pain comprising the step of:
administering to a patient a pharmaceutical composition comprising 6-hydroxy oxymorphone in an amount sufficient to induce analgesia.
2. The method of claim 1 wherein said pharmaceutical composition is administered orally.
3. The method of claim 2 wherein said pharmaceutical composition is administered in a form selected from a liquid formulation, syrup, suspension, solid formulation, tablet, capsule, liquid-filled gel cap, and a semi-solid formulation.
4. The method of claim 1 wherein said administration is sufficient to raise blood plasma levels of 6-hydroxy oxymorphone to at least about 0.2 ng/mL.
5. The method of claim 1 wherein said administration is sufficient to raise blood plasma levels of 6-hydroxy oxymorphone to at least about 0.3 ng/mL.
6. A method of treating pain comprising the step of:
orally administering to a patient a pharmaceutical composition comprising 6-hydroxy oxymorphone, and one or more carriers, diluents, and excipients in an amount sufficient to induce analgesia.
7. A method of treating pain comprising the step of:
orally administering to a patient a pharmaceutical composition comprising 6-hydroxy oxymorphone and oxymorphone in an amount sufficient to induce analgesia.
8. A pharmaceutical composition comprising 6-hydroxy oxymorphone in a formulation for oral delivery to animals including hormone.
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
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US30335701P true | 2001-07-06 | 2001-07-06 | |
US32944501P true | 2001-10-15 | 2001-10-15 | |
US32943201P true | 2001-10-15 | 2001-10-15 | |
US32944401P true | 2001-10-15 | 2001-10-15 | |
US10/189,897 US20030130297A1 (en) | 2001-07-06 | 2002-07-03 | Oral administration of 6-hydroxy-oxymorphone for use as an analgesic |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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US10/189,897 US20030130297A1 (en) | 2001-07-06 | 2002-07-03 | Oral administration of 6-hydroxy-oxymorphone for use as an analgesic |
Publications (1)
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US20030130297A1 true US20030130297A1 (en) | 2003-07-10 |
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Family Applications (12)
Application Number | Title | Priority Date | Filing Date |
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US10/190,192 Active 2023-07-07 US9820982B2 (en) | 2001-07-06 | 2002-07-03 | Oxymorphone controlled release formulations |
US10/189,653 Abandoned US20040214849A1 (en) | 2001-07-06 | 2002-07-03 | Parenteral administration of 6-hydroxy-oxymorphone for use as an analgesic |
US10/189,897 Abandoned US20030130297A1 (en) | 2001-07-06 | 2002-07-03 | Oral administration of 6-hydroxy-oxymorphone for use as an analgesic |
US11/425,966 Abandoned US20070098792A1 (en) | 2001-07-06 | 2006-06-22 | Oxymorphone controlled release formulations |
US11/426,170 Abandoned US20070098793A1 (en) | 2001-07-06 | 2006-06-23 | Oxymorphone controlled release formulations |
US11/680,432 Active 2026-03-08 US8309122B2 (en) | 2001-07-06 | 2007-02-28 | Oxymorphone controlled release formulations |
US12/167,859 Abandoned US20080262013A1 (en) | 2001-07-06 | 2008-07-03 | Oxymorphone controlled release formulations |
US12/426,112 Abandoned US20090192183A1 (en) | 2001-07-06 | 2009-04-17 | Oxymorphone Controlled Release Formulations |
US13/908,328 Abandoned US20140134250A1 (en) | 2001-07-06 | 2013-06-03 | Oxymorphone controlled release formulations |
US14/492,701 Abandoned US20150011577A1 (en) | 2001-07-06 | 2014-09-22 | Oxymorphone controlled release formulations |
US14/798,619 Abandoned US20160136152A1 (en) | 2001-07-06 | 2015-07-14 | Oxymorphone controlled release compositions |
US16/049,390 Pending US20180338967A1 (en) | 2001-07-06 | 2018-07-30 | Oxymorphone controlled release compositions |
Family Applications Before (2)
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US10/190,192 Active 2023-07-07 US9820982B2 (en) | 2001-07-06 | 2002-07-03 | Oxymorphone controlled release formulations |
US10/189,653 Abandoned US20040214849A1 (en) | 2001-07-06 | 2002-07-03 | Parenteral administration of 6-hydroxy-oxymorphone for use as an analgesic |
Family Applications After (9)
Application Number | Title | Priority Date | Filing Date |
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US11/425,966 Abandoned US20070098792A1 (en) | 2001-07-06 | 2006-06-22 | Oxymorphone controlled release formulations |
US11/426,170 Abandoned US20070098793A1 (en) | 2001-07-06 | 2006-06-23 | Oxymorphone controlled release formulations |
US11/680,432 Active 2026-03-08 US8309122B2 (en) | 2001-07-06 | 2007-02-28 | Oxymorphone controlled release formulations |
US12/167,859 Abandoned US20080262013A1 (en) | 2001-07-06 | 2008-07-03 | Oxymorphone controlled release formulations |
US12/426,112 Abandoned US20090192183A1 (en) | 2001-07-06 | 2009-04-17 | Oxymorphone Controlled Release Formulations |
US13/908,328 Abandoned US20140134250A1 (en) | 2001-07-06 | 2013-06-03 | Oxymorphone controlled release formulations |
US14/492,701 Abandoned US20150011577A1 (en) | 2001-07-06 | 2014-09-22 | Oxymorphone controlled release formulations |
US14/798,619 Abandoned US20160136152A1 (en) | 2001-07-06 | 2015-07-14 | Oxymorphone controlled release compositions |
US16/049,390 Pending US20180338967A1 (en) | 2001-07-06 | 2018-07-30 | Oxymorphone controlled release compositions |
Country Status (13)
Country | Link |
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US (12) | US9820982B2 (en) |
EP (4) | EP1406630A1 (en) |
JP (4) | JP4440635B2 (en) |
KR (1) | KR20030034171A (en) |
CN (3) | CN1551770A (en) |
AT (1) | AT359077T (en) |
AU (3) | AU2002318211B2 (en) |
BR (1) | BR0205721A (en) |
CA (3) | CA2452871C (en) |
DE (1) | DE60219478T2 (en) |
ES (1) | ES2284888T3 (en) |
NO (1) | NO20031018A (en) |
WO (3) | WO2003004031A1 (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030157167A1 (en) * | 2001-07-06 | 2003-08-21 | Endo Pharmaceuticals, Inc. | Oxymorphone controlled release formulations |
WO2005092337A1 (en) * | 2004-03-22 | 2005-10-06 | Endo Pharmaceuticals Inc. | 6 α-OXYMORPHOL AND A METHOD OF USE |
US20060269604A1 (en) * | 1993-11-23 | 2006-11-30 | Purdue Pharma L.P. | Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level |
Families Citing this family (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20110104214A1 (en) | 2004-04-15 | 2011-05-05 | Purdue Pharma L.P. | Once-a-day oxycodone formulations |
US8329216B2 (en) | 2001-07-06 | 2012-12-11 | Endo Pharmaceuticals Inc. | Oxymorphone controlled release formulations |
PL208484B1 (en) * | 2001-07-06 | 2011-05-31 | Penwest Pharmaceuticals Company | Methods of making sustained release formulations of oxymorphone related applications |
JP2005523876A (en) * | 2001-09-26 | 2005-08-11 | ペンウェスト ファーマシューティカルズ カンパニー | Opioid formulations potential for abuse is reduced |
US7776314B2 (en) | 2002-06-17 | 2010-08-17 | Grunenthal Gmbh | Abuse-proofed dosage system |
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US20070048228A1 (en) | 2003-08-06 | 2007-03-01 | Elisabeth Arkenau-Maric | Abuse-proofed dosage form |
DE10336400A1 (en) | 2003-08-06 | 2005-03-24 | Grünenthal GmbH | Abuse-proofed dosage form |
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US8394812B2 (en) | 2005-08-24 | 2013-03-12 | Penwest Pharmaceuticals Co. | Sustained release formulations of nalbuphine |
US20070212414A1 (en) * | 2006-03-08 | 2007-09-13 | Penwest Pharmaceuticals Co. | Ethanol-resistant sustained release formulations |
US20080119501A1 (en) * | 2006-04-28 | 2008-05-22 | Hein William A | Immediate release oxymorphone compositions and methods of using same |
HUE032156T2 (en) | 2006-06-19 | 2017-09-28 | Alpharma Pharmaceuticals Llc | Pharmaceutical compositions |
WO2008045046A1 (en) * | 2006-10-10 | 2008-04-17 | Penwest Pharmaceuticals Co. | Robust sustained release formulations of oxymorphone |
JP5422388B2 (en) * | 2006-10-10 | 2014-02-19 | ペンウェスト ファーマシューティカルズ カンパニー | Robust sustained release formulations |
US20080085303A1 (en) * | 2006-10-10 | 2008-04-10 | Penwest Pharmaceuticals Co. | Robust sustained release formulations of oxymorphone and methods of use thereof |
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US20080085305A1 (en) * | 2006-10-10 | 2008-04-10 | Penwest Pharmaceuticals Co. | Robust sustained release formulations of oxymorphone |
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JP5965583B2 (en) * | 2007-08-13 | 2016-08-10 | インスピリオン デリバリー テクノロジーズ エルエルシー | Abuse-resistant pharmaceutical composition, its use and a manufacturing method |
US8623418B2 (en) | 2007-12-17 | 2014-01-07 | Alpharma Pharmaceuticals Llc | Pharmaceutical composition |
TWI454288B (en) | 2008-01-25 | 2014-10-01 | Gruenenthal Chemie | Pharmaceutical dosage form |
CA2723438C (en) | 2008-05-09 | 2016-10-11 | Gruenenthal Gmbh | Process for the preparation of an intermediate powder formulation and a final solid dosage form under usage of a spray congealing step |
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JP5933553B2 (en) | 2010-09-02 | 2016-06-15 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | Abuse-resistant dosage form comprising an anionic polymer |
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WO2014011830A1 (en) | 2012-07-12 | 2014-01-16 | Mallinckrodt Llc | Extended release, abuse deterrent pharmaceutical compositions |
CA2913209A1 (en) | 2013-05-29 | 2014-12-04 | Grunenthal Gmbh | Tamper resistant dosage form with bimodal release profile |
JP6445537B2 (en) | 2013-05-29 | 2018-12-26 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | Modified anti containing one or more particles (tamper-resistant) dosage forms |
EP3027622A1 (en) | 2013-08-02 | 2016-06-08 | Johnson Matthey Public Limited Company | Process for the preparation of oxymorphone |
US9062063B1 (en) | 2014-03-21 | 2015-06-23 | Johnson Matthey Public Limited Company | Forms of oxymorphone hydrochloride |
JP2017518980A (en) | 2014-05-12 | 2017-07-13 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | Containing tapentadol, modified prevent immediate release capsule formulation |
MX2016015417A (en) | 2014-05-26 | 2017-02-22 | Grünenthal GmbH | Multiparticles safeguarded against ethanolic dose-dumping. |
US9918979B2 (en) | 2015-01-29 | 2018-03-20 | Johnson Matthey Public Limited Company | Process of preparing low ABUK oxymorphone hydrochloride |
KR20170139158A (en) | 2015-04-24 | 2017-12-18 | 그뤼넨탈 게엠베하 | Immediately released and prevent the tamper-resistant dosage form extraction solvent |
US9861629B1 (en) | 2015-10-07 | 2018-01-09 | Banner Life Sciences Llc | Opioid abuse deterrent dosage forms |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4366159A (en) * | 1981-09-08 | 1982-12-28 | Michael Richard Magruder | Nalbuphine-narcotic analgesic composition and method of producing analgesia |
Family Cites Families (204)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US458349A (en) * | 1891-08-25 | Hose-coupling | ||
US591431A (en) * | 1897-10-12 | Coupling for traps and pipes | ||
US2806033A (en) | 1955-08-03 | 1957-09-10 | Lewenstein | Morphine derivative |
DE1517480A1 (en) | 1962-11-16 | 1969-05-22 | Permutit Co Ltd | Apparatus for regeneration of ion exchangers, in particular for water softening |
US3400197A (en) * | 1965-01-26 | 1968-09-03 | Robins Co Inc A H | Compressible sustained release pharmaceutical tablet lipid-colloidal silica gel matrix fragment granules |
US3456049A (en) * | 1965-05-25 | 1969-07-15 | Ciba Geigy Corp | Gradual-release tablet |
IL26896A (en) | 1966-01-19 | 1970-11-30 | Endo Lab | 14-hydroxynormorphines and 14-hydroxynormorphinones |
US3558768A (en) * | 1969-12-19 | 1971-01-26 | Sterling Drug Inc | Sustained release pharmaceutical compositions |
US3879555A (en) * | 1970-11-16 | 1975-04-22 | Bristol Myers Co | Method of treating drug addicts |
US3980766A (en) * | 1973-08-13 | 1976-09-14 | West Laboratories, Inc. | Orally administered drug composition for therapy in the treatment of narcotic drug addiction |
US3845770A (en) | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
US3966940A (en) * | 1973-11-09 | 1976-06-29 | Bristol-Myers Company | Analgetic compositions |
DE2530563C2 (en) | 1975-07-09 | 1986-07-24 | Bayer Ag, 5090 Leverkusen, De | |
US4140755A (en) * | 1976-02-13 | 1979-02-20 | Hoffmann-La Roche Inc. | Sustained release tablet formulations |
JPS5936110B2 (en) * | 1976-11-01 | 1984-09-01 | Hitachi Ltd | |
US4303691A (en) * | 1977-11-09 | 1981-12-01 | Anderson, Clayton & Co. | Proteinaceous food product |
NO793297A (en) | 1978-10-19 | 1980-04-22 | Mallinckrodt Inc | A process for preparing oxymorphone |
US4309405A (en) * | 1979-08-09 | 1982-01-05 | American Home Products Corporation | Sustained release pharmaceutical compositions |
US4248858A (en) * | 1979-08-09 | 1981-02-03 | American Home Products Corporation | Sustained release pharmaceutical compositions |
US4252786A (en) * | 1979-11-16 | 1981-02-24 | E. R. Squibb & Sons, Inc. | Controlled release tablet |
US4457933A (en) * | 1980-01-24 | 1984-07-03 | Bristol-Myers Company | Prevention of analgesic abuse |
US4489080A (en) * | 1981-06-26 | 1984-12-18 | The Upjohn Company | Process for analgesic treatment |
US4415547A (en) * | 1982-06-14 | 1983-11-15 | Sterling Drug Inc. | Sustained-release pharmaceutical tablet and process for preparation thereof |
US4656177A (en) * | 1982-07-22 | 1987-04-07 | Analgesic Associates | Analgesic and anti-inflammatory compositions comprising caffeine and methods of using same |
US4558051A (en) | 1983-10-11 | 1985-12-10 | Richardson-Vicks, Inc. | Analgesic and anti-inflammatory compositions comprising xanthines and methods of using same |
US4567183A (en) * | 1983-03-11 | 1986-01-28 | Analgesic Associates | Analgesic and anti-inflammatory compositions comprising xanthines and methods of using same |
US4464376A (en) * | 1982-07-22 | 1984-08-07 | Richardson-Vicks, Inc. | Analgesic and anti-inflammatory compositions comprising caffeine and methods of using same |
US4587249A (en) * | 1982-07-22 | 1986-05-06 | Analgesic Associates | Analgesic and anti-inflammatory compositions comprising caffeine and methods of using same |
US4486436A (en) | 1982-07-22 | 1984-12-04 | Analgesic Associates | Analgesic and anti-inflammatory compositions comprising caffeine and methods of using same |
US4777174A (en) | 1982-07-22 | 1988-10-11 | Analgesic Associates | Analgesic and anti-inflammatory compositions comprising caffeine and methods of using same |
US4461759A (en) * | 1983-01-03 | 1984-07-24 | Verex Laboratories, Inc. | Constant release rate solid oral dosage formulations of veropamil |
US4521402A (en) * | 1983-01-03 | 1985-06-04 | Verex Laboratories, Inc. | Constant release rate solid oral dosage formulations of hydrazine |
US4521401A (en) * | 1983-01-03 | 1985-06-04 | Verex Laboratories, Inc. | Constant release rate solid oral dosage formulations of quinidine |
US4522804A (en) * | 1983-01-03 | 1985-06-11 | Verex Laboratories, Inc. | Constant release rate solid oral dosage formulations of propranolol |
US4479956A (en) | 1983-04-26 | 1984-10-30 | Analgeic Associates | Analgesic compositions comprising propiram and methods of using same |
JPH0157087B2 (en) * | 1983-11-04 | 1989-12-04 | Takeda Chemical Industries Ltd | |
GB8332556D0 (en) * | 1983-12-06 | 1984-01-11 | Reckitt & Colmann Prod Ltd | Analgesic compositions |
JPS6124516A (en) * | 1984-07-12 | 1986-02-03 | Fujisawa Pharmaceut Co Ltd | Long active tablet |
US4610870A (en) * | 1984-10-05 | 1986-09-09 | E. R. Squibb & Sons, Inc. | Controlled release formulation |
GB8430346D0 (en) * | 1984-11-30 | 1985-01-09 | Reckitt & Colmann Prod Ltd | Analgesic compositions |
US4569937A (en) * | 1985-02-11 | 1986-02-11 | E. I. Du Pont De Nemours And Company | Analgesic mixture of oxycodone and ibuprofen |
US4599114A (en) * | 1985-02-11 | 1986-07-08 | Atkinson George K | Treatment of titanium dioxide and other pigments to improve dispersibility |
GB8514665D0 (en) * | 1985-06-11 | 1985-07-10 | Eroceltique Sa | Oral pharmaceutical composition |
GB2176999B (en) | 1985-06-22 | 1989-07-12 | Stanley Stewart Davis | Sustained release medicament |
GB8521350D0 (en) * | 1985-08-28 | 1985-10-02 | Euro Celtique Sa | Analgesic composition |
GB8601204D0 (en) * | 1986-01-18 | 1986-02-19 | Boots Co Plc | Therapeutic agents |
IE63321B1 (en) * | 1986-02-03 | 1995-04-05 | Elan Corp Plc | Drug delivery system |
IT1191674B (en) * | 1986-03-07 | 1988-03-23 | Eurand Spa | Formulations for the preparation of sustained-release drugs suitable for oral administration |
SE8601624D0 (en) * | 1986-04-11 | 1986-04-11 | Haessle Ab | New Pharmaceutical Preparations |
US4795642A (en) * | 1986-05-01 | 1989-01-03 | Pharmacaps, Inc. | Gelatin-encapsulated controlled-release composition |
US4861598A (en) | 1986-07-18 | 1989-08-29 | Euroceltique, S.A. | Controlled release bases for pharmaceuticals |
US4859461A (en) * | 1986-07-30 | 1989-08-22 | Fisons Corporation | Coatable ion exchange resins |
GB8626098D0 (en) * | 1986-10-31 | 1986-12-03 | Euro Celtique Sa | Controlled release hydromorphone composition |
US4968508A (en) * | 1987-02-27 | 1990-11-06 | Eli Lilly And Company | Sustained release matrix |
GB8705083D0 (en) * | 1987-03-04 | 1987-04-08 | Euro Celtique Sa | Spheroids |
FR2618073B1 (en) * | 1987-07-16 | 1990-09-07 | Pf Medicament | type tablets hydrophilic matrix base of salbutamol and their method of preparing |
US4792452A (en) * | 1987-07-28 | 1988-12-20 | E. R. Squibb & Sons, Inc. | Controlled release formulation |
SE8703881D0 (en) * | 1987-10-08 | 1987-10-08 | Haessle Ab | New pharmaceutical preparation |
GB8723896D0 (en) * | 1987-10-12 | 1987-11-18 | Aps Research Ltd | Controlled-release formulation |
US5096714A (en) * | 1988-06-28 | 1992-03-17 | Hauser-Kuhrts, Inc. | Prolonged release drug tablet formulations |
GB8728294D0 (en) * | 1987-12-03 | 1988-01-06 | Reckitt & Colmann Prod Ltd | Treatment compositions |
DE3822095A1 (en) | 1988-06-30 | 1990-01-04 | Klinge Co Chem Pharm Fab | New drug formulation and process for their preparation |
GB8820353D0 (en) * | 1988-08-26 | 1988-09-28 | Staniforth J N | Controlled release tablet |
US5135757A (en) * | 1988-09-19 | 1992-08-04 | Edward Mendell Co., Inc. | Compressible sustained release solid dosage forms |
US5169639A (en) | 1988-09-19 | 1992-12-08 | Edward Mendell Co., Inc. | Controlled release verapamil tablets |
US5128143A (en) * | 1988-09-19 | 1992-07-07 | Edward Mendell Co., Inc. | Sustained release excipient and tablet formulation |
US4994276A (en) * | 1988-09-19 | 1991-02-19 | Edward Mendell Co., Inc. | Directly compressible sustained release excipient |
US5236714A (en) * | 1988-11-01 | 1993-08-17 | Alza Corporation | Abusable substance dosage form having reduced abuse potential |
US5202128A (en) * | 1989-01-06 | 1993-04-13 | F. H. Faulding & Co. Limited | Sustained release pharmaceutical composition |
GB8903328D0 (en) * | 1989-02-14 | 1989-04-05 | Ethical Pharma Ltd | Nifedipine-containing pharmaceutical compositions and process for the preparation thereof |
US5126145A (en) * | 1989-04-13 | 1992-06-30 | Upsher Smith Laboratories Inc | Controlled release tablet containing water soluble medicament |
US4990535A (en) * | 1989-05-03 | 1991-02-05 | Schering Corporation | Pharmaceutical composition comprising loratadine, ibuprofen and pseudoephedrine |
US5126147A (en) * | 1990-02-08 | 1992-06-30 | Biosearch, Inc. | Sustained release dosage form |
JP2572673B2 (en) | 1990-07-25 | 1997-01-16 | エスエス製薬株式会社 | Sustained-release tablets |
SE9003903D0 (en) * | 1990-12-07 | 1990-12-07 | Astra Ab | New pharmaceutical formulations |
US5431922A (en) | 1991-03-05 | 1995-07-11 | Bristol-Myers Squibb Company | Method for administration of buspirone |
US5286497A (en) | 1991-05-20 | 1994-02-15 | Carderm Capital L.P. | Diltiazem formulation |
US5215758A (en) * | 1991-09-11 | 1993-06-01 | Euroceltique, S.A. | Controlled release matrix suppository for pharmaceuticals |
US5226331A (en) * | 1991-10-03 | 1993-07-13 | General Electric Company | Apparatus and method for measuring the particle number rate and the velocity distribution of a sprayed stream |
US5169638A (en) * | 1991-10-23 | 1992-12-08 | E. R. Squibb & Sons, Inc. | Buoyant controlled release powder formulation |
US5266331A (en) | 1991-11-27 | 1993-11-30 | Euroceltique, S.A. | Controlled release oxycodone compositions |
US5681585A (en) | 1991-12-24 | 1997-10-28 | Euro-Celtique, S.A. | Stabilized controlled release substrate having a coating derived from an aqueous dispersion of hydrophobic polymer |
US5958459A (en) | 1991-12-24 | 1999-09-28 | Purdue Pharma L.P. | Opioid formulations having extended controlled released |
US5968551A (en) * | 1991-12-24 | 1999-10-19 | Purdue Pharma L.P. | Orally administrable opioid formulations having extended duration of effect |
US5580578A (en) * | 1992-01-27 | 1996-12-03 | Euro-Celtique, S.A. | Controlled release formulations coated with aqueous dispersions of acrylic polymers |
GB9202464D0 (en) * | 1992-02-05 | 1992-03-18 | Danbiosyst Uk | Composition for nasal administration |
WO1993017673A1 (en) | 1992-03-03 | 1993-09-16 | Top Gold Pty., Limited | Sustained release analgesics |
DE4227385A1 (en) * | 1992-08-19 | 1994-02-24 | Kali Chemie Pharma Gmbh | pancreatin |
US5512578A (en) * | 1992-09-21 | 1996-04-30 | Albert Einstein College Of Medicine Of Yeshiva University, A Division Of Yeshiva University | Method of simultaneously enhancing analgesic potency and attenuating dependence liability caused by exogenous and endogenous opiod agonists |
USRE36547E (en) | 1992-09-21 | 2000-02-01 | Albert Einstein College Of Medicine Of Yeshiva University | Method of simultaneously enhancing analgesic potency and attenuating dependence liability caused by exogenous and endogenous opioid agonists |
US5330761A (en) * | 1993-01-29 | 1994-07-19 | Edward Mendell Co. Inc. | Bioadhesive tablet for non-systemic use products |
US5849240A (en) | 1993-11-23 | 1998-12-15 | Euro-Celtique, S.A. | Method of preparing sustained release pharmaceutical compositions |
IL110014A (en) * | 1993-07-01 | 1999-11-30 | Euro Celtique Sa | Solid controlled-release oral dosage forms of opioid analgesics |
US5455046A (en) | 1993-09-09 | 1995-10-03 | Edward Mendell Co., Inc. | Sustained release heterodisperse hydrogel systems for insoluble drugs |
US5662933A (en) * | 1993-09-09 | 1997-09-02 | Edward Mendell Co., Inc. | Controlled release formulation (albuterol) |
US5773025A (en) | 1993-09-09 | 1998-06-30 | Edward Mendell Co., Inc. | Sustained release heterodisperse hydrogel systems--amorphous drugs |
CA2461157C (en) | 1996-04-18 | 2007-08-28 | Penwest Pharmaceutical Co. | Sustained release heterodisperse hydrogel systems - amorphous drugs |
US5399358A (en) * | 1993-11-12 | 1995-03-21 | Edward Mendell Co., Inc. | Sustained release formulations for 24 hour release of metroprolol |
US5478577A (en) | 1993-11-23 | 1995-12-26 | Euroceltique, S.A. | Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level |
GB9401894D0 (en) * | 1994-02-01 | 1994-03-30 | Rhone Poulenc Rorer Ltd | New compositions of matter |
US5543434A (en) * | 1994-02-25 | 1996-08-06 | Weg; Stuart L. | Nasal administration of ketamine to manage pain |
US5399359A (en) * | 1994-03-04 | 1995-03-21 | Edward Mendell Co., Inc. | Controlled release oxybutynin formulations |
WO1995028916A1 (en) | 1994-04-25 | 1995-11-02 | Edward Mendell Co., Inc. | Sustained release excipient |
US5399362A (en) * | 1994-04-25 | 1995-03-21 | Edward Mendell Co., Inc. | Once-a-day metoprolol oral dosage form |
US5958458A (en) * | 1994-06-15 | 1999-09-28 | Dumex-Alpharma A/S | Pharmaceutical multiple unit particulate formulation in the form of coated cores |
US5633000A (en) * | 1994-06-23 | 1997-05-27 | Axxia Technologies | Subcutaneous implant |
US5914131A (en) | 1994-07-07 | 1999-06-22 | Alza Corporation | Hydromorphone therapy |
US5556837A (en) * | 1994-08-01 | 1996-09-17 | Regeneron Pharmaceuticals Inc. | Methods for treating addictive disorders |
US5965161A (en) * | 1994-11-04 | 1999-10-12 | Euro-Celtique, S.A. | Extruded multi-particulates |
US5948438A (en) | 1995-01-09 | 1999-09-07 | Edward Mendell Co., Inc. | Pharmaceutical formulations having improved disintegration and/or absorptivity |
FR2729857B1 (en) * | 1995-01-27 | 1997-04-04 | Rhone Poulenc Chimie | Pharmaceutical compositions in the form of sustained release tablets has a base granules of high molecular weight polysaccharides |
US5686107A (en) * | 1995-01-30 | 1997-11-11 | Fmc Corporation | Chewable pharmaceutical tablets |
US5612053A (en) | 1995-04-07 | 1997-03-18 | Edward Mendell Co., Inc. | Controlled release insufflation carrier for medicaments |
US5567754A (en) | 1995-08-23 | 1996-10-22 | Kerr-Mcgee Corporation | Pigments with improved dispersibility in thermoplastic resins |
US6248789B1 (en) * | 1996-08-29 | 2001-06-19 | Stuart L. Weg | Administration of ketamine to manage pain and to reduce drug dependency |
AU2068797A (en) * | 1996-01-29 | 1997-08-20 | Edward Mendell Co. Inc. | Sustained release excipient |
JP3134187B2 (en) | 1996-03-07 | 2001-02-13 | 武田薬品工業株式会社 | Controlled release compositions |
US6245351B1 (en) | 1996-03-07 | 2001-06-12 | Takeda Chemical Industries, Ltd. | Controlled-release composition |
US6103258A (en) * | 1996-04-12 | 2000-08-15 | Simon; David Lew | Salts and bases of the 17-(Cyclopropylmethyl)-4,5 alpha-epoxy-6-Methylenemorphinan-3,14 diol molecule for optimizing dopamine homeostasis during administration of opioid analgesics |
WO1998000143A1 (en) | 1996-06-28 | 1998-01-08 | Knoll Pharmaceutical Company | Slow release pharmaceutical compositions and methods of making same |
ES2322405T3 (en) * | 1996-07-08 | 2009-06-19 | Penwest Pharmaceuticals Co. | Matrix controlled to high doses insoluble drugs release. |
US5891474A (en) * | 1997-01-29 | 1999-04-06 | Poli Industria Chimica, S.P.A. | Time-specific controlled release dosage formulations and method of preparing same |
DE19710008A1 (en) | 1997-03-12 | 1998-09-17 | Basf Ag | Solid, at least two-phase preparation forms of an opioid sustained release Analgeticums |
AT302597T (en) * | 1997-06-06 | 2005-09-15 | Depomed Inc | In the stomach, lingering oral dosage forms of water-soluble drugs with controlled release |
WO1999001111A1 (en) | 1997-07-02 | 1999-01-14 | Euro-Celtique, S.A. | Stabilized sustained release tramadol formulations |
US6391336B1 (en) * | 1997-09-22 | 2002-05-21 | Royer Biomedical, Inc. | Inorganic-polymer complexes for the controlled release of compounds including medicinals |
CA2305183C (en) | 1997-10-03 | 2008-09-23 | The Governors Of The University Of Alberta | Postsurgical treatment with dichloroacetate |
US5904937A (en) | 1997-10-03 | 1999-05-18 | Fmc Corporation | Taste masked pharmaceutical compositions |
US6056977A (en) | 1997-10-15 | 2000-05-02 | Edward Mendell Co., Inc. | Once-a-day controlled release sulfonylurea formulation |
US6193991B1 (en) * | 1997-10-29 | 2001-02-27 | Atul J. Shukla | Biodegradable delivery systems of biologically active substances |
US6102358A (en) * | 1997-11-03 | 2000-08-15 | Mcleary; Joseph Butler | Counterpoise and mounting clamp for a musical drum |
US6375957B1 (en) * | 1997-12-22 | 2002-04-23 | Euro-Celtique, S.A. | Opioid agonist/opioid antagonist/acetaminophen combinations |
AT323491T (en) | 1997-12-22 | 2006-05-15 | Euro Celtique Sa | Orally administrable dosage form containing an opioid agonist, a combination of naltrexone and |
CA2314896C (en) | 1997-12-22 | 2005-09-13 | Euro-Celtique, S.A. | A method of preventing abuse of opioid dosage forms |
US6245357B1 (en) * | 1998-03-06 | 2001-06-12 | Alza Corporation | Extended release dosage form |
US6143325A (en) | 1998-06-05 | 2000-11-07 | Bristol-Myers Squibb Company | Nefazodone dosage form |
KR20000011247A (en) * | 1998-07-23 | 2000-02-25 | 김윤 | Composition and pharmaceutical dosage form for colonic drug delivery using polysaccharides |
GB9816723D0 (en) | 1998-08-01 | 1998-09-30 | Boots Co Plc | Therapeutic agents |
US6806294B2 (en) * | 1998-10-15 | 2004-10-19 | Euro-Celtique S.A. | Opioid analgesic |
DE29818454U1 (en) | 1998-10-15 | 1999-01-14 | Euro Celtique Sa | Opioid analgesic |
AT411011T (en) * | 1998-11-02 | 2008-10-15 | Elan Pharma Int Ltd | Multiparticulate composition of methylphenidate with modified release |
US6242001B1 (en) * | 1998-11-30 | 2001-06-05 | Mcneil-Ppc, Inc. | Method for producing dispersible sterol and stanol compounds |
EP1005863A1 (en) * | 1998-12-04 | 2000-06-07 | Synthelabo | Controlled-release dosage forms comprising a short acting hypnotic or a salt thereof |
PE13962000A1 (en) * | 1999-01-18 | 2000-12-23 | Gruenenthal Chemie | pharmaceutical formulations containing delayed a combination of an opioid or a physiologically tolerable salt thereof, one or agonist |
US6166211A (en) * | 1999-03-19 | 2000-12-26 | Endo Pharmaceuticals, Inc. | Sequential benzylic oxidations of the naloxone ring system |
US20030170181A1 (en) | 1999-04-06 | 2003-09-11 | Midha Kamal K. | Method for preventing abuse of methylphenidate |
US6306425B1 (en) | 1999-04-09 | 2001-10-23 | Southern Research Institute | Injectable naltrexone microsphere compositions and their use in reducing consumption of heroin and alcohol |
CO5170471A1 (en) | 1999-04-13 | 2002-06-27 | Beecham Pharmaceutical Pte Ltd | Modified release tablets including amoxycillin and potassium clavulanate |
EP1204406A2 (en) | 1999-07-29 | 2002-05-15 | Roxane Laboratories, Inc. | Opioid sustained-released formulation |
US20030118641A1 (en) * | 2000-07-27 | 2003-06-26 | Roxane Laboratories, Inc. | Abuse-resistant sustained-release opioid formulation |
KR100345214B1 (en) * | 1999-08-17 | 2002-07-25 | 이강춘 | The nasal transmucosal delivery of peptides conjugated with biocompatible polymers |
CN100387228C (en) | 1999-08-27 | 2008-05-14 | 布鲁克伍德药品公司 | Injectable methadone, partial opioid-opium agonist or opioid-opium antagonist particle composition, and use thereof |
US6436977B1 (en) | 1999-09-29 | 2002-08-20 | Pfizer Inc. | Dosing regimens for lasofoxifene |
AU762291B2 (en) | 1999-09-30 | 2003-06-19 | Penwest Pharmaceutical Co. | Sustained release matrix systems for highly soluble drugs |
AU764453B2 (en) | 1999-10-29 | 2003-08-21 | Euro-Celtique S.A. | Controlled release hydrocodone formulations |
AU783685B2 (en) | 1999-12-23 | 2005-11-24 | Pfizer Products Inc. | Hydrogel-driven drug dosage form |
DK1248594T3 (en) * | 2000-01-19 | 2006-02-06 | Mannkind Corp | Formulation of multi-peak release drug delivery |
US6716449B2 (en) * | 2000-02-08 | 2004-04-06 | Euro-Celtique S.A. | Controlled-release compositions containing opioid agonist and antagonist |
IL151057D0 (en) * | 2000-02-08 | 2003-04-10 | Euro Celtique Sa | Tamper-resistant oral opioid agonist formulations |
US20020032581A1 (en) | 2000-07-17 | 2002-03-14 | Reitberg Donald P. | Single-patient drug trials used with accumulated database: risk of habituation |
US6296842B1 (en) | 2000-08-10 | 2001-10-02 | Alkermes Controlled Therapeutics, Inc. | Process for the preparation of polymer-based sustained release compositions |
US6948492B2 (en) | 2000-08-15 | 2005-09-27 | University Of Kentucky Research Foundation | Programmable multi-dose intranasal drug delivery device |
IL155102D0 (en) | 2000-10-03 | 2003-10-31 | Penwest Pharmaceuticals Co | Delivery system for multi-pharmaceutical active materials at various release rates |
US20020187192A1 (en) | 2001-04-30 | 2002-12-12 | Yatindra Joshi | Pharmaceutical composition which reduces or eliminates drug abuse potential |
AU2002303718B2 (en) | 2001-05-11 | 2008-02-28 | Endo Pharmaceuticals, Inc. | Abuse-resistant opioid dosage form |
CA2446550C (en) | 2001-05-11 | 2012-03-06 | Endo Pharmaceuticals, Inc. | Abuse-resistant controlled-release opioid dosage form |
US20030064122A1 (en) | 2001-05-23 | 2003-04-03 | Endo Pharmaceuticals, Inc. | Abuse resistant pharmaceutical composition containing capsaicin |
PL208484B1 (en) | 2001-07-06 | 2011-05-31 | Penwest Pharmaceuticals Company | Methods of making sustained release formulations of oxymorphone related applications |
US8329216B2 (en) * | 2001-07-06 | 2012-12-11 | Endo Pharmaceuticals Inc. | Oxymorphone controlled release formulations |
EP1406630A1 (en) * | 2001-07-06 | 2004-04-14 | Endo Pharmaceuticals Inc. | Parenteral administration of 6-hydroxy-oxymorphone for use as an analgesic |
WO2003007802A2 (en) | 2001-07-18 | 2003-01-30 | Euro-Celtique, S.A. | Pharmaceutical combinations of oxycodone and naloxone |
US20030044458A1 (en) | 2001-08-06 | 2003-03-06 | Curtis Wright | Oral dosage form comprising a therapeutic agent and an adverse-effect agent |
US7332182B2 (en) | 2001-08-06 | 2008-02-19 | Purdue Pharma L.P. | Pharmaceutical formulation containing opioid agonist, opioid antagonist and irritant |
US7144587B2 (en) | 2001-08-06 | 2006-12-05 | Euro-Celtique S.A. | Pharmaceutical formulation containing opioid agonist, opioid antagonist and bittering agent |
US20030068375A1 (en) | 2001-08-06 | 2003-04-10 | Curtis Wright | Pharmaceutical formulation containing gelling agent |
US7157103B2 (en) | 2001-08-06 | 2007-01-02 | Euro-Celtique S.A. | Pharmaceutical formulation containing irritant |
US20030157168A1 (en) | 2001-08-06 | 2003-08-21 | Christopher Breder | Sequestered antagonist formulations |
EP1414451B1 (en) | 2001-08-06 | 2009-05-20 | Euro-Celtique S.A. | Opioid agonist formulations with releasable and sequestered antagonist |
US7141250B2 (en) | 2001-08-06 | 2006-11-28 | Euro-Celtique S.A. | Pharmaceutical formulation containing bittering agent |
US7842307B2 (en) | 2001-08-06 | 2010-11-30 | Purdue Pharma L.P. | Pharmaceutical formulation containing opioid agonist, opioid antagonist and gelling agent |
US20030049272A1 (en) | 2001-08-30 | 2003-03-13 | Yatindra Joshi | Pharmaceutical composition which produces irritation |
US20030068276A1 (en) | 2001-09-17 | 2003-04-10 | Lyn Hughes | Dosage forms |
US20030059397A1 (en) | 2001-09-17 | 2003-03-27 | Lyn Hughes | Dosage forms |
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CA2464528A1 (en) | 2001-11-02 | 2003-05-15 | Elan Corporation, Plc | Pharmaceutical composition |
US20030158264A1 (en) | 2002-02-20 | 2003-08-21 | Ramachandran Radhakrishnan | Orally administrable pharmaceutical formulation comprising ephedrine hydrochloride and process for preparing the same |
ES2327034T3 (en) | 2002-03-26 | 2009-10-23 | Euro-Celtique S.A. | Gel compositions coated with sustained release. |
US7524515B2 (en) | 2003-01-10 | 2009-04-28 | Mutual Pharmaceuticals, Inc. | Pharmaceutical safety dosage forms |
WO2006068760A2 (en) * | 2004-11-19 | 2006-06-29 | The Regents Of The University Of California | Anti-inflammatory pyrazolopyrimidines |
US20060193911A1 (en) | 2005-02-28 | 2006-08-31 | Penwest Pharmaceuticals Co., | Controlled release venlafaxine formulations |
CA2617164A1 (en) | 2005-08-01 | 2007-02-08 | Alpharma Inc. | Alcohol resistant pharmaceutical formulations |
CA2620224C (en) | 2005-08-24 | 2015-11-24 | Penwest Pharmaceuticals Company | Sustained release formulations of nalbuphine |
PL116330U1 (en) | 2005-10-31 | 2007-04-02 | Alza Corp | Method for the reduction of alcohol provoked rapid increase in the released dose of the orally administered opioide with prolonged liberation |
WO2007078895A2 (en) | 2005-12-30 | 2007-07-12 | Biovail Laboratories International S.R.L. | Modified release formulations of tramadol and uses thereof |
US20070212414A1 (en) | 2006-03-08 | 2007-09-13 | Penwest Pharmaceuticals Co. | Ethanol-resistant sustained release formulations |
US20080119501A1 (en) | 2006-04-28 | 2008-05-22 | Hein William A | Immediate release oxymorphone compositions and methods of using same |
WO2008045046A1 (en) | 2006-10-10 | 2008-04-17 | Penwest Pharmaceuticals Co. | Robust sustained release formulations of oxymorphone |
BRPI0621951A2 (en) | 2006-10-10 | 2011-10-18 | Penwest Pharmaceuticals Co | Sustained release formulations of oxymorphone and dosage forms |
US20080085305A1 (en) * | 2006-10-10 | 2008-04-10 | Penwest Pharmaceuticals Co. | Robust sustained release formulations of oxymorphone |
JP5422388B2 (en) | 2006-10-10 | 2014-02-19 | ペンウェスト ファーマシューティカルズ カンパニー | Robust sustained release formulations |
US20080085304A1 (en) * | 2006-10-10 | 2008-04-10 | Penwest Pharmaceuticals Co. | Robust sustained release formulations |
US20080085303A1 (en) * | 2006-10-10 | 2008-04-10 | Penwest Pharmaceuticals Co. | Robust sustained release formulations of oxymorphone and methods of use thereof |
US20080318993A1 (en) | 2007-06-21 | 2008-12-25 | Endo Pharmaceuticals, Inc. | Method of Treating Pain Utilizing Controlled Release Oxymorphone Pharmaceutical Compositions and Instruction on Dosing for Hepatic Impairment |
US20080318994A1 (en) | 2007-06-21 | 2008-12-25 | Endo Pharmaceuticals, Inc. | Method of Treating Pain Utilizing Controlled Release Oxymorphone Pharmaceutical Compositions and Instruction on Dosing for Renal Impairment |
-
2002
- 2002-07-03 EP EP02748086A patent/EP1406630A1/en not_active Withdrawn
- 2002-07-03 BR BR0205721-2A patent/BR0205721A/en not_active Application Discontinuation
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- 2002-07-03 US US10/190,192 patent/US9820982B2/en active Active
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- 2002-07-03 EP EP10162749A patent/EP2311460A1/en not_active Withdrawn
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- 2002-07-03 DE DE60219478T patent/DE60219478T2/en active Active
- 2002-07-03 JP JP2003510043A patent/JP2005515966A/en active Granted
- 2002-07-03 US US10/189,897 patent/US20030130297A1/en not_active Abandoned
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- 2002-07-03 KR KR10-2003-7003330A patent/KR20030034171A/en active Search and Examination
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- 2002-07-03 JP JP2003510042A patent/JP2005520778A/en active Granted
- 2002-07-03 CA CA002452872A patent/CA2452872A1/en not_active Abandoned
- 2002-07-03 WO PCT/US2002/021400 patent/WO2003004032A1/en active IP Right Grant
- 2002-07-03 AU AU2002320309A patent/AU2002320309B2/en active Active
- 2002-07-03 CA CA002452874A patent/CA2452874A1/en not_active Abandoned
- 2002-07-03 EP EP02749821A patent/EP1404333A1/en not_active Ceased
- 2002-07-03 AT AT02746895T patent/AT359077T/en not_active IP Right Cessation
-
2003
- 2003-03-05 NO NO20031018A patent/NO20031018A/en not_active Application Discontinuation
-
2006
- 2006-06-22 US US11/425,966 patent/US20070098792A1/en not_active Abandoned
- 2006-06-23 US US11/426,170 patent/US20070098793A1/en not_active Abandoned
-
2007
- 2007-02-28 US US11/680,432 patent/US8309122B2/en active Active
-
2008
- 2008-07-03 US US12/167,859 patent/US20080262013A1/en not_active Abandoned
-
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- 2009-02-26 JP JP2009044920A patent/JP2009114209A/en active Pending
- 2009-04-17 US US12/426,112 patent/US20090192183A1/en not_active Abandoned
-
2013
- 2013-06-03 US US13/908,328 patent/US20140134250A1/en not_active Abandoned
-
2014
- 2014-09-22 US US14/492,701 patent/US20150011577A1/en not_active Abandoned
-
2015
- 2015-07-14 US US14/798,619 patent/US20160136152A1/en not_active Abandoned
-
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- 2018-07-30 US US16/049,390 patent/US20180338967A1/en active Pending
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4366159A (en) * | 1981-09-08 | 1982-12-28 | Michael Richard Magruder | Nalbuphine-narcotic analgesic composition and method of producing analgesia |
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Publication number | Priority date | Publication date | Assignee | Title |
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US20100209514A1 (en) * | 1993-11-23 | 2010-08-19 | Sackler Richard S | Method of treating pain by administering 24 hour oral oploid formulations exhibiting rapid rate of initial rise of plasma drug level |
US20100209351A1 (en) * | 1993-11-23 | 2010-08-19 | Sackler Richard S | Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level |
US20060269604A1 (en) * | 1993-11-23 | 2006-11-30 | Purdue Pharma L.P. | Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level |
US20070237832A1 (en) * | 1993-11-23 | 2007-10-11 | Purdue Pharma L.P. | Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level |
US20070237833A1 (en) * | 1993-11-23 | 2007-10-11 | Purdue Pharma L.P. | Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level |
US20080031963A1 (en) * | 1993-11-23 | 2008-02-07 | Purdue Pharma L.P. | Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level |
US20030157167A1 (en) * | 2001-07-06 | 2003-08-21 | Endo Pharmaceuticals, Inc. | Oxymorphone controlled release formulations |
US9820982B2 (en) | 2001-07-06 | 2017-11-21 | Endo Pharmaceuticals Inc. | Oxymorphone controlled release formulations |
WO2005092337A1 (en) * | 2004-03-22 | 2005-10-06 | Endo Pharmaceuticals Inc. | 6 α-OXYMORPHOL AND A METHOD OF USE |
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