JPH11511466A - 苦痛を管理しおよび薬物依存性を軽減するための、ケタミンの投与 - Google Patents
苦痛を管理しおよび薬物依存性を軽減するための、ケタミンの投与Info
- Publication number
- JPH11511466A JPH11511466A JP9510636A JP51063697A JPH11511466A JP H11511466 A JPH11511466 A JP H11511466A JP 9510636 A JP9510636 A JP 9510636A JP 51063697 A JP51063697 A JP 51063697A JP H11511466 A JPH11511466 A JP H11511466A
- Authority
- JP
- Japan
- Prior art keywords
- pain
- ketamine
- administration
- transmucosal
- dose
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Epidemiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.苦痛に悩まされる対象に、苦痛を軽減するのに有効な用量のケタミンを、経 粘膜経路で投与する工程を含む、対象における苦痛を処置する方法。 2.該投与の経粘膜経路が経口腔、経直腸、経膣および経口−経咽頭からなる群 から選ばれる、請求の範囲第1項に記載の方法。 3.苦痛に悩まされる対象に、苦痛を軽減するのに有効な用量のケタミンを、経 皮経路で投与する工程を含む、対象における苦痛を処置する方法。 4.苦痛に悩まされる対象に、苦痛を軽減するのに有効な用量のケタミンを、経 口経路で投与する工程を含む、対象における苦痛を処置する方法。 5.該ケタミンの用量が約0.01〜約1mg/kg体重である、請求の範囲1、3または 4項に記載の方法。 6.該ケタミンの用量が約0.05〜約0.7mg/kg体重である、請求の範囲5項に記載 の方法。 7.該苦痛が著しい苦痛である、請求の範囲1、3または4項に記載の方法。 8.該苦痛が、苦痛である、請求の範囲1、3または4項に記載の方法。 9.苦痛に対する処置を受けている対象に、苦痛を軽減するのに有効な用量のケ タミンを投与する工程を含む、対象における苦痛を、協力作用的に処置するため の方法。 10.該ケタミンを、経粘膜経路で投与する、請求の範囲第9項に記載の方法。 11.該投与の経粘膜経路を、経口腔、経直腸、経膣、および経口−経咽頭からな る群から選ぶ、請求の範囲第10項に記載の方法。 12.該ケタミンを、経皮経路で投与する、請求の範囲第9項に記載の方法。 13.該ケタミンを、経口経路で投与する、請求の範囲第9項に記載の方法。 14.該ケタミンを、非経口経路で投与する、請求の範囲第9項に記載の方法。 15.該非経口投与を、静脈内、動脈内、腹腔内、皮内、筋肉内、心室内、および 皮下投与からなる群から選ぶ、請求の範囲第14項に記載の方法。 16.該苦痛に対する処置が、麻薬性鎮痛剤の投与を含む、請求の範囲第9項に記 載の方法。 17.該苦痛の処置の有効性を減ずることなしに、該麻薬性鎮痛剤の用量を低減す る、請求の範囲第16項に記載の方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US294695P | 1995-08-30 | 1995-08-30 | |
US60/002,946 | 1995-08-30 | ||
PCT/US1996/014095 WO1997007750A1 (en) | 1995-08-30 | 1996-08-29 | Administration of ketamine to manage pain and to reduce drug dependency |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2008256699A Division JP2009073842A (ja) | 1995-08-30 | 2008-10-01 | 苦痛を管理しおよび薬物依存性を軽減するための、ケタミンの投与 |
Publications (1)
Publication Number | Publication Date |
---|---|
JPH11511466A true JPH11511466A (ja) | 1999-10-05 |
Family
ID=21703322
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP9510636A Withdrawn JPH11511466A (ja) | 1995-08-30 | 1996-08-29 | 苦痛を管理しおよび薬物依存性を軽減するための、ケタミンの投与 |
JP2008256699A Pending JP2009073842A (ja) | 1995-08-30 | 2008-10-01 | 苦痛を管理しおよび薬物依存性を軽減するための、ケタミンの投与 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2008256699A Pending JP2009073842A (ja) | 1995-08-30 | 2008-10-01 | 苦痛を管理しおよび薬物依存性を軽減するための、ケタミンの投与 |
Country Status (3)
Country | Link |
---|---|
JP (2) | JPH11511466A (ja) |
CA (1) | CA2230690C (ja) |
WO (1) | WO1997007750A1 (ja) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1103256A1 (de) * | 1999-11-26 | 2001-05-30 | Claudius Dr. med. Böck | Verwendung von Ketamin zur Behandlung von neuroendokriner Immundysfunktion und algogenem Psychosyndrom |
DE10025946A1 (de) * | 2000-05-26 | 2001-11-29 | Gruenenthal Gmbh | Wirkstoffkombination |
US8329216B2 (en) | 2001-07-06 | 2012-12-11 | Endo Pharmaceuticals Inc. | Oxymorphone controlled release formulations |
KR20030034171A (ko) | 2001-07-06 | 2003-05-01 | 엔도 파마슈티걸즈, 인크. | 옥시모르폰 제어 방출 제형 |
JP2006510618A (ja) * | 2002-11-18 | 2006-03-30 | ヤウポン セラピューティクス,インコーポレーテッド | ノルケタミンおよびケタミン/ノルケタミンプロドラッグの鎮痛的使用 |
WO2004087209A1 (ja) * | 2003-03-27 | 2004-10-14 | Hisamitsu Pharmaceutical Co., Inc. | 鎮痛剤活性増強剤の治療上有効な血中濃度を維持するための製剤 |
CN104395283A (zh) * | 2011-10-14 | 2015-03-04 | 美国政府健康及人类服务部 | (2r,6r)-羟基去甲氯胺酮、(s)-脱氢去甲氯胺酮以及(r,s)-氯胺酮的其他立体异构脱氢和羟基化代谢物在治疗忧郁症和神经性疼痛中的应用 |
US20140079740A1 (en) * | 2012-08-02 | 2014-03-20 | ClinPharm Support GmbH | Oral transmucosal adminstration forms of s-ketamine |
SG11201507347QA (en) | 2013-03-15 | 2015-10-29 | Janssen Pharmaceutica Nv | Pharmaceutical composition of s-ketamine hydrochloride |
AU2015318123A1 (en) | 2014-09-15 | 2017-03-30 | Janssen Pharmaceutica Nv | Val66Met (SNP rs6265) genotype specific dosing regimens and methods for the treatment of depression |
CA2987909C (en) * | 2015-06-27 | 2022-04-26 | Shenox Pharmaceuticals, Llc | Ketamine transdermal delivery system |
US9963435B2 (en) | 2016-08-31 | 2018-05-08 | Dart Neuroscience, Llc | Compounds for therapeutic use |
JP7069295B2 (ja) | 2017-08-17 | 2022-05-17 | エックスダブリューファルマ リミテッド | 活性酸素種スカベンジャー誘導体の調製および使用 |
EP3988561B1 (en) | 2017-09-04 | 2023-06-07 | XWPharma Ltd. | Preparation and use of reactive oxygen species scavenger |
US20200009081A1 (en) | 2017-09-13 | 2020-01-09 | Janssen Pharmaceutica N.V. | Delivery Of Esketamine For The Treatment Of Depression |
WO2019126108A1 (en) | 2017-12-22 | 2019-06-27 | Janssen Pharmaceutica Nv | Esketamine for the treatment of depression |
KR20230110828A (ko) * | 2018-01-10 | 2023-07-25 | 엑스더블유파마 리미티드 | 케타민의 전구약물, 및 이의 조성물 및 용도 |
MX2021010683A (es) | 2019-03-05 | 2021-12-10 | Janssen Pharmaceuticals Inc | Esketamina para el tratamiento de la depresión. |
US11690811B2 (en) | 2021-08-13 | 2023-07-04 | XWPharma Ltd. | Pharmaceutical compositions and oral dosage forms of ketamine derivatives |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4671953A (en) * | 1985-05-01 | 1987-06-09 | University Of Utah Research Foundation | Methods and compositions for noninvasive administration of sedatives, analgesics, and anesthetics |
CA2115792C (en) * | 1993-03-05 | 2005-11-01 | David J. Mayer | Method for the treatment of pain |
US5543434A (en) * | 1994-02-25 | 1996-08-06 | Weg; Stuart L. | Nasal administration of ketamine to manage pain |
-
1996
- 1996-08-29 WO PCT/US1996/014095 patent/WO1997007750A1/en active Application Filing
- 1996-08-29 CA CA002230690A patent/CA2230690C/en not_active Expired - Fee Related
- 1996-08-29 JP JP9510636A patent/JPH11511466A/ja not_active Withdrawn
-
2008
- 2008-10-01 JP JP2008256699A patent/JP2009073842A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
CA2230690C (en) | 2008-12-23 |
CA2230690A1 (en) | 1997-03-06 |
JP2009073842A (ja) | 2009-04-09 |
WO1997007750A1 (en) | 1997-03-06 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20070529 |
|
A601 | Written request for extension of time |
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A602 | Written permission of extension of time |
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A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20080603 |
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A761 | Written withdrawal of application |
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A521 | Written amendment |
Free format text: JAPANESE INTERMEDIATE CODE: A821 Effective date: 20081119 |