JP2005514441A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2005514441A5 JP2005514441A5 JP2003559507A JP2003559507A JP2005514441A5 JP 2005514441 A5 JP2005514441 A5 JP 2005514441A5 JP 2003559507 A JP2003559507 A JP 2003559507A JP 2003559507 A JP2003559507 A JP 2003559507A JP 2005514441 A5 JP2005514441 A5 JP 2005514441A5
- Authority
- JP
- Japan
- Prior art keywords
- phenylphenylmethyl
- oxopropyl
- carboxy
- amino
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003839 salts Chemical class 0.000 claims description 9
- 239000004072 C09CA03 - Valsartan Substances 0.000 claims description 3
- 206010020772 Hypertension Diseases 0.000 claims description 3
- 125000004494 ethyl ester group Chemical group 0.000 claims description 3
- SJSNUMAYCRRIOM-QFIPXVFZSA-N valsartan Chemical compound C1=CC(CN(C(=O)CCCC)[C@@H](C(C)C)C(O)=O)=CC=C1C1=CC=CC=C1C1=NN=N[N]1 SJSNUMAYCRRIOM-QFIPXVFZSA-N 0.000 claims description 3
- 229960004699 valsartan Drugs 0.000 claims description 3
- 239000003814 drug Substances 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims description 2
- 239000003112 inhibitor Substances 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- -1 3- carboxy-1-oxopropyl Chemical group 0.000 claims 4
- ZBSFEPOXERUZFE-SFHVURJKSA-N (2R)-4-amino-2-methyl-2-[(4-phenylphenyl)methyl]butanoic acid Chemical compound C1(=CC=CC=C1)C1=CC=C(C=C1)C[C@@](C(=O)O)(CCN)C ZBSFEPOXERUZFE-SFHVURJKSA-N 0.000 claims 1
- 206010019280 Heart failures Diseases 0.000 claims 1
- 239000000400 angiotensin II type 1 receptor blocker Substances 0.000 claims 1
- 239000005557 antagonist Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- UEBQNXUHSKFIIR-FQEVSTJZSA-N ethyl (2R)-4-amino-2-methyl-2-[(4-phenylphenyl)methyl]butanoate Chemical compound C(C)OC([C@](CCN)(C)CC1=CC=C(C=C1)C1=CC=CC=C1)=O UEBQNXUHSKFIIR-FQEVSTJZSA-N 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 239000002552 dosage form Substances 0.000 description 3
- 241000700159 Rattus Species 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 235000005911 diet Nutrition 0.000 description 2
- 230000037213 diet Effects 0.000 description 2
- 238000011699 spontaneously hypertensive rat Methods 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- XAIFNLJOYACUNR-IBGZPJMESA-N CC(C)[C@@H](C(O)=O)N(Cc(cc1)ccc1-c(cccc1)c1-c1nnn[nH]1)C(C)=O Chemical compound CC(C)[C@@H](C(O)=O)N(Cc(cc1)ccc1-c(cccc1)c1-c1nnn[nH]1)C(C)=O XAIFNLJOYACUNR-IBGZPJMESA-N 0.000 description 1
- VPGRYOFKCNULNK-ACXQXYJUSA-N Deoxycorticosterone acetate Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)COC(=O)C)[C@@]1(C)CC2 VPGRYOFKCNULNK-ACXQXYJUSA-N 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000003276 anti-hypertensive effect Effects 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 238000011284 combination treatment Methods 0.000 description 1
- 229960004486 desoxycorticosterone acetate Drugs 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
- 235000020188 drinking water Nutrition 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 230000001631 hypertensive effect Effects 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 208000019553 vascular disease Diseases 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34966002P | 2002-01-17 | 2002-01-17 | |
| US60/349,660 | 2002-01-17 | ||
| PCT/EP2003/000415 WO2003059345A1 (en) | 2002-01-17 | 2003-01-16 | Pharmaceutical compositions comprising valsartan and nep inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011116928A Division JP2011207898A (ja) | 2002-01-17 | 2011-05-25 | バルサルタンおよびｎｅｐ阻害剤を含む医薬組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005514441A JP2005514441A (ja) | 2005-05-19 |
| JP2005514441A5 true JP2005514441A5 (https=) | 2011-08-04 |
| JP4820056B2 JP4820056B2 (ja) | 2011-11-24 |
Family
ID=23373410
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003559507A Expired - Lifetime JP4820056B2 (ja) | 2002-01-17 | 2003-01-16 | バルサルタンおよびｎｅｐ阻害剤を含む医薬組成物 |
| JP2011116928A Withdrawn JP2011207898A (ja) | 2002-01-17 | 2011-05-25 | バルサルタンおよびｎｅｐ阻害剤を含む医薬組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011116928A Withdrawn JP2011207898A (ja) | 2002-01-17 | 2011-05-25 | バルサルタンおよびｎｅｐ阻害剤を含む医薬組成物 |
Country Status (29)
| Country | Link |
|---|---|
| EP (1) | EP1467728B1 (https=) |
| JP (2) | JP4820056B2 (https=) |
| KR (2) | KR100984939B1 (https=) |
| CN (2) | CN102091330B (https=) |
| AT (1) | ATE370732T1 (https=) |
| AU (1) | AU2003206738C1 (https=) |
| BE (1) | BE2016C025I2 (https=) |
| BR (2) | BR122018015003B8 (https=) |
| CA (1) | CA2472399C (https=) |
| CO (1) | CO5600999A2 (https=) |
| CY (2) | CY1106959T1 (https=) |
| DE (1) | DE60315795T2 (https=) |
| DK (1) | DK1467728T3 (https=) |
| EC (1) | ECSP045190A (https=) |
| ES (1) | ES2290429T3 (https=) |
| FR (1) | FR16C0019I2 (https=) |
| HU (1) | HUS1600024I1 (https=) |
| IL (2) | IL162661A0 (https=) |
| LU (1) | LU93074I2 (https=) |
| MX (1) | MXPA04006917A (https=) |
| NL (1) | NL300811I2 (https=) |
| NO (2) | NO333191B1 (https=) |
| NZ (1) | NZ533968A (https=) |
| PL (1) | PL212318B1 (https=) |
| PT (1) | PT1467728E (https=) |
| RU (1) | RU2334513C3 (https=) |
| SI (1) | SI1467728T1 (https=) |
| WO (1) | WO2003059345A1 (https=) |
| ZA (1) | ZA200405117B (https=) |
Families Citing this family (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1972679B (zh) * | 2004-06-23 | 2010-07-28 | 索尔瓦药物有限公司 | 包括nep-抑制剂、内源性内皮缩血管肽产生系统抑制剂和at1受体拮抗剂的药物组合物 |
| DK2033629T3 (da) * | 2004-12-24 | 2013-02-04 | Krka | Fast farmaceutisk sammensætning omfattende valsartan |
| MY146830A (en) * | 2005-02-11 | 2012-09-28 | Novartis Ag | Combination of organic compounds |
| WO2007045663A2 (en) * | 2005-10-19 | 2007-04-26 | Novartis Ag | Combination of an ati receptor antagonist and a np inhibitor fro treating ia hypertension and heartfailure |
| WO2007051007A2 (en) * | 2005-10-28 | 2007-05-03 | Novartis Ag | Combination of antihypertensives with cholesterol-lowering agent |
| AR057882A1 (es) * | 2005-11-09 | 2007-12-26 | Novartis Ag | Compuestos de accion doble de bloqueadores del receptor de angiotensina e inhibidores de endopeptidasa neutra |
| WO2007106708A2 (en) * | 2006-03-10 | 2007-09-20 | Novartis Ag | Combinations of the angiotensin ii antagonist valsartan and the nep inhibitor daglutril |
| CZ300801B6 (cs) * | 2006-06-07 | 2009-08-12 | Helvetia Pharma A.S. | Kompozice s valsartanem v pevných lékových formách |
| PH12012502091A1 (en) | 2007-01-12 | 2019-06-14 | Novartis Ag | Process for preparing 5-biphenyl-4-amino-2-methyl pentanoic acid |
| GB0708507D0 (en) | 2007-05-02 | 2007-06-13 | Queen Mary & Westfield College | Substituted phosphonates and their use |
| NZ584686A (en) | 2007-11-06 | 2013-03-28 | Novartis Ag | Compositions of trisodium [3-((1S,3R)-1-biphenyl-4-ylmethyl-3-ethoxycarbonyl-1-butylcarbamoyl) propionate(S)-3'-methyl-2' -(pentanoyl{ 2 -(tetrazol-5-ylate)biphenyl-4'-ylmethyl} amino)butyrate]hemipentahydrate |
| CN101774941A (zh) | 2009-01-13 | 2010-07-14 | 浙江九洲药业股份有限公司 | 2-酰基氨基-3-联苯基丙酸的制备及拆分方法 |
| SG176009A1 (en) | 2009-05-28 | 2011-12-29 | Novartis Ag | Substituted aminopropionic derivatives as neprilysin inhibitors |
| JP5466759B2 (ja) | 2009-05-28 | 2014-04-09 | ノバルティス アーゲー | ネプリライシン阻害剤としての置換アミノ酪酸誘導体 |
| JO2967B1 (en) | 2009-11-20 | 2016-03-15 | نوفارتس ايه جي | Acetic acid derivatives of carbamoyl methyl amino are substituted as new NEP inhibitors |
| BR112013004164A2 (pt) | 2010-08-23 | 2016-05-10 | Novartis Ag | processo para a preparação de intermediários para a produção de inibidores da nep |
| US8673974B2 (en) | 2010-11-16 | 2014-03-18 | Novartis Ag | Substituted amino bisphenyl pentanoic acid derivatives as NEP inhibitors |
| AU2013304949C1 (en) * | 2012-08-24 | 2020-12-24 | Novartis Ag | NEP inhibitors for treating diseases characterized by atrial enlargement or remodeling |
| JP6301371B2 (ja) | 2013-02-14 | 2018-04-11 | ノバルティス アーゲー | インビボ効力が改善されたｎｅｐ阻害剤としての置換ビスフェニルブタン酸誘導体 |
| TR201808541T4 (tr) | 2013-02-14 | 2018-07-23 | Novartis Ag | Nep (nötr endopeptidaz) inhibitörleri olarak ikame edilmiş bisfenil butanoik fosfonik asit türevleri. |
| CN104230865B (zh) * | 2013-06-13 | 2018-01-09 | 上海翰森生物医药科技有限公司 | 联芳基取代的4‑氨基丁酸衍生物及其制备方法和用途 |
| ES2968541T3 (es) | 2013-08-26 | 2024-05-10 | Novartis Ag | Tratamiento de enfermedades cardiovasculares |
| EP3038653A1 (en) | 2013-08-26 | 2016-07-06 | Novartis AG | New use |
| CN106458857A (zh) * | 2014-08-27 | 2017-02-22 | 上海翰森生物医药科技有限公司 | AHU‑377结晶型游离酸、半钙盐、α﹣苯乙胺盐及其制备方法和应用 |
| WO2016037098A1 (en) * | 2014-09-04 | 2016-03-10 | Concert Pharmaceuticals, Inc. | Deuterated sacubitril |
| CN106414416B (zh) * | 2014-09-09 | 2020-03-27 | 上海翰森生物医药科技有限公司 | 结晶型ARB-NEPi复合物及其制备方法和应用 |
| CN105503760A (zh) * | 2014-10-10 | 2016-04-20 | 上海翰森生物医药科技有限公司 | 结晶型ARB-NEPi双阳离子复合物及其制备方法和应用 |
| LT3218351T (lt) | 2014-11-14 | 2019-09-25 | Zentiva K.S. | Ahu-377 farmaciniu požiūriu priimtinų formų gavimo, atskyrimo ir gryninimo būdas |
| WO2016086798A1 (zh) * | 2014-12-03 | 2016-06-09 | 上海翰森生物医药科技有限公司 | Nep抑制剂结晶型游离酸、钙盐多晶型及其制备方法和应用 |
| CN110938042B (zh) * | 2014-12-08 | 2022-12-13 | 苏州晶云药物科技股份有限公司 | 一种包含缬沙坦和ahu377的三钠盐超分子复合物的新晶型及其制备方法 |
| CN105693543B (zh) * | 2014-12-15 | 2018-08-10 | 四川海思科制药有限公司 | 沙库比曲类衍生物、其药物组合物、制备方法及用途 |
| CN104826115A (zh) * | 2015-04-19 | 2015-08-12 | 浙江巨泰药业有限公司 | 一种抗心衰药物组合物及其制备方法 |
| CN106138069A (zh) * | 2015-04-21 | 2016-11-23 | 刘春丽 | 作为治疗来自非角化复层上皮组织的不适的局部药剂的1-二仲丁基膦酰基戊烷 |
| EP4570314A3 (en) | 2015-05-11 | 2025-09-10 | Novartis AG | Sacubitril-valsartan dosage regimen for treating chronic systolic heart failure |
| WO2016193883A1 (en) | 2015-05-29 | 2016-12-08 | Novartis Ag | Sacubitril and valsartan for treating metabolic disease |
| WO2017006254A1 (en) | 2015-07-08 | 2017-01-12 | Novartis Ag | Drug combination comprising an angiotensin ii receptor antagonist, a neutral endopeptidase inhibitor and a mineralcorticoid receptor antagonist |
| WO2017012600A1 (en) | 2015-07-20 | 2017-01-26 | Zentiva, K.S. | A pharmaceutical composition containing valsartan and sacubitril and methods for preparation and stabilization thereof |
| CN106397249A (zh) * | 2015-08-03 | 2017-02-15 | 深圳信立泰药业股份有限公司 | 一种高稳定性lcz696结晶粉末及其制备方法 |
| WO2017037577A1 (en) | 2015-08-28 | 2017-03-09 | Novartis Ag | New use |
| WO2017036420A1 (zh) * | 2015-09-06 | 2017-03-09 | 常州方楠医药技术有限公司 | 含沙库比曲和缬沙坦的药用组合物及其制备方法 |
| CN105348209B (zh) | 2015-12-09 | 2017-12-26 | 浙江天宇药业股份有限公司 | 一种抗心衰药lcz696的制备方法 |
| EP3386945A1 (en) | 2015-12-11 | 2018-10-17 | Zentiva, K.S. | Solid forms of (2r,4s)-5-(biphenyl-4-yl)-4-[(3-carboxypropionyl)amino]-2- -methylpentanoic acid ethyl ester, its salts and a preparation method |
| JP7156945B2 (ja) | 2016-02-03 | 2022-10-19 | ノバルティス アーゲー | 有機化合物のガレヌス製剤 |
| US10722471B2 (en) | 2016-02-03 | 2020-07-28 | Novartis Ag | Galenic formulations of organic compounds |
| FI3524250T3 (fi) | 2016-10-08 | 2025-08-29 | Wuhan Ll Science & Technology Development Co Ltd | Neutraalia endopeptidaasin (nep) estäjää ja atsilsartaaniesterijohdannaista sisältävä farmaseuttinen koostumus ja sen käyttö sydän- ja verisuonitautien hoitoon |
| WO2018211479A1 (en) | 2017-05-19 | 2018-11-22 | Lupin Limited | Stabilized compositions of angiotensin ii inhibitors and neutral endopeptidase inhibitors and process for preparation thereof |
| WO2019008485A1 (en) * | 2017-07-06 | 2019-01-10 | Mankind Pharma Ltd | FIXED DOSE PHARMACEUTICAL COMPOSITION BASED ON VALSARTAN AND SACUBITRIL |
| WO2019020706A1 (en) | 2017-07-28 | 2019-01-31 | Synthon B.V. | PHARMACEUTICAL COMPOSITION COMPRISING SACUBITRIL AND VALSARTAN |
| UY38072A (es) | 2018-02-07 | 2019-10-01 | Novartis Ag | Compuestos derivados de éster butanoico sustituido con bisfenilo como inhibidores de nep, composiciones y combinaciones de los mismos |
| CN110237071B (zh) | 2018-03-09 | 2022-03-22 | 武汉朗来科技发展有限公司 | 药物制剂及其应用 |
| WO2020039386A1 (en) | 2018-08-23 | 2020-02-27 | Novartis Ag | New pharmaceutical use for the treatment of heart failure |
| WO2020039394A1 (en) | 2018-08-24 | 2020-02-27 | Novartis Ag | New drug combinations |
| KR20210101164A (ko) | 2020-02-07 | 2021-08-18 | 보령제약 주식회사 | 하이브리드 화합물 및 그 제조방법 |
| WO2021158084A1 (ko) * | 2020-02-07 | 2021-08-12 | 보령제약 주식회사 | 하이브리드 화합물 및 그 제조방법 |
| KR20200020746A (ko) | 2020-02-07 | 2020-02-26 | 보령제약 주식회사 | 하이브리드 화합물 및 그 제조방법 |
| KR20210120560A (ko) | 2020-03-27 | 2021-10-07 | 주식회사 유영제약 | 고함량의 주성분을 포함하는 정제 및 그 제조방법 |
| KR20220091767A (ko) | 2020-12-24 | 2022-07-01 | 주식회사 보령 | 사쿠비트릴 발사르탄 하이브리드 화합물 또는 그 약제학적으로 허용되는 염을 유효성분으로 포함하는 약제학적 조성물 |
| CN120390636A (zh) | 2022-12-20 | 2025-07-29 | 斯法姆公司 | 包含钠-葡萄糖协同转运蛋白2抑制剂和血管紧张素ⅱ受体阻滞剂的口服药物制剂 |
| CN120417911A (zh) | 2022-12-20 | 2025-08-01 | 斯法姆公司 | 包含钠-葡萄糖协同转运蛋白2抑制剂和血管紧张素ⅱ受体阻滞剂的用于预防或治疗心血管疾病的药物组合物 |
| CN116687921A (zh) * | 2023-06-14 | 2023-09-05 | 宁波大学 | 沙库巴曲缬沙坦类物质在制备神经毒性和认知障碍类药物的应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU1256692A (en) * | 1991-02-06 | 1992-09-07 | Schering Corporation | Combination of an angiotensin II antagonist or renin inhibitor with a neutral endopeptidase inhibitor |
| US5217996A (en) * | 1992-01-22 | 1993-06-08 | Ciba-Geigy Corporation | Biaryl substituted 4-amino-butyric acid amides |
| CA2168066A1 (en) * | 1995-02-08 | 1996-08-09 | James R. Powell | Treatment of hypertension and congestive heart failure |
| EP1267855A2 (en) * | 2000-04-03 | 2003-01-02 | Bristol-Myers Squibb Company | Vasopeptidase inhibitors to treat isolated systolic hypertension |
| NZ522953A (en) * | 2000-06-22 | 2005-10-28 | Novartis Ag | Tablet containing valsartan, microcrystalline cellulose, crospovidone, colloidal anhydrous silica/colloidal silicon dioxide and magnesium stearate |
| AR032758A1 (es) * | 2000-07-19 | 2003-11-26 | Novartis Ag | Sales valsartan, un proceso para su fabricacion, composiciones farmaceuticas y el uso de dichas sales para la preparacion de medicamentos |
| US6777443B2 (en) * | 2001-05-15 | 2004-08-17 | Novartis Ag | Dipeptide derivatives |
-
2003
- 2003-01-16 NZ NZ533968A patent/NZ533968A/en not_active IP Right Cessation
- 2003-01-16 SI SI200331029T patent/SI1467728T1/sl unknown
- 2003-01-16 RU RU2004125178A patent/RU2334513C3/ru active
- 2003-01-16 KR KR1020047011124A patent/KR100984939B1/ko not_active Ceased
- 2003-01-16 WO PCT/EP2003/000415 patent/WO2003059345A1/en not_active Ceased
- 2003-01-16 CN CN201110029600.7A patent/CN102091330B/zh not_active Expired - Lifetime
- 2003-01-16 AT AT03704413T patent/ATE370732T1/de active
- 2003-01-16 KR KR1020107010521A patent/KR20100057704A/ko not_active Ceased
- 2003-01-16 PT PT03704413T patent/PT1467728E/pt unknown
- 2003-01-16 DK DK03704413T patent/DK1467728T3/da active
- 2003-01-16 CN CNA038022680A patent/CN1615134A/zh active Pending
- 2003-01-16 BR BR122018015003A patent/BR122018015003B8/pt not_active IP Right Cessation
- 2003-01-16 BR BRPI0306907A patent/BRPI0306907B8/pt active IP Right Grant
- 2003-01-16 CA CA2472399A patent/CA2472399C/en not_active Expired - Lifetime
- 2003-01-16 EP EP03704413A patent/EP1467728B1/en not_active Expired - Lifetime
- 2003-01-16 DE DE60315795T patent/DE60315795T2/de not_active Expired - Lifetime
- 2003-01-16 IL IL16266103A patent/IL162661A0/xx unknown
- 2003-01-16 JP JP2003559507A patent/JP4820056B2/ja not_active Expired - Lifetime
- 2003-01-16 PL PL369773A patent/PL212318B1/pl unknown
- 2003-01-16 AU AU2003206738A patent/AU2003206738C1/en active Active
- 2003-01-16 MX MXPA04006917A patent/MXPA04006917A/es active IP Right Grant
- 2003-01-16 ES ES03704413T patent/ES2290429T3/es not_active Expired - Lifetime
-
2004
- 2004-06-21 IL IL162661A patent/IL162661A/en active Protection Beyond IP Right Term
- 2004-06-28 ZA ZA2004/05117A patent/ZA200405117B/en unknown
- 2004-07-14 EC EC2004005190A patent/ECSP045190A/es unknown
- 2004-08-06 CO CO04076723A patent/CO5600999A2/es active IP Right Grant
- 2004-08-13 NO NO20043380A patent/NO333191B1/no not_active IP Right Cessation
-
2007
- 2007-10-25 CY CY20071101386T patent/CY1106959T1/el unknown
-
2011
- 2011-05-25 JP JP2011116928A patent/JP2011207898A/ja not_active Withdrawn
-
2016
- 2016-05-17 FR FR16C0019C patent/FR16C0019I2/fr active Active
- 2016-05-18 BE BE2016C025C patent/BE2016C025I2/nl unknown
- 2016-05-18 CY CY2016013C patent/CY2016013I2/el unknown
- 2016-05-18 LU LU93074C patent/LU93074I2/fr unknown
- 2016-05-18 HU HUS1600024C patent/HUS1600024I1/hu unknown
- 2016-05-18 NL NL300811C patent/NL300811I2/nl unknown
- 2016-05-18 NO NO2016009C patent/NO2016009I1/no unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2005514441A5 (https=) | ||
| JP5631053B2 (ja) | 門脈圧亢進症の予防及び／又は治療 | |
| JP4804004B2 (ja) | 関節軟骨細胞外マトリクス分解阻害剤 | |
| KR101715008B1 (ko) | Ｌ―오르니틴 페닐아세테이트를 사용한 문맥압 항진증의 치료 및 간 기능 회복 | |
| CA2515293A1 (en) | Eicosapentaenoic acid for use in improving prognosis in the treatment of subarachnoid hemorrhage | |
| US8343947B2 (en) | Therapeutic treatment | |
| CN1194681C (zh) | 用于抗血栓形成的甘氨酸甜菜碱 | |
| JP2005538104A (ja) | コレステロール吸収阻害剤、ＨＭＧ−ＣｏＡレダクターゼ阻害剤および安定化剤を含有する組成物 | |
| WO2001005394A1 (en) | Agents inhibiting chronic rejection reactions after organ transplantation | |
| JP2005528430A5 (https=) | ||
| WO2024173556A3 (en) | Uses of certain 1,4-oxazepane-2-carboxamides as dpp1 inhibitors | |
| JPS63141934A (ja) | ディルチアゼムおよびアンギオテンシン変換酵素阻害剤を含有する医薬組成物 | |
| US20050020657A1 (en) | Compositions and methods involving the combination of a thromboxane A2 receptor antagonist and an inhibitor of cyclooxygenase-2 | |
| JP2010532348A5 (https=) | ||
| JP2007517911A (ja) | 心臓血管の適応症および腎臓の適応症に対してｃｇｒｐを使用する方法 | |
| JPH0616570A (ja) | 心臓血管障害の処置のためのａｃｅ阻害剤を配合するｌ−カルニチンまたはアシル−ｌ−カルニチンを含む医薬組成物 | |
| JP4839309B2 (ja) | 血栓症治療剤 | |
| CN1271283A (zh) | 内皮素拮抗剂和血管紧张肽原酶－血管紧张肽系统抑制剂的药物组合物 | |
| US20060160896A1 (en) | Therapeutic treatment | |
| CA2489705A1 (en) | Use of amide derivative of ge 2270 factor a3 for the treatment of acne | |
| Liu et al. | Synergism of telmisartan and amlodipine on blood pressure reduction and cardiorenal protection in hypertensive rats | |
| KR20080074122A (ko) | 항-혈소판 약물, 영양 및 비타민 보충물로서의 아세틸화된아미노산 | |
| RU2007169C1 (ru) | Средство, обладающее антигипертензивным действием | |
| JP2003504404A (ja) | 抗虚血薬 | |
| AU2003259261B2 (en) | Use of chymase inhibitors for the prevention and/or treatment of arterio-venous graft failure |