JP2005514381A5 - - Google Patents

Download PDF

Info

Publication number
JP2005514381A5
JP2005514381A5 JP2003548836A JP2003548836A JP2005514381A5 JP 2005514381 A5 JP2005514381 A5 JP 2005514381A5 JP 2003548836 A JP2003548836 A JP 2003548836A JP 2003548836 A JP2003548836 A JP 2003548836A JP 2005514381 A5 JP2005514381 A5 JP 2005514381A5
Authority
JP
Japan
Prior art keywords
mixture
ethyl ester
ethyl acetate
acid ethyl
added
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2003548836A
Other languages
English (en)
Japanese (ja)
Other versions
JP4176020B2 (ja
JP2005514381A (ja
Filing date
Publication date
Priority claimed from GBGB0128996.6A external-priority patent/GB0128996D0/en
Application filed filed Critical
Publication of JP2005514381A publication Critical patent/JP2005514381A/ja
Publication of JP2005514381A5 publication Critical patent/JP2005514381A5/ja
Application granted granted Critical
Publication of JP4176020B2 publication Critical patent/JP4176020B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

JP2003548836A 2001-12-04 2002-12-03 Ｍｇｌｕｒ５アンタゴニスト活性を有するアセチレン誘導体 Expired - Lifetime JP4176020B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0128996.6A GB0128996D0 (en) 2001-12-04 2001-12-04 Organic compounds
PCT/EP2002/013670 WO2003047581A1 (en) 2001-12-04 2002-12-03 Acetylene derivatives having mglur 5 antagonistic activity

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2008179005A Division JP5036648B2 (ja) 2001-12-04 2008-07-09 Ｍｇｌｕｒ５アンタゴニスト活性を有するアセチレン誘導体

Publications (3)

Publication Number Publication Date
JP2005514381A JP2005514381A (ja) 2005-05-19
JP2005514381A5 true JP2005514381A5 (enExample) 2006-01-05
JP4176020B2 JP4176020B2 (ja) 2008-11-05

Family

ID=9926969

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2003548836A Expired - Lifetime JP4176020B2 (ja) 2001-12-04 2002-12-03 Ｍｇｌｕｒ５アンタゴニスト活性を有するアセチレン誘導体
JP2008179005A Expired - Lifetime JP5036648B2 (ja) 2001-12-04 2008-07-09 Ｍｇｌｕｒ５アンタゴニスト活性を有するアセチレン誘導体

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2008179005A Expired - Lifetime JP5036648B2 (ja) 2001-12-04 2008-07-09 Ｍｇｌｕｒ５アンタゴニスト活性を有するアセチレン誘導体

Country Status (31)

Country Link
US (4) US7348353B2 (enExample)
EP (1) EP1453512B8 (enExample)
JP (2) JP4176020B2 (enExample)
KR (2) KR100980901B1 (enExample)
CN (2) CN101366714B (enExample)
AR (2) AR037682A1 (enExample)
AT (1) ATE327755T1 (enExample)
AU (1) AU2002358585B2 (enExample)
BR (1) BR0214666A (enExample)
CA (1) CA2466560C (enExample)
CO (1) CO5590929A2 (enExample)
CY (1) CY1105460T1 (enExample)
DE (1) DE60211944T2 (enExample)
DK (1) DK1453512T3 (enExample)
EC (1) ECSP045139A (enExample)
EG (1) EG24936A (enExample)
ES (1) ES2263842T3 (enExample)
GB (1) GB0128996D0 (enExample)
HU (1) HU229429B1 (enExample)
IL (1) IL161990A0 (enExample)
MX (1) MXPA04005456A (enExample)
MY (1) MY137774A (enExample)
NO (1) NO327005B1 (enExample)
NZ (1) NZ533266A (enExample)
PE (1) PE20030640A1 (enExample)
PL (1) PL212996B1 (enExample)
PT (1) PT1453512E (enExample)
RU (1) RU2341515C2 (enExample)
TW (1) TWI328578B (enExample)
WO (1) WO2003047581A1 (enExample)
ZA (1) ZA200403713B (enExample)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0128996D0 (en) 2001-12-04 2002-01-23 Novartis Ag Organic compounds
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
GB0325956D0 (en) * 2003-11-06 2003-12-10 Addex Pharmaceuticals Sa Novel compounds
WO2005097127A2 (en) 2004-04-02 2005-10-20 Merck & Co., Inc. Method of treating men with metabolic and anthropometric disorders
GB0503646D0 (en) * 2005-02-22 2005-03-30 Novartis Ag Organic compounds
GB0508314D0 (en) * 2005-04-25 2005-06-01 Novartis Ag Organic compounds
GB0508318D0 (en) * 2005-04-25 2005-06-01 Novartis Ag Organic compounds
GB0508319D0 (en) 2005-04-25 2005-06-01 Novartis Ag Organic compounds
GB0514296D0 (en) * 2005-07-12 2005-08-17 Novartis Ag Organic compounds
JP2010502664A (ja) * 2006-09-11 2010-01-28 ノバルティス アクチエンゲゼルシャフト 代謝型グルタミン酸受容体の調節剤としてのニコチン酸誘導体
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
CN103601792B (zh) 2007-06-04 2016-06-29 协同医药品公司 有效用于胃肠功能紊乱、炎症、癌症和其他疾病治疗的鸟苷酸环化酶激动剂
RU2508107C2 (ru) * 2007-10-12 2014-02-27 Новартис Аг Модуляторы метаботропного глутаматного рецептора для лечения болезни паркинсона
AU2012254934B2 (en) * 2007-10-12 2013-10-17 Novartis Ag Metabotropic glutamate receptor modulators for the treatment of Parkinson's disease
AU2009256157B2 (en) 2008-06-04 2014-12-18 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US8703809B2 (en) 2008-06-30 2014-04-22 Novartis Ag Combination products
RU2513856C2 (ru) * 2008-08-12 2014-04-20 Новартис Аг Способы получения метилового эфира 4-оксооктагидроиндол-1-карбоновой кислоты и ее производные
US8334287B2 (en) 2009-07-17 2012-12-18 Hoffmann-La Roche Inc. Imidazoles
US20120157464A1 (en) 2009-07-23 2012-06-21 Novartis Ag Use of azabicycloalkyl derivatives or pyrrolidine-2-one derivatives for the treatment or prevention of ataxia
JO3250B1 (ar) 2009-09-22 2018-09-16 Novartis Ag إستعمال منشطات مستقبل نيكوتينيك أسيتيل كولين ألفا 7
EP2490691A1 (en) 2009-10-20 2012-08-29 Novartis AG Use of 1h-quinazoline-2,4-diones
US20130052644A1 (en) * 2010-04-30 2013-02-28 Baltazar Gomez-Mancilla Predictive Markers Useful in the Treatment of Fragile X Syndrome (FXS)
US20130096145A1 (en) 2010-06-24 2013-04-18 Novartis Ag Use of 1H-quinazoline-2,4-diones
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
EP2655326A1 (en) * 2010-12-20 2013-10-30 Novartis AG 4- (hetero) aryl - ethynyl - octahydro - indole - 1 - carboxylic acid esters
WO2012101058A1 (en) 2011-01-24 2012-08-02 Novartis Ag 4-tolyl-ethynyl-octahydro-indole-1-ester derivatives
JP2014503568A (ja) 2011-01-27 2014-02-13 ノバルティス アーゲー ニコチン酸アセチルコリン受容体α７活性化因子の使用
AU2012232711B2 (en) 2011-03-18 2016-04-28 Novartis Ag Combinations of alpha 7 nicotinic acetylcholine receptor activators and mGluR5 antagonists for use in dopamine induced dyskinesia in Parkinson's Disease
BR112014005210A2 (pt) 2011-09-07 2017-03-21 Novartis Ag uso de 1h-quinazolina-2,4-dionas para uso na prevenção ou tratamento da epilepsia fotossensível
WO2013131981A1 (en) 2012-03-08 2013-09-12 Novartis Ag Predictive markers useful in the diagnosis and treatment of fragile x syndrome (fxs)
GB201215033D0 (en) 2012-08-23 2012-10-10 Novartis Ag Diazepinone derivatives
CA2898045C (en) 2013-01-15 2018-08-28 Novartis Ag Use of alpha 7 nicotinic acetylcholine receptor agonists
JP6137336B2 (ja) 2013-01-15 2017-05-31 ノバルティス アーゲー ナルコレプシーの処置のためのアルファ７ニコチン性受容体アゴニストの使用
US9486494B2 (en) 2013-03-15 2016-11-08 Synergy Pharmaceuticals, Inc. Compositions useful for the treatment of gastrointestinal disorders
WO2014151206A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
EP4424697A3 (en) 2013-06-05 2024-12-25 Bausch Health Ireland Limited Ultra-pure agonists of guanylate cyclase c, method of making and using same
PT3007682T (pt) * 2013-06-12 2017-11-02 Novartis Ag Formulação de libertação modificada
GB201312800D0 (en) 2013-07-17 2013-08-28 Heptares Therapeutics Ltd mGlu5 modulators
CN105669686B (zh) * 2014-11-19 2018-08-03 上海合全药业股份有限公司 一种6-(叔丁氧羰基)八氢呋喃[2,3-c]吡啶-4-羧酸的合成方法
CN110891564A (zh) 2017-07-31 2020-03-17 诺华股份有限公司 玛沃谷兰在减少酒精使用或在预防复用酒精中的用途
CA3066711A1 (en) 2017-07-31 2019-02-07 Novartis Ag Use of mavoglurant in the reduction of cocaine use or in preventing relapse into cocaine use
BR112021014342A2 (pt) 2019-01-29 2021-09-21 Novartis Ag Uso de um antagonista mglur5 para tratar tolerância a analgésico opioide
ES2961678T3 (es) * 2019-11-05 2024-03-13 Claes Thulin 4-[5-[(rac)-1-[5-(3-clorofenil)-3-isoxazolil]etoxi]-4-metil-4h-1,2,4-triazol-3-il]piridina para su uso en la prevención y/o el tratamiento del estrés
CA3181961A1 (en) * 2020-07-17 2022-01-20 Novartis Ag Use of mglur5 antagonists
CN116710084A (zh) 2020-12-11 2023-09-05 诺华股份有限公司 mGluR5拮抗剂用于治疗安非他命成瘾的用途
CN116981456A (zh) 2020-12-14 2023-10-31 诺华股份有限公司 mGluR5拮抗剂用于治疗赌博障碍的用途

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2741009A1 (de) * 1976-09-22 1978-03-23 Sandoz Ag 4-styryl-4-indolinol-derivate, ihre verwendung und herstellung
DE2802833A1 (de) 1978-01-23 1979-07-26 Sandoz Ag 4-styryl-4-indolinol-derivate, ihre verwendung und herstellung
US5264456A (en) * 1989-12-29 1993-11-23 Allergan, Inc. Acetylenes disubstituted with a furyl group and a substituted phenyl group having retinoid like activity
US5284957A (en) * 1992-09-03 1994-02-08 Eli Lilly And Company Excitatory amino acid receptor antagonists
US5593994A (en) 1994-09-29 1997-01-14 The Dupont Merck Pharmaceutical Company Prostaglandin synthase inhibitors
WO1997008133A1 (fr) 1995-08-22 1997-03-06 Japan Tobacco Inc. Composes amide et leur utilisation
CA2258728C (en) 1996-06-19 2011-09-27 Rhone Poulenc Rorer Limited Substituted azabicylic compounds and their use as inhibitors of the production of tnf and cyclic amp phosphodiesterase
TW544448B (en) * 1997-07-11 2003-08-01 Novartis Ag Pyridine derivatives
DE69915472T2 (de) 1998-06-04 2004-08-19 Kumiai Chemical Industry Co., Ltd. Phenylacetylenderivate und bakterizide für landwirtschaft und gartenbau
WO2000020001A1 (en) 1998-10-02 2000-04-13 Novartis Ag Mglur5 antagonists for the treatment of pain and anxiety
HRP20020013A2 (en) 1999-07-06 2003-08-31 Lilly Co Eli SELECTIVE iGluR<SUB>5</SUB> RECEPTOR ANTAGONISTS FOR THE TREATMENT OF MIGRAINE
GB0007108D0 (en) 2000-03-23 2000-05-17 Novartis Ag Organic compounds
CA2426430C (en) 2000-10-20 2014-10-07 Biocryst Pharmaceuticals, Inc. Biaryl compounds as serine protease inhibitors
KR100515549B1 (ko) 2000-12-04 2005-09-20 에프. 호프만-라 로슈 아게 글루타메이트 수용체 길항제로서의 페닐에테닐 또는페닐에티닐 유도체
GB0103045D0 (en) * 2001-02-07 2001-03-21 Novartis Ag Organic Compounds
US7138404B2 (en) 2001-05-23 2006-11-21 Hoffmann-La Roche Inc. 4-aminopyrimidine derivatives
TW200303309A (en) 2001-12-04 2003-09-01 Bristol Myers Squibb Co Novel n-[4-(1h-imidazol-1-yl)-2-fluorophenyl]-3-trifluoromethyl)-1h-pyrazole-5-carboxamides as factor Xa inhibitors
MXPA04005263A (es) 2001-12-04 2004-10-11 Hoffmann La Roche 2-amino-cicloalcanocarboxamidas substituidas y su uso como inhibidores de cisteina proteasa.
GB0128996D0 (en) * 2001-12-04 2002-01-23 Novartis Ag Organic compounds

Similar Documents

Publication Publication Date Title
JP2005514381A5 (enExample)
KR880001426B1 (ko) 세팔로스포린 제조용 중간체의 제조방법
CA2481742C (fr) Procedes de preparation de combretastatines
JPH11263764A5 (enExample)
JPH0583550B2 (enExample)
JP2769058B2 (ja) シクロプロパン誘導体の製法
JPS621392B2 (enExample)
BE858864A (fr) Nouveaux esters d&#39;acides phenyl- et pyridine-3-carboxylique et procede permettant leur preparation
JP2716243B2 (ja) Ｎ―ベンジル―３―ヒドロキシスクシンアミド酸およびその製造法
CN110590641B (zh) 一种3-羟基异吲哚-1-酮系列化合物的绿色制备方法
CN102898373B (zh) Z-3-酰氧基-3-(1-乙基吡唑基)丙烯腈类化合物的制备方法
JPH06184108A (ja) ５−クロロオキシインドールの製造方法
JPH0129793B2 (enExample)
US5153330A (en) Thiapentanamide derivatives
JP2671401B2 (ja) α‐アミノチオアセトアミド誘導体およびその製造法
JP3224584B2 (ja) ２，３−ジヒドロインドール−３，３−ジカルボン酸及び２，３−ジヒドロインドール−３−カルボン酸誘導体
JPS6310143B2 (enExample)
JPH01168664A (ja) シクロヘキセノン誘導体およびその製造法
JPS6125716B2 (enExample)
JP2711435B2 (ja) 新規な２，３−ジヒドロ−４ｈ−１−ベンゾピラン−４−オン誘導体またはその塩
JPS5935369B2 (ja) 光学活性化合物の立体選択的合成法
JPH0459315B2 (enExample)
JPS58164573A (ja) １−（４−クロロベンゾイル）−５−メトキシ−２−メチル−３−インド−ルアセトキシ酢酸類の製法
JP2001039947A (ja) アシルジスルフィド類の製造方法
CN1290247A (zh) 制备抗叶酸剂的方法和中间体