JP2005509590A5 - - Google Patents
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- Publication number
- JP2005509590A5 JP2005509590A5 JP2003503584A JP2003503584A JP2005509590A5 JP 2005509590 A5 JP2005509590 A5 JP 2005509590A5 JP 2003503584 A JP2003503584 A JP 2003503584A JP 2003503584 A JP2003503584 A JP 2003503584A JP 2005509590 A5 JP2005509590 A5 JP 2005509590A5
- Authority
- JP
- Japan
- Prior art keywords
- phenyl
- methoxy
- phenoxy
- compound
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 CC1CC(*)CC1 Chemical compound CC1CC(*)CC1 0.000 description 6
- KBUMRZDHHWZVLY-QHCPKHFHSA-N CC(C)CCOc(cc1)ccc1OCCCOc1ccc(C[C@@H](C(O)=O)OC)cc1 Chemical compound CC(C)CCOc(cc1)ccc1OCCCOc1ccc(C[C@@H](C(O)=O)OC)cc1 KBUMRZDHHWZVLY-QHCPKHFHSA-N 0.000 description 1
- ZHTXOZRZDZMDFO-RBPNCNDUSA-N CCO[C@@H](Cc(cc1)ccc1[U]CCCOc1ccc(Cc2ccccc2)cc1)C(O)=O Chemical compound CCO[C@@H](Cc(cc1)ccc1[U]CCCOc1ccc(Cc2ccccc2)cc1)C(O)=O ZHTXOZRZDZMDFO-RBPNCNDUSA-N 0.000 description 1
- MROYGGAYTUSPIQ-AWEZNQCLSA-N CNOc(cccc1)c1-c1cc(C[C@@H](C(O)=O)O)ccc1O Chemical compound CNOc(cccc1)c1-c1cc(C[C@@H](C(O)=O)O)ccc1O MROYGGAYTUSPIQ-AWEZNQCLSA-N 0.000 description 1
- BDKJFRYEWUMYHB-WNMGUVTHSA-N CO[C@@H](Cc(cc1)ccc1OC(CC1)CC1Oc(cc1)ccc1-c1ccccc1)C(O)=O Chemical compound CO[C@@H](Cc(cc1)ccc1OC(CC1)CC1Oc(cc1)ccc1-c1ccccc1)C(O)=O BDKJFRYEWUMYHB-WNMGUVTHSA-N 0.000 description 1
- VRQBRUCGPYEDQT-DEOSSOPVSA-N CO[C@@H](Cc(cc1)ccc1OCCCOc(cc1)ccc1-c(cc1)ccc1O)C(O)=O Chemical compound CO[C@@H](Cc(cc1)ccc1OCCCOc(cc1)ccc1-c(cc1)ccc1O)C(O)=O VRQBRUCGPYEDQT-DEOSSOPVSA-N 0.000 description 1
- JZQPRALNKOORGZ-XMMPIXPASA-N CO[C@H](Cc(ccc(OCCCOc(cc1)ccc1-c1ccccc1)c1)c1F)C(O)=O Chemical compound CO[C@H](Cc(ccc(OCCCOc(cc1)ccc1-c1ccccc1)c1)c1F)C(O)=O JZQPRALNKOORGZ-XMMPIXPASA-N 0.000 description 1
- ZJBQYRLHEYPLEL-VIFPVBQESA-N C[C@@H](Cc1ccc(C)cc1)C(O)=O Chemical compound C[C@@H](Cc1ccc(C)cc1)C(O)=O ZJBQYRLHEYPLEL-VIFPVBQESA-N 0.000 description 1
- NJDSWUXGRSJHKV-UHFFFAOYSA-N C[O]#CC(Cc(cc1)ccc1OCCCOc(cc1)ccc1C(c1c(cccc2)c2ccc1)=O)C(O)=O Chemical compound C[O]#CC(Cc(cc1)ccc1OCCCOc(cc1)ccc1C(c1c(cccc2)c2ccc1)=O)C(O)=O NJDSWUXGRSJHKV-UHFFFAOYSA-N 0.000 description 1
- YXVFYQXJAXKLAK-UHFFFAOYSA-N Oc(cc1)ccc1-c1ccccc1 Chemical compound Oc(cc1)ccc1-c1ccccc1 YXVFYQXJAXKLAK-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29714401P | 2001-06-07 | 2001-06-07 | |
| US60/297,144 | 2001-06-07 | ||
| PCT/US2002/016950 WO2002100813A2 (en) | 2001-06-07 | 2002-05-30 | Modulators of peroxisome proliferator activated receptors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005509590A JP2005509590A (ja) | 2005-04-14 |
| JP2005509590A6 JP2005509590A6 (ja) | 2005-08-04 |
| JP2005509590A5 true JP2005509590A5 (https=) | 2006-01-05 |
Family
ID=23145037
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003503584A Pending JP2005509590A (ja) | 2001-06-07 | 2002-05-30 | ペルオキシソーム増殖因子活性化受容体の調節物質 |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US7192982B2 (https=) |
| EP (1) | EP1392637A2 (https=) |
| JP (1) | JP2005509590A (https=) |
| KR (1) | KR20040012905A (https=) |
| CN (1) | CN1543451A (https=) |
| AR (1) | AR036084A1 (https=) |
| BR (1) | BR0210190A (https=) |
| CA (1) | CA2449256A1 (https=) |
| CO (1) | CO5640097A2 (https=) |
| CZ (1) | CZ20033309A3 (https=) |
| EA (1) | EA200400010A1 (https=) |
| EC (1) | ECSP034877A (https=) |
| EE (1) | EE200400001A (https=) |
| HR (1) | HRP20031001A2 (https=) |
| HU (1) | HUP0400280A3 (https=) |
| IL (1) | IL158873A0 (https=) |
| MX (1) | MXPA03011201A (https=) |
| NO (1) | NO20035439D0 (https=) |
| NZ (1) | NZ529351A (https=) |
| PE (1) | PE20030099A1 (https=) |
| PL (1) | PL368051A1 (https=) |
| SK (1) | SK14912003A3 (https=) |
| WO (1) | WO2002100813A2 (https=) |
| ZA (1) | ZA200308863B (https=) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA200400011A1 (ru) | 2001-06-07 | 2004-06-24 | Эли Лилли Энд Компани | Модуляторы рецепторов, активируемых пролифераторами пероксисом (prar) |
| MXPA03011201A (es) * | 2001-06-07 | 2004-02-26 | Lilly Co Eli | Moduladores de receptores activados por proliferadores de persoxisomas. |
| MXPA03011558A (es) * | 2001-06-12 | 2004-03-26 | Wellstat Therapeutics Corp | Compuestos para el tratamiento de desordenes metabolicos. |
| ITRM20020016A1 (it) * | 2002-01-15 | 2003-07-15 | Sigma Tau Ind Farmaceuti | Derivati di acidi fenil(alchil)carbossilici e derivati fenilalchileterociclici dionici, loro uso come medicamenti ad attivita' ipoglicemizza |
| PL376736A1 (pl) * | 2002-11-25 | 2006-01-09 | Galderma Research & Development, S.N.C. | Nowe związki diaromatyczne, które aktywują receptor typu PPAR<$Egamma> i ich zastosowanie w kompozycjach kosmetycznych lub farmaceutycznych |
| FR2847580B1 (fr) * | 2002-11-25 | 2006-03-03 | Galderma Res & Dev | NOUVEAUX COMPOSES BI-AROMATIQUES ACTIVATEURS DES RECEPTEURS DE TYPE PPARy ET LEUR UTILISATION DANS DES COMPOSITIONS COSMETIQUES OU PHARMACEUTIQUES |
| US7192970B2 (en) * | 2002-11-26 | 2007-03-20 | Chipscreen Biosciences, Ltd. | Noncyclic 1,3-dicarbonyl compounds as dual PPAR agonists with potent antihyperglycemic and antihyperlipidemic activity |
| CN1751037A (zh) | 2003-02-14 | 2006-03-22 | 伊莱利利公司 | 作为ppar调节剂的磺酰胺衍生物 |
| GB0314075D0 (en) * | 2003-06-18 | 2003-07-23 | Astrazeneca Ab | Therapeutic agents |
| WO2005009104A2 (en) * | 2003-07-16 | 2005-02-03 | Ligand Pharmacueticals Incorporated | Benzoic and phenyl acetic acid derivatives as hnf-4 modulators |
| JP2007502815A (ja) * | 2003-08-20 | 2007-02-15 | イーライ リリー アンド カンパニー | Ｐｐａｒ調節因子 |
| EP1667964B1 (en) | 2003-09-19 | 2009-07-22 | Janssen Pharmaceutica N.V. | 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs |
| EP1675814A1 (en) * | 2003-10-14 | 2006-07-05 | Eli Lilly And Company | Phenoxyether derivatives as ppar modulators |
| JP4074616B2 (ja) * | 2003-12-25 | 2008-04-09 | 武田薬品工業株式会社 | ３−（４−ベンジルオキシフェニル）プロパン酸誘導体 |
| AU2004309271A1 (en) | 2003-12-25 | 2005-07-14 | Takeda Pharmaceutical Company Limited | 3-(4-benzyloxyphenyl)propanoic acid derivatives |
| US7262318B2 (en) * | 2004-03-10 | 2007-08-28 | Pfizer, Inc. | Substituted heteroaryl- and phenylsulfamoyl compounds |
| BRPI0510803A (pt) * | 2004-05-12 | 2007-11-06 | Proteotech Inc | composto, composição farmacêutica, artigo de fabricação, métodos de tratar ou prevenir a formação, deposição, acúmulo ou persistência de fibrilas de amilóide e de fibrilas de sinucleìna, e de tratar, prevenir ou melhorar um ou mais sintomas de uma doença amilóide ou uma sinucleinopatia em um mamìfero, e, uso do composto |
| FR2872159B1 (fr) * | 2004-06-28 | 2007-10-05 | Merck Sante Soc Par Actions Si | Nouveaux derives acides carboxyliques phenyliques et leur utilisation dans le traitement du diabete |
| US20050288340A1 (en) * | 2004-06-29 | 2005-12-29 | Pfizer Inc | Substituted heteroaryl- and phenylsulfamoyl compounds |
| TW200608967A (en) | 2004-07-29 | 2006-03-16 | Sankyo Co | Pharmaceutical compositions containing with diabetic agent |
| US7622491B2 (en) * | 2004-08-13 | 2009-11-24 | Metabolex Inc. | Modulators of PPAR and methods of their preparation |
| US7405236B2 (en) * | 2004-08-16 | 2008-07-29 | Hoffman-La Roche Inc. | Indole derivatives comprising an acetylene group |
| CN101014332A (zh) * | 2004-09-13 | 2007-08-08 | 参天制药株式会社 | 角膜结膜病变治疗剂 |
| MY147518A (en) | 2004-09-15 | 2012-12-31 | Janssen Pharmaceutica Nv | 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs |
| MY145712A (en) * | 2004-09-15 | 2012-03-30 | Janssen Pharmaceutica Nv | 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs |
| US7635779B2 (en) * | 2004-10-15 | 2009-12-22 | Council Of Scientific & Industrial Research | Oxy substituted flavones as antihyperglycemic and antidyslipidemic agents |
| FR2882359A1 (fr) * | 2005-02-24 | 2006-08-25 | Negma Lerads Soc Par Actions S | Derives activateurs de ppar, procede de preparation et application en therapeutique |
| JO3006B1 (ar) * | 2005-09-14 | 2016-09-05 | Janssen Pharmaceutica Nv | املاح ليسين مبتكرة من مشتقات حامض 4-((فينوكسي الكيل)ثيو) فينوكسي الخليك |
| KR20080106455A (ko) * | 2006-03-31 | 2008-12-05 | 웰스태트 테러퓨틱스 코포레이션 | 대사장애의 조합치료 |
| UY30288A1 (es) | 2006-04-18 | 2007-08-31 | Janssen Pharmaceutica Nv | Derivados del ácido benzoazepin-oxi-acético como agonistas de ppar-delta usados para aumentar hdl-c. reducir ldl-c y reducir colesterol |
| JP2010502670A (ja) | 2006-09-07 | 2010-01-28 | ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング | 真性糖尿病のための組合せ治療 |
| CN102114076B (zh) * | 2006-10-25 | 2013-04-10 | 中国科学院上海生命科学研究院 | 肉桂提取物的制备方法、肉桂提取物、其组合物以及用途 |
| ES2465216T3 (es) | 2007-06-04 | 2014-06-05 | Ben Gurion University Of The Negev Research And Development Authority | Compuestos de triarilo y composiciones que comprenden los mismos |
| JP5496913B2 (ja) * | 2008-01-15 | 2014-05-21 | ウェルスタット セラピューティクス コーポレイション | 代謝異常の治療のための化合物 |
| US20090238900A1 (en) * | 2008-03-24 | 2009-09-24 | Himalaya Global Holdings Limited | Novel anti-diabetic herbal composition, method for preparing the same and use thereof |
| JP5436941B2 (ja) * | 2009-06-03 | 2014-03-05 | あすか製薬株式会社 | ラクタム化合物又はその塩及びｐｐａｒ活性化剤 |
| AU2011281134B2 (en) * | 2010-07-23 | 2015-05-14 | Connexios Life Sciences Pvt. Ltd. | Agonists of GPR40 |
| RU2015140066A (ru) | 2013-02-22 | 2017-03-30 | Мерк Шарп И Доум Корп. | Противодиабетические бициклические соединения |
| CR20160207A (es) | 2013-11-05 | 2016-08-10 | Ben Gurion Univ Of The Negev Res And Dev Authority | Compuestos para el tratamiento de la diabetes y las complicaciones que surgen de la misma enfermedad |
| CN105037290A (zh) * | 2015-07-14 | 2015-11-11 | 佛山市赛维斯医药科技有限公司 | 一类含苯并异恶唑和腈基苯类结构化合物及其用途 |
| CN104974103A (zh) * | 2015-07-14 | 2015-10-14 | 佛山市赛维斯医药科技有限公司 | 一类含苯并异恶唑和烷氧苯基类结构的化合物及其用途 |
| CN104961702A (zh) * | 2015-07-14 | 2015-10-07 | 佛山市赛维斯医药科技有限公司 | 苯并异恶唑类11β-HSD1抑制剂、制备方法及其用途 |
| CN104926742A (zh) * | 2015-07-14 | 2015-09-23 | 佛山市赛维斯医药科技有限公司 | 一类含苯并异恶唑和硝基苯基类结构的化合物及其用途 |
| CN104987314A (zh) * | 2015-07-14 | 2015-10-21 | 佛山市赛维斯医药科技有限公司 | 含苯并异恶唑和末端硝基苄基类结构的化合物及其用途 |
| CN104926746A (zh) * | 2015-07-14 | 2015-09-23 | 佛山市赛维斯医药科技有限公司 | 含苯并异恶唑和末端胺基苄基类结构的化合物及其用途 |
| CN105001174A (zh) * | 2015-07-14 | 2015-10-28 | 佛山市赛维斯医药科技有限公司 | 含苯并异恶唑和末端腈基苄基类结构的化合物及其用途 |
| CN104926744A (zh) * | 2015-07-14 | 2015-09-23 | 佛山市赛维斯医药科技有限公司 | 一类含苯并异恶唑和末端苄基类结构的化合物及其用途 |
| CN104945344A (zh) * | 2015-07-14 | 2015-09-30 | 佛山市赛维斯医药科技有限公司 | 一类含苯并异恶唑和末端胺基结构化合物及其用途 |
| CN104926743A (zh) * | 2015-07-14 | 2015-09-23 | 佛山市赛维斯医药科技有限公司 | 含苯并异恶唑和末端苄基类结构的化合物及其用途 |
| CN104961703A (zh) * | 2015-07-14 | 2015-10-07 | 佛山市赛维斯医药科技有限公司 | 一类苯并异恶唑类11β-HSD1抑制剂、制备方法及其用途 |
| CN104926745A (zh) * | 2015-07-14 | 2015-09-23 | 佛山市赛维斯医药科技有限公司 | 含苯并异恶唑和末端卤代苄基类结构的化合物及其用途 |
| MX2020003242A (es) | 2017-09-22 | 2020-09-18 | Jubilant Epipad LLC | Compuestos heterociclicos como inhibidores de pad. |
| AU2018352142B2 (en) | 2017-10-18 | 2022-08-25 | Jubilant Epipad LLC | Imidazo-pyridine compounds as PAD inhibitors |
| KR20200085836A (ko) | 2017-11-06 | 2020-07-15 | 주빌런트 프로델 엘엘씨 | Pd1/pd-l1 활성화 억제제로서의 피리미딘 유도체 |
| BR112020010322A2 (pt) | 2017-11-24 | 2020-11-17 | Jubilant Episcribe Llc | composto da fórmula i; composto da fórmula ia; composto da fórmula ib; processo de preparação de compostos da fórmula i; composição farmacêutica; método para o tratamento e/ou prevenção de várias doenças; uso dos compostos; método para o tratamento de câncer; e método para o tratamento e/ou prevenção de uma afecção mediada por prmt5 ou um distúrbio proliferativo ou câncer |
| SG11202008950PA (en) | 2018-03-13 | 2020-10-29 | Jubilant Prodel LLC | Bicyclic compounds as inhibitors of pd1/pd-l1 interaction/activation |
| SG11202107614PA (en) | 2019-01-18 | 2021-08-30 | Astrazeneca Ab | Pcsk9 inhibitors and methods of use thereof |
| WO2025079680A1 (ja) * | 2023-10-13 | 2025-04-17 | 国立研究開発法人国立精神・神経医療研究センター | 神経保護剤 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5089514A (en) | 1990-06-14 | 1992-02-18 | Pfizer Inc. | 3-coxazolyl [phenyl, chromanyl or benzofuranyl]-2-hydroxypropionic acid derivatives and analogs as hypoglycemic agents |
| PH30449A (en) * | 1991-11-25 | 1997-05-28 | Lilly Co Eli | Substituted phenyl phenol leukotriene antagonists |
| US5232945A (en) | 1992-07-20 | 1993-08-03 | Pfizer Inc. | 3-aryl-2-hydroxypropionic acid derivatives and analogs as antihypertensives |
| US5387672A (en) * | 1993-03-02 | 1995-02-07 | The University Of Maryland At Baltimore | Hemoglobin intramolecularly cross-linked withlong chain divalent reagents |
| EP0743064A1 (en) * | 1995-05-17 | 1996-11-20 | Eli Lilly And Company | Leukotriene antagonists for use in the treatment or prevention of alzheimer's disease |
| JP3964478B2 (ja) | 1995-06-30 | 2007-08-22 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ヘテロ環含有カルボン酸誘導体及びそれを含有する医薬 |
| GB9604242D0 (en) * | 1996-02-28 | 1996-05-01 | Glaxo Wellcome Inc | Chemical compounds |
| EP0903343B1 (en) | 1997-09-19 | 2003-05-28 | SSP Co., Ltd. | Alpha-Substituted phenylpropionic acid derivative and medicine containing the same |
| AU749505B2 (en) | 1997-10-27 | 2002-06-27 | Dr. Reddy's Laboratories Limited | Novel tricyclic compounds and their use in medicine; process for their preparation and pharmaceutical compositions containing them |
| ATE451346T1 (de) | 1998-03-10 | 2009-12-15 | Ono Pharmaceutical Co | Carbonsäurederivate und medikamente die diese als aktiven wirkstoff enthalten |
| SE9801992D0 (sv) | 1998-06-04 | 1998-06-04 | Astra Ab | New 3-aryl-2-hydroxypropionic acid derivative I |
| SE9801990D0 (sv) | 1998-06-04 | 1998-06-04 | Astra Ab | New 3-aryl propionic acid derivatives and analogs |
| DE60005973T2 (de) * | 1999-08-27 | 2004-05-13 | Eli Lilly And Co., Indianapolis | Biaryl-oxa(thia)zolderivate und ihre verwendung als ppars modulatoren |
| TWI262185B (en) | 1999-10-01 | 2006-09-21 | Eisai Co Ltd | Carboxylic acid derivatives having anti-hyperglycemia and anti-hyperlipemia action, and pharmaceutical composition containing the derivatives |
| AU2001248279A1 (en) * | 2000-04-17 | 2001-10-30 | Novo-Nordisk A/S | New compounds, their preparation and use |
| EP1313717B1 (en) * | 2000-08-23 | 2007-10-17 | Eli Lilly And Company | Oxazolyl-arylpropionic acid derivatives and their use as ppar agonists |
| KR100659679B1 (ko) | 2000-09-01 | 2006-12-21 | 에자이 가부시키가이샤 | 1-벤질-4-[(5,6-디메톡시-2-플루오로-1-인다논)-2-일]메틸피페리딘 |
| JPWO2002080899A1 (ja) * | 2001-03-30 | 2005-01-06 | エーザイ株式会社 | 消化器疾患治療剤 |
| TWI311133B (en) * | 2001-04-20 | 2009-06-21 | Eisai R&D Man Co Ltd | Carboxylic acid derivativeand the salt thereof |
| MXPA03011201A (es) * | 2001-06-07 | 2004-02-26 | Lilly Co Eli | Moduladores de receptores activados por proliferadores de persoxisomas. |
-
2002
- 2002-05-30 MX MXPA03011201A patent/MXPA03011201A/es unknown
- 2002-05-30 NZ NZ529351A patent/NZ529351A/en unknown
- 2002-05-30 BR BR0210190-4A patent/BR0210190A/pt not_active IP Right Cessation
- 2002-05-30 EA EA200400010A patent/EA200400010A1/ru unknown
- 2002-05-30 SK SK1491-2003A patent/SK14912003A3/sk not_active Application Discontinuation
- 2002-05-30 PL PL02368051A patent/PL368051A1/xx not_active Application Discontinuation
- 2002-05-30 JP JP2003503584A patent/JP2005509590A/ja active Pending
- 2002-05-30 CZ CZ20033309A patent/CZ20033309A3/cs unknown
- 2002-05-30 EE EEP200400001A patent/EE200400001A/xx unknown
- 2002-05-30 IL IL15887302A patent/IL158873A0/xx unknown
- 2002-05-30 HU HU0400280A patent/HUP0400280A3/hu unknown
- 2002-05-30 US US10/479,262 patent/US7192982B2/en not_active Expired - Fee Related
- 2002-05-30 CN CNA028115309A patent/CN1543451A/zh active Pending
- 2002-05-30 WO PCT/US2002/016950 patent/WO2002100813A2/en not_active Ceased
- 2002-05-30 EP EP02739503A patent/EP1392637A2/en not_active Withdrawn
- 2002-05-30 KR KR10-2003-7016050A patent/KR20040012905A/ko not_active Withdrawn
- 2002-05-30 CA CA002449256A patent/CA2449256A1/en not_active Abandoned
- 2002-05-30 HR HR20031001A patent/HRP20031001A2/hr not_active Application Discontinuation
- 2002-06-06 AR ARP020102096A patent/AR036084A1/es not_active Application Discontinuation
- 2002-06-07 PE PE2002000484A patent/PE20030099A1/es not_active Application Discontinuation
-
2003
- 2003-11-13 ZA ZA200308863A patent/ZA200308863B/en unknown
- 2003-12-04 EC EC2003004877A patent/ECSP034877A/es unknown
- 2003-12-05 NO NO20035439A patent/NO20035439D0/no not_active Application Discontinuation
- 2003-12-05 CO CO03107407A patent/CO5640097A2/es not_active Application Discontinuation
-
2006
- 2006-12-11 US US11/637,223 patent/US20070276138A1/en not_active Abandoned
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| Publication | Publication Date | Title |
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| JP2005509590A5 (https=) | ||
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