JP2005508978A - Ｐｄｅ９阻害薬によるインスリン抵抗性症候群及び２型糖尿病の治療 - Google Patents
Ｐｄｅ９阻害薬によるインスリン抵抗性症候群及び２型糖尿病の治療 Download PDFInfo
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- JP2005508978A JP2005508978A JP2003539771A JP2003539771A JP2005508978A JP 2005508978 A JP2005508978 A JP 2005508978A JP 2003539771 A JP2003539771 A JP 2003539771A JP 2003539771 A JP2003539771 A JP 2003539771A JP 2005508978 A JP2005508978 A JP 2005508978A
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- alkyl
- optionally substituted
- phenyl
- inhibitor
- halo
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Classifications
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- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A61K31/5375—1,4-Oxazines, e.g. morpholine
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Landscapes
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33698101P | 2001-11-02 | 2001-11-02 | |
| PCT/IB2002/003754 WO2003037432A1 (en) | 2001-11-02 | 2002-09-12 | Treatment of insulin resistance syndrome and type 2 diabetes with pde9 inhibitors |
Publications (2)
| Publication Number | Publication Date |
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| JP2005508978A true JP2005508978A (ja) | 2005-04-07 |
| JP2005508978A5 JP2005508978A5 (enExample) | 2005-12-22 |
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Country Status (13)
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| US (2) | US6967204B2 (enExample) |
| EP (1) | EP1444009A1 (enExample) |
| JP (1) | JP2005508978A (enExample) |
| KR (1) | KR20040053210A (enExample) |
| CN (1) | CN1575191A (enExample) |
| BR (1) | BR0213817A (enExample) |
| CA (1) | CA2465632A1 (enExample) |
| HU (1) | HUP0401998A2 (enExample) |
| IL (1) | IL161155A0 (enExample) |
| MX (1) | MXPA04004170A (enExample) |
| PL (1) | PL370599A1 (enExample) |
| WO (1) | WO2003037432A1 (enExample) |
| ZA (1) | ZA200402173B (enExample) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2005527565A (ja) * | 2002-03-28 | 2005-09-15 | ウスタフ エクスペリメンタルニ ボタニキ エーブイ シーアール （インスティチュート オブ エクスペリメンタル ボタニー アカデミー オブ サイエンシーズ オブ ザ チェコ リパブリック） | 新しいピラゾロ［４，３−ｄ］ピリミジン、その調整方法、及び治療方法 |
| WO2008018306A1 (en) * | 2006-08-08 | 2008-02-14 | Aska Pharmaceutical Co., Ltd. | Quinazoline derivative |
| WO2008072778A1 (ja) * | 2006-12-13 | 2008-06-19 | Aska Pharmaceutical Co., Ltd. | 尿路系疾患の処置剤 |
| JP2010526863A (ja) * | 2007-05-11 | 2010-08-05 | ファイザー・インク | アミノ複素環式化合物 |
| JP2011504913A (ja) * | 2007-11-30 | 2011-02-17 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | １，５−ジヒドロ−ピラゾロ［３，４−ｄ］ピリミジン−４−オン誘導体及びｃｎｓ障害の治療のためのｐｄｅ９ａモジュレーターとしてのそれらの使用 |
| JP2013540755A (ja) * | 2010-09-20 | 2013-11-07 | エンビボ・ファーマシューティカルズ・インコーポレイテッド | イミダゾトリアジノン化合物 |
| JP2015067538A (ja) * | 2013-09-26 | 2015-04-13 | 株式会社アイエイアイ | 血糖値降下剤 |
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| KR20040066788A (ko) | 2001-08-31 | 2004-07-27 | 더 락커펠러 유니버시티 | 프스포다이에스터레이즈 활성 및 뇌에서프스포다이에스터레이즈 1ｂ 매개되는 신호의 조절 |
| KR20040053210A (ko) * | 2001-11-02 | 2004-06-23 | 화이자 프로덕츠 인크. | Ｐｄｅ9 억제제를 사용한 인슐린 저항 증후군 및 2형당뇨병의 치료 |
| US20030195205A1 (en) * | 2001-11-02 | 2003-10-16 | Pfizer Inc. | PDE9 inhibitors for treating cardiovascular disorders |
| AU2002351183B2 (en) * | 2001-12-06 | 2008-05-08 | Merck Sharp & Dohme Corp. | Mitotic kinesin inhibitors |
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| JP5567503B2 (ja) | 2008-02-29 | 2014-08-06 | コンサート ファーマシューティカルズ インコーポレイテッド | 置換キサンチン誘導体 |
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| US4666908A (en) * | 1985-04-05 | 1987-05-19 | Warner-Lambert Company | 5-Substituted pyrazolo[4,3-d]pyrimidine-7-ones and methods of use |
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| US6683080B2 (en) * | 2001-02-02 | 2004-01-27 | Pfizer Inc. | Treatment of diabetes mellitus |
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| KR20040053210A (ko) * | 2001-11-02 | 2004-06-23 | 화이자 프로덕츠 인크. | Ｐｄｅ9 억제제를 사용한 인슐린 저항 증후군 및 2형당뇨병의 치료 |
| US20040220186A1 (en) * | 2003-04-30 | 2004-11-04 | Pfizer Inc. | PDE9 inhibitors for treating type 2 diabetes,metabolic syndrome, and cardiovascular disease |
-
2002
- 2002-09-12 KR KR10-2004-7006251A patent/KR20040053210A/ko not_active Ceased
- 2002-09-12 BR BR0213817-4A patent/BR0213817A/pt not_active IP Right Cessation
- 2002-09-12 WO PCT/IB2002/003754 patent/WO2003037432A1/en not_active Ceased
- 2002-09-12 JP JP2003539771A patent/JP2005508978A/ja not_active Withdrawn
- 2002-09-12 HU HU0401998A patent/HUP0401998A2/hu unknown
- 2002-09-12 MX MXPA04004170A patent/MXPA04004170A/es unknown
- 2002-09-12 CA CA002465632A patent/CA2465632A1/en not_active Abandoned
- 2002-09-12 EP EP02762720A patent/EP1444009A1/en not_active Withdrawn
- 2002-09-12 PL PL02370599A patent/PL370599A1/xx not_active Application Discontinuation
- 2002-09-12 CN CNA028211529A patent/CN1575191A/zh active Pending
- 2002-09-12 IL IL16115502A patent/IL161155A0/xx unknown
- 2002-10-29 US US10/283,814 patent/US6967204B2/en not_active Expired - Fee Related
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2004
- 2004-03-18 ZA ZA200402173A patent/ZA200402173B/en unknown
- 2004-09-15 US US10/942,438 patent/US20050070557A1/en not_active Abandoned
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005527565A (ja) * | 2002-03-28 | 2005-09-15 | ウスタフ エクスペリメンタルニ ボタニキ エーブイ シーアール （インスティチュート オブ エクスペリメンタル ボタニー アカデミー オブ サイエンシーズ オブ ザ チェコ リパブリック） | 新しいピラゾロ［４，３−ｄ］ピリミジン、その調整方法、及び治療方法 |
| WO2008018306A1 (en) * | 2006-08-08 | 2008-02-14 | Aska Pharmaceutical Co., Ltd. | Quinazoline derivative |
| US8101624B2 (en) | 2006-08-08 | 2012-01-24 | Aska Pharmaceutical Co., Ltd. | Quinazoline derivatives |
| JP5193866B2 (ja) * | 2006-08-08 | 2013-05-08 | あすか製薬株式会社 | キナゾリン誘導体 |
| WO2008072778A1 (ja) * | 2006-12-13 | 2008-06-19 | Aska Pharmaceutical Co., Ltd. | 尿路系疾患の処置剤 |
| JP2010526863A (ja) * | 2007-05-11 | 2010-08-05 | ファイザー・インク | アミノ複素環式化合物 |
| JP2011504913A (ja) * | 2007-11-30 | 2011-02-17 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | １，５−ジヒドロ−ピラゾロ［３，４−ｄ］ピリミジン−４−オン誘導体及びｃｎｓ障害の治療のためのｐｄｅ９ａモジュレーターとしてのそれらの使用 |
| JP2013540755A (ja) * | 2010-09-20 | 2013-11-07 | エンビボ・ファーマシューティカルズ・インコーポレイテッド | イミダゾトリアジノン化合物 |
| JP2016104747A (ja) * | 2010-09-20 | 2016-06-09 | フォーラム・ファーマシューティカルズ・インコーポレイテッドＦｏｒｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃ． | イミダゾトリアジノン化合物 |
| JP2015067538A (ja) * | 2013-09-26 | 2015-04-13 | 株式会社アイエイアイ | 血糖値降下剤 |
Also Published As
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| ZA200402173B (en) | 2005-03-18 |
| BR0213817A (pt) | 2004-10-19 |
| IL161155A0 (en) | 2004-08-31 |
| US20040023989A1 (en) | 2004-02-05 |
| MXPA04004170A (es) | 2004-09-06 |
| US6967204B2 (en) | 2005-11-22 |
| PL370599A1 (en) | 2005-05-30 |
| HUP0401998A2 (hu) | 2005-01-28 |
| CA2465632A1 (en) | 2003-05-08 |
| KR20040053210A (ko) | 2004-06-23 |
| EP1444009A1 (en) | 2004-08-11 |
| CN1575191A (zh) | 2005-02-02 |
| US20050070557A1 (en) | 2005-03-31 |
| WO2003037432A1 (en) | 2003-05-08 |
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