BR0213817A - Tratamento de sìndrome de resistência à insulina e diabete do tipo 2 com inibidores da pde9 - Google Patents
Tratamento de sìndrome de resistência à insulina e diabete do tipo 2 com inibidores da pde9Info
- Publication number
- BR0213817A BR0213817A BR0213817-4A BR0213817A BR0213817A BR 0213817 A BR0213817 A BR 0213817A BR 0213817 A BR0213817 A BR 0213817A BR 0213817 A BR0213817 A BR 0213817A
- Authority
- BR
- Brazil
- Prior art keywords
- type
- diabetes
- treatment
- insulin resistance
- resistance syndrome
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/541—Non-condensed thiazines containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Abstract
"TRATAMENTO DE SìNDROME DE RESISTêNCIA à INSULINA E DIABETE DO TIPO 2 COM INIBIDORES DA PDE9". A presente invenção refere-se a um método de tratamento de síndrome de resistência à insulina (IRS), hipertensão e/ou diabete do tipo 2 em um mamífero, compreendendo administração ao dito mamífero de um inibidor da PDE9 do CGMP ou uma composição farmacêutica do mesmo. Esta invenção é também dirigida a métodos nos quais é usado o dito inibidor da PDE9 do CGMP em combinação com outros agentes para o tratamento de IRS, hipertensão e/ou diabete do tipo 2.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US33698101P | 2001-11-02 | 2001-11-02 | |
PCT/IB2002/003754 WO2003037432A1 (en) | 2001-11-02 | 2002-09-12 | Treatment of insulin resistance syndrome and type 2 diabetes with pde9 inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0213817A true BR0213817A (pt) | 2004-10-19 |
Family
ID=23318571
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0213817-4A BR0213817A (pt) | 2001-11-02 | 2002-09-12 | Tratamento de sìndrome de resistência à insulina e diabete do tipo 2 com inibidores da pde9 |
Country Status (13)
Country | Link |
---|---|
US (2) | US6967204B2 (pt) |
EP (1) | EP1444009A1 (pt) |
JP (1) | JP2005508978A (pt) |
KR (1) | KR20040053210A (pt) |
CN (1) | CN1575191A (pt) |
BR (1) | BR0213817A (pt) |
CA (1) | CA2465632A1 (pt) |
HU (1) | HUP0401998A2 (pt) |
IL (1) | IL161155A0 (pt) |
MX (1) | MXPA04004170A (pt) |
PL (1) | PL370599A1 (pt) |
WO (1) | WO2003037432A1 (pt) |
ZA (1) | ZA200402173B (pt) |
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DE19541264A1 (de) * | 1995-11-06 | 1997-05-07 | Bayer Ag | Purin-6-on-derivate |
JP3063162B2 (ja) * | 1995-12-28 | 2000-07-12 | 藤沢薬品工業株式会社 | ベンズイミダゾール誘導体 |
GB9722520D0 (en) * | 1997-10-24 | 1997-12-24 | Pfizer Ltd | Compounds |
US6444816B1 (en) * | 1997-10-27 | 2002-09-03 | Dr. Reddy's Research Foundation | Fused 7-oxo-pyrimidinyl compounds, preparation, composition and use thereof |
US5922595A (en) * | 1997-12-09 | 1999-07-13 | Incyte Pharmaceuticals, Inc. | Cyclic GMP phosphodiesterase |
US6225456B1 (en) | 1998-05-07 | 2001-05-01 | University Technololy Corporation | Ras suppressor SUR-5 |
CA2346937A1 (en) | 1998-10-15 | 2000-04-27 | Per O. G. Arkhammar | Specific therapeutic interventions obtained by interference with redistribution and/or targeting |
KR20030023747A (ko) * | 2000-08-11 | 2003-03-19 | 화이자 인코포레이티드 | 인슐린 저항성 증후군의 치료 |
WO2002060422A2 (en) * | 2001-02-02 | 2002-08-08 | Pfizer Limited | Treatment of diabetes mellitus using vardenafil |
AUPR576801A0 (en) | 2001-06-19 | 2001-07-12 | University Of Tasmania | Methods and pharmaceuticals for treating muscle insulin resistance and related conditions |
HUP0401998A2 (hu) * | 2001-11-02 | 2005-01-28 | Pfizer Products Inc., | PDE9 inhibitorok alkalmazása olyan gyógyszer előállítására, amellyel inzulin-rezisztencia szindróma és 2-es típusú diabétesz kezelhető |
US20040220186A1 (en) * | 2003-04-30 | 2004-11-04 | Pfizer Inc. | PDE9 inhibitors for treating type 2 diabetes,metabolic syndrome, and cardiovascular disease |
-
2002
- 2002-09-12 HU HU0401998A patent/HUP0401998A2/hu unknown
- 2002-09-12 CN CNA028211529A patent/CN1575191A/zh active Pending
- 2002-09-12 PL PL02370599A patent/PL370599A1/xx not_active Application Discontinuation
- 2002-09-12 BR BR0213817-4A patent/BR0213817A/pt not_active IP Right Cessation
- 2002-09-12 IL IL16115502A patent/IL161155A0/xx unknown
- 2002-09-12 WO PCT/IB2002/003754 patent/WO2003037432A1/en not_active Application Discontinuation
- 2002-09-12 CA CA002465632A patent/CA2465632A1/en not_active Abandoned
- 2002-09-12 EP EP02762720A patent/EP1444009A1/en not_active Withdrawn
- 2002-09-12 MX MXPA04004170A patent/MXPA04004170A/es unknown
- 2002-09-12 KR KR10-2004-7006251A patent/KR20040053210A/ko not_active Application Discontinuation
- 2002-09-12 JP JP2003539771A patent/JP2005508978A/ja not_active Withdrawn
- 2002-10-29 US US10/283,814 patent/US6967204B2/en not_active Expired - Fee Related
-
2004
- 2004-03-18 ZA ZA200402173A patent/ZA200402173B/en unknown
- 2004-09-15 US US10/942,438 patent/US20050070557A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
JP2005508978A (ja) | 2005-04-07 |
US20050070557A1 (en) | 2005-03-31 |
IL161155A0 (en) | 2004-08-31 |
CN1575191A (zh) | 2005-02-02 |
ZA200402173B (en) | 2005-03-18 |
PL370599A1 (en) | 2005-05-30 |
US6967204B2 (en) | 2005-11-22 |
MXPA04004170A (es) | 2004-09-06 |
EP1444009A1 (en) | 2004-08-11 |
KR20040053210A (ko) | 2004-06-23 |
CA2465632A1 (en) | 2003-05-08 |
US20040023989A1 (en) | 2004-02-05 |
WO2003037432A1 (en) | 2003-05-08 |
HUP0401998A2 (hu) | 2005-01-28 |
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