BR0014003A - Tratamento de combinação com compostos de diaril sufonil uréia e il-1ra - Google Patents

Tratamento de combinação com compostos de diaril sufonil uréia e il-1ra

Info

Publication number
BR0014003A
BR0014003A BR0014003-1A BR0014003A BR0014003A BR 0014003 A BR0014003 A BR 0014003A BR 0014003 A BR0014003 A BR 0014003A BR 0014003 A BR0014003 A BR 0014003A
Authority
BR
Brazil
Prior art keywords
sufonil
urea
compounds
combination treatment
diaryl
Prior art date
Application number
BR0014003-1A
Other languages
English (en)
Inventor
Bruce Henry Littman
Thasia Louise Goodwi Woodworth
Mark Anthony Dombroski
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of BR0014003A publication Critical patent/BR0014003A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/64—Sulfonylureas, e.g. glibenclamide, tolbutamide, chlorpropamide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Patente de Invenção: "TRATAMENTO DE COMBINAçãO COM COMPOSTOS DE DIARIL SUFONIL URéIA E IL-1RA". A invenção refere-se com métodos e composições para tratar e prevenir estados de doença mediados pela interleucina 1 (IL-1). Os métodos e composições utilizam um polipeptídeo antagonista do receptor da interleucina 1 (IL-1 ra) ou uma variante deste em combinação com um agente não esteroidal de inibição do processamento e liberação de IL-1.
BR0014003-1A 1999-09-14 2000-08-28 Tratamento de combinação com compostos de diaril sufonil uréia e il-1ra BR0014003A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15401099P 1999-09-14 1999-09-14
PCT/IB2000/001192 WO2001019390A1 (en) 1999-09-14 2000-08-28 Combination treatment with il-1ra and diaryl sulphonyl urea compounds

Publications (1)

Publication Number Publication Date
BR0014003A true BR0014003A (pt) 2002-05-21

Family

ID=22549650

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0014003-1A BR0014003A (pt) 1999-09-14 2000-08-28 Tratamento de combinação com compostos de diaril sufonil uréia e il-1ra

Country Status (13)

Country Link
EP (1) EP1214087A1 (pt)
JP (1) JP2003509378A (pt)
AR (1) AR033650A1 (pt)
AU (1) AU6464400A (pt)
BR (1) BR0014003A (pt)
CA (1) CA2383026A1 (pt)
CO (1) CO5190701A1 (pt)
EC (1) ECSP003652A (pt)
GT (1) GT200000155A (pt)
PA (1) PA8502901A1 (pt)
PE (1) PE20010685A1 (pt)
TN (1) TNSN00183A1 (pt)
WO (1) WO2001019390A1 (pt)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2557910C (en) 2004-04-02 2012-05-29 Amgen Inc. Methods of reducing aggregation of il-1ra
WO2008129288A2 (en) * 2007-04-19 2008-10-30 Boehringer Ingelheim International Gmbh Disulfonamides useful in the treatment of inflammation
PE20221627A1 (es) 2015-02-16 2022-10-19 Univ Queensland Sulfonilureas y compuestos relacionados y uso de estos
CA3014487A1 (en) 2016-02-16 2017-08-24 The Provost, Fellows, Foundation Scholars, And The Other Members Of Board, Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth Near Dublin Sulfonylureas and related compounds and use of same
AU2017254522B2 (en) 2016-04-18 2021-09-23 Novartis Ag Compounds and compositions for treating conditions associated with NLRP activity
CA3047336A1 (en) 2017-01-23 2018-07-26 Jecure Therapeutics, Inc. Chemical compounds as inhibitors of interleukin-1 activity
JP7072586B2 (ja) 2017-05-24 2022-05-20 ザ ユニバーシティ オブ クィーンズランド 新規な化合物及び使用
WO2018225018A1 (en) 2017-06-09 2018-12-13 Cadila Healthcare Limited Novel substituted sulfoximine compounds
US11370776B2 (en) 2017-07-07 2022-06-28 Inflazome Limited Sulfonylureas and sulfonylthioureas as NLRP3 inhibitors
RS62910B1 (sr) 2017-07-07 2022-03-31 Inflazome Ltd Nova jedinjenja sulfonamid karboksamida
EP3658539B1 (en) 2017-07-24 2024-02-21 Novartis AG Compounds and compositions for treating conditions associated with nlrp activity
US11926600B2 (en) 2017-08-15 2024-03-12 Inflazome Limited Sulfonylureas and sulfonylthioureas as NLRP3 inhibitors
UY37847A (es) * 2017-08-15 2019-03-29 Inflazome Ltd Sulfonilureas y sulfoniltioureas útiles como inhibidores de nlrp3
TW201910317A (zh) 2017-08-15 2019-03-16 愛爾蘭商英弗雷佐姆有限公司 新穎化合物
CN111107903A (zh) 2017-08-15 2020-05-05 英夫拉索姆有限公司 新颖的磺酰胺羧酰胺化合物
US11518739B2 (en) 2017-08-15 2022-12-06 Inflazome Limited Sulfonamide carboxamide compounds
WO2019043610A1 (en) 2017-08-31 2019-03-07 Cadila Healthcare Limited NEW SUBSTITUTED SULFONYLUREA DERIVATIVES
EP3692020A1 (en) 2017-10-03 2020-08-12 Inflazome Limited Novel compounds
US11884645B2 (en) 2018-03-02 2024-01-30 Inflazome Limited Sulfonyl acetamides as NLRP3 inhibitors
US11905252B2 (en) 2018-03-02 2024-02-20 Inflazome Limited Compounds
US11834433B2 (en) 2018-03-02 2023-12-05 Inflazome Limited Compounds
EP3759103A1 (en) 2018-03-02 2021-01-06 Inflazome Limited Novel compounds
GB201806578D0 (en) * 2018-04-23 2018-06-06 Inflazome Ltd Novel compound
CN112584899A (zh) 2018-07-03 2021-03-30 诺华股份有限公司 Nlrp调节剂
BR112021001012A2 (pt) 2018-07-20 2021-04-20 F. Hoffmann-La Roche Ag compostos de sulfonilureia como inibidores da atividade de interleucina-1
JP2022505525A (ja) 2018-10-24 2022-01-14 ノバルティス アーゲー Ｎｌｒｐ活性に関連する状態を治療するための化合物及び組成物
EA202191968A1 (ru) 2019-01-14 2021-11-16 Кадила Хелзкэр Лимитед Новые замещенные производные сульфонилмочевины
CA3171969A1 (en) * 2020-05-25 2021-12-02 Beijing Vdjbio Co., Ltd. An interleukin-1 receptor antagonist and a fusion protein containing the same

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5874424A (en) * 1995-12-20 1999-02-23 Vertex Pharmaceuticals Incorporated Inhibitors of interleukin-1β converting enzyme
TR199901816T2 (xx) * 1997-01-29 1999-11-22 Pfizer Inc S�lfonil �re t�revleri, bunlar�n interl�kin-1 aktivitesinin kontrol�nde kullan�mlar�.
US6015790A (en) * 1997-10-06 2000-01-18 Basf Aktiengesellschaft Methods and compositions for treating rheumatoid arthritis
EP0987552A3 (en) * 1998-08-31 2000-06-07 Pfizer Products Inc. Diarylsulfonylurea binding proteins

Also Published As

Publication number Publication date
EP1214087A1 (en) 2002-06-19
JP2003509378A (ja) 2003-03-11
AU6464400A (en) 2001-04-17
CO5190701A1 (es) 2002-08-29
AR033650A1 (es) 2004-01-07
CA2383026A1 (en) 2001-03-22
WO2001019390A1 (en) 2001-03-22
ECSP003652A (es) 2002-04-23
PA8502901A1 (es) 2002-02-21
TNSN00183A1 (fr) 2005-11-10
GT200000155A (es) 2002-03-08
PE20010685A1 (es) 2001-07-03

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Legal Events

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B08F Application fees: dismissal - article 86 of industrial property law

Free format text: REFERENTE A 6A, 7A E 8A ANUIDADES.

B08K Lapse as no evidence of payment of the annual fee has been furnished to inpi (acc. art. 87)

Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 1962 DE 12/08/2008.