JP2005508849A5 - - Google Patents
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- Publication number
- JP2005508849A5 JP2005508849A5 JP2002579004A JP2002579004A JP2005508849A5 JP 2005508849 A5 JP2005508849 A5 JP 2005508849A5 JP 2002579004 A JP2002579004 A JP 2002579004A JP 2002579004 A JP2002579004 A JP 2002579004A JP 2005508849 A5 JP2005508849 A5 JP 2005508849A5
- Authority
- JP
- Japan
- Prior art keywords
- immunogenic composition
- oligosaccharide
- capsular polysaccharide
- carrier protein
- type
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 44
- 150000004676 glycans Chemical class 0.000 claims 41
- 229920001542 oligosaccharide Polymers 0.000 claims 41
- 150000002482 oligosaccharides Chemical class 0.000 claims 41
- 229920001282 polysaccharide Polymers 0.000 claims 41
- 239000005017 polysaccharide Substances 0.000 claims 41
- 230000002163 immunogen Effects 0.000 claims 39
- 102000014914 Carrier Proteins Human genes 0.000 claims 23
- 108010078791 Carrier Proteins Proteins 0.000 claims 23
- 229960005486 vaccine Drugs 0.000 claims 22
- 241000588650 Neisseria meningitidis Species 0.000 claims 15
- 241000606768 Haemophilus influenzae Species 0.000 claims 14
- 229960000814 tetanus toxoid Drugs 0.000 claims 14
- 241000193998 Streptococcus pneumoniae Species 0.000 claims 12
- 229940031000 streptococcus pneumoniae Drugs 0.000 claims 12
- 229960003983 diphtheria toxoid Drugs 0.000 claims 11
- 108010071134 CRM197 (non-toxic variant of diphtheria toxin) Proteins 0.000 claims 8
- 241000894006 Bacteria Species 0.000 claims 6
- 241000991587 Enterovirus C Species 0.000 claims 6
- 239000002671 adjuvant Substances 0.000 claims 6
- 229940045808 haemophilus influenzae type b Drugs 0.000 claims 6
- 239000000427 antigen Substances 0.000 claims 5
- 102000036639 antigens Human genes 0.000 claims 5
- 108091007433 antigens Proteins 0.000 claims 5
- 229940047650 haemophilus influenzae Drugs 0.000 claims 5
- 241000588832 Bordetella pertussis Species 0.000 claims 4
- 241000700721 Hepatitis B virus Species 0.000 claims 4
- 201000005702 Pertussis Diseases 0.000 claims 4
- 206010043376 Tetanus Diseases 0.000 claims 4
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical group [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 claims 4
- 206010013023 diphtheria Diseases 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 238000001727 in vivo Methods 0.000 claims 4
- 208000037798 influenza B Diseases 0.000 claims 4
- 102100037840 Dehydrogenase/reductase SDR family member 2, mitochondrial Human genes 0.000 claims 3
- 101710188053 Protein D Proteins 0.000 claims 3
- 101710132893 Resolvase Proteins 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 208000002672 hepatitis B Diseases 0.000 claims 3
- 102000016607 Diphtheria Toxin Human genes 0.000 claims 2
- 108010053187 Diphtheria Toxin Proteins 0.000 claims 2
- 101000597577 Gluconacetobacter diazotrophicus (strain ATCC 49037 / DSM 5601 / CCUG 37298 / CIP 103539 / LMG 7603 / PAl5) Outer membrane protein Proteins 0.000 claims 2
- 101710183389 Pneumolysin Proteins 0.000 claims 2
- 230000007123 defense Effects 0.000 claims 2
- 230000006806 disease prevention Effects 0.000 claims 2
- 230000005847 immunogenicity Effects 0.000 claims 2
- 230000001771 impaired effect Effects 0.000 claims 2
- 208000015181 infectious disease Diseases 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 210000002966 serum Anatomy 0.000 claims 2
- 108010077805 Bacterial Proteins Proteins 0.000 claims 1
- 241000709721 Hepatovirus A Species 0.000 claims 1
- ILRRQNADMUWWFW-UHFFFAOYSA-K aluminium phosphate Chemical compound O1[Al]2OP1(=O)O2 ILRRQNADMUWWFW-UHFFFAOYSA-K 0.000 claims 1
- 230000002238 attenuated effect Effects 0.000 claims 1
- 238000011260 co-administration Methods 0.000 claims 1
- 230000001629 suppression Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0108364.1 | 2001-04-03 | ||
| GBGB0108364.1A GB0108364D0 (en) | 2001-04-03 | 2001-04-03 | Vaccine composition |
| PCT/EP2002/003573 WO2002080965A2 (en) | 2001-04-03 | 2002-03-28 | Vaccine composition |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008320381A Division JP5095595B2 (ja) | 2001-04-03 | 2008-12-17 | ワクチン組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005508849A JP2005508849A (ja) | 2005-04-07 |
| JP2005508849A5 true JP2005508849A5 (https=) | 2005-12-22 |
| JP5281224B2 JP5281224B2 (ja) | 2013-09-04 |
Family
ID=9912183
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002579004A Expired - Fee Related JP5281224B2 (ja) | 2001-04-03 | 2002-03-28 | ワクチン組成物 |
| JP2008320381A Expired - Fee Related JP5095595B2 (ja) | 2001-04-03 | 2008-12-17 | ワクチン組成物 |
| JP2011265563A Expired - Fee Related JP5410498B2 (ja) | 2001-04-03 | 2011-12-05 | ワクチン組成物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008320381A Expired - Fee Related JP5095595B2 (ja) | 2001-04-03 | 2008-12-17 | ワクチン組成物 |
| JP2011265563A Expired - Fee Related JP5410498B2 (ja) | 2001-04-03 | 2011-12-05 | ワクチン組成物 |
Country Status (25)
| Country | Link |
|---|---|
| US (4) | US20040202668A1 (https=) |
| EP (4) | EP1946772B1 (https=) |
| JP (3) | JP5281224B2 (https=) |
| KR (7) | KR20080048094A (https=) |
| CN (3) | CN1273190C (https=) |
| AR (1) | AR040922A1 (https=) |
| AT (2) | ATE553775T1 (https=) |
| BR (1) | BR0208595A (https=) |
| CA (3) | CA2442865C (https=) |
| CY (3) | CY1112879T1 (https=) |
| CZ (1) | CZ20032698A3 (https=) |
| DK (3) | DK1390066T3 (https=) |
| ES (3) | ES2384065T3 (https=) |
| GB (1) | GB0108364D0 (https=) |
| HU (1) | HUP0303996A3 (https=) |
| IL (2) | IL158066A0 (https=) |
| MX (1) | MXPA03008961A (https=) |
| MY (1) | MY129263A (https=) |
| NO (1) | NO20034410L (https=) |
| NZ (3) | NZ581373A (https=) |
| PL (5) | PL211911B1 (https=) |
| PT (3) | PT1390066E (https=) |
| SI (3) | SI1946771T1 (https=) |
| WO (1) | WO2002080965A2 (https=) |
| ZA (1) | ZA200307640B (https=) |
Families Citing this family (79)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030157129A1 (en) * | 1995-06-23 | 2003-08-21 | Smithkline Beecham Biologicals S.A. | Vaccine comprising a polysaccharide antigen - carrier protein conjugate and free carrier protein |
| GB9928196D0 (en) | 1999-11-29 | 2000-01-26 | Chiron Spa | Combinations of B, C and other antigens |
| GB0108364D0 (en) * | 2001-04-03 | 2001-05-23 | Glaxosmithkline Biolog Sa | Vaccine composition |
| HU227893B1 (en) * | 2000-06-29 | 2012-05-29 | Glaxosmithkline Biolog Sa | Vaccine compositions |
| AU2000278267A1 (en) * | 2000-09-01 | 2002-03-22 | The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services | Vibrio cholerae o139 conjugate vaccines |
| GB0115176D0 (en) * | 2001-06-20 | 2001-08-15 | Chiron Spa | Capular polysaccharide solubilisation and combination vaccines |
| GB0227346D0 (en) | 2002-11-22 | 2002-12-31 | Chiron Spa | 741 |
| CA2524853A1 (en) | 2003-05-07 | 2005-01-20 | Aventis Pasteur, Inc. | Method of enhanced immunogenicity to meningococcal vaccination |
| EP2364725A3 (en) * | 2003-06-23 | 2012-05-09 | Sanofi Pasteur Inc. | Immunization method against neisseria meningitidis serogroups a and c |
| CN103357002A (zh) | 2003-10-02 | 2013-10-23 | 诺华疫苗和诊断有限公司 | 多种脑膜炎球菌血清群的液体疫苗 |
| ATE512670T1 (de) | 2004-04-30 | 2011-07-15 | Novartis Vaccines & Diagnostic | Meningokokken-konjugat-impfung |
| GB0409795D0 (en) * | 2004-04-30 | 2004-06-09 | Glaxosmithkline Biolog Sa | Drying method |
| GB0500787D0 (en) | 2005-01-14 | 2005-02-23 | Chiron Srl | Integration of meningococcal conjugate vaccination |
| GB0409745D0 (en) | 2004-04-30 | 2004-06-09 | Chiron Srl | Compositions including unconjugated carrier proteins |
| GB0505518D0 (en) * | 2005-03-17 | 2005-04-27 | Chiron Srl | Combination vaccines with whole cell pertussis antigen |
| CA2604363C (en) * | 2005-04-08 | 2015-06-16 | Wyeth | Multivalent pneumococcal polysaccharide-protein conjugate composition |
| US8398983B2 (en) | 2005-06-27 | 2013-03-19 | Glaxosmithkline Biologicals, S.A. | Immunogenic composition |
| NZ598367A (en) * | 2005-09-01 | 2013-10-25 | Novartis Vaccines & Diagnostic | Multiple vaccination including serogroup C meningococcus |
| GB0522303D0 (en) * | 2005-11-01 | 2005-12-07 | Chiron Srl | Culture method |
| US7740855B2 (en) * | 2005-11-30 | 2010-06-22 | Yeda Research & Development Co. Ltd | Inactivated CD8+ T-cells for the treatment of HIV infection |
| PL1973564T3 (pl) | 2005-12-22 | 2017-04-28 | Glaxosmithkline Biologicals S.A. | Szczepionki zawierające koniugaty polisacharydu otoczkowego streptococcus pneumoniae |
| GB0607088D0 (en) * | 2006-04-07 | 2006-05-17 | Glaxosmithkline Biolog Sa | Vaccine |
| AU2012216698B2 (en) * | 2005-12-22 | 2014-03-06 | Glaxosmithkline Biologicals Sa | Pneumococcal polysaccharide conjugate vaccine |
| JP2009520771A (ja) * | 2005-12-23 | 2009-05-28 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | コンジュゲートワクチン |
| PL2004225T3 (pl) | 2006-03-22 | 2012-09-28 | Novartis Ag | Schematy immunizacji koniugatami meningokokowymi |
| US10828361B2 (en) | 2006-03-22 | 2020-11-10 | Glaxosmithkline Biologicals Sa | Regimens for immunisation with meningococcal conjugates |
| TW200806315A (en) * | 2006-04-26 | 2008-02-01 | Wyeth Corp | Novel formulations which stabilize and inhibit precipitation of immunogenic compositions |
| US8808707B1 (en) | 2006-05-08 | 2014-08-19 | Wyeth Llc | Pneumococcal dosing regimen |
| US8945582B2 (en) | 2006-09-07 | 2015-02-03 | Glaxosmithkline Biologicals S.A. | Vaccine |
| BRPI0810778A2 (pt) * | 2007-05-02 | 2011-09-13 | Glaxosmithkline Biolog Sa | kit, vacina combinada, e, métodos de diminuição da interferência de vizinhança de crm sobre um antìgeno sensìvel em um esquema de imunização primária de uma vacina, e de diminuição da interferência de vizinhança sobre um antìgeno sensìvel, e, uso de conjugados de sacarìdeo |
| SI2167121T1 (sl) | 2007-06-26 | 2015-12-31 | Glaxosmithkline Biologicals S.A. | Cepivo, ki obsega kapsularne polisaharidne konjugate Streptococcusa pneumoniae |
| CN101559223B (zh) * | 2008-04-18 | 2013-02-13 | 重庆智仁生物技术有限公司 | 流脑白百破联合疫苗 |
| EP2298344B1 (en) | 2008-06-04 | 2016-08-17 | The Chemo-Sero-Therapeutic Research Institute | Use of inactivated japanese encephalitis virus particle as adjuvant |
| CN102065868A (zh) | 2008-06-16 | 2011-05-18 | 中央研究院 | 诱发对于Globo H及SSEA3的特异免疫反应的组合物以及其在癌症治疗中的用途 |
| GB0822633D0 (en) | 2008-12-11 | 2009-01-21 | Novartis Ag | Formulation |
| TWI392502B (zh) * | 2009-06-16 | 2013-04-11 | Academia Sinica | 聚己醣抗原及含新穎醣脂質佐劑之相關抗癌疫苗 |
| ES2443952T3 (es) | 2009-09-02 | 2014-02-21 | Novartis Ag | Composiciones inmunógenas que incluyen moduladores de la actividad de TLR |
| AU2011258165B2 (en) * | 2010-05-26 | 2016-11-17 | Selecta Biosciences, Inc. | Dose selection of adjuvanted synthetic nanocarriers |
| PT2575870T (pt) | 2010-06-04 | 2017-02-10 | Wyeth Llc | Formulações de vacinas |
| ES2458355T3 (es) | 2010-09-01 | 2014-05-05 | Novartis Ag | Adsorción de inmunopotenciadores sobre sales metálicas insolubles |
| WO2012038801A1 (en) | 2010-09-21 | 2012-03-29 | National Institute Of Immunology | A spray dried powder formulation for vaccines entrapping alum and the antigen in biodegradable polymer particles |
| CN102068690A (zh) * | 2010-12-31 | 2011-05-25 | 北京民海生物科技有限公司 | 多价肺炎球菌荚膜多糖结合疫苗及其制备方法 |
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| CN104159603A (zh) * | 2012-03-08 | 2014-11-19 | 诺华股份有限公司 | 带有tlr4激动剂的联合疫苗 |
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| KR102057217B1 (ko) | 2012-06-20 | 2020-01-22 | 에스케이바이오사이언스 주식회사 | 다가 폐렴구균 다당류-단백질 접합체 조성물 |
| CN103623404B (zh) * | 2012-08-28 | 2016-08-03 | 天士力制药集团股份有限公司 | 一种b型流感嗜血杆菌多糖结合疫苗的制备方法 |
| CN103656631B (zh) * | 2012-09-24 | 2015-08-19 | 北京科兴中维生物技术有限公司 | 多价肺炎球菌荚膜多糖-蛋白缀合物组合物及其制备方法 |
| AR092897A1 (es) * | 2012-10-03 | 2015-05-06 | Novartis Ag | Composiciones inmunogenicas |
| CN102876707B (zh) * | 2012-10-15 | 2014-05-28 | 北京工业大学 | 一种重组脊髓灰质炎病毒ⅰ型病毒样颗粒的制备方法 |
| US20140193451A1 (en) * | 2012-10-17 | 2014-07-10 | Glaxosmithkline Biologicals Sa | Immunogenic composition |
| JP2015534964A (ja) * | 2012-10-17 | 2015-12-07 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 免疫原性組成物 |
| KR20140075196A (ko) | 2012-12-11 | 2014-06-19 | 에스케이케미칼주식회사 | 다가 폐렴구균 다당류-단백질 접합체 조성물 |
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| EP3363806B1 (en) | 2012-12-20 | 2022-11-16 | Pfizer Inc. | Glycoconjugation process |
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| WO2015095868A1 (en) * | 2013-12-20 | 2015-06-25 | Wake Forest University Health Sciences | Methods and compositions for increasing protective antibody levels induced by pneumococcal polysaccharide vaccines |
| US11160855B2 (en) | 2014-01-21 | 2021-11-02 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| IL312327B2 (en) * | 2014-01-21 | 2026-02-01 | Pfizer | Immunogenic preparations comprising conjugated capsular saccharide antigens and their uses |
| CN120718167A (zh) | 2014-01-21 | 2025-09-30 | 辉瑞大药厂 | 肺炎链球菌荚膜多糖及其缀合物 |
| CN107427568B (zh) * | 2015-01-15 | 2021-12-14 | 辉瑞公司 | 用于肺炎球菌疫苗中的免疫原性组合物 |
| CN106109486A (zh) * | 2015-07-06 | 2016-11-16 | 北京科兴中维生物技术有限公司 | 一种组合物及其制备方法与应用 |
| CN108367063A (zh) | 2015-07-21 | 2018-08-03 | 辉瑞公司 | 包含缀合的荚膜糖抗原的免疫原性组合物及其试剂盒和用途 |
| CN106039301A (zh) * | 2016-06-30 | 2016-10-26 | 武汉博沃生物科技有限公司 | 肺炎球菌‑b型流感嗜血杆菌‑百白破联合疫苗的制备方法 |
| JP7001686B2 (ja) | 2016-08-05 | 2022-02-04 | サノフィ パスツール インコーポレイティッド | 多価肺炎球菌多糖体－タンパク質コンジュゲート組成物 |
| KR102437120B1 (ko) | 2016-08-05 | 2022-08-25 | 사노피 파스퇴르 인코포레이티드 | 다가 폐렴구균 다당류-단백질 접합체 조성물 |
| CN106432512B (zh) * | 2016-09-30 | 2022-03-01 | 康希诺生物股份公司 | 一种增强多糖抗原免疫原性蛋白载体及其制备方法与应用 |
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| ES3024474T3 (en) * | 2016-12-30 | 2025-06-04 | Vaxcyte Inc | Polypeptide-antigen conjugates with non-natural amino acids |
| WO2019043245A1 (en) * | 2017-09-04 | 2019-03-07 | London School Of Hygiene And Tropical Medicine | MICROBIAL CELLS EXPRESSING STREPTOCOCCAL SERROTYPES |
| CN111479558A (zh) * | 2017-10-13 | 2020-07-31 | 纽约州立大学研究基金会 | 用于共生疾病进展的综合疫苗设计 |
| KR20230008923A (ko) | 2018-02-05 | 2023-01-16 | 사노피 파스퇴르 인코포레이티드 | 다가 폐렴구균성 다당류-단백질 접합체 조성물 |
| AU2019215212B2 (en) | 2018-02-05 | 2025-05-15 | Sk Bioscience Co., Ltd. | Multivalent pneumococcal polysaccharide-protein conjugate composition |
| JP2021522213A (ja) | 2018-04-18 | 2021-08-30 | エスケー バイオサイエンス カンパニー リミテッド | ストレプトコッカス・ニューモニエ莢膜多糖類及びその免疫原性接合体 |
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| UA56132C2 (uk) | 1995-04-25 | 2003-05-15 | Смітклайн Бічем Байолоджікалс С.А. | Композиція вакцини (варіанти), спосіб стабілізації qs21 відносно гідролізу (варіанти), спосіб приготування композиції вакцини |
| US5780606A (en) * | 1995-06-07 | 1998-07-14 | Connaught Laboratories Limited | Neisseria meningitidis capsular polysaccharide conjugates |
| PL184872B1 (pl) * | 1995-06-23 | 2003-01-31 | Smithkline Beecham Biolog | Kombinowana szczepionkaĆ zestaw do przygotowania kombinowanej szczepionkiĆ sposób wytwarzania kombinowanej szczepionki i jej zastosowanie |
| SE9601158D0 (sv) * | 1996-03-26 | 1996-03-26 | Stefan Svenson | Method of producing immunogenic products and vaccines |
| BRPI9710460B8 (pt) * | 1996-07-02 | 2021-05-25 | Aventis Pasteur | composição imunogênica multi-valente e composição de vacina |
| GB9623233D0 (en) * | 1996-11-07 | 1997-01-08 | Smithkline Beecham Biolog | Vaccine composition |
| FR2763244B1 (fr) * | 1997-05-14 | 2003-08-01 | Pasteur Merieux Serums Vacc | Composition vaccinale multivalente a porteur mixte |
| CA2303105A1 (en) | 1997-09-15 | 1999-03-25 | Pasteur Merieux Msd | Multivalent vaccines |
| GB9806456D0 (en) | 1998-03-25 | 1998-05-27 | Smithkline Beecham Biolog | Vaccine composition |
| ES2275499T3 (es) * | 1999-03-19 | 2007-06-16 | Glaxosmithkline Biologicals S.A. | Vacuna contra streptococcus pneumoniae. |
| GB0108364D0 (en) * | 2001-04-03 | 2001-05-23 | Glaxosmithkline Biolog Sa | Vaccine composition |
| HU227893B1 (en) * | 2000-06-29 | 2012-05-29 | Glaxosmithkline Biolog Sa | Vaccine compositions |
-
2001
- 2001-04-03 GB GBGB0108364.1A patent/GB0108364D0/en not_active Ceased
- 2001-06-28 AR ARP010103098A patent/AR040922A1/es not_active Application Discontinuation
-
2002
- 2002-03-28 KR KR1020087012215A patent/KR20080048094A/ko not_active Ceased
- 2002-03-28 PT PT02735199T patent/PT1390066E/pt unknown
- 2002-03-28 KR KR1020097004040A patent/KR20090026371A/ko not_active Ceased
- 2002-03-28 CA CA2442865A patent/CA2442865C/en not_active Expired - Fee Related
- 2002-03-28 CN CNB028110919A patent/CN1273190C/zh not_active Expired - Fee Related
- 2002-03-28 DK DK02735199.8T patent/DK1390066T3/da active
- 2002-03-28 IL IL15806602A patent/IL158066A0/xx unknown
- 2002-03-28 NZ NZ581373A patent/NZ581373A/en not_active IP Right Cessation
- 2002-03-28 PL PL393585A patent/PL211911B1/pl not_active IP Right Cessation
- 2002-03-28 EP EP08153847A patent/EP1946772B1/en not_active Revoked
- 2002-03-28 CN CN2006101074101A patent/CN101112618B/zh not_active Expired - Fee Related
- 2002-03-28 US US10/473,769 patent/US20040202668A1/en not_active Abandoned
- 2002-03-28 PL PL374106A patent/PL211958B1/pl not_active IP Right Cessation
- 2002-03-28 EP EP08153845A patent/EP1946771B1/en not_active Expired - Lifetime
- 2002-03-28 WO PCT/EP2002/003573 patent/WO2002080965A2/en not_active Ceased
- 2002-03-28 SI SI200230995T patent/SI1946771T1/sl unknown
- 2002-03-28 NZ NZ551621A patent/NZ551621A/en not_active IP Right Cessation
- 2002-03-28 PT PT08153847T patent/PT1946772E/pt unknown
- 2002-03-28 HU HU0303996A patent/HUP0303996A3/hu unknown
- 2002-03-28 DK DK08153845.6T patent/DK1946771T3/da active
- 2002-03-28 AT AT02735199T patent/ATE553775T1/de active
- 2002-03-28 PL PL393583A patent/PL211910B1/pl not_active IP Right Cessation
- 2002-03-28 PL PL393618A patent/PL211912B1/pl not_active IP Right Cessation
- 2002-03-28 SI SI200230988T patent/SI1946772T1/sl unknown
- 2002-03-28 ES ES08153847T patent/ES2384065T3/es not_active Expired - Lifetime
- 2002-03-28 CA CA2727715A patent/CA2727715C/en not_active Expired - Fee Related
- 2002-03-28 KR KR1020117027470A patent/KR101292708B1/ko not_active Expired - Fee Related
- 2002-03-28 KR KR1020117004885A patent/KR20110036641A/ko not_active Ceased
- 2002-03-28 ES ES02735199T patent/ES2384041T3/es not_active Expired - Lifetime
- 2002-03-28 KR KR1020037012971A patent/KR100870280B1/ko not_active Expired - Fee Related
- 2002-03-28 CZ CZ20032698A patent/CZ20032698A3/cs unknown
- 2002-03-28 PT PT08153845T patent/PT1946771E/pt unknown
- 2002-03-28 JP JP2002579004A patent/JP5281224B2/ja not_active Expired - Fee Related
- 2002-03-28 AT AT08153847T patent/ATE553776T1/de active
- 2002-03-28 EP EP10179818A patent/EP2311488A3/en not_active Withdrawn
- 2002-03-28 SI SI200230987T patent/SI1390066T1/sl unknown
- 2002-03-28 CA CA2810326A patent/CA2810326A1/en not_active Abandoned
- 2002-03-28 CN CN2006101074116A patent/CN101112619B/zh not_active Expired - Fee Related
- 2002-03-28 BR BRPI0208595-0A patent/BR0208595A/pt not_active IP Right Cessation
- 2002-03-28 KR KR1020097023347A patent/KR101045412B1/ko not_active Expired - Fee Related
- 2002-03-28 DK DK08153847.2T patent/DK1946772T3/da active
- 2002-03-28 EP EP02735199A patent/EP1390066B1/en not_active Revoked
- 2002-03-28 ES ES08153845T patent/ES2388690T3/es not_active Expired - Lifetime
- 2002-03-28 NZ NZ568317A patent/NZ568317A/en not_active IP Right Cessation
- 2002-03-28 KR KR1020117028214A patent/KR20120005534A/ko not_active Ceased
- 2002-03-28 PL PL393582A patent/PL211909B1/pl not_active IP Right Cessation
- 2002-03-28 MX MXPA03008961A patent/MXPA03008961A/es active IP Right Grant
- 2002-04-01 MY MYPI20021176A patent/MY129263A/en unknown
-
2003
- 2003-09-30 ZA ZA2003/07640A patent/ZA200307640B/en unknown
- 2003-10-02 NO NO20034410A patent/NO20034410L/no not_active Application Discontinuation
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2007
- 2007-09-11 US US11/853,108 patent/US20080069835A1/en not_active Abandoned
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2008
- 2008-12-17 JP JP2008320381A patent/JP5095595B2/ja not_active Expired - Fee Related
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2011
- 2011-05-09 US US13/103,397 patent/US20110212124A1/en not_active Abandoned
- 2011-12-05 JP JP2011265563A patent/JP5410498B2/ja not_active Expired - Fee Related
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2012
- 2012-06-27 CY CY20121100572T patent/CY1112879T1/el unknown
- 2012-06-27 CY CY20121100573T patent/CY1112880T1/el unknown
- 2012-08-29 CY CY20121100777T patent/CY1113078T1/el unknown
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2013
- 2013-06-03 US US13/908,064 patent/US20130266609A1/en not_active Abandoned
- 2013-08-15 IL IL227966A patent/IL227966A0/en unknown
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