JP2005506367A5 - - Google Patents
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- Publication number
- JP2005506367A5 JP2005506367A5 JP2003537620A JP2003537620A JP2005506367A5 JP 2005506367 A5 JP2005506367 A5 JP 2005506367A5 JP 2003537620 A JP2003537620 A JP 2003537620A JP 2003537620 A JP2003537620 A JP 2003537620A JP 2005506367 A5 JP2005506367 A5 JP 2005506367A5
- Authority
- JP
- Japan
- Prior art keywords
- active substance
- pain
- weight
- release
- formulations
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000013543 active substance Substances 0.000 description 19
- 208000002193 Pain Diseases 0.000 description 12
- 238000009472 formulation Methods 0.000 description 12
- 239000000203 mixture Substances 0.000 description 12
- 230000036407 pain Effects 0.000 description 9
- KWTWDQCKEHXFFR-UHFFFAOYSA-N 3-[1-(dimethylamino)-2-methylpentan-3-yl]phenol Chemical compound CN(C)CC(C)C(CC)C1=CC=CC(O)=C1 KWTWDQCKEHXFFR-UHFFFAOYSA-N 0.000 description 6
- 230000000202 analgesic effect Effects 0.000 description 5
- 239000003814 drug Substances 0.000 description 5
- 229940079593 drug Drugs 0.000 description 4
- 210000002966 serum Anatomy 0.000 description 4
- 238000013268 sustained release Methods 0.000 description 4
- 239000012730 sustained-release form Substances 0.000 description 4
- 208000000094 Chronic Pain Diseases 0.000 description 3
- 230000036592 analgesia Effects 0.000 description 3
- 238000000576 coating method Methods 0.000 description 3
- 239000010410 layer Substances 0.000 description 3
- 239000008194 pharmaceutical composition Substances 0.000 description 3
- 239000011247 coating layer Substances 0.000 description 2
- 230000005923 long-lasting effect Effects 0.000 description 2
- 230000000638 stimulation Effects 0.000 description 2
- 230000002459 sustained effect Effects 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 230000001627 detrimental effect Effects 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000002688 persistence Effects 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 230000036470 plasma concentration Effects 0.000 description 1
- 229920000193 polymethacrylate Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 238000009495 sugar coating Methods 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10152469A DE10152469A1 (de) | 2001-10-24 | 2001-10-24 | 3-(3-Dimethylamino-1-ethyl-2-methyl-propyl)phenol enthaltendes Arzneimittel mit verzögerter Wirkstofffreisetzung |
| DE10152469.2 | 2001-10-24 | ||
| DE10248309.4 | 2002-10-16 | ||
| DE2002148309 DE10248309A1 (de) | 2002-10-16 | 2002-10-16 | 3-(3- Dimethylamino-1-ethyl-2-methyl-propyl) phenol enthaltendes Arzeimittel mit verzögerter Wirkstofffreisetzung |
| PCT/EP2002/011809 WO2003035053A1 (de) | 2001-10-24 | 2002-10-22 | 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)phenol enthaltendes arzneimittel mit verzögerter wirkstofffreisetzung |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010176084A Division JP2010280697A (ja) | 2001-10-24 | 2010-08-05 | 有効物質を徐放する３−（３−ジメチルアミノ−１−エチル−２−メチル−プロピル）フェノール含有医薬 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005506367A JP2005506367A (ja) | 2005-03-03 |
| JP2005506367A5 true JP2005506367A5 (enExample) | 2010-10-07 |
| JP4758064B2 JP4758064B2 (ja) | 2011-08-24 |
Family
ID=26010444
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003537620A Expired - Lifetime JP4758064B2 (ja) | 2001-10-24 | 2002-10-22 | 有効物質を徐放する３−（３−ジメチルアミノ−１−エチル−２−メチル−プロピル）フェノール含有医薬 |
| JP2010176084A Pending JP2010280697A (ja) | 2001-10-24 | 2010-08-05 | 有効物質を徐放する３−（３−ジメチルアミノ−１−エチル−２−メチル−プロピル）フェノール含有医薬 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010176084A Pending JP2010280697A (ja) | 2001-10-24 | 2010-08-05 | 有効物質を徐放する３−（３−ジメチルアミノ−１−エチル−２−メチル−プロピル）フェノール含有医薬 |
Country Status (28)
| Country | Link |
|---|---|
| US (7) | US20050058706A1 (enExample) |
| EP (1) | EP1439829B1 (enExample) |
| JP (2) | JP4758064B2 (enExample) |
| KR (1) | KR100958045B1 (enExample) |
| CN (1) | CN100402021C (enExample) |
| AR (1) | AR036943A1 (enExample) |
| AT (1) | ATE303802T1 (enExample) |
| AU (1) | AU2002349001C1 (enExample) |
| BR (1) | BRPI0213653B8 (enExample) |
| CA (1) | CA2464578C (enExample) |
| CO (1) | CO5570662A2 (enExample) |
| CY (1) | CY2012022I1 (enExample) |
| DE (1) | DE50204198D1 (enExample) |
| DK (1) | DK1439829T3 (enExample) |
| EC (1) | ECSP045102A (enExample) |
| ES (1) | ES2248622T3 (enExample) |
| HU (1) | HU230161B1 (enExample) |
| IL (2) | IL161587A0 (enExample) |
| MX (1) | MXPA04003742A (enExample) |
| MY (1) | MY127797A (enExample) |
| NO (2) | NO331896B1 (enExample) |
| NZ (1) | NZ532999A (enExample) |
| PE (1) | PE20030527A1 (enExample) |
| PL (1) | PL216535B1 (enExample) |
| PT (1) | PT1439829E (enExample) |
| SI (1) | SI1439829T1 (enExample) |
| WO (2) | WO2003035054A1 (enExample) |
| ZA (1) | ZA200403928B (enExample) |
Families Citing this family (78)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7776314B2 (en) | 2002-06-17 | 2010-08-17 | Grunenthal Gmbh | Abuse-proofed dosage system |
| DE50312678D1 (de) | 2002-11-22 | 2010-06-10 | Gruenenthal Gmbh | Verwendung von (1R, 2R)-3-(3-Dimenthylamino-1-ethyl-2-methyl-propyl)-phenol zur Behandlung von Entzündungsschmerz |
| DE10336400A1 (de) * | 2003-08-06 | 2005-03-24 | Grünenthal GmbH | Gegen Missbrauch gesicherte Darreichungsform |
| DE102005005446A1 (de) * | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Bruchfeste Darreichungsformen mit retardierter Freisetzung |
| DE102004032051A1 (de) | 2004-07-01 | 2006-01-19 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten, festen Darreichungsform |
| PT1842533E (pt) * | 2003-08-06 | 2013-05-17 | Gruenenthal Gmbh | Forma de dosagem protegida contra abuso |
| DE102004020220A1 (de) * | 2004-04-22 | 2005-11-10 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten, festen Darreichungsform |
| DE10361596A1 (de) | 2003-12-24 | 2005-09-29 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
| US20070048228A1 (en) | 2003-08-06 | 2007-03-01 | Elisabeth Arkenau-Maric | Abuse-proofed dosage form |
| US8075872B2 (en) | 2003-08-06 | 2011-12-13 | Gruenenthal Gmbh | Abuse-proofed dosage form |
| ES2291780T3 (es) | 2004-06-28 | 2008-03-01 | Grunenthal Gmbh | Formas cristalinas del clorhidrato de (-)-(1r,2r)-3-(3-dimetilamino-1-etil-2-metilpropil)fenol. |
| DE102004032103A1 (de) * | 2004-07-01 | 2006-01-19 | Grünenthal GmbH | Gegen Missbrauch gesicherte, orale Darreichungsform |
| DE102004032049A1 (de) * | 2004-07-01 | 2006-01-19 | Grünenthal GmbH | Gegen Missbrauch gesicherte, orale Darreichungsform |
| AR053304A1 (es) * | 2004-07-01 | 2007-05-02 | Gruenenthal Gmbh | Formas farmaceuticas orales protegidas frente al abuso con liberacion controlada de (1r,2r)-3-(3 dimetilamino-1-etil-2metil-propil)fenol y procedimiento para su produccion. |
| DE102005005449A1 (de) * | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
| CN101431990B (zh) * | 2006-04-28 | 2011-08-03 | 格吕伦塔尔有限公司 | 包含3-（3-二甲基氨基-1-乙基-2-甲基-丙基）-酚和对乙酰氨基酚的药物结合 |
| CN102675136B (zh) * | 2006-04-28 | 2016-01-20 | 格吕伦塔尔有限公司 | 包含3-(3-二甲基氨基-1-乙基-2-甲基-丙基)-苯酚和nsaid的药物组合物 |
| CN101091725A (zh) * | 2006-06-23 | 2007-12-26 | 天津天士力制药股份有限公司 | 一种中药颗粒及其制备方法 |
| SA07280459B1 (ar) | 2006-08-25 | 2011-07-20 | بيورديو فارما إل. بي. | أشكال جرعة صيدلانية للتناول عن طريق الفم مقاومة للعبث تشتمل على مسكن شبه أفيوني |
| DE102007011485A1 (de) * | 2007-03-07 | 2008-09-11 | Grünenthal GmbH | Darreichungsform mit erschwertem Missbrauch |
| DE102007019417A1 (de) * | 2007-04-23 | 2008-11-13 | Grünenthal GmbH | Tapentadol zur Schmerzbehandlung bei Arthrose |
| EP1985292A1 (en) * | 2007-04-23 | 2008-10-29 | Grünenthal GmbH | Titration of tapentadol |
| MX2010005680A (es) * | 2007-11-23 | 2010-12-21 | Protect Pharmaceutical Corp | Composiciones de tapentadol. |
| HRP20170481T1 (hr) * | 2007-12-07 | 2017-05-19 | Grünenthal GmbH | Kristalne modifikacije (1r, 2r)-3-(3-dimentil amino-1-etil-2-metil-propil) fenola |
| TWI454288B (zh) | 2008-01-25 | 2014-10-01 | Gruenenthal Chemie | 藥物劑型 |
| ES2599031T3 (es) | 2008-05-09 | 2017-01-31 | Grünenthal GmbH | Proceso para la preparación de una formulación de polvo intermedia y una forma de dosificación solida final utilizando un paso de congelación por pulverización |
| US20100190752A1 (en) * | 2008-09-05 | 2010-07-29 | Gruenenthal Gmbh | Pharmaceutical Combination |
| SI2352494T1 (sl) | 2008-10-30 | 2019-12-31 | Gruenenthal Gmbh | Nove in potentne dozirne oblike tapentadola |
| BR112012001466A2 (pt) | 2009-07-22 | 2020-08-11 | Grünenthal GmbH | forma de dosagem resistente à falsificação para opioides sensíveis à oxidação, seu processo de fabricação, e embalagem |
| ES2534908T3 (es) | 2009-07-22 | 2015-04-30 | Grünenthal GmbH | Forma de dosificación de liberación controlada extruida por fusión en caliente |
| US9579285B2 (en) * | 2010-02-03 | 2017-02-28 | Gruenenthal Gmbh | Preparation of a powdery pharmaceutical composition by means of an extruder |
| US9884022B2 (en) | 2010-04-07 | 2018-02-06 | Lupin Limited | Controlled release pharmaceutical compositions of tapentadol |
| EP2566461A2 (de) * | 2010-05-05 | 2013-03-13 | Ratiopharm GmbH | Festes tapentadol in nicht-kristalliner form |
| AU2011267474B2 (en) * | 2010-06-15 | 2016-05-26 | Grünenthal GmbH | Pharmaceutical combination for the treatment of pain |
| MX2012012509A (es) | 2010-06-30 | 2012-12-05 | Gruenenthal Gmbh | Tapentadol para usarse en el tratamiento del sindrome del intestino irritable. |
| PT3650439T (pt) | 2010-07-23 | 2021-03-03 | Gruenenthal Gmbh | Sais ou cocristais de 3-(3-dimetilamino-1-etil-2-metilpropil)fenol |
| WO2012028318A1 (en) | 2010-09-02 | 2012-03-08 | Grünenthal GmbH | Tamper resistant dosage form comprising an anionic polymer |
| CA2808219C (en) | 2010-09-02 | 2019-05-14 | Gruenenthal Gmbh | Tamper resistant dosage form comprising inorganic salt |
| PL2680833T3 (pl) | 2011-03-04 | 2016-08-31 | Gruenenthal Gmbh | Pozajelitowe podawanie tapentadolu |
| EP3685827A1 (en) | 2011-03-04 | 2020-07-29 | Grünenthal GmbH | Aqueous pharmaceutical formulation of tapentadol for oral administration |
| PT2694050T (pt) | 2011-04-05 | 2019-11-22 | Gruenenthal Gmbh | Tapentadol para uso no tratamento da dor associada à neuralgia trigeminal |
| SI2694049T1 (sl) | 2011-04-05 | 2019-01-31 | Gruenenthal Gmbh | Tapentadol za preprečevanje razvoja kronične bolečine |
| PT2701693T (pt) | 2011-04-29 | 2017-11-16 | Gruenenthal Gmbh | Tapentadol para prevenção e tratamento de depressão e ansiedade |
| PT3766489T (pt) | 2011-05-03 | 2022-04-07 | Gruenenthal Gmbh | Composição farmacêutica aquosa semissólida contendo tapentadol |
| BR112014002022A2 (pt) | 2011-07-29 | 2017-02-21 | Gruenenthal Gmbh | comprimido resistente à violação proporcionando liberação de fármaco imediata |
| EP3300726A1 (en) * | 2011-07-29 | 2018-04-04 | Grünenthal GmbH | Intrathecal or epidural administration of 3-[(1s,2s)-3-(dimethylamino)-1-ethyl-2-methylpropyl]phenol |
| JP6063462B2 (ja) | 2011-07-29 | 2017-01-18 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | 即時薬剤放出を提供するタンパーレジスタント錠剤 |
| EP2606879A1 (en) | 2011-12-21 | 2013-06-26 | Hexal AG | Multiple unit pellet tablet formulation comprising an opioid |
| BR112014019988A8 (pt) | 2012-02-28 | 2017-07-11 | Gruenenthal Gmbh | Forma de dosagem resistente a socamento compreendendo um composto farmacologicamente ativo e um polímero aniônico |
| LT2838512T (lt) | 2012-04-18 | 2018-11-12 | GrĆ¼nenthal GmbH | Pažeidimui atspari ir dozės atpalaidavimo nuokrypiui atspari farmacinė vaisto forma |
| US10064945B2 (en) | 2012-05-11 | 2018-09-04 | Gruenenthal Gmbh | Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc |
| MX2015016254A (es) | 2013-05-29 | 2016-04-20 | Gruenenthal Gmbh | Forma de dosificacion resistente al uso indebido con perfil de liberacion bimodal. |
| AU2014273227B2 (en) | 2013-05-29 | 2019-08-15 | Grunenthal Gmbh | Tamper-resistant dosage form containing one or more particles |
| EP2808319A1 (en) | 2013-05-31 | 2014-12-03 | Arevipharma GmbH | 3-[3-(Dimethylamino)-1-ethyl-2-methylpropyl]phenol resin complex |
| AU2014289187B2 (en) | 2013-07-12 | 2019-07-11 | Grunenthal Gmbh | Tamper-resistant dosage form containing ethylene-vinyl acetate polymer |
| EP2845625A1 (en) | 2013-09-04 | 2015-03-11 | Grünenthal GmbH | Tapentadol for use in the treatment of fibromyalgia and chronic fatigue syndrome |
| WO2015071248A1 (en) | 2013-11-15 | 2015-05-21 | Synthon B.V. | Abuse-proofed extended release pharmaceutical composition comprising tapentadol |
| HK1224189A1 (zh) | 2013-11-26 | 2017-08-18 | Grünenthal GmbH | 通过低温研磨制备粉状药物组合物 |
| EP2942054A1 (en) * | 2014-05-09 | 2015-11-11 | G.L. Pharma GmbH | Slow-release pharmaceutical formulation |
| WO2015173195A1 (en) | 2014-05-12 | 2015-11-19 | Grünenthal GmbH | Tamper resistant immediate release capsule formulation comprising tapentadol |
| US9872835B2 (en) | 2014-05-26 | 2018-01-23 | Grünenthal GmbH | Multiparticles safeguarded against ethanolic dose-dumping |
| JP6923447B2 (ja) | 2015-03-27 | 2021-08-18 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | タペンタドールの非経口投与のための安定な製剤 |
| WO2016170097A1 (en) | 2015-04-24 | 2016-10-27 | Grünenthal GmbH | Tamper-resistant dosage form with immediate release and resistance against solvent extraction |
| CA2998259A1 (en) | 2015-09-10 | 2017-03-16 | Grunenthal Gmbh | Protecting oral overdose with abuse deterrent immediate release formulations |
| EP3231420A1 (en) | 2016-02-29 | 2017-10-18 | G.L. Pharma GmbH | Abuse-deterrent pharmaceutical compositions |
| EP3515412B1 (en) | 2016-09-23 | 2025-04-23 | Grünenthal GmbH | Stable formulation for parenteral administration of tapentadol |
| WO2018153947A1 (en) | 2017-02-23 | 2018-08-30 | Grünenthal GmbH | Tapentadol as local anesthetic |
| EP3630074B1 (en) * | 2017-05-29 | 2023-10-25 | Grünenthal GmbH | Multiparticulate oral dosage form providing prolonged release of tapentadol |
| EP3875079A1 (en) * | 2020-03-02 | 2021-09-08 | Grünenthal GmbH | Dosage form providing prolonged release of tapentadol phosphoric acid salt |
| ES3060121T3 (en) * | 2020-03-02 | 2026-03-25 | Gruenenthal Gmbh | Dosage form providing prolonged release of tapentadol phosphoric acid salt |
| AU2020100442B4 (en) * | 2020-03-02 | 2020-06-18 | Grünenthal GmbH | Dosage form providing prolonged release of tapentadol phosphoric acid salt |
| PE20230105A1 (es) | 2020-03-02 | 2023-01-25 | Gruenenthal Chemie | Forma de dosificacion que proporciona liberacion prolongada de sal de acido fosforico de tapentadol |
| EP3875077B1 (en) * | 2020-03-02 | 2023-12-13 | Grünenthal GmbH | Dosage form providing prolonged release of tapentadol phosphoric acid salt |
| EP4121013B1 (en) | 2020-03-16 | 2025-01-15 | Grünenthal GmbH | Scored tablet comprising tapentadol |
| DE202020104285U1 (de) | 2020-07-24 | 2020-12-18 | Grünenthal GmbH | Ethylcellulose-beschichtete Partikel enthaltend ein Salz aus Tapentadol und Phosphorsäure |
| DE202020005470U1 (de) | 2020-11-10 | 2022-01-25 | Grünenthal GmbH | Darreichungsformen mit verlängerter Freisetzung eines Salzes von Tapentadol mit L-(+)-Weinsäure |
| PE20240113A1 (es) | 2020-11-10 | 2024-01-22 | Gruenenthal Chemie | Formas de dosificacion de liberacion sostenida de una sal de tapentadol con acido l-(+)-tartarico |
| RS63521B1 (sr) | 2020-11-10 | 2022-09-30 | Gruenenthal Gmbh | Oblici doze sa produženim oslobađanjem soli tapentadola sa l-(+)-vinskom kiselinom |
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| DE19525137C2 (de) | 1995-07-11 | 2003-02-27 | Gruenenthal Gmbh | 6-Dimethylaminomethyl-1-phenyl-cyclohexanverbin -dungen als Zwischenprodukte zur Herstellung pharmazeutischer Wirkstoffe |
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| EP2295043A1 (en) * | 1999-10-29 | 2011-03-16 | Euro-Celtique S.A. | Controlled release hydrocodone formulations |
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2002
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- 2002-10-22 MX MXPA04003742A patent/MXPA04003742A/es active IP Right Grant
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- 2002-10-22 EP EP02781278A patent/EP1439829B1/de not_active Expired - Lifetime
- 2002-10-22 BR BRPI0213653A patent/BRPI0213653B8/pt active IP Right Grant
- 2002-10-22 DE DE50204198T patent/DE50204198D1/de not_active Expired - Lifetime
- 2002-10-22 WO PCT/EP2002/011806 patent/WO2003035054A1/de not_active Ceased
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- 2002-10-22 CN CNB028259769A patent/CN100402021C/zh not_active Expired - Lifetime
- 2002-10-22 KR KR1020047006113A patent/KR100958045B1/ko not_active Expired - Lifetime
- 2002-10-22 WO PCT/EP2002/011809 patent/WO2003035053A1/de not_active Ceased
- 2002-10-22 AT AT02781278T patent/ATE303802T1/de active
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- 2002-10-23 AR ARP020104010A patent/AR036943A1/es not_active Application Discontinuation
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2004
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- 2004-04-22 IL IL161587A patent/IL161587A/en active IP Right Grant
- 2004-04-26 US US10/831,368 patent/US20050058706A1/en not_active Abandoned
- 2004-05-11 NO NO20041924A patent/NO331896B1/no not_active IP Right Cessation
- 2004-05-12 EC EC2004005102A patent/ECSP045102A/es unknown
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2010
- 2010-08-05 JP JP2010176084A patent/JP2010280697A/ja active Pending
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2011
- 2011-09-23 US US13/242,800 patent/US20120034304A1/en not_active Abandoned
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2012
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2013
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2016
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2018
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