DK3241550T3 - Anvendelse af (1r,2r)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol til behandling af inflammatoriske smerter - Google Patents
Anvendelse af (1r,2r)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol til behandling af inflammatoriske smerter Download PDFInfo
- Publication number
- DK3241550T3 DK3241550T3 DK17020237.8T DK17020237T DK3241550T3 DK 3241550 T3 DK3241550 T3 DK 3241550T3 DK 17020237 T DK17020237 T DK 17020237T DK 3241550 T3 DK3241550 T3 DK 3241550T3
- Authority
- DK
- Denmark
- Prior art keywords
- alkyl
- hydrogen
- optionally substituted
- och
- hydroxy
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
- A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Emergency Medicine (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10254785A DE10254785A1 (de) | 2002-11-22 | 2002-11-22 | Kombination ausgewählter Analgetika mit COX II-Inhibitoren |
DE2003126103 DE10326103A1 (de) | 2003-06-06 | 2003-06-06 | Kombination ausgewählter Analgetika mit COX II-Inhibitoren |
EP03775368.8A EP1562567B1 (de) | 2002-11-22 | 2003-11-18 | Kombination ausgewählter analgetika mit cox ii-inhibitoren |
Publications (1)
Publication Number | Publication Date |
---|---|
DK3241550T3 true DK3241550T3 (da) | 2020-08-24 |
Family
ID=32395002
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK05027145T DK1685829T3 (da) | 2002-11-22 | 2003-11-18 | Anvendelse af (1RS,3RS,6RS)-6-dimethylaminomethyl-1-(3-methoxy-phenyl)-cyclohexan-1,3-diol til behandling af betændelsessmerte |
DK03775368.8T DK1562567T3 (da) | 2002-11-22 | 2003-11-18 | Kombination af udvalgte analgetika med COX II-hæmmere |
DK07014417.5T DK1839654T3 (da) | 2002-11-22 | 2003-11-18 | Anvendelse af (1R, 2R)-3-(3-dimenthylamino-1-ethyl-2-methylpropyl)- phenol til behandling af betændelsessmerte |
DK17020237.8T DK3241550T3 (da) | 2002-11-22 | 2003-11-18 | Anvendelse af (1r,2r)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol til behandling af inflammatoriske smerter |
Family Applications Before (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK05027145T DK1685829T3 (da) | 2002-11-22 | 2003-11-18 | Anvendelse af (1RS,3RS,6RS)-6-dimethylaminomethyl-1-(3-methoxy-phenyl)-cyclohexan-1,3-diol til behandling af betændelsessmerte |
DK03775368.8T DK1562567T3 (da) | 2002-11-22 | 2003-11-18 | Kombination af udvalgte analgetika med COX II-hæmmere |
DK07014417.5T DK1839654T3 (da) | 2002-11-22 | 2003-11-18 | Anvendelse af (1R, 2R)-3-(3-dimenthylamino-1-ethyl-2-methylpropyl)- phenol til behandling af betændelsessmerte |
Country Status (13)
Country | Link |
---|---|
US (7) | US7786160B2 (da) |
EP (6) | EP1685829B1 (da) |
AT (2) | ATE465726T1 (da) |
AU (1) | AU2003283410A1 (da) |
CY (4) | CY1108141T1 (da) |
DE (2) | DE50309605D1 (da) |
DK (4) | DK1685829T3 (da) |
ES (4) | ES2819854T3 (da) |
HU (2) | HUE033042T2 (da) |
LT (1) | LT1562567T (da) |
PT (4) | PT1562567T (da) |
SI (4) | SI1562567T1 (da) |
WO (1) | WO2004047823A1 (da) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT1562567T (pt) * | 2002-11-22 | 2017-08-24 | Gruenenthal Gmbh | Combinação de analgésicos selecionados e inibidores da cox-ii |
DE10356362A1 (de) * | 2003-11-28 | 2005-06-23 | Grünenthal GmbH | Verwendung von 1-Phenyl-3-dimethylamino-propanverbindungen zur Therapie von Angststörungen |
CA2649459C (en) * | 2006-04-28 | 2014-07-22 | Gruenenthal Gmbh | Pharmaceutical combination comprising 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol and an nsaid |
AU2007247481B2 (en) * | 2006-04-28 | 2013-02-14 | Grunenthal Gmbh | Pharmaceutical combination comprising 3- ( 3-Dimethylamino-1-ethyl-2-methyl-propyl) -phenol and paracetamol |
US20070254960A1 (en) * | 2006-04-28 | 2007-11-01 | Gruenenthal Gmbh | Pharmaceutical combination |
DE102007012165A1 (de) * | 2007-03-12 | 2008-09-18 | Grünenthal GmbH | Verwendung von 1-Phenyl-3-dimethylamino-propanverbindungen zur Therapie des Neuropathieschmerzes |
DE102007022790A1 (de) * | 2007-05-11 | 2008-11-20 | Grünenthal GmbH | Axomadol zur Schmerzbehandlung bei Arthrose |
KR101607112B1 (ko) * | 2007-11-23 | 2016-03-29 | 그뤼넨탈 게엠베하 | 타펜타돌 조성물 |
EP2085081A1 (de) | 2008-02-04 | 2009-08-05 | Grünenthal GmbH | 3-(2-Dimethylaminomethyl-cyclohexyl)-phenol gegen polyneuropathischen Schmerz |
AU2009289824A1 (en) * | 2008-09-05 | 2010-03-11 | Grunenthal Gmbh | Pharmaceutical combination comprising 6-Dimethylaminomethyl-1-(3-methoxy-phenyl)-cyclohexane-1,3 diol and Paracetamol |
EP2331102A1 (en) * | 2008-09-05 | 2011-06-15 | Grünenthal GmbH | Pharmaceutical combination comprising 6-dimethylaminomethyl-1-(3-methoxy-phenyl)-cyclohexane-1,3-diol and an nsaid |
US20100190752A1 (en) | 2008-09-05 | 2010-07-29 | Gruenenthal Gmbh | Pharmaceutical Combination |
RU2673882C1 (ru) * | 2008-10-30 | 2018-12-03 | Грюненталь Гмбх | Новые и эффективные лекарственные формы тапентадола |
WO2010124856A1 (en) * | 2009-04-30 | 2010-11-04 | Grünenthal GmbH | Use of 1-phenyl-3-dimethylaminopropane compounds for treating rheumatoid pain |
WO2011023392A1 (en) * | 2009-08-28 | 2011-03-03 | Grünenthal GmbH | Pharmaceutical combination comprising 6-dimethylaminomethyl-1-(3-methoxy-phenyl)-cyclohexane-1,3-diol or 6-dimethylaminomethyl-1-(3-hydroxy-phenyl)-cyclohexane-1,3-diol and an antiepileptic |
CN104276960B (zh) * | 2014-09-26 | 2016-09-28 | 安徽省逸欣铭医药科技有限公司 | 盐酸他喷他多和塞来昔布共晶及其组合物和制备方法 |
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US4389393A (en) | 1982-03-26 | 1983-06-21 | Forest Laboratories, Inc. | Sustained release therapeutic compositions based on high molecular weight hydroxypropylmethylcellulose |
US4612008A (en) | 1983-05-11 | 1986-09-16 | Alza Corporation | Osmotic device with dual thermodynamic activity |
US4783337A (en) | 1983-05-11 | 1988-11-08 | Alza Corporation | Osmotic system comprising plurality of members for dispensing drug |
US4765989A (en) | 1983-05-11 | 1988-08-23 | Alza Corporation | Osmotic device for administering certain drugs |
US5516803A (en) * | 1991-10-30 | 1996-05-14 | Mcneilab, Inc. | Composition comprising a tramadol material and a non-steroidal anti-inflammatory drug |
US5472711A (en) | 1992-07-30 | 1995-12-05 | Edward Mendell Co., Inc. | Agglomerated hydrophilic complexes with multi-phasic release characteristics |
US5330761A (en) | 1993-01-29 | 1994-07-19 | Edward Mendell Co. Inc. | Bioadhesive tablet for non-systemic use products |
US5455046A (en) | 1993-09-09 | 1995-10-03 | Edward Mendell Co., Inc. | Sustained release heterodisperse hydrogel systems for insoluble drugs |
US5399362A (en) | 1994-04-25 | 1995-03-21 | Edward Mendell Co., Inc. | Once-a-day metoprolol oral dosage form |
DE4425459C2 (de) | 1994-07-19 | 1997-11-27 | Meinecke Ag H | Woltmannzähler |
IT1276322B1 (it) | 1994-07-21 | 1997-10-28 | Vbc Srl | Procedimento per la purificazione dell'idrossido di magnesio |
DE4426245A1 (de) * | 1994-07-23 | 1996-02-22 | Gruenenthal Gmbh | 1-Phenyl-3-dimethylamino-propanverbindungen mit pharmakologischer Wirkung |
DE19525137C2 (de) * | 1995-07-11 | 2003-02-27 | Gruenenthal Gmbh | 6-Dimethylaminomethyl-1-phenyl-cyclohexanverbin -dungen als Zwischenprodukte zur Herstellung pharmazeutischer Wirkstoffe |
RS49982B (sr) | 1997-09-17 | 2008-09-29 | Euro-Celtique S.A., | Sinergistička analgetička kombinacija analgetičkog opijata i inhibitora ciklooksigenaze-2 |
EP0945134A1 (de) | 1998-03-27 | 1999-09-29 | Boehringer Ingelheim Pharma KG | Neue galenische Zubereitungsformen von Meloxicam zur oralen Applikation |
ES2141688B1 (es) * | 1998-11-06 | 2001-02-01 | Vita Invest Sa | Nuevos esteres derivados de compuestos fenil-ciclohexil sustituidos. |
SA99191255B1 (ar) | 1998-11-30 | 2006-11-25 | جي دي سيرل اند كو | مركبات سيليكوكسيب celecoxib |
CN1349423A (zh) * | 1999-03-01 | 2002-05-15 | 奥索-麦克尼尔药品公司 | 包含曲马多物质和选择性cox-2抑制剂药物的组合物 |
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DE10000312A1 (de) * | 2000-01-05 | 2001-07-12 | Gruenenthal Gmbh | Substituierte Aminomethyl-Phenyl-Cyclohexanderivate |
DE10004926A1 (de) * | 2000-02-04 | 2001-08-09 | Gruenenthal Gmbh | Verfahren zur enzymatischen Racematspaltung von Aminomethyl-Aryl-Cyclohexanol-Derivaten |
AR035642A1 (es) | 2000-05-26 | 2004-06-23 | Pharmacia Corp | Uso de una composicion de celecoxib para el alivio rapido del dolor |
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DE10059412A1 (de) * | 2000-11-30 | 2002-06-13 | Gruenenthal Gmbh | Verwendung von 1-Phenyl-3-dimethylamino-propanverbindungen zur Therapie der Harninkontinenz |
DE10059411A1 (de) * | 2000-11-30 | 2002-06-13 | Gruenenthal Gmbh | Verwendung von 6-Dimethylaminomethyl-1-phenyl-cyclohexanverbindungen zur Therapie der Harninkontinenz |
DE10109763A1 (de) | 2001-02-28 | 2002-09-05 | Gruenenthal Gmbh | Pharmazeutische Salze |
UA78529C2 (en) * | 2001-10-10 | 2007-04-10 | Wyeth Corp | Derivatives of [[2-(amino-3,4-dioxo-1-cyclobutene-1-yl)amino]alkyl] acid for treating pain |
PE20030527A1 (es) * | 2001-10-24 | 2003-07-26 | Gruenenthal Chemie | Formulacion farmaceutica con liberacion retardada que contiene 3-(3-dimetilamino-1-etil-2-metil-propil) fenol o una sal farmaceuticamente aceptable del mismo y tabletas para administracion oral que la contienen |
DE10225315A1 (de) * | 2002-06-06 | 2003-12-24 | Gruenenthal Gmbh | Wirkstoffsalze und Ester von 1-Dimethylamino-3-(3-methoxy-phenyl)-2-methyl- pentan-3-ol und 3-(3-Dimethylamino-1-ethyl-1-hydroxy-2-methyl- propyl)-phenol |
DE10250083A1 (de) * | 2002-06-17 | 2003-12-24 | Gruenenthal Gmbh | Gegen Missbrauch gesicherte Darreichungsform |
DE10233048A1 (de) * | 2002-07-19 | 2004-01-29 | Grünenthal GmbH | Verwendung von 1-Phenyl-3dimethylamino-propanverbindungen zur Therapie von depressiven Symptomatiken |
PT1562567T (pt) | 2002-11-22 | 2017-08-24 | Gruenenthal Gmbh | Combinação de analgésicos selecionados e inibidores da cox-ii |
-
2003
- 2003-11-18 PT PT37753688T patent/PT1562567T/pt unknown
- 2003-11-18 DK DK05027145T patent/DK1685829T3/da active
- 2003-11-18 DE DE50309605T patent/DE50309605D1/de not_active Expired - Lifetime
- 2003-11-18 PT PT170202378T patent/PT3241550T/pt unknown
- 2003-11-18 ES ES17020237T patent/ES2819854T3/es not_active Expired - Lifetime
- 2003-11-18 DK DK03775368.8T patent/DK1562567T3/da active
- 2003-11-18 AU AU2003283410A patent/AU2003283410A1/en not_active Abandoned
- 2003-11-18 HU HUE03775368A patent/HUE033042T2/en unknown
- 2003-11-18 LT LTEP03775368.8T patent/LT1562567T/lt unknown
- 2003-11-18 DE DE50312678T patent/DE50312678D1/de not_active Expired - Lifetime
- 2003-11-18 WO PCT/EP2003/012882 patent/WO2004047823A1/de not_active Application Discontinuation
- 2003-11-18 SI SI200332541T patent/SI1562567T1/sl unknown
- 2003-11-18 EP EP05027145A patent/EP1685829B1/de not_active Expired - Lifetime
- 2003-11-18 DK DK07014417.5T patent/DK1839654T3/da active
- 2003-11-18 EP EP19217676.6A patent/EP3662904A1/de not_active Withdrawn
- 2003-11-18 SI SI200331816T patent/SI1839654T1/sl unknown
- 2003-11-18 PT PT05027145T patent/PT1685829E/pt unknown
- 2003-11-18 AT AT07014417T patent/ATE465726T1/de active
- 2003-11-18 EP EP03775368.8A patent/EP1562567B1/de not_active Expired - Lifetime
- 2003-11-18 PT PT07014417T patent/PT1839654E/pt unknown
- 2003-11-18 SI SI200332616T patent/SI3241550T1/sl unknown
- 2003-11-18 ES ES05027145T patent/ES2304659T3/es not_active Expired - Lifetime
- 2003-11-18 EP EP07014417A patent/EP1839654B9/de not_active Revoked
- 2003-11-18 EP EP07023952A patent/EP1908460A1/de not_active Withdrawn
- 2003-11-18 ES ES03775368.8T patent/ES2640404T3/es not_active Expired - Lifetime
- 2003-11-18 EP EP17020237.8A patent/EP3241550B1/de not_active Revoked
- 2003-11-18 HU HUE17020237A patent/HUE051024T2/hu unknown
- 2003-11-18 AT AT05027145T patent/ATE391498T1/de active
- 2003-11-18 SI SI200331224T patent/SI1685829T1/sl unknown
- 2003-11-18 ES ES07014417T patent/ES2345062T3/es not_active Expired - Lifetime
- 2003-11-18 DK DK17020237.8T patent/DK3241550T3/da active
-
2005
- 2005-05-20 US US11/133,190 patent/US7786160B2/en not_active Expired - Lifetime
-
2007
- 2007-07-09 US US11/774,816 patent/US8003701B2/en not_active Expired - Lifetime
-
2008
- 2008-06-12 CY CY20081100631T patent/CY1108141T1/el unknown
-
2010
- 2010-07-12 US US12/834,641 patent/US8420691B2/en not_active Expired - Lifetime
- 2010-07-12 US US12/834,664 patent/US8404749B2/en not_active Expired - Lifetime
- 2010-07-12 US US12/834,655 patent/US8618177B2/en not_active Expired - Lifetime
- 2010-07-15 CY CY20101100665T patent/CY1110246T1/el unknown
-
2012
- 2012-12-18 US US13/717,977 patent/US20130109733A1/en not_active Abandoned
-
2016
- 2016-06-07 US US15/175,564 patent/US10471079B2/en not_active Expired - Lifetime
-
2017
- 2017-07-18 CY CY20171100762T patent/CY1119082T1/el unknown
-
2020
- 2020-08-25 CY CY20201100793T patent/CY1123286T1/el unknown
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