BR0210468A - Derivados 6-(aril-amido ou aril-amidometil)-naftalen-2-ilóxi-acìdicos como inibidores de inibidor de ativador de plasminogênio tipo-1 (pai-1) - Google Patents
Derivados 6-(aril-amido ou aril-amidometil)-naftalen-2-ilóxi-acìdicos como inibidores de inibidor de ativador de plasminogênio tipo-1 (pai-1)Info
- Publication number
- BR0210468A BR0210468A BR0210468-7A BR0210468A BR0210468A BR 0210468 A BR0210468 A BR 0210468A BR 0210468 A BR0210468 A BR 0210468A BR 0210468 A BR0210468 A BR 0210468A
- Authority
- BR
- Brazil
- Prior art keywords
- phenyl
- aryl
- alkyl
- alkoxy
- substituted
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/67—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/68—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/73—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/48—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D307/85—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Furan Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
"DERIVADOS 6-(ARIL-AMIDO OU ARIL-AMIDOMETIL)-NAFTALEN-2-ILóXI-ACìDICOS COMO INIBIDORES DE INIBIDOR DE ATIVADOR DE PLASMINOGêNIO TIPO-1 (PAI-1)". Esta invenção fornece novos compostos, composições farmacêuticas e métodos de tratar distúrbios trombóticos em mamíferos, os compostos tendo a fórmula (I), em que: Ar é fenila, naftila, furanila, benzofuranila, indolila, pirazolila, oxazolila, fluorenila, fenilcicioalcano, onde o cicloalcano pode ser ciclopropila, ciclobutila, ciclopentila ou cicloexila e Ar pode ser opcionalmente substituído por um ou mais grupos selecionados de C~ 1~-C~ 6~ alquila, C~ 1~-C~ 6~ alcóxi, hidróxi, fenil-(CH~ 2~) 0-6-~, fenil-(CH~ 2~)~ 0-6~O-, C~ 3~-C~ 6~ cicloalquila, -(CH~ 2~)-C~ 3~-C~ 6~ cicloalquila, halógeno, C~ 1~-C~ 3~ perfluoroalquila e C~ 1~-C~ 3~ perfluoroalcóxi onde fenila pode ser substituída por um ou mais grupos selecionados de C~ 1~-C~ 6~ alquila, C~ 1~-C~ 6~ alcóxi, fenila, halógeno, trifluorometila e trifluorometóxi; R~ 1~, é hidrogênio, C~ 1~-C~ 6~ alquila ou fenil-(CH~ 2~)~ 1-6-~ onde fenila pode ser substituída por C~ 1~-C~ 6~ alquila, C~ 1~-C~ 6~ alcóxi, halo, trifluorometila e trifluorometóxi; R~ 2~ e R~ 3~ são H, C~ 1~-C~ 6~ alquila, fenil-(CH~ 2~)~ 0-3-~, halo e C~ 1~-C~ 3~ perfluoroalquila onde fenila pode ser substituída por C~ 1~-C~ 6~ alquila, C~ 1~-C~ 6~ alcóxi, halo, trifluorometila e trifluorometóxi; R~ 4~ é -CHR~ 5~CO~ 2~H ou -CH~ 2~-tetrazol onde R~ 5~ é H ou benzila; e n = 0 ou 1; ou uma forma de sal ou de éster farmaceuticamente aceitável deste.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US29965201P | 2001-06-20 | 2001-06-20 | |
US30865601P | 2001-07-30 | 2001-07-30 | |
PCT/US2002/019193 WO2003000649A1 (en) | 2001-06-20 | 2002-06-18 | 6-(aryl-amido or aryl-amidomethyl)-naphthalen-2-yloxy-acidic derivatives as inhibitors of plasminogen activator inhibitor type-1 (pai-1) |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0210468A true BR0210468A (pt) | 2004-08-10 |
Family
ID=26971330
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0210468-7A BR0210468A (pt) | 2001-06-20 | 2002-06-18 | Derivados 6-(aril-amido ou aril-amidometil)-naftalen-2-ilóxi-acìdicos como inibidores de inibidor de ativador de plasminogênio tipo-1 (pai-1) |
Country Status (12)
Country | Link |
---|---|
US (1) | US6589970B2 (pt) |
EP (1) | EP1397341B1 (pt) |
JP (1) | JP4394949B2 (pt) |
CN (1) | CN100467443C (pt) |
AR (1) | AR036099A1 (pt) |
AT (1) | ATE403643T1 (pt) |
BR (1) | BR0210468A (pt) |
CA (1) | CA2450174A1 (pt) |
DE (1) | DE60228079D1 (pt) |
MX (1) | MXPA03011409A (pt) |
TW (1) | TW591020B (pt) |
WO (1) | WO2003000649A1 (pt) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7291639B2 (en) * | 2001-06-20 | 2007-11-06 | Wyeth | Aryloxy-acetic acid compounds useful as inhibitors of plasminogen activator inhibitor-1 (PAI-1) |
CA2497901A1 (en) | 2002-09-06 | 2004-03-18 | Takeda Pharmaceutical Company Limited | Furan or thiophene derivative and medicinal use thereof |
JP4629657B2 (ja) * | 2003-04-11 | 2011-02-09 | ハイ・ポイント・ファーマスーティカルズ、エルエルシー | 11β−ヒドロキシステロイドデヒドロゲナーゼ1型化活性化合物 |
US7446201B2 (en) * | 2003-09-25 | 2008-11-04 | Wyeth | Substituted heteroaryl benzofuran acids |
US7534894B2 (en) * | 2003-09-25 | 2009-05-19 | Wyeth | Biphenyloxy-acids |
US7265148B2 (en) * | 2003-09-25 | 2007-09-04 | Wyeth | Substituted pyrrole-indoles |
US7326732B2 (en) * | 2004-02-12 | 2008-02-05 | Pharmagene Laboratories Limited | EP2 receptor agonists |
US7605172B2 (en) * | 2004-08-23 | 2009-10-20 | Wyeth | Thiazolo-naphthyl acids |
CN101039936A (zh) * | 2004-08-23 | 2007-09-19 | 惠氏公司 | 作为i-型纤溶酶原激活剂抑制剂(pai-1)调节剂用于治疗血栓形成和心血管疾病的唑基-萘基酸 |
DE102004051277A1 (de) | 2004-10-21 | 2006-04-27 | Merck Patent Gmbh | Heterocyclische Carbonylverbindungen |
US7214704B2 (en) * | 2004-11-15 | 2007-05-08 | Bristol-Myers Squibb Company | 2-Amino-1-functionalized tetralin derivatives and related glycogen phosphorylase inhibitors |
WO2006055462A1 (en) | 2004-11-15 | 2006-05-26 | Bristol-Myers Squibb Company | 2-amino-4-functionalized tetralin derivatives and related glycogen phosphorylase inhibitors |
WO2006055463A2 (en) * | 2004-11-15 | 2006-05-26 | Bristol-Myers Squibb Company | 2-amino-3-functionalized tetralin derivatives and related glycogen phosphorylase inhibitors |
WO2006055435A1 (en) * | 2004-11-15 | 2006-05-26 | Bristol-Myers Squibb Company | 2-aminonaphthalene derivatives and related glycogen phosphorylase inhibitors |
KR20070103744A (ko) | 2005-01-27 | 2007-10-24 | 와이어쓰 | 치환된 나프틸인돌 유도체를 제조하기 위한 방법 및 화합물 |
KR101394245B1 (ko) | 2005-12-30 | 2014-05-14 | 에스케이바이오팜 주식회사 | 아이속사졸 유도체 및 이의 용도 |
JP2009528290A (ja) * | 2006-02-27 | 2009-08-06 | ワイス | 筋肉病の処置のためのpai−1阻害剤 |
JP5374840B2 (ja) | 2006-07-20 | 2013-12-25 | Jnc株式会社 | カルシウム結合発光蛋白質、それをコードする遺伝子およびその用途 |
RU2447070C2 (ru) | 2006-08-15 | 2012-04-10 | Актелион Фармасьютиклз Лтд | Соединения азетидина в качестве антагонистов рецептора орексина |
EP2072498A4 (en) * | 2006-10-12 | 2012-07-18 | Inst Med Molecular Design Inc | N-PHENYLOXAMIDE ACID DERIVATIVE |
EP2080751A4 (en) | 2006-10-12 | 2011-06-22 | Inst Med Molecular Design Inc | CARBOXYLIC ACID DERIVATIVE |
US20110009453A1 (en) * | 2008-03-17 | 2011-01-13 | Donello John E | s1p3 receptor inhibitors for treating inflammation |
EP2272817A4 (en) | 2008-04-11 | 2011-12-14 | Inst Med Molecular Design Inc | INHIBITOR OF PAI-1 |
US8633245B2 (en) * | 2008-04-11 | 2014-01-21 | Institute Of Medicinal Molecular Design, Inc. | PAI-1 inhibitor |
CN104860907A (zh) | 2010-06-07 | 2015-08-26 | 诺沃梅迪科斯有限公司 | 呋喃基化合物及其用途 |
UA113499C2 (xx) | 2010-09-21 | 2017-02-10 | Фармацевтична композиція | |
US10730886B2 (en) * | 2015-09-04 | 2020-08-04 | Shin Poong Pharmaceutical Co., Ltd. | Compound having effect of inhibiting platelet aggregation and salt thereof, and composition for preventing or treating thrombotic diseases, containing same |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH07507574A (ja) * | 1993-04-05 | 1995-08-24 | 藤沢薬品工業株式会社 | テストステロン5α−レダクターゼ阻害剤用インドール誘導体 |
ES2103181B1 (es) * | 1994-08-01 | 1998-04-01 | Menarini Lab | Amidas naftalenicas con accion antagonista de los leucotrienos. |
DE4404662C2 (de) * | 1994-02-14 | 1997-10-23 | Windmoeller & Hoelscher | Abreißwalzenpaar |
GB9402807D0 (en) * | 1994-02-14 | 1994-04-06 | Xenova Ltd | Pharmaceutical compounds |
AU4058399A (en) | 1998-11-20 | 2000-06-13 | Torii Pharmaceutical Co., Ltd. | Naphthalene derivatives |
-
2002
- 2002-06-10 TW TW091112528A patent/TW591020B/zh not_active IP Right Cessation
- 2002-06-13 US US10/170,558 patent/US6589970B2/en not_active Expired - Fee Related
- 2002-06-18 WO PCT/US2002/019193 patent/WO2003000649A1/en active Application Filing
- 2002-06-18 JP JP2003506853A patent/JP4394949B2/ja not_active Expired - Fee Related
- 2002-06-18 EP EP02746561A patent/EP1397341B1/en not_active Expired - Lifetime
- 2002-06-18 CA CA002450174A patent/CA2450174A1/en not_active Abandoned
- 2002-06-18 DE DE60228079T patent/DE60228079D1/de not_active Expired - Fee Related
- 2002-06-18 BR BR0210468-7A patent/BR0210468A/pt not_active IP Right Cessation
- 2002-06-18 MX MXPA03011409A patent/MXPA03011409A/es active IP Right Grant
- 2002-06-18 AT AT02746561T patent/ATE403643T1/de not_active IP Right Cessation
- 2002-06-18 CN CNB028161866A patent/CN100467443C/zh not_active Expired - Fee Related
- 2002-06-20 AR ARP020102313A patent/AR036099A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
US20030045560A1 (en) | 2003-03-06 |
EP1397341B1 (en) | 2008-08-06 |
DE60228079D1 (en) | 2008-09-18 |
JP4394949B2 (ja) | 2010-01-06 |
ATE403643T1 (de) | 2008-08-15 |
CN100467443C (zh) | 2009-03-11 |
US6589970B2 (en) | 2003-07-08 |
WO2003000649A1 (en) | 2003-01-03 |
AR036099A1 (es) | 2004-08-11 |
CA2450174A1 (en) | 2003-01-03 |
JP2004536091A (ja) | 2004-12-02 |
EP1397341A1 (en) | 2004-03-17 |
CN1543453A (zh) | 2004-11-03 |
MXPA03011409A (es) | 2004-06-08 |
TW591020B (en) | 2004-06-11 |
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