DK1562567T3 - Kombination af udvalgte analgetika med COX II-hæmmere - Google Patents
Kombination af udvalgte analgetika med COX II-hæmmere Download PDFInfo
- Publication number
- DK1562567T3 DK1562567T3 DK03775368.8T DK03775368T DK1562567T3 DK 1562567 T3 DK1562567 T3 DK 1562567T3 DK 03775368 T DK03775368 T DK 03775368T DK 1562567 T3 DK1562567 T3 DK 1562567T3
- Authority
- DK
- Denmark
- Prior art keywords
- alkyl
- acid
- compound
- hydrogen
- cox
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
- A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Emergency Medicine (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Claims (4)
1. Kombination af virksomme bestanddele, bestående af mindst en analgetisk forbindelse A og mindst en COX Il-hæmmer, kendetegnet ved, at COX II-hæmmeren er udvalgt blandt celecoxib og rofecoxib, og forbindelse A er udvalgt blandt: (lR,2R)-3-(3-dimethylamino-l-ethyl-2-methyl-propyl)-phenol; hydrochlorid og (lS,2S)-3-(3-dimethylamino-l-ethyl-2-methyl-propyl)-phenol; hydrochlorid, i fremstillet form eller i form af syrer eller baser deraf eller i form af salte deraf, navnlig fysiologisk forligelige salte, eller i form af solvater deraf, navnlig hydrater.
2. Lægemiddel indeholdende en kombination af virksomme bestanddele ifølge krav 1 samt eventuelt egnede tilsætnings- og/eller hjælpestoffer eller yderligere virksomme bestanddele.
3. Anvendelse af en kombination af virksomme bestanddele ifølge et af kravene 1 eller 2 til fremstilling af et lægemiddel til behandling af smerte, navnlig neuropatisk, akut, kronisk, visceral eller cancerbetinget smerte.
4. Anvendelse ifølge krav 3, hvor smerten er inflammationssmerte.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10254785A DE10254785A1 (de) | 2002-11-22 | 2002-11-22 | Kombination ausgewählter Analgetika mit COX II-Inhibitoren |
DE2003126103 DE10326103A1 (de) | 2003-06-06 | 2003-06-06 | Kombination ausgewählter Analgetika mit COX II-Inhibitoren |
PCT/EP2003/012882 WO2004047823A1 (de) | 2002-11-22 | 2003-11-18 | Kombination ausgewählter analgetika mit cox ii-inhibitoren |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1562567T3 true DK1562567T3 (da) | 2017-07-17 |
Family
ID=32395002
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK07014417.5T DK1839654T3 (da) | 2002-11-22 | 2003-11-18 | Anvendelse af (1R, 2R)-3-(3-dimenthylamino-1-ethyl-2-methylpropyl)- phenol til behandling af betændelsessmerte |
DK05027145T DK1685829T3 (da) | 2002-11-22 | 2003-11-18 | Anvendelse af (1RS,3RS,6RS)-6-dimethylaminomethyl-1-(3-methoxy-phenyl)-cyclohexan-1,3-diol til behandling af betændelsessmerte |
DK17020237.8T DK3241550T3 (da) | 2002-11-22 | 2003-11-18 | Anvendelse af (1r,2r)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol til behandling af inflammatoriske smerter |
DK03775368.8T DK1562567T3 (da) | 2002-11-22 | 2003-11-18 | Kombination af udvalgte analgetika med COX II-hæmmere |
Family Applications Before (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK07014417.5T DK1839654T3 (da) | 2002-11-22 | 2003-11-18 | Anvendelse af (1R, 2R)-3-(3-dimenthylamino-1-ethyl-2-methylpropyl)- phenol til behandling af betændelsessmerte |
DK05027145T DK1685829T3 (da) | 2002-11-22 | 2003-11-18 | Anvendelse af (1RS,3RS,6RS)-6-dimethylaminomethyl-1-(3-methoxy-phenyl)-cyclohexan-1,3-diol til behandling af betændelsessmerte |
DK17020237.8T DK3241550T3 (da) | 2002-11-22 | 2003-11-18 | Anvendelse af (1r,2r)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol til behandling af inflammatoriske smerter |
Country Status (13)
Country | Link |
---|---|
US (7) | US7786160B2 (da) |
EP (6) | EP3662904A1 (da) |
AT (2) | ATE391498T1 (da) |
AU (1) | AU2003283410A1 (da) |
CY (4) | CY1108141T1 (da) |
DE (2) | DE50309605D1 (da) |
DK (4) | DK1839654T3 (da) |
ES (4) | ES2640404T3 (da) |
HU (2) | HUE033042T2 (da) |
LT (1) | LT1562567T (da) |
PT (4) | PT1562567T (da) |
SI (4) | SI1562567T1 (da) |
WO (1) | WO2004047823A1 (da) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HUE033042T2 (en) * | 2002-11-22 | 2017-11-28 | Gruenenthal Gmbh | Combination of selected analgesics with COX II inhibitors |
DE10356362A1 (de) | 2003-11-28 | 2005-06-23 | Grünenthal GmbH | Verwendung von 1-Phenyl-3-dimethylamino-propanverbindungen zur Therapie von Angststörungen |
PL2012763T3 (pl) * | 2006-04-28 | 2011-08-31 | Gruenenthal Gmbh | Kombinacja farmaceutyczna zawierająca 3-(3-dimetyloamino-1-etylo-2-metylo-propylo)-fenol i NSAID |
ES2356093T3 (es) | 2006-04-28 | 2011-04-04 | Grünenthal GmbH | Combinación farmacéutica que comprende 3-(3-dimetilamino-1-etil-2-metilpropil)fenol y paracetamol. |
US20070254960A1 (en) * | 2006-04-28 | 2007-11-01 | Gruenenthal Gmbh | Pharmaceutical combination |
DE102007012165A1 (de) * | 2007-03-12 | 2008-09-18 | Grünenthal GmbH | Verwendung von 1-Phenyl-3-dimethylamino-propanverbindungen zur Therapie des Neuropathieschmerzes |
DE102007022790A1 (de) * | 2007-05-11 | 2008-11-20 | Grünenthal GmbH | Axomadol zur Schmerzbehandlung bei Arthrose |
EP3170494A3 (en) * | 2007-11-23 | 2017-09-06 | Grünenthal GmbH | Tapentadol compositions |
EP2085081A1 (de) * | 2008-02-04 | 2009-08-05 | Grünenthal GmbH | 3-(2-Dimethylaminomethyl-cyclohexyl)-phenol gegen polyneuropathischen Schmerz |
JP2012501985A (ja) * | 2008-09-05 | 2012-01-26 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | 6−ジメチルアミノメチル−1−(3−メトキシフェニル)−シクロヘキサン−1,3−ジオールとパラセタモールを含む医薬の組み合わせ |
US20100190752A1 (en) | 2008-09-05 | 2010-07-29 | Gruenenthal Gmbh | Pharmaceutical Combination |
KR20110065488A (ko) * | 2008-09-05 | 2011-06-15 | 그뤼넨탈 게엠베하 | 6-디메틸아미노메틸-1-(3-메톡시-페닐)-사이클로헥산-1,3-디올 및 nsaid를 포함하는 약제학적 병용물 |
SI2352494T1 (sl) * | 2008-10-30 | 2019-12-31 | Gruenenthal Gmbh | Nove in potentne dozirne oblike tapentadola |
LT2424514T (lt) * | 2009-04-30 | 2017-04-25 | Grünenthal GmbH | Tapentadolis reumatoidinio artrito skausmo gydymui |
WO2011023392A1 (en) * | 2009-08-28 | 2011-03-03 | Grünenthal GmbH | Pharmaceutical combination comprising 6-dimethylaminomethyl-1-(3-methoxy-phenyl)-cyclohexane-1,3-diol or 6-dimethylaminomethyl-1-(3-hydroxy-phenyl)-cyclohexane-1,3-diol and an antiepileptic |
CN104276960B (zh) * | 2014-09-26 | 2016-09-28 | 安徽省逸欣铭医药科技有限公司 | 盐酸他喷他多和塞来昔布共晶及其组合物和制备方法 |
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PE20030527A1 (es) * | 2001-10-24 | 2003-07-26 | Gruenenthal Chemie | Formulacion farmaceutica con liberacion retardada que contiene 3-(3-dimetilamino-1-etil-2-metil-propil) fenol o una sal farmaceuticamente aceptable del mismo y tabletas para administracion oral que la contienen |
DE10225315A1 (de) * | 2002-06-06 | 2003-12-24 | Gruenenthal Gmbh | Wirkstoffsalze und Ester von 1-Dimethylamino-3-(3-methoxy-phenyl)-2-methyl- pentan-3-ol und 3-(3-Dimethylamino-1-ethyl-1-hydroxy-2-methyl- propyl)-phenol |
DE10250083A1 (de) * | 2002-06-17 | 2003-12-24 | Gruenenthal Gmbh | Gegen Missbrauch gesicherte Darreichungsform |
DE10233048A1 (de) * | 2002-07-19 | 2004-01-29 | Grünenthal GmbH | Verwendung von 1-Phenyl-3dimethylamino-propanverbindungen zur Therapie von depressiven Symptomatiken |
HUE033042T2 (en) | 2002-11-22 | 2017-11-28 | Gruenenthal Gmbh | Combination of selected analgesics with COX II inhibitors |
-
2003
- 2003-11-18 HU HUE03775368A patent/HUE033042T2/en unknown
- 2003-11-18 ES ES03775368.8T patent/ES2640404T3/es not_active Expired - Lifetime
- 2003-11-18 ES ES05027145T patent/ES2304659T3/es not_active Expired - Lifetime
- 2003-11-18 PT PT37753688T patent/PT1562567T/pt unknown
- 2003-11-18 ES ES17020237T patent/ES2819854T3/es not_active Expired - Lifetime
- 2003-11-18 EP EP19217676.6A patent/EP3662904A1/de not_active Withdrawn
- 2003-11-18 DE DE50309605T patent/DE50309605D1/de not_active Expired - Lifetime
- 2003-11-18 EP EP07023952A patent/EP1908460A1/de not_active Withdrawn
- 2003-11-18 DK DK07014417.5T patent/DK1839654T3/da active
- 2003-11-18 HU HUE17020237A patent/HUE051024T2/hu unknown
- 2003-11-18 EP EP07014417A patent/EP1839654B9/de not_active Revoked
- 2003-11-18 LT LTEP03775368.8T patent/LT1562567T/lt unknown
- 2003-11-18 AT AT05027145T patent/ATE391498T1/de active
- 2003-11-18 PT PT07014417T patent/PT1839654E/pt unknown
- 2003-11-18 DE DE50312678T patent/DE50312678D1/de not_active Expired - Lifetime
- 2003-11-18 EP EP03775368.8A patent/EP1562567B1/de not_active Expired - Lifetime
- 2003-11-18 SI SI200332541T patent/SI1562567T1/sl unknown
- 2003-11-18 SI SI200332616T patent/SI3241550T1/sl unknown
- 2003-11-18 WO PCT/EP2003/012882 patent/WO2004047823A1/de not_active Application Discontinuation
- 2003-11-18 SI SI200331816T patent/SI1839654T1/sl unknown
- 2003-11-18 DK DK05027145T patent/DK1685829T3/da active
- 2003-11-18 DK DK17020237.8T patent/DK3241550T3/da active
- 2003-11-18 DK DK03775368.8T patent/DK1562567T3/da active
- 2003-11-18 PT PT170202378T patent/PT3241550T/pt unknown
- 2003-11-18 AT AT07014417T patent/ATE465726T1/de active
- 2003-11-18 EP EP05027145A patent/EP1685829B1/de not_active Expired - Lifetime
- 2003-11-18 ES ES07014417T patent/ES2345062T3/es not_active Expired - Lifetime
- 2003-11-18 AU AU2003283410A patent/AU2003283410A1/en not_active Abandoned
- 2003-11-18 SI SI200331224T patent/SI1685829T1/sl unknown
- 2003-11-18 PT PT05027145T patent/PT1685829E/pt unknown
- 2003-11-18 EP EP17020237.8A patent/EP3241550B1/de not_active Revoked
-
2005
- 2005-05-20 US US11/133,190 patent/US7786160B2/en not_active Expired - Lifetime
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2007
- 2007-07-09 US US11/774,816 patent/US8003701B2/en not_active Expired - Lifetime
-
2008
- 2008-06-12 CY CY20081100631T patent/CY1108141T1/el unknown
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2010
- 2010-07-12 US US12/834,641 patent/US8420691B2/en not_active Expired - Lifetime
- 2010-07-12 US US12/834,664 patent/US8404749B2/en not_active Expired - Lifetime
- 2010-07-12 US US12/834,655 patent/US8618177B2/en not_active Expired - Lifetime
- 2010-07-15 CY CY20101100665T patent/CY1110246T1/el unknown
-
2012
- 2012-12-18 US US13/717,977 patent/US20130109733A1/en not_active Abandoned
-
2016
- 2016-06-07 US US15/175,564 patent/US10471079B2/en not_active Expired - Lifetime
-
2017
- 2017-07-18 CY CY20171100762T patent/CY1119082T1/el unknown
-
2020
- 2020-08-25 CY CY20201100793T patent/CY1123286T1/el unknown
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