SI1685829T1 - Uporaba (1RS,3RS,6RS)-6-dimetilaminometil-1- (3-metoksi-fenil)-cikloheksan-1, 3-diola za zdravljenje vnetne bolečine - Google Patents

Uporaba (1RS,3RS,6RS)-6-dimetilaminometil-1- (3-metoksi-fenil)-cikloheksan-1, 3-diola za zdravljenje vnetne bolečine

Info

Publication number
SI1685829T1
SI1685829T1 SI200331224T SI200331224T SI1685829T1 SI 1685829 T1 SI1685829 T1 SI 1685829T1 SI 200331224 T SI200331224 T SI 200331224T SI 200331224 T SI200331224 T SI 200331224T SI 1685829 T1 SI1685829 T1 SI 1685829T1
Authority
SI
Slovenia
Prior art keywords
alkyl
hydrogen
optionally substituted
phenyl
och
Prior art date
Application number
SI200331224T
Other languages
English (en)
Inventor
Klaus Dr Schiene
Gunter Haase
Babette-Yvonne Dr Kogel
Elmar Dr Friderichs
Urich Dr Jahnel
Original Assignee
Gruenenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32395002&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI1685829(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from DE10254785A external-priority patent/DE10254785A1/de
Priority claimed from DE2003126103 external-priority patent/DE10326103A1/de
Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh
Publication of SI1685829T1 publication Critical patent/SI1685829T1/sl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
    • A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
SI200331224T 2002-11-22 2003-11-18 Uporaba (1RS,3RS,6RS)-6-dimetilaminometil-1- (3-metoksi-fenil)-cikloheksan-1, 3-diola za zdravljenje vnetne bolečine SI1685829T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10254785A DE10254785A1 (de) 2002-11-22 2002-11-22 Kombination ausgewählter Analgetika mit COX II-Inhibitoren
DE2003126103 DE10326103A1 (de) 2003-06-06 2003-06-06 Kombination ausgewählter Analgetika mit COX II-Inhibitoren
EP05027145A EP1685829B1 (de) 2002-11-22 2003-11-18 Verwendung von (1RS,3RS,6RS)-6-dimethylaminomethyl-1-(3-methoxy-phenyl)-cyclohexan-1,3-diol zur Behandlung von Entzündungsschmerz

Publications (1)

Publication Number Publication Date
SI1685829T1 true SI1685829T1 (sl) 2008-08-31

Family

ID=32395002

Family Applications (4)

Application Number Title Priority Date Filing Date
SI200332616T SI3241550T1 (sl) 2002-11-22 2003-11-18 Uporaba (1R, 2R) -3- (3-dimetilimanino-1-etil-2-metil-propil)-fenola za zdravljenje vnetnih bolečin
SI200331816T SI1839654T1 (sl) 2002-11-22 2003-11-18 Uporaba (1R, 2R)-3-(3-dimetilamino-1-etil-2-metil- propil)-fenola za zdravljenje vnetne bolečine
SI200332541T SI1562567T1 (sl) 2002-11-22 2003-11-18 Kombinacija izbranih analgetikov s COX II-zaviralci
SI200331224T SI1685829T1 (sl) 2002-11-22 2003-11-18 Uporaba (1RS,3RS,6RS)-6-dimetilaminometil-1- (3-metoksi-fenil)-cikloheksan-1, 3-diola za zdravljenje vnetne bolečine

Family Applications Before (3)

Application Number Title Priority Date Filing Date
SI200332616T SI3241550T1 (sl) 2002-11-22 2003-11-18 Uporaba (1R, 2R) -3- (3-dimetilimanino-1-etil-2-metil-propil)-fenola za zdravljenje vnetnih bolečin
SI200331816T SI1839654T1 (sl) 2002-11-22 2003-11-18 Uporaba (1R, 2R)-3-(3-dimetilamino-1-etil-2-metil- propil)-fenola za zdravljenje vnetne bolečine
SI200332541T SI1562567T1 (sl) 2002-11-22 2003-11-18 Kombinacija izbranih analgetikov s COX II-zaviralci

Country Status (13)

Country Link
US (7) US7786160B2 (sl)
EP (6) EP3241550B1 (sl)
AT (2) ATE465726T1 (sl)
AU (1) AU2003283410A1 (sl)
CY (4) CY1108141T1 (sl)
DE (2) DE50309605D1 (sl)
DK (4) DK1839654T3 (sl)
ES (4) ES2345062T3 (sl)
HU (2) HUE033042T2 (sl)
LT (1) LT1562567T (sl)
PT (4) PT1685829E (sl)
SI (4) SI3241550T1 (sl)
WO (1) WO2004047823A1 (sl)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003283410A1 (en) * 2002-11-22 2004-06-18 Grunenthal Gmbh Combination of selected analgesics and cox-ii inhibitors
DE10356362A1 (de) * 2003-11-28 2005-06-23 Grünenthal GmbH Verwendung von 1-Phenyl-3-dimethylamino-propanverbindungen zur Therapie von Angststörungen
US20070254960A1 (en) * 2006-04-28 2007-11-01 Gruenenthal Gmbh Pharmaceutical combination
AU2007247480B8 (en) * 2006-04-28 2013-04-11 Grunenthal Gmbh Pharmaceutical combination comprising 3- (3-dimethylamino-1-ethyl-2-methyl-propyl) -phenol and an NSAID
MX2008013779A (es) 2006-04-28 2008-11-14 Gruenenthal Gmbh Combinacion farmaceutica que comprende 3-(3-dimetilamino-1-etil-2- metil-propil)-fenol y paracetamol.
DE102007012165A1 (de) * 2007-03-12 2008-09-18 Grünenthal GmbH Verwendung von 1-Phenyl-3-dimethylamino-propanverbindungen zur Therapie des Neuropathieschmerzes
DE102007022790A1 (de) * 2007-05-11 2008-11-20 Grünenthal GmbH Axomadol zur Schmerzbehandlung bei Arthrose
BRPI0819451A2 (pt) * 2007-11-23 2017-10-03 Protect Pharmaceutical Corp Composição farmacêutica, método para tratar dor, kit farmacêutico, e, uso de uma composição
EP2085081A1 (de) * 2008-02-04 2009-08-05 Grünenthal GmbH 3-(2-Dimethylaminomethyl-cyclohexyl)-phenol gegen polyneuropathischen Schmerz
US20100190752A1 (en) 2008-09-05 2010-07-29 Gruenenthal Gmbh Pharmaceutical Combination
NZ591419A (en) * 2008-09-05 2011-11-25 Gruenenthal Chemie Pharmaceutical combination comprising 6-dimethylaminomethyl-1-(3-methoxy-phenyl)-cyclohexane-1,3 diol and paracetamol
BRPI0918919A2 (pt) * 2008-09-05 2015-12-01 Gruenenthal Gmbh composição farmaceutica compreendendo 6-dimetilaminometil-1-(3-metoxifenil)-ciclo-hexano-1,3-diol e um nsaid
CN102281876A (zh) * 2008-10-30 2011-12-14 格吕伦塔尔有限公司 新型有效的他喷他多剂型
PT2424514T (pt) * 2009-04-30 2017-05-30 Gruenenthal Gmbh Tapentadol para o tratamento da dor artrítica reumatoide
WO2011023392A1 (en) * 2009-08-28 2011-03-03 Grünenthal GmbH Pharmaceutical combination comprising 6-dimethylaminomethyl-1-(3-methoxy-phenyl)-cyclohexane-1,3-diol or 6-dimethylaminomethyl-1-(3-hydroxy-phenyl)-cyclohexane-1,3-diol and an antiepileptic
CN104276960B (zh) * 2014-09-26 2016-09-28 安徽省逸欣铭医药科技有限公司 盐酸他喷他多和塞来昔布共晶及其组合物和制备方法

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4389393A (en) 1982-03-26 1983-06-21 Forest Laboratories, Inc. Sustained release therapeutic compositions based on high molecular weight hydroxypropylmethylcellulose
US4765989A (en) 1983-05-11 1988-08-23 Alza Corporation Osmotic device for administering certain drugs
US4783337A (en) 1983-05-11 1988-11-08 Alza Corporation Osmotic system comprising plurality of members for dispensing drug
US4612008A (en) 1983-05-11 1986-09-16 Alza Corporation Osmotic device with dual thermodynamic activity
US5516803A (en) * 1991-10-30 1996-05-14 Mcneilab, Inc. Composition comprising a tramadol material and a non-steroidal anti-inflammatory drug
US5472711A (en) 1992-07-30 1995-12-05 Edward Mendell Co., Inc. Agglomerated hydrophilic complexes with multi-phasic release characteristics
US5330761A (en) 1993-01-29 1994-07-19 Edward Mendell Co. Inc. Bioadhesive tablet for non-systemic use products
US5455046A (en) 1993-09-09 1995-10-03 Edward Mendell Co., Inc. Sustained release heterodisperse hydrogel systems for insoluble drugs
US5399362A (en) 1994-04-25 1995-03-21 Edward Mendell Co., Inc. Once-a-day metoprolol oral dosage form
DE4425459C2 (de) 1994-07-19 1997-11-27 Meinecke Ag H Woltmannzähler
IT1276322B1 (it) 1994-07-21 1997-10-28 Vbc Srl Procedimento per la purificazione dell'idrossido di magnesio
DE4426245A1 (de) 1994-07-23 1996-02-22 Gruenenthal Gmbh 1-Phenyl-3-dimethylamino-propanverbindungen mit pharmakologischer Wirkung
DE19525137C2 (de) * 1995-07-11 2003-02-27 Gruenenthal Gmbh 6-Dimethylaminomethyl-1-phenyl-cyclohexanverbin -dungen als Zwischenprodukte zur Herstellung pharmazeutischer Wirkstoffe
RS49982B (sr) 1997-09-17 2008-09-29 Euro-Celtique S.A., Sinergistička analgetička kombinacija analgetičkog opijata i inhibitora ciklooksigenaze-2
EP0945134A1 (de) 1998-03-27 1999-09-29 Boehringer Ingelheim Pharma KG Neue galenische Zubereitungsformen von Meloxicam zur oralen Applikation
ES2141688B1 (es) * 1998-11-06 2001-02-01 Vita Invest Sa Nuevos esteres derivados de compuestos fenil-ciclohexil sustituidos.
SA99191255B1 (ar) 1998-11-30 2006-11-25 جي دي سيرل اند كو مركبات سيليكوكسيب celecoxib
EP1156855A1 (en) * 1999-03-01 2001-11-28 Ortho-McNeil Pharmaceutical, Inc. Composition comprising a tramadol material and a selective cox-2 inhibitor drug
JP2003516353A (ja) 1999-12-08 2003-05-13 ファルマシア コーポレイション ヴァルデコキシブ組成物
DE10000312A1 (de) 2000-01-05 2001-07-12 Gruenenthal Gmbh Substituierte Aminomethyl-Phenyl-Cyclohexanderivate
DE10004926A1 (de) * 2000-02-04 2001-08-09 Gruenenthal Gmbh Verfahren zur enzymatischen Racematspaltung von Aminomethyl-Aryl-Cyclohexanol-Derivaten
AR035642A1 (es) 2000-05-26 2004-06-23 Pharmacia Corp Uso de una composicion de celecoxib para el alivio rapido del dolor
DE10049483A1 (de) * 2000-09-29 2002-05-02 Gruenenthal Gmbh Substituierte 1-Aminobutan-3-ol-Derivate
DE10059411A1 (de) * 2000-11-30 2002-06-13 Gruenenthal Gmbh Verwendung von 6-Dimethylaminomethyl-1-phenyl-cyclohexanverbindungen zur Therapie der Harninkontinenz
DE10059412A1 (de) * 2000-11-30 2002-06-13 Gruenenthal Gmbh Verwendung von 1-Phenyl-3-dimethylamino-propanverbindungen zur Therapie der Harninkontinenz
DE10109763A1 (de) * 2001-02-28 2002-09-05 Gruenenthal Gmbh Pharmazeutische Salze
UA78529C2 (en) * 2001-10-10 2007-04-10 Wyeth Corp Derivatives of [[2-(amino-3,4-dioxo-1-cyclobutene-1-yl)amino]alkyl] acid for treating pain
PE20030527A1 (es) * 2001-10-24 2003-07-26 Gruenenthal Chemie Formulacion farmaceutica con liberacion retardada que contiene 3-(3-dimetilamino-1-etil-2-metil-propil) fenol o una sal farmaceuticamente aceptable del mismo y tabletas para administracion oral que la contienen
DE10225315A1 (de) * 2002-06-06 2003-12-24 Gruenenthal Gmbh Wirkstoffsalze und Ester von 1-Dimethylamino-3-(3-methoxy-phenyl)-2-methyl- pentan-3-ol und 3-(3-Dimethylamino-1-ethyl-1-hydroxy-2-methyl- propyl)-phenol
DE10250083A1 (de) * 2002-06-17 2003-12-24 Gruenenthal Gmbh Gegen Missbrauch gesicherte Darreichungsform
DE10233048A1 (de) * 2002-07-19 2004-01-29 Grünenthal GmbH Verwendung von 1-Phenyl-3dimethylamino-propanverbindungen zur Therapie von depressiven Symptomatiken
AU2003283410A1 (en) * 2002-11-22 2004-06-18 Grunenthal Gmbh Combination of selected analgesics and cox-ii inhibitors

Also Published As

Publication number Publication date
SI3241550T1 (sl) 2020-11-30
PT1685829E (pt) 2008-05-15
US8420691B2 (en) 2013-04-16
EP1685829B1 (de) 2008-04-09
DE50312678D1 (de) 2010-06-10
CY1123286T1 (el) 2021-12-31
EP1839654A2 (de) 2007-10-03
US8003701B2 (en) 2011-08-23
CY1110246T1 (el) 2015-01-14
ES2640404T3 (es) 2017-11-02
US20130109733A1 (en) 2013-05-02
ES2304659T3 (es) 2008-10-16
EP1562567B1 (de) 2017-06-14
US8618177B2 (en) 2013-12-31
DK1685829T3 (da) 2008-07-21
US20050277687A1 (en) 2005-12-15
EP1908460A1 (de) 2008-04-09
US20100280126A1 (en) 2010-11-04
US20100280017A1 (en) 2010-11-04
CY1119082T1 (el) 2018-01-10
ATE465726T1 (de) 2010-05-15
EP1839654B1 (de) 2010-04-28
EP1839654B9 (de) 2012-01-11
HUE051024T2 (hu) 2021-03-01
WO2004047823A1 (de) 2004-06-10
US8404749B2 (en) 2013-03-26
US20070249724A1 (en) 2007-10-25
EP1685829A1 (de) 2006-08-02
PT3241550T (pt) 2020-08-11
CY1108141T1 (el) 2014-04-09
US10471079B2 (en) 2019-11-12
PT1562567T (pt) 2017-08-24
SI1562567T1 (sl) 2017-09-29
DK1839654T3 (da) 2010-08-16
EP3241550B1 (de) 2020-07-22
DE50309605D1 (de) 2008-05-21
HUE033042T2 (en) 2017-11-28
AU2003283410A1 (en) 2004-06-18
PT1839654E (pt) 2010-07-06
EP3241550A1 (de) 2017-11-08
EP1839654A3 (de) 2007-11-07
DK3241550T3 (da) 2020-08-24
ES2345062T3 (es) 2010-09-14
EP3662904A1 (de) 2020-06-10
ATE391498T1 (de) 2008-04-15
SI1839654T1 (sl) 2010-08-31
EP1562567A1 (de) 2005-08-17
DK1562567T3 (en) 2017-07-17
US20100280129A1 (en) 2010-11-04
US20160279150A1 (en) 2016-09-29
LT1562567T (lt) 2017-08-25
ES2819854T3 (es) 2021-04-19
US7786160B2 (en) 2010-08-31

Similar Documents

Publication Publication Date Title
CY1123286T1 (el) Χρηση (1r,2r)-3-(3-διμεθυλαμινο-1-αιθυλ-2-μεθυλ-προπυλ)-φαινολης για την αγωγη του φλεγμονωδους πονου
HRP20110078T1 (hr) Postupak reduciranja alfa, beta nezasićenih ketona u opioidnim sastavima
HK1095736A1 (en) Use of r-(+)-2-(3-diisopropylamino-1-phenylpropyl)-4-hydroxy-methyl- phenylisobutyric acid ester hydrogenfumarate for the treatment of urinary incontinence and other spasmogenic disorders r-(+)-2-(3-
CA2616721C (en) Methods for treating substance-related disorders
RU2008146816A (ru) Фармацевтическая комбинация, содержащая 3-(3-диметиламино-1-этил-2-метилпропил)фенол и парацетамол
ZA200803643B (en) Aminoacid derivatives containing a disulfanyl group in the form of mixed disulfanyl and aminopeptidase N inhibitors
RU2008146815A (ru) Фармацевтическая комбинация, включающая 3-(3-диметиламино-1-этил-2-метилпропил)фенол т нестероидный противовоспалительный препарат
EP1022026A3 (en) Pharmaceutical compositions for treating nitrate-induced tolerance
WO2005067903A8 (en) Pharmaceutical compositions comprising higher primary alcohols and ezetimibe and process of preparation thereof
MX2007012300A (es) Uso de nefopam y analogos del mismo para el tratamiento de un sindrome caracterizado por dolor cronico y fatiga.
RU2004111788A (ru) Комбинация определенных опиоидов с мускариновыми антагонистами для терапии недержания мочи
DE602005009126D1 (de) Benzoxazine zur vorbeugung oder behandlung der durch morphinderivaten verursachte hyperalgesia
EA200700611A1 (ru) Производные бетулинола в качестве противораковых агентов
AR009484A1 (es) Un compuesto de acido n-sustituido-2-amino-4-fenil-4-oxo-butanoico, su utilizacion como inhibidor de la quinurenina-3-hidroxilasa y una composicionfarmaceutica que lo comprende.
AR012124A1 (es) Un procedimiento para la preparacion de derivados de tiazolidinadiona, derivados de tiazolidinadiona, su uso y preparados farmaceuticos que contienen a dichos derivados.
RU2003117705A (ru) Применение замещенных 6-диметиламинометил-1-фенилциклогексановых соединений для терапии недержания мочи
ATE341609T1 (de) Zusammensetzung enthaltend eine mischung aus mono-und polylactylalkyllactaten
AR019664A1 (es) Composicion para el tratamiento de enfermedades del cartilago
TW351667B (en) Antibacterial-antifungal composition
RU2000128495A (ru) Новые ингибиторы тромбина, их получение и применение