HUE051024T2 - (1R,2R)-3-(3-dimetilamino-1-etil-2-metil-propil)-fenol alkalmazása gyulladásos fájdalom kezelésére - Google Patents

(1R,2R)-3-(3-dimetilamino-1-etil-2-metil-propil)-fenol alkalmazása gyulladásos fájdalom kezelésére

Info

Publication number
HUE051024T2
HUE051024T2 HUE17020237A HUE17020237A HUE051024T2 HU E051024 T2 HUE051024 T2 HU E051024T2 HU E17020237 A HUE17020237 A HU E17020237A HU E17020237 A HUE17020237 A HU E17020237A HU E051024 T2 HUE051024 T2 HU E051024T2
Authority
HU
Hungary
Prior art keywords
alkyl
hydrogen
optionally substituted
och
hydroxy
Prior art date
Application number
HUE17020237A
Other languages
English (en)
Inventor
Klaus Schiene
Guenter Haase
Babette-Yvonne Koegel
Elmar Friderichs
Ulrich Jahnel
Original Assignee
Gruenenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32395002&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUE051024(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from DE10254785A external-priority patent/DE10254785A1/de
Priority claimed from DE2003126103 external-priority patent/DE10326103A1/de
Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh
Publication of HUE051024T2 publication Critical patent/HUE051024T2/hu

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/63Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
    • A61K31/635Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365Lactones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4151,2-Diazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Emergency Medicine (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HUE17020237A 2002-11-22 2003-11-18 (1R,2R)-3-(3-dimetilamino-1-etil-2-metil-propil)-fenol alkalmazása gyulladásos fájdalom kezelésére HUE051024T2 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10254785A DE10254785A1 (de) 2002-11-22 2002-11-22 Kombination ausgewählter Analgetika mit COX II-Inhibitoren
DE2003126103 DE10326103A1 (de) 2003-06-06 2003-06-06 Kombination ausgewählter Analgetika mit COX II-Inhibitoren

Publications (1)

Publication Number Publication Date
HUE051024T2 true HUE051024T2 (hu) 2021-03-01

Family

ID=32395002

Family Applications (2)

Application Number Title Priority Date Filing Date
HUE17020237A HUE051024T2 (hu) 2002-11-22 2003-11-18 (1R,2R)-3-(3-dimetilamino-1-etil-2-metil-propil)-fenol alkalmazása gyulladásos fájdalom kezelésére
HUE03775368A HUE033042T2 (hu) 2002-11-22 2003-11-18 Kiválasztott analgetikum kombinációja COX II-inhibitorokkal

Family Applications After (1)

Application Number Title Priority Date Filing Date
HUE03775368A HUE033042T2 (hu) 2002-11-22 2003-11-18 Kiválasztott analgetikum kombinációja COX II-inhibitorokkal

Country Status (13)

Country Link
US (7) US7786160B2 (hu)
EP (6) EP1839654B9 (hu)
AT (2) ATE391498T1 (hu)
AU (1) AU2003283410A1 (hu)
CY (4) CY1108141T1 (hu)
DE (2) DE50312678D1 (hu)
DK (4) DK1839654T3 (hu)
ES (4) ES2640404T3 (hu)
HU (2) HUE051024T2 (hu)
LT (1) LT1562567T (hu)
PT (4) PT3241550T (hu)
SI (4) SI1685829T1 (hu)
WO (1) WO2004047823A1 (hu)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI1685829T1 (sl) 2002-11-22 2008-08-31 Gruenenthal Gmbh Uporaba (1RS,3RS,6RS)-6-dimetilaminometil-1- (3-metoksi-fenil)-cikloheksan-1, 3-diola za zdravljenje vnetne bolečine
DE10356362A1 (de) 2003-11-28 2005-06-23 Grünenthal GmbH Verwendung von 1-Phenyl-3-dimethylamino-propanverbindungen zur Therapie von Angststörungen
PL2012763T3 (pl) * 2006-04-28 2011-08-31 Gruenenthal Gmbh Kombinacja farmaceutyczna zawierająca 3-(3-dimetyloamino-1-etylo-2-metylo-propylo)-fenol i NSAID
US20070254960A1 (en) * 2006-04-28 2007-11-01 Gruenenthal Gmbh Pharmaceutical combination
BRPI0710682B8 (pt) * 2006-04-28 2021-05-25 Gruenenthal Gmbh combinação farmacêutica compreendendo 3-(3-dimetilamino-1-etil-2-metil-propil)-fenol e paracetamol
DE102007012165A1 (de) * 2007-03-12 2008-09-18 Grünenthal GmbH Verwendung von 1-Phenyl-3-dimethylamino-propanverbindungen zur Therapie des Neuropathieschmerzes
DE102007022790A1 (de) * 2007-05-11 2008-11-20 Grünenthal GmbH Axomadol zur Schmerzbehandlung bei Arthrose
ES2619329T3 (es) * 2007-11-23 2017-06-26 Grünenthal GmbH Composiciones de tapentadol
EP2085081A1 (de) 2008-02-04 2009-08-05 Grünenthal GmbH 3-(2-Dimethylaminomethyl-cyclohexyl)-phenol gegen polyneuropathischen Schmerz
US20100190752A1 (en) 2008-09-05 2010-07-29 Gruenenthal Gmbh Pharmaceutical Combination
US20100069501A1 (en) * 2008-09-05 2010-03-18 Gruenenthal Gmbh Pharmaceutical Composition Comprising 6-Dimethylaminomethyl-1-(3-methoxy-phenyl)-cyclohexane-1,3-diol and Paracetamol
KR20110065488A (ko) * 2008-09-05 2011-06-15 그뤼넨탈 게엠베하 6-디메틸아미노메틸-1-(3-메톡시-페닐)-사이클로헥산-1,3-디올 및 nsaid를 포함하는 약제학적 병용물
PE20190391A1 (es) * 2008-10-30 2019-03-13 Gruenenthal Chemie Formas de dosificacion del tapentadol novedosas y potentes
DK2424514T3 (en) * 2009-04-30 2017-05-08 Gruenenthal Gmbh Tapentadol for the treatment of rheumatoid arthritic pain
WO2011023392A1 (en) * 2009-08-28 2011-03-03 Grünenthal GmbH Pharmaceutical combination comprising 6-dimethylaminomethyl-1-(3-methoxy-phenyl)-cyclohexane-1,3-diol or 6-dimethylaminomethyl-1-(3-hydroxy-phenyl)-cyclohexane-1,3-diol and an antiepileptic
CN104276960B (zh) * 2014-09-26 2016-09-28 安徽省逸欣铭医药科技有限公司 盐酸他喷他多和塞来昔布共晶及其组合物和制备方法

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4389393A (en) 1982-03-26 1983-06-21 Forest Laboratories, Inc. Sustained release therapeutic compositions based on high molecular weight hydroxypropylmethylcellulose
US4765989A (en) 1983-05-11 1988-08-23 Alza Corporation Osmotic device for administering certain drugs
US4783337A (en) 1983-05-11 1988-11-08 Alza Corporation Osmotic system comprising plurality of members for dispensing drug
US4612008A (en) 1983-05-11 1986-09-16 Alza Corporation Osmotic device with dual thermodynamic activity
US5516803A (en) * 1991-10-30 1996-05-14 Mcneilab, Inc. Composition comprising a tramadol material and a non-steroidal anti-inflammatory drug
US5472711A (en) 1992-07-30 1995-12-05 Edward Mendell Co., Inc. Agglomerated hydrophilic complexes with multi-phasic release characteristics
US5330761A (en) 1993-01-29 1994-07-19 Edward Mendell Co. Inc. Bioadhesive tablet for non-systemic use products
US5455046A (en) 1993-09-09 1995-10-03 Edward Mendell Co., Inc. Sustained release heterodisperse hydrogel systems for insoluble drugs
US5399362A (en) 1994-04-25 1995-03-21 Edward Mendell Co., Inc. Once-a-day metoprolol oral dosage form
DE4425459C2 (de) 1994-07-19 1997-11-27 Meinecke Ag H Woltmannzähler
IT1276322B1 (it) 1994-07-21 1997-10-28 Vbc Srl Procedimento per la purificazione dell'idrossido di magnesio
DE4426245A1 (de) * 1994-07-23 1996-02-22 Gruenenthal Gmbh 1-Phenyl-3-dimethylamino-propanverbindungen mit pharmakologischer Wirkung
DE19525137C2 (de) * 1995-07-11 2003-02-27 Gruenenthal Gmbh 6-Dimethylaminomethyl-1-phenyl-cyclohexanverbin -dungen als Zwischenprodukte zur Herstellung pharmazeutischer Wirkstoffe
RS49982B (sr) 1997-09-17 2008-09-29 Euro-Celtique S.A., Sinergistička analgetička kombinacija analgetičkog opijata i inhibitora ciklooksigenaze-2
EP0945134A1 (de) 1998-03-27 1999-09-29 Boehringer Ingelheim Pharma KG Neue galenische Zubereitungsformen von Meloxicam zur oralen Applikation
ES2141688B1 (es) * 1998-11-06 2001-02-01 Vita Invest Sa Nuevos esteres derivados de compuestos fenil-ciclohexil sustituidos.
SA99191255B1 (ar) 1998-11-30 2006-11-25 جي دي سيرل اند كو مركبات سيليكوكسيب celecoxib
NZ513924A (en) * 1999-03-01 2001-09-28 Ortho Mcneil Pharm Inc Composition comprising a tramadol material and a selective cox-2 inhibitor drug
CA2362816C (en) 1999-12-08 2007-02-06 Pharmacia Corporation Valdecoxib compositions
DE10000312A1 (de) 2000-01-05 2001-07-12 Gruenenthal Gmbh Substituierte Aminomethyl-Phenyl-Cyclohexanderivate
DE10004926A1 (de) * 2000-02-04 2001-08-09 Gruenenthal Gmbh Verfahren zur enzymatischen Racematspaltung von Aminomethyl-Aryl-Cyclohexanol-Derivaten
AR035642A1 (es) 2000-05-26 2004-06-23 Pharmacia Corp Uso de una composicion de celecoxib para el alivio rapido del dolor
DE10049483A1 (de) * 2000-09-29 2002-05-02 Gruenenthal Gmbh Substituierte 1-Aminobutan-3-ol-Derivate
DE10059411A1 (de) * 2000-11-30 2002-06-13 Gruenenthal Gmbh Verwendung von 6-Dimethylaminomethyl-1-phenyl-cyclohexanverbindungen zur Therapie der Harninkontinenz
DE10059412A1 (de) 2000-11-30 2002-06-13 Gruenenthal Gmbh Verwendung von 1-Phenyl-3-dimethylamino-propanverbindungen zur Therapie der Harninkontinenz
DE10109763A1 (de) * 2001-02-28 2002-09-05 Gruenenthal Gmbh Pharmazeutische Salze
UA78529C2 (en) * 2001-10-10 2007-04-10 Wyeth Corp Derivatives of [[2-(amino-3,4-dioxo-1-cyclobutene-1-yl)amino]alkyl] acid for treating pain
PE20030527A1 (es) 2001-10-24 2003-07-26 Gruenenthal Chemie Formulacion farmaceutica con liberacion retardada que contiene 3-(3-dimetilamino-1-etil-2-metil-propil) fenol o una sal farmaceuticamente aceptable del mismo y tabletas para administracion oral que la contienen
DE10225315A1 (de) * 2002-06-06 2003-12-24 Gruenenthal Gmbh Wirkstoffsalze und Ester von 1-Dimethylamino-3-(3-methoxy-phenyl)-2-methyl- pentan-3-ol und 3-(3-Dimethylamino-1-ethyl-1-hydroxy-2-methyl- propyl)-phenol
DE10250083A1 (de) * 2002-06-17 2003-12-24 Gruenenthal Gmbh Gegen Missbrauch gesicherte Darreichungsform
DE10233048A1 (de) * 2002-07-19 2004-01-29 Grünenthal GmbH Verwendung von 1-Phenyl-3dimethylamino-propanverbindungen zur Therapie von depressiven Symptomatiken
SI1685829T1 (sl) 2002-11-22 2008-08-31 Gruenenthal Gmbh Uporaba (1RS,3RS,6RS)-6-dimetilaminometil-1- (3-metoksi-fenil)-cikloheksan-1, 3-diola za zdravljenje vnetne bolečine

Also Published As

Publication number Publication date
ATE391498T1 (de) 2008-04-15
CY1108141T1 (el) 2014-04-09
ES2819854T3 (es) 2021-04-19
US20100280126A1 (en) 2010-11-04
US8420691B2 (en) 2013-04-16
US8404749B2 (en) 2013-03-26
DK3241550T3 (da) 2020-08-24
EP1839654B9 (de) 2012-01-11
EP3241550B1 (de) 2020-07-22
EP1839654A3 (de) 2007-11-07
HUE033042T2 (hu) 2017-11-28
EP1562567A1 (de) 2005-08-17
CY1123286T1 (el) 2021-12-31
ES2345062T3 (es) 2010-09-14
CY1110246T1 (el) 2015-01-14
PT1839654E (pt) 2010-07-06
US8618177B2 (en) 2013-12-31
SI1839654T1 (sl) 2010-08-31
EP1839654B1 (de) 2010-04-28
US20130109733A1 (en) 2013-05-02
EP1839654A2 (de) 2007-10-03
EP1908460A1 (de) 2008-04-09
SI1685829T1 (sl) 2008-08-31
WO2004047823A1 (de) 2004-06-10
US20050277687A1 (en) 2005-12-15
US20100280129A1 (en) 2010-11-04
EP1562567B1 (de) 2017-06-14
PT3241550T (pt) 2020-08-11
AU2003283410A1 (en) 2004-06-18
LT1562567T (lt) 2017-08-25
SI3241550T1 (sl) 2020-11-30
DE50312678D1 (de) 2010-06-10
ES2640404T3 (es) 2017-11-02
EP1685829A1 (de) 2006-08-02
DK1685829T3 (da) 2008-07-21
US7786160B2 (en) 2010-08-31
US8003701B2 (en) 2011-08-23
EP1685829B1 (de) 2008-04-09
US20070249724A1 (en) 2007-10-25
US10471079B2 (en) 2019-11-12
PT1685829E (pt) 2008-05-15
EP3241550A1 (de) 2017-11-08
DE50309605D1 (de) 2008-05-21
ES2304659T3 (es) 2008-10-16
ATE465726T1 (de) 2010-05-15
CY1119082T1 (el) 2018-01-10
EP3662904A1 (de) 2020-06-10
SI1562567T1 (sl) 2017-09-29
US20100280017A1 (en) 2010-11-04
US20160279150A1 (en) 2016-09-29
DK1562567T3 (en) 2017-07-17
PT1562567T (pt) 2017-08-24
DK1839654T3 (da) 2010-08-16

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