JP2005527535A5 - - Google Patents
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- Publication number
- JP2005527535A5 JP2005527535A5 JP2003577852A JP2003577852A JP2005527535A5 JP 2005527535 A5 JP2005527535 A5 JP 2005527535A5 JP 2003577852 A JP2003577852 A JP 2003577852A JP 2003577852 A JP2003577852 A JP 2003577852A JP 2005527535 A5 JP2005527535 A5 JP 2005527535A5
- Authority
- JP
- Japan
- Prior art keywords
- analgesic
- delivery substance
- composition
- chitosan
- delivery
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000000126 substance Substances 0.000 claims 19
- 230000000202 analgesic effect Effects 0.000 claims 13
- 239000000203 mixture Substances 0.000 claims 13
- 229920001661 Chitosan Polymers 0.000 claims 8
- 230000032050 esterification Effects 0.000 claims 5
- 238000005886 esterification reaction Methods 0.000 claims 5
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 5
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 5
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 5
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 5
- 210000003928 nasal cavity Anatomy 0.000 claims 5
- 239000001814 pectin Substances 0.000 claims 5
- 235000010987 pectin Nutrition 0.000 claims 5
- 229920001277 pectin Polymers 0.000 claims 5
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 239000007864 aqueous solution Substances 0.000 claims 3
- 229940079593 drug Drugs 0.000 claims 3
- 230000036470 plasma concentration Effects 0.000 claims 3
- 230000001225 therapeutic effect Effects 0.000 claims 3
- 229920002101 Chitin Polymers 0.000 claims 2
- ZRVUJXDFFKFLMG-UHFFFAOYSA-N Meloxicam Chemical compound OC=1C2=CC=CC=C2S(=O)(=O)N(C)C=1C(=O)NC1=NC=C(C)S1 ZRVUJXDFFKFLMG-UHFFFAOYSA-N 0.000 claims 2
- 229960001259 diclofenac Drugs 0.000 claims 2
- DCOPUUMXTXDBNB-UHFFFAOYSA-N diclofenac Chemical compound OC(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl DCOPUUMXTXDBNB-UHFFFAOYSA-N 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- 229960005293 etodolac Drugs 0.000 claims 2
- XFBVBWWRPKNWHW-UHFFFAOYSA-N etodolac Chemical compound C1COC(CC)(CC(O)=O)C2=N[C]3C(CC)=CC=CC3=C21 XFBVBWWRPKNWHW-UHFFFAOYSA-N 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 229960001929 meloxicam Drugs 0.000 claims 2
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 claims 2
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims 2
- 239000000014 opioid analgesic Substances 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 229960002702 piroxicam Drugs 0.000 claims 2
- QYSPLQLAKJAUJT-UHFFFAOYSA-N piroxicam Chemical compound OC=1C2=CC=CC=C2S(=O)(=O)N(C)C=1C(=O)NC1=CC=CC=N1 QYSPLQLAKJAUJT-UHFFFAOYSA-N 0.000 claims 2
- 230000036592 analgesia Effects 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 230000036407 pain Effects 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0206448A GB0206448D0 (en) | 2002-03-19 | 2002-03-19 | Analgesics |
| GB0225040A GB0225040D0 (en) | 2002-10-28 | 2002-10-28 | Formulation |
| GB0225041A GB0225041D0 (en) | 2002-10-28 | 2002-10-28 | Pharmaceutical formulation |
| GB0225042A GB0225042D0 (en) | 2002-10-28 | 2002-10-28 | Pharmaceutical composition |
| PCT/GB2003/001184 WO2003080022A2 (en) | 2002-03-19 | 2003-03-19 | Analgesics for nasal administration |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010071698A Division JP2010174029A (ja) | 2002-03-19 | 2010-03-26 | 鎮痛薬 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005527535A JP2005527535A (ja) | 2005-09-15 |
| JP2005527535A5 true JP2005527535A5 (enExample) | 2006-05-11 |
Family
ID=28457822
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003577852A Withdrawn JP2005527535A (ja) | 2002-03-19 | 2003-03-19 | 鎮痛薬 |
| JP2003577851A Expired - Fee Related JP4728580B2 (ja) | 2002-03-19 | 2003-03-19 | 製剤 |
| JP2010071698A Pending JP2010174029A (ja) | 2002-03-19 | 2010-03-26 | 鎮痛薬 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003577851A Expired - Fee Related JP4728580B2 (ja) | 2002-03-19 | 2003-03-19 | 製剤 |
| JP2010071698A Pending JP2010174029A (ja) | 2002-03-19 | 2010-03-26 | 鎮痛薬 |
Country Status (19)
| Country | Link |
|---|---|
| US (5) | US7666876B2 (enExample) |
| EP (3) | EP1878446A3 (enExample) |
| JP (3) | JP2005527535A (enExample) |
| KR (2) | KR20110005919A (enExample) |
| CN (1) | CN1642577B (enExample) |
| AT (2) | ATE422902T1 (enExample) |
| AU (2) | AU2003219282A1 (enExample) |
| BR (1) | BRPI0308527B1 (enExample) |
| CA (2) | CA2479711C (enExample) |
| DE (2) | DE60323958D1 (enExample) |
| DK (2) | DK1499360T3 (enExample) |
| ES (2) | ES2315485T3 (enExample) |
| GB (1) | GB2397016B (enExample) |
| IL (2) | IL164129A0 (enExample) |
| MX (1) | MXPA04009055A (enExample) |
| NZ (2) | NZ535973A (enExample) |
| PT (1) | PT1513493E (enExample) |
| SI (1) | SI1499360T1 (enExample) |
| WO (2) | WO2003080021A2 (enExample) |
Families Citing this family (59)
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| DE10141650C1 (de) * | 2001-08-24 | 2002-11-28 | Lohmann Therapie Syst Lts | Transdermales Therapeutisches System mit Fentanyl bzw. verwandten Substanzen |
| US7666876B2 (en) * | 2002-03-19 | 2010-02-23 | Vernalis (R&D) Limited | Buprenorphine formulations for intranasal delivery |
| GB0300531D0 (en) * | 2003-01-10 | 2003-02-12 | West Pharm Serv Drug Res Ltd | Pharmaceutical compositions |
| GB0315632D0 (en) | 2003-07-04 | 2003-08-13 | West Pharm Serv Drug Res Ltd | Pharmaceutical formulations |
| GB0328186D0 (en) * | 2003-12-05 | 2004-01-07 | West Pharm Serv Drug Res Ltd | Intranasal compositions |
| US20050129679A1 (en) | 2003-12-15 | 2005-06-16 | Nastech Pharmaceutical Company Inc. | Method for opening tight junctions |
| GB0329918D0 (en) * | 2003-12-24 | 2004-01-28 | West Pharm Serv Drug Res Ltd | Intranasal compositions |
| US8202550B2 (en) * | 2004-10-11 | 2012-06-19 | Nasaleze Ppm Limited | Compositions for intranasal administration |
| CA2586288A1 (en) * | 2004-12-06 | 2006-06-15 | Janssen Pharmaceutica Nv | Oral suspension comprising meloxicam |
| EP1928484B1 (en) | 2005-08-26 | 2010-02-24 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for treatment of headaches by administration of oxytocin |
| GB0606124D0 (en) * | 2006-03-28 | 2006-05-03 | Reckitt Benckiser Healthcare | Buprenorphine derivatives and uses thereof |
| DK2001456T3 (da) * | 2006-04-04 | 2010-04-12 | Emodys Gmbh | Anvendelse af kappa-opiodreceptorantagonistholde sammensætninger til behandling af dissociative forstyrrelser |
| RS54764B1 (sr) * | 2006-07-21 | 2016-10-31 | Biodelivery Sciences Int Inc | Sredstvo za transmukozalnu isporuku sa povećanim nakupljanjem |
| EP1897543A1 (en) | 2006-08-30 | 2008-03-12 | Euro-Celtique S.A. | Buprenorphine- wafer for drug substitution therapy |
| US20090270438A1 (en) * | 2006-10-18 | 2009-10-29 | Clive Booles | Novel compositions and formulations |
| KR20090125748A (ko) * | 2007-04-02 | 2009-12-07 | 토요 보세키 가부시기가이샤 | 대상포진 후 신경통 치료용 정제 및 대상포진 후 신경통의 치료 방법 |
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| GB2499769B (en) * | 2010-12-08 | 2018-04-18 | Bhushan Kondhalkar Mrinmayee | Composition for inhibiting mammalian hair growth |
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| RU2020125871A (ru) | 2018-01-05 | 2022-02-07 | Импел Ньюрофарма, Инк. | Интраназальная доставка дигидроэрготамина с помощью прецизионного устройства для доставки в обонятельную область |
| CN112955134A (zh) | 2018-07-19 | 2021-06-11 | 英倍尔药业股份有限公司 | 用于治疗帕金森氏病的左旋多巴和多巴脱羧酶抑制剂的呼吸道递送 |
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| GB2378383A (en) | 2001-06-06 | 2003-02-12 | Gursharan Moonga | Nasal delivery of pharmaceutical compositions in powder form |
| US7666876B2 (en) * | 2002-03-19 | 2010-02-23 | Vernalis (R&D) Limited | Buprenorphine formulations for intranasal delivery |
| GB0300531D0 (en) * | 2003-01-10 | 2003-02-12 | West Pharm Serv Drug Res Ltd | Pharmaceutical compositions |
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2002
- 2002-03-19 US US10/508,336 patent/US7666876B2/en not_active Expired - Fee Related
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2003
- 2003-03-19 JP JP2003577852A patent/JP2005527535A/ja not_active Withdrawn
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- 2003-03-19 EP EP07020868A patent/EP1878446A3/en not_active Withdrawn
- 2003-03-19 EP EP03712380A patent/EP1499360B1/en not_active Expired - Lifetime
- 2003-03-19 CN CN038063646A patent/CN1642577B/zh not_active Expired - Fee Related
- 2003-03-19 DK DK03715087T patent/DK1513493T3/da active
- 2003-03-19 DE DE60323958T patent/DE60323958D1/de not_active Expired - Lifetime
- 2003-03-19 WO PCT/GB2003/001183 patent/WO2003080021A2/en not_active Ceased
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- 2003-03-19 MX MXPA04009055A patent/MXPA04009055A/es active IP Right Grant
- 2003-03-19 US US10/508,315 patent/US20050142072A1/en not_active Abandoned
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- 2003-03-19 AU AU2003219282A patent/AU2003219282A1/en not_active Abandoned
- 2003-03-19 KR KR1020117000035A patent/KR20110005919A/ko not_active Ceased
- 2003-03-19 NZ NZ535973A patent/NZ535973A/en unknown
- 2003-03-19 NZ NZ535972A patent/NZ535972A/en not_active IP Right Cessation
- 2003-03-19 BR BRPI0308527-9A patent/BRPI0308527B1/pt not_active IP Right Cessation
- 2003-03-19 KR KR1020047014665A patent/KR101030403B1/ko not_active Expired - Fee Related
- 2003-03-19 EP EP03715087A patent/EP1513493B8/en not_active Expired - Lifetime
- 2003-03-19 ES ES03715087T patent/ES2325364T3/es not_active Expired - Lifetime
- 2003-03-19 CA CA002479718A patent/CA2479718A1/en not_active Abandoned
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- 2003-03-19 AU AU2003216842A patent/AU2003216842B2/en not_active Ceased
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2004
- 2004-09-19 IL IL164129A patent/IL164129A/en not_active IP Right Cessation
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2007
- 2007-05-14 US US11/798,384 patent/US20070231269A1/en not_active Abandoned
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- 2009-10-19 US US12/588,528 patent/US20100041624A1/en not_active Abandoned
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- 2010-03-26 JP JP2010071698A patent/JP2010174029A/ja active Pending
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