DK1499360T3 - Formulering omfattende buprenorphin - Google Patents
Formulering omfattende buprenorphinInfo
- Publication number
- DK1499360T3 DK1499360T3 DK03712380T DK03712380T DK1499360T3 DK 1499360 T3 DK1499360 T3 DK 1499360T3 DK 03712380 T DK03712380 T DK 03712380T DK 03712380 T DK03712380 T DK 03712380T DK 1499360 T3 DK1499360 T3 DK 1499360T3
- Authority
- DK
- Denmark
- Prior art keywords
- buprenorphine
- chitosan
- ester
- delivered
- formulation
- Prior art date
Links
- RMRJXGBAOAMLHD-IHFGGWKQSA-N buprenorphine Chemical compound C([C@]12[C@H]3OC=4C(O)=CC=C(C2=4)C[C@@H]2[C@]11CC[C@]3([C@H](C1)[C@](C)(O)C(C)(C)C)OC)CN2CC1CC1 RMRJXGBAOAMLHD-IHFGGWKQSA-N 0.000 title abstract 5
- 229960001736 buprenorphine Drugs 0.000 title abstract 4
- 238000009472 formulation Methods 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 229920001661 Chitosan Polymers 0.000 abstract 2
- 150000002148 esters Chemical class 0.000 abstract 2
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 abstract 1
- 230000036592 analgesia Effects 0.000 abstract 1
- 239000013011 aqueous formulation Substances 0.000 abstract 1
- 230000032050 esterification Effects 0.000 abstract 1
- 238000005886 esterification reaction Methods 0.000 abstract 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 abstract 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 abstract 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 abstract 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 abstract 1
- 239000001814 pectin Substances 0.000 abstract 1
- 235000010987 pectin Nutrition 0.000 abstract 1
- 229920001277 pectin Polymers 0.000 abstract 1
- 230000036470 plasma concentration Effects 0.000 abstract 1
- 229960000502 poloxamer Drugs 0.000 abstract 1
- 229920001983 poloxamer Polymers 0.000 abstract 1
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 abstract 1
- 230000002035 prolonged effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Emergency Medicine (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Endocrinology (AREA)
- Otolaryngology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Inorganic Chemistry (AREA)
- Reproductive Health (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyrane Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0206448A GB0206448D0 (en) | 2002-03-19 | 2002-03-19 | Analgesics |
| GB0225041A GB0225041D0 (en) | 2002-10-28 | 2002-10-28 | Pharmaceutical formulation |
| GB0225040A GB0225040D0 (en) | 2002-10-28 | 2002-10-28 | Formulation |
| GB0225042A GB0225042D0 (en) | 2002-10-28 | 2002-10-28 | Pharmaceutical composition |
| PCT/GB2003/001183 WO2003080021A2 (en) | 2002-03-19 | 2003-03-19 | Formulation comprising buprenorphine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1499360T3 true DK1499360T3 (da) | 2009-02-09 |
Family
ID=28457822
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK03712380T DK1499360T3 (da) | 2002-03-19 | 2003-03-19 | Formulering omfattende buprenorphin |
| DK03715087T DK1513493T3 (da) | 2002-03-19 | 2003-03-19 | Analgetika |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK03715087T DK1513493T3 (da) | 2002-03-19 | 2003-03-19 | Analgetika |
Country Status (19)
| Country | Link |
|---|---|
| US (5) | US7666876B2 (da) |
| EP (3) | EP1499360B1 (da) |
| JP (3) | JP4728580B2 (da) |
| KR (2) | KR20110005919A (da) |
| CN (1) | CN1642577B (da) |
| AT (2) | ATE410187T1 (da) |
| AU (2) | AU2003216842B2 (da) |
| BR (1) | BRPI0308527B1 (da) |
| CA (2) | CA2479711C (da) |
| DE (2) | DE60326231D1 (da) |
| DK (2) | DK1499360T3 (da) |
| ES (2) | ES2315485T3 (da) |
| GB (1) | GB2397016B (da) |
| IL (2) | IL164129A0 (da) |
| MX (1) | MXPA04009055A (da) |
| NZ (2) | NZ535972A (da) |
| PT (1) | PT1513493E (da) |
| SI (1) | SI1499360T1 (da) |
| WO (2) | WO2003080022A2 (da) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10141650C1 (de) * | 2001-08-24 | 2002-11-28 | Lohmann Therapie Syst Lts | Transdermales Therapeutisches System mit Fentanyl bzw. verwandten Substanzen |
| US7666876B2 (en) * | 2002-03-19 | 2010-02-23 | Vernalis (R&D) Limited | Buprenorphine formulations for intranasal delivery |
| GB0300531D0 (en) | 2003-01-10 | 2003-02-12 | West Pharm Serv Drug Res Ltd | Pharmaceutical compositions |
| GB0315632D0 (en) | 2003-07-04 | 2003-08-13 | West Pharm Serv Drug Res Ltd | Pharmaceutical formulations |
| GB0328186D0 (en) * | 2003-12-05 | 2004-01-07 | West Pharm Serv Drug Res Ltd | Intranasal compositions |
| US20050129679A1 (en) | 2003-12-15 | 2005-06-16 | Nastech Pharmaceutical Company Inc. | Method for opening tight junctions |
| GB0329918D0 (en) * | 2003-12-24 | 2004-01-28 | West Pharm Serv Drug Res Ltd | Intranasal compositions |
| US8202550B2 (en) * | 2004-10-11 | 2012-06-19 | Nasaleze Ppm Limited | Compositions for intranasal administration |
| ES2313452T3 (es) * | 2004-12-06 | 2009-03-01 | Janssen Pharmaceutica Nv | Suspension oral que comprende meloxicam. |
| EP2179741B1 (en) | 2005-08-26 | 2014-10-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for treatment of headaches by administraton of oxytocin |
| GB0606124D0 (en) * | 2006-03-28 | 2006-05-03 | Reckitt Benckiser Healthcare | Buprenorphine derivatives and uses thereof |
| CA2646899C (en) * | 2006-04-04 | 2014-05-06 | Holger Lars Hermann | Use of compositions containing kappa-opioid receptor antagonists for the treatment of dissociative disorders |
| SI2054031T1 (sl) * | 2006-07-21 | 2016-09-30 | Biodelivery Sciences International, Inc. | Transmukozne naprave za administracijo z izboljšanim vnosom |
| EP1897543A1 (en) | 2006-08-30 | 2008-03-12 | Euro-Celtique S.A. | Buprenorphine- wafer for drug substitution therapy |
| US20090270438A1 (en) * | 2006-10-18 | 2009-10-29 | Clive Booles | Novel compositions and formulations |
| JPWO2008120562A1 (ja) * | 2007-04-02 | 2010-07-15 | 東洋紡績株式会社 | 帯状疱疹後神経痛治療用錠剤および帯状疱疹後神経痛の治療方法 |
| EP2057982A1 (en) * | 2007-11-09 | 2009-05-13 | Archimedes Development Limited | Intranasal compositions |
| US8757146B2 (en) | 2008-02-07 | 2014-06-24 | University Of Washington Through Its Center For Commercialization | Circumferential aerosol device |
| CN101297973B (zh) * | 2008-05-22 | 2010-06-09 | 武汉华纳生物工程有限公司 | 高生物粘附温敏水凝胶及其制备方法和用途 |
| WO2010072398A2 (en) * | 2008-12-22 | 2010-07-01 | Boehringer Ingelheim Limited | Veterinary formulations |
| DE102009001041A1 (de) * | 2009-02-20 | 2010-08-26 | Marien-Apotheke Fulda Ohg | Notfallset zur Herstellung eines Arzneimittels zur nasalen Anwendung von Opioiden bei Atemnot |
| DE102009024542A1 (de) | 2009-06-10 | 2010-12-16 | Arivine Pharma Ag | Zusammensetzungen auf Basis von Chitosan-Oligosacchariden |
| NZ597763A (en) | 2009-07-27 | 2014-07-25 | Nocicepta Llc | Methods for treatment of pain |
| US8475832B2 (en) | 2009-08-07 | 2013-07-02 | Rb Pharmaceuticals Limited | Sublingual and buccal film compositions |
| CZ302789B6 (cs) | 2009-11-25 | 2011-11-09 | Zentiva, K. S. | Zpusob zvýšení rozpustnosti farmaceuticky aktivních látek a cílený (kontrolovaný) transport do streva |
| WO2012077024A1 (en) * | 2010-12-08 | 2012-06-14 | Mrinmayee Kondhalkar | Composition for inhibiting the growth of mammalian hair |
| RU2612506C2 (ru) | 2011-03-03 | 2017-03-09 | Импел Ньюрофарма Инк. | Устройство для назальной доставки лекарственных средств |
| WO2012154859A1 (en) | 2011-05-09 | 2012-11-15 | Impel Neuropharma Inc. | Nozzles for nasal drug delivery |
| BR112013029126A2 (pt) | 2011-05-13 | 2017-02-07 | Euro Celtique Sa | formas de dosagem farmacêuticas intranasais compreendendo naloxona |
| US11413239B2 (en) * | 2011-07-20 | 2022-08-16 | Torrent Pharmaceuticals Ltd. | Pharmaceutical composition of tapentadol for nasal administration |
| AU2012296346A1 (en) | 2011-08-18 | 2014-04-03 | Biodelivery Sciences International, Inc. | Abuse-resistant mucoadhesive devices for delivery of buprenorphine |
| US9375400B2 (en) | 2011-09-14 | 2016-06-28 | University Of South Florida | Manganese ion coated nanoparticles for delivery of compositions into the central nervous system by nasal insufflation |
| US9901539B2 (en) | 2011-12-21 | 2018-02-27 | Biodelivery Sciences International, Inc. | Transmucosal drug delivery devices for use in chronic pain relief |
| JP2016520378A (ja) | 2013-04-28 | 2016-07-14 | インペル ニューロファーマ インコーポレイテッド | 医用単位用量コンテナ |
| US9867818B2 (en) | 2013-09-10 | 2018-01-16 | Insys Development Company, Inc. | Sublingual buprenorphine spray |
| US9839611B2 (en) | 2013-09-10 | 2017-12-12 | Insys Development Company, Inc. | Sublingual buprenorphine spray |
| US9918981B2 (en) | 2013-09-10 | 2018-03-20 | Insys Development Company, Inc. | Liquid buprenorphine formulations |
| CA2923811C (en) | 2013-09-10 | 2021-07-27 | Insys Pharma, Inc. | Sublingual buprenorphine spray |
| EP3082816B1 (en) | 2013-12-20 | 2019-03-20 | Indivior UK Limited | Intranasal naloxone compositions and methods of making and using same |
| WO2015155544A1 (en) * | 2014-04-10 | 2015-10-15 | Patrick Crowley | Delivery of non-steroidal antiinflammatory agents to the brain via the nasal tract to treat neurological disorders |
| US20150359738A1 (en) * | 2014-06-16 | 2015-12-17 | Loewi LLC | Methods of Anesthetizing Nerve Tissue in the Trigeminal Nerve Pathway and Medical Uses Thereof |
| CN107847552B (zh) | 2015-01-07 | 2022-07-01 | 三叉神经股份公司 | 含镁的催产素制剂和使用方法 |
| KR20180027506A (ko) * | 2015-07-10 | 2018-03-14 | 디에스엠 아이피 어셋츠 비.브이. | 염증 질병의 예방 및 치료를 위한 식품 및/또는 사료 조성물 |
| US11266799B2 (en) | 2015-09-10 | 2022-03-08 | Impel Neuropharma, Inc. | In-line nasal delivery device |
| UA126910C2 (uk) * | 2016-10-28 | 2023-02-22 | Ле Лаборатуар Сервьє | Ліпосомальний препарат для застосування в лікуванні злоякісного новоутворення |
| MA50394A (fr) * | 2017-10-20 | 2021-04-28 | Chiesi Farm Spa | Formulations pharmaceutiques comprenant un agoniste de récepteur d'opioïde en tant que substances actives, leurs procédés de fabrication et leurs utilisations thérapeutiques |
| JP2021503988A (ja) | 2017-11-21 | 2021-02-15 | インペル ニューロファーマ インコーポレイテッド | インレットインターフェースを用いた鼻腔内装置 |
| EP3713628A4 (en) | 2017-11-21 | 2021-08-18 | Impel Neuropharma Inc. | INTRA-NASAL DEVICE WITH DIVER TUBE |
| EP3735244B1 (en) | 2018-01-05 | 2022-11-23 | Impel Pharmaceuticals Inc. | Intranasal delivery of dihydroergotamine by precision olfactory device |
| EP3735223A4 (en) | 2018-01-05 | 2021-10-13 | Impel Neuropharma Inc. | INTRANASAL ADMINISTRATION OF OLANZAPINE BY A PRECISION OLFACTORY DEVICE |
| WO2020018959A1 (en) | 2018-07-19 | 2020-01-23 | Impel Neuropharma, Inc. | Respiratory tract delivery of levodopa and dopa decarboxylase inhibitor for treatment of parkinson's disease |
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| IT201900006104A1 (it) * | 2019-04-18 | 2020-10-18 | S I I T S R L Servizio Int Imballaggi Termosaldanti | Metodo di preparazione di un prodotto a base di chitosano |
| KR20210149157A (ko) * | 2019-05-14 | 2021-12-08 | 파모사 바이오팜 인코포레이티드 | 약산성 약물의 약제학적 조성물 및 투여 방법 |
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-
2002
- 2002-03-19 US US10/508,336 patent/US7666876B2/en not_active Expired - Fee Related
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2003
- 2003-03-19 GB GB0318346A patent/GB2397016B/en not_active Expired - Fee Related
- 2003-03-19 PT PT03715087T patent/PT1513493E/pt unknown
- 2003-03-19 SI SI200331468T patent/SI1499360T1/sl unknown
- 2003-03-19 AU AU2003216842A patent/AU2003216842B2/en not_active Ceased
- 2003-03-19 AU AU2003219282A patent/AU2003219282A1/en not_active Abandoned
- 2003-03-19 US US10/508,315 patent/US20050142072A1/en not_active Abandoned
- 2003-03-19 AT AT03712380T patent/ATE410187T1/de active
- 2003-03-19 CN CN038063646A patent/CN1642577B/zh not_active Expired - Fee Related
- 2003-03-19 EP EP03712380A patent/EP1499360B1/en not_active Expired - Lifetime
- 2003-03-19 NZ NZ535972A patent/NZ535972A/en not_active IP Right Cessation
- 2003-03-19 EP EP03715087A patent/EP1513493B8/en not_active Expired - Lifetime
- 2003-03-19 DK DK03712380T patent/DK1499360T3/da active
- 2003-03-19 BR BRPI0308527-9A patent/BRPI0308527B1/pt not_active IP Right Cessation
- 2003-03-19 MX MXPA04009055A patent/MXPA04009055A/es active IP Right Grant
- 2003-03-19 ES ES03712380T patent/ES2315485T3/es not_active Expired - Lifetime
- 2003-03-19 IL IL16412903A patent/IL164129A0/xx unknown
- 2003-03-19 DK DK03715087T patent/DK1513493T3/da active
- 2003-03-19 KR KR1020117000035A patent/KR20110005919A/ko not_active Application Discontinuation
- 2003-03-19 WO PCT/GB2003/001184 patent/WO2003080022A2/en active Application Filing
- 2003-03-19 JP JP2003577851A patent/JP4728580B2/ja not_active Expired - Fee Related
- 2003-03-19 DE DE60326231T patent/DE60326231D1/de not_active Expired - Lifetime
- 2003-03-19 DE DE60323958T patent/DE60323958D1/de not_active Expired - Lifetime
- 2003-03-19 JP JP2003577852A patent/JP2005527535A/ja not_active Withdrawn
- 2003-03-19 ES ES03715087T patent/ES2325364T3/es not_active Expired - Lifetime
- 2003-03-19 CA CA2479711A patent/CA2479711C/en not_active Expired - Fee Related
- 2003-03-19 AT AT03715087T patent/ATE422902T1/de active
- 2003-03-19 WO PCT/GB2003/001183 patent/WO2003080021A2/en active Application Filing
- 2003-03-19 KR KR1020047014665A patent/KR101030403B1/ko not_active IP Right Cessation
- 2003-03-19 EP EP07020868A patent/EP1878446A3/en not_active Withdrawn
- 2003-03-19 NZ NZ535973A patent/NZ535973A/en unknown
- 2003-03-19 CA CA002479718A patent/CA2479718A1/en not_active Abandoned
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2004
- 2004-09-19 IL IL164129A patent/IL164129A/en not_active IP Right Cessation
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2007
- 2007-05-14 US US11/798,384 patent/US20070231269A1/en not_active Abandoned
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2009
- 2009-10-19 US US12/588,528 patent/US20100041624A1/en not_active Abandoned
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2010
- 2010-03-26 JP JP2010071698A patent/JP2010174029A/ja active Pending
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- 2011-01-12 US US12/929,279 patent/US20110105551A1/en not_active Abandoned
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