|
US6582959B2
(en)
*
|
1991-03-29 |
2003-06-24 |
Genentech, Inc. |
Antibodies to vascular endothelial cell growth factor
|
|
US20030206899A1
(en)
*
|
1991-03-29 |
2003-11-06 |
Genentech, Inc. |
Vascular endothelial cell growth factor antagonists
|
|
US20030108545A1
(en)
*
|
1994-02-10 |
2003-06-12 |
Patricia Rockwell |
Combination methods of inhibiting tumor growth with a vascular endothelial growth factor receptor antagonist
|
|
US6448077B1
(en)
*
|
1994-02-10 |
2002-09-10 |
Imclone Systems, Inc. |
Chimeric and humanized monoclonal antibodies specific to VEGF receptors
|
|
IL117645A
(en)
*
|
1995-03-30 |
2005-08-31 |
Genentech Inc |
Vascular endothelial cell growth factor antagonists for use as medicaments in the treatment of age-related macular degeneration
|
|
ZA9811162B
(en)
*
|
1997-12-12 |
2000-06-07 |
Genentech Inc |
Treatment with anti-ERBB2 antibodies.
|
|
US6852533B1
(en)
*
|
1998-01-23 |
2005-02-08 |
Cornell Research Foundation, Inc. |
Purified populations of stem cells
|
|
EP1158985B1
(en)
|
1999-01-13 |
2011-12-28 |
Bayer HealthCare LLC |
OMEGA-CARBOXY ARYL SUBSTITUTED DIPHENYL UREAS AS p38 KINASE INHIBITORS
|
|
US8124630B2
(en)
|
1999-01-13 |
2012-02-28 |
Bayer Healthcare Llc |
ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
|
|
IT1306704B1
(it)
*
|
1999-05-26 |
2001-10-02 |
Sirs Societa Italiana Per La R |
Anticorpi monoclonali e suoi derivati sintetici o biotecnologici ingrado di agire come molecole antagoniste per il ngf.
|
|
US20030086924A1
(en)
*
|
1999-06-25 |
2003-05-08 |
Genentech, Inc. |
Treatment with anti-ErbB2 antibodies
|
|
US20040013667A1
(en)
*
|
1999-06-25 |
2004-01-22 |
Genentech, Inc. |
Treatment with anti-ErbB2 antibodies
|
|
US6949245B1
(en)
|
1999-06-25 |
2005-09-27 |
Genentech, Inc. |
Humanized anti-ErbB2 antibodies and treatment with anti-ErbB2 antibodies
|
|
EP1280923A2
(en)
*
|
2000-04-28 |
2003-02-05 |
Millennium Pharmaceuticals, Inc. |
14094, a human trypsin family member and uses thereof
|
|
CA2407556C
(en)
*
|
2000-05-19 |
2011-06-21 |
Genentech, Inc. |
Gene detection assay for improving the likelihood of an effective response to an erbb antagonist cancer therapy
|
|
AU9598601A
(en)
*
|
2000-10-20 |
2002-04-29 |
Eisai Co Ltd |
Nitrogenous aromatic ring compounds
|
|
US7018371B2
(en)
*
|
2001-05-07 |
2006-03-28 |
Xoft, Inc. |
Combination ionizing radiation and radiosensitizer delivery devices and methods for inhibiting hyperplasia
|
|
US20040247597A1
(en)
*
|
2001-06-20 |
2004-12-09 |
Peter Carmeliet |
Method of treating atherosclerosis and other inflammatory diseases
|
|
JP2005515967A
(ja)
*
|
2001-07-13 |
2005-06-02 |
イムクローン システムズ インコーポレイティド |
乳癌を治療するためのvegfr−1抗体
|
|
US20050026220A1
(en)
*
|
2001-08-10 |
2005-02-03 |
Shahin Rafii |
Isolation and mobilization of stem cells expressing vegfr-1
|
|
SI1478358T1
(sl)
|
2002-02-11 |
2013-09-30 |
Bayer Healthcare Llc |
Sorafenib tozilat za zdravljenje bolezni, značilnih po abnormalni angiogenezi
|
|
AU2003215163A1
(en)
*
|
2002-02-12 |
2003-09-04 |
Vanderbilt University |
Inhibition of vegf receptor signaling reverses tumor resistance to radiotherapy
|
|
CN101474404A
(zh)
*
|
2002-03-04 |
2009-07-08 |
伊姆克罗尼系统公司 |
用血管内皮生长因子受体拮抗剂抑制肿瘤生长的联合疗法
|
|
EP2298346A3
(en)
*
|
2002-03-04 |
2011-11-16 |
Imclone LLC |
Human antibodies specific to kdr and uses thereof
|
|
US20050186204A1
(en)
*
|
2002-06-28 |
2005-08-25 |
Peter Carmeliet |
Use of antibodies against FLT-1 for the treatment of osteoporosis
|
|
US7696320B2
(en)
|
2004-08-24 |
2010-04-13 |
Domantis Limited |
Ligands that have binding specificity for VEGF and/or EGFR and methods of use therefor
|
|
CN101972478B
(zh)
*
|
2002-10-08 |
2012-10-31 |
免疫医疗公司 |
抗体治疗
|
|
WO2004048525A2
(en)
*
|
2002-11-21 |
2004-06-10 |
Genentech, Inc. |
Therapy of non-malignant diseases or disorders with anti-erbb2 antibodies
|
|
ATE508747T1
(de)
*
|
2003-03-10 |
2011-05-15 |
Eisai R&D Man Co Ltd |
C-kit kinase-hemmer
|
|
EP1473043A1
(en)
*
|
2003-04-29 |
2004-11-03 |
Boehringer Ingelheim Pharma GmbH & Co.KG |
Pharmaceutical combination for the treatment of diseases involving cell proliferation, migration or apotosis of myeloma cells, or angiogenesis
|
|
US20050043233A1
(en)
|
2003-04-29 |
2005-02-24 |
Boehringer Ingelheim International Gmbh |
Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis
|
|
EP1636585B2
(en)
|
2003-05-20 |
2012-06-13 |
Bayer HealthCare LLC |
Diaryl ureas with kinase inhibiting activity
|
|
US7205148B2
(en)
|
2003-06-11 |
2007-04-17 |
Regeneron Pharmaceuticals, Inc. |
Genome mutation by intron insertion into an embryonic stem cell genome
|
|
AU2013200394B2
(en)
*
|
2003-07-23 |
2015-07-09 |
Bayer Healthcare Llc |
Fluoro substituted omega-carboxyaryl diphenyl urea for the treatment and prevention of diseases and conditions
|
|
EP1663978B1
(en)
*
|
2003-07-23 |
2007-11-28 |
Bayer Pharmaceuticals Corporation |
Fluoro substituted omega-carboxyaryl diphenyl urea for the treatment and prevention of diseases and conditions
|
|
AR046510A1
(es)
*
|
2003-07-25 |
2005-12-14 |
Regeneron Pharma |
Composicion de un antagonista de vegf y un agente anti-proliferativo
|
|
US20050027196A1
(en)
*
|
2003-07-30 |
2005-02-03 |
Fitzgerald Loretta A. |
System for processing patient radiation treatment data
|
|
US20050196340A1
(en)
*
|
2003-08-06 |
2005-09-08 |
Jocelyn Holash |
Use of a VEGF antagonist in combination with radiation therapy
|
|
WO2005016369A1
(en)
*
|
2003-08-06 |
2005-02-24 |
Regeneron Pharmaceuticals, Inc. |
Use of a vegf antagonist in combination with radiation therapy
|
|
US7683172B2
(en)
*
|
2003-11-11 |
2010-03-23 |
Eisai R&D Management Co., Ltd. |
Urea derivative and process for preparing the same
|
|
WO2005069906A2
(en)
*
|
2004-01-16 |
2005-08-04 |
Yale University |
Methods and compositions relating to vascular endothelial growth factor and th2 mediated inflammatory diseases
|
|
CA2560305C
(en)
*
|
2004-03-19 |
2016-07-05 |
Imclone Systems Incorporated |
Human anti-epidermal growth factor receptor antibody
|
|
GB0406446D0
(en)
*
|
2004-03-23 |
2004-04-28 |
Astrazeneca Ab |
Combination therapy
|
|
WO2005097086A2
(en)
*
|
2004-04-02 |
2005-10-20 |
Adventrx Pharmaceuticals, Inc. |
Use of 5,10-methylene tetrahydrofolate for the treatment of cancer
|
|
EP1761264A1
(en)
*
|
2004-06-03 |
2007-03-14 |
F.Hoffmann-La Roche Ag |
Treatment with irinotecan (cpt-11) and an egfr-inhibitor
|
|
WO2006030947A1
(ja)
|
2004-09-13 |
2006-03-23 |
Eisai R & D Management Co., Ltd. |
スルホンアミド含有化合物の血管新生阻害物質との併用
|
|
US8772269B2
(en)
*
|
2004-09-13 |
2014-07-08 |
Eisai R&D Management Co., Ltd. |
Use of sulfonamide-including compounds in combination with angiogenesis inhibitors
|
|
ATE428421T1
(de)
*
|
2004-09-17 |
2009-05-15 |
Eisai R&D Man Co Ltd |
Medizinische zusammensetzung mit verbesserter stabilität und reduzierten gelierungseigenschaften
|
|
CN101102791B
(zh)
*
|
2004-11-18 |
2011-12-14 |
英克隆有限责任公司 |
抗血管内皮生长因子受体-1的抗体
|
|
WO2006083355A2
(en)
*
|
2004-11-19 |
2006-08-10 |
Cornell Research Foundation, Inc. |
Use of vascular endothelial growth factor receptor 1+ cells in treating and monitoring cancer and in screening for chemotherapeutics
|
|
JP5202956B2
(ja)
*
|
2004-11-19 |
2013-06-05 |
コーネル リサーチ ファンデーション インコーポレーティッド |
癌の治療およびモニタリングならびに化学療法薬に関するスクリーニングにおける血管内皮増殖因子受容体1+細胞の使用法
|
|
WO2006078746A2
(en)
*
|
2005-01-19 |
2006-07-27 |
Mathew Mark Zuckerman |
Method, compositions and classification for tumor diagnostics and treatment
|
|
CN102580084B
(zh)
|
2005-01-21 |
2016-11-23 |
健泰科生物技术公司 |
Her抗体的固定剂量给药
|
|
EP1850874B1
(en)
*
|
2005-02-23 |
2013-10-16 |
Genentech, Inc. |
Extending time to disease progression or survival in ovarian cancer patients using pertuzumab
|
|
US20060204505A1
(en)
*
|
2005-03-08 |
2006-09-14 |
Sliwkowski Mark X |
Methods for identifying tumors responsive to treatment with HER dimerization inhibitors (HDIs)
|
|
JP2006316040A
(ja)
|
2005-05-13 |
2006-11-24 |
Genentech Inc |
Herceptin(登録商標)補助療法
|
|
US20080219977A1
(en)
*
|
2005-07-27 |
2008-09-11 |
Isaiah Josh Fidler |
Combinations Comprising Gemcitabine and Tyrosine Kinase Inhibitors for the Treatment of Pancreatic Cancer
|
|
WO2007015569A1
(ja)
*
|
2005-08-01 |
2007-02-08 |
Eisai R & D Management Co., Ltd. |
血管新生阻害物質の効果を予測する方法
|
|
JP4989476B2
(ja)
|
2005-08-02 |
2012-08-01 |
エーザイ・アール・アンド・ディー・マネジメント株式会社 |
血管新生阻害物質の効果を検定する方法
|
|
AU2006309551B2
(en)
|
2005-11-07 |
2012-04-19 |
Eisai R & D Management Co., Ltd. |
Use of combination of anti-angiogenic substance and c-kit kinase inhibitor
|
|
BRPI0618677A2
(pt)
|
2005-11-15 |
2011-09-06 |
Neovista Inc |
métodos e aparelho para braquiterapia intra-ocular
|
|
EP1964837A4
(en)
*
|
2005-11-22 |
2010-12-22 |
Eisai R&D Man Co Ltd |
Antitumor agent against multiple myeloma
|
|
CN104706637A
(zh)
*
|
2006-05-18 |
2015-06-17 |
卫材R&D管理有限公司 |
针对甲状腺癌的抗肿瘤剂
|
|
JPWO2008001956A1
(ja)
*
|
2006-06-29 |
2009-12-03 |
エーザイ・アール・アンド・ディー・マネジメント株式会社 |
肝線維症治療剤
|
|
WO2008026748A1
(en)
*
|
2006-08-28 |
2008-03-06 |
Eisai R & D Management Co., Ltd. |
Antitumor agent for undifferentiated gastric cancer
|
|
CA2676796C
(en)
*
|
2007-01-29 |
2016-02-23 |
Eisai R & D Management Co., Ltd. |
Composition for treatment of undifferentiated gastric cancer
|
|
SI2132573T1
(sl)
|
2007-03-02 |
2014-07-31 |
Genentech, Inc. |
Napovedovanje odziva na inhibitor dimerizacije HER na osnovi nizke ekspresije HER3
|
|
CA2682390A1
(en)
*
|
2007-04-17 |
2008-10-30 |
Imclone Llc |
Pdgfr.beta.-specific inhibitors
|
|
US9551033B2
(en)
*
|
2007-06-08 |
2017-01-24 |
Genentech, Inc. |
Gene expression markers of tumor resistance to HER2 inhibitor treatment
|
|
PL2171090T3
(pl)
*
|
2007-06-08 |
2013-09-30 |
Genentech Inc |
Markery ekspresji genów odporności guza na leczenie hamujące HER2
|
|
KR100883430B1
(ko)
*
|
2007-06-13 |
2009-02-12 |
한국생명공학연구원 |
혈관내피성장인자 수용체를 중화하는 인간 단클론항체 및그 용도
|
|
LT2631248T
(lt)
|
2007-06-15 |
2018-04-25 |
Medigene Ag |
Navikų gydymas, naudojant specifinį anti-l1 antikūną
|
|
US8952035B2
(en)
|
2007-11-09 |
2015-02-10 |
Eisai R&D Management Co., Ltd. |
Combination of anti-angiogenic substance and anti-tumor platinum complex
|
|
KR101506062B1
(ko)
*
|
2008-01-29 |
2015-03-25 |
에자이 알앤드디 매니지먼트 가부시키가이샤 |
혈관 저해 물질과 탁산의 병용
|
|
CN101970499B
(zh)
|
2008-02-11 |
2014-12-31 |
治疗科技公司 |
用于肿瘤治疗的单克隆抗体
|
|
BRPI0812682A2
(pt)
|
2008-06-16 |
2010-06-22 |
Genentech Inc |
tratamento de cáncer de mama metastático
|
|
JP2012517434A
(ja)
|
2009-02-06 |
2012-08-02 |
ザ ジェネラル ホスピタル コーポレイション |
血管病変を治療する方法
|
|
MY152068A
(en)
|
2009-03-20 |
2014-08-15 |
Genentech Inc |
Bispecific anti-her antibodies
|
|
US8663210B2
(en)
|
2009-05-13 |
2014-03-04 |
Novian Health, Inc. |
Methods and apparatus for performing interstitial laser therapy and interstitial brachytherapy
|
|
CN102421448A
(zh)
|
2009-05-29 |
2012-04-18 |
霍夫曼-拉罗奇有限公司 |
Her2信号传导调控剂在表达her2的胃癌患者中
|
|
MY162940A
(en)
|
2009-08-19 |
2017-07-31 |
Eisai R&D Man Co Ltd |
Quinoline derivative-containing pharmaceutical composition
|
|
US8642515B2
(en)
|
2009-09-04 |
2014-02-04 |
University Of Louisville Research Foundation, Inc. |
Genetic determinants of prostate cancer risk
|
|
US9556249B2
(en)
|
2010-02-18 |
2017-01-31 |
Genentech, Inc. |
Neuregulin antagonists and use thereof in treating cancer
|
|
WO2011146568A1
(en)
|
2010-05-19 |
2011-11-24 |
Genentech, Inc. |
Predicting response to a her inhibitor
|
|
CN102958523B
(zh)
|
2010-06-25 |
2014-11-19 |
卫材R&D管理有限公司 |
使用具有激酶抑制作用的组合的抗肿瘤剂
|
|
WO2012069466A1
(en)
|
2010-11-24 |
2012-05-31 |
Novartis Ag |
Multispecific molecules
|
|
SG191153A1
(en)
|
2010-12-23 |
2013-07-31 |
Hoffmann La Roche |
Polypeptide-polynucleotide-complex and its use in targeted effector moiety delivery
|
|
CN103402519B
(zh)
|
2011-04-18 |
2015-11-25 |
卫材R&D管理有限公司 |
肿瘤治疗剂
|
|
JO3283B1
(ar)
|
2011-04-26 |
2018-09-16 |
Sanofi Sa |
تركيب يتضمن أفليبيرسيبت, حمض فولينيك, 5- فلورويوراسيل (5- Fu) وإرينوسيتان (FOLFIRI)
|
|
JP6038128B2
(ja)
|
2011-06-03 |
2016-12-07 |
エーザイ・アール・アンド・ディー・マネジメント株式会社 |
レンバチニブ化合物に対する甲状腺癌対象及び腎臓癌対象の反応性を予測及び評価するためのバイオマーカー
|
|
MX2014001766A
(es)
|
2011-08-17 |
2014-05-01 |
Genentech Inc |
Anticuerpos de neuregulina y sus usos.
|
|
US9327023B2
(en)
|
2011-10-25 |
2016-05-03 |
The Regents Of The University Of Michigan |
HER2 targeting agent treatment in non-HER2-amplified cancers having HER2 expressing cancer stem cells
|
|
BR112014012979A2
(pt)
|
2011-11-30 |
2020-10-20 |
Genentech, Inc. |
mutações erbb3 em câncer
|
|
US9376715B2
(en)
|
2011-12-09 |
2016-06-28 |
Roche Molecular Systems, Inc |
Methods for detecting mutations in the catalytic subunit of the phosphoinositol-3 kinase (PIK3CA) gene
|
|
US20130259867A1
(en)
|
2012-03-27 |
2013-10-03 |
Genentech, Inc. |
Diagnosis and treatments relating to her3 inhibitors
|
|
KR102291355B1
(ko)
|
2012-11-30 |
2021-08-19 |
에프. 호프만-라 로슈 아게 |
Pd-l1 억제제 공동치료를 필요로 하는 환자의 식별방법
|
|
KR20150098605A
(ko)
|
2012-12-21 |
2015-08-28 |
에자이 알앤드디 매니지먼트 가부시키가이샤 |
퀴놀린 유도체의 비정질 형태 및 그의 제조방법
|
|
WO2014110261A1
(en)
|
2013-01-11 |
2014-07-17 |
Massachusetts Eye And Ear Infirmary |
Cyp450 lipid metabolites reduce inflammation and angiogenesis
|
|
NZ714049A
(en)
|
2013-05-14 |
2020-05-29 |
Eisai R&D Man Co Ltd |
Biomarkers for predicting and assessing responsiveness of endometrial cancer subjects to lenvatinib compounds
|
|
TW201622744A
(zh)
*
|
2014-03-04 |
2016-07-01 |
美國禮來大藥廠 |
癌症之組合療法
|
|
EA035674B1
(ru)
|
2014-07-18 |
2020-07-24 |
Санофи |
Способ определения того, является ли пациент, предположительно страдающий от рака, кандидатом для терапии афлиберцептом
|
|
PT3524595T
(pt)
|
2014-08-28 |
2022-09-19 |
Eisai R&D Man Co Ltd |
Derivado de quinolina altamente puro e método para produção do mesmo
|
|
LT3263106T
(lt)
|
2015-02-25 |
2024-01-10 |
Eisai R&D Management Co., Ltd. |
Chinolino darinių kartumo sumažinimo būdas
|
|
KR102662228B1
(ko)
|
2015-03-04 |
2024-05-02 |
머크 샤프 앤드 돔 코포레이션 |
암을 치료하기 위한 pd-1 길항제 및 vegfr/fgfr/ret 티로신 키나제 억제제의 조합
|
|
JP6542383B2
(ja)
*
|
2015-04-14 |
2019-07-10 |
アカデミア シニカAcademia Sinica |
抗血管新生及び標的がん療法のための抗vegfr2ヒト抗体
|
|
MX373231B
(es)
|
2015-06-16 |
2020-05-08 |
Eisai R&D Man Co Ltd |
Agente anticancerigeno.
|
|
US12220398B2
(en)
|
2015-08-20 |
2025-02-11 |
Eisai R&D Management Co., Ltd. |
Tumor therapeutic agent
|
|
US20190151346A1
(en)
|
2016-05-10 |
2019-05-23 |
INSERM (Institute National de la Santé et de la Recherche Médicale) |
Combinations therapies for the treatment of cancer
|
|
CN106892980B
(zh)
*
|
2017-01-25 |
2020-08-04 |
长春金赛药业有限责任公司 |
抗vegfr2单克隆抗体及其应用
|
|
US12303505B2
(en)
|
2017-02-08 |
2025-05-20 |
Eisai R&D Management Co., Ltd. |
Tumor-treating pharmaceutical composition
|
|
RU2019134940A
(ru)
|
2017-05-16 |
2021-06-16 |
Эйсай Ар Энд Ди Менеджмент Ко., Лтд. |
Лечение гепатоцеллюлярной карциномы
|
|
WO2019009879A1
(en)
*
|
2017-07-03 |
2019-01-10 |
Development Center For Biotechnology |
ANTI-VEGFR ANTIBODIES AND USES THEREOF
|
|
US11912775B2
(en)
*
|
2017-07-18 |
2024-02-27 |
Kyowa Kirin Co., Ltd. |
Anti-human CCR1 monoclonal antibody
|
|
KR20220044612A
(ko)
|
2019-03-22 |
2022-04-08 |
리플렉시온 파마슈티컬스, 인크. |
Vegf에 대한 d-펩티드성 화합물
|
|
SG11202110968VA
(en)
*
|
2019-12-06 |
2021-10-28 |
Regeneron Pharma |
Anti-vegf protein compositions and methods for producing the same
|