JP2005505595A5 - - Google Patents
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- Publication number
- JP2005505595A5 JP2005505595A5 JP2003534423A JP2003534423A JP2005505595A5 JP 2005505595 A5 JP2005505595 A5 JP 2005505595A5 JP 2003534423 A JP2003534423 A JP 2003534423A JP 2003534423 A JP2003534423 A JP 2003534423A JP 2005505595 A5 JP2005505595 A5 JP 2005505595A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- substituted
- unsubstituted
- alkyl
- independently selected
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 CC(*)(*)C=C(C)c(cccc1)c1O Chemical compound CC(*)(*)C=C(C)c(cccc1)c1O 0.000 description 14
- ZLMRSEMZMODMON-ZETCQYMHSA-N CC(C)c1c[o]c([C@H](C)C(F)(F)F)c1 Chemical compound CC(C)c1c[o]c([C@H](C)C(F)(F)F)c1 ZLMRSEMZMODMON-ZETCQYMHSA-N 0.000 description 1
- FCUVMBDTELBGLE-MRVPVSSYSA-N CC[C@@H](C)c1cc(C)c[o]1 Chemical compound CC[C@@H](C)c1cc(C)c[o]1 FCUVMBDTELBGLE-MRVPVSSYSA-N 0.000 description 1
- BQHXHLNNDLHKHD-LURJTMIESA-N CCc1c[o]c([C@H](C)C(F)(F)F)c1 Chemical compound CCc1c[o]c([C@H](C)C(F)(F)F)c1 BQHXHLNNDLHKHD-LURJTMIESA-N 0.000 description 1
- STZZJEHODURTIM-LURJTMIESA-N C[C@H](C(F)(F)F)c1cc(C)c[o]1 Chemical compound C[C@H](C(F)(F)F)c1cc(C)c[o]1 STZZJEHODURTIM-LURJTMIESA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32900501P | 2001-10-12 | 2001-10-12 | |
| PCT/US2002/032628 WO2003031440A1 (en) | 2001-10-12 | 2002-10-11 | 3,4-di-substituted maleimide compounds as cxc-chemokine receptor antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005505595A JP2005505595A (ja) | 2005-02-24 |
| JP2005505595A5 true JP2005505595A5 (enExample) | 2006-01-05 |
Family
ID=23283431
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003534423A Pending JP2005505595A (ja) | 2001-10-12 | 2002-10-11 | Cxc−ケモカインレセプターアンタゴニストとしての3,4−二置換マレイミド化合物 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US6903131B2 (enExample) |
| EP (1) | EP1434775A1 (enExample) |
| JP (1) | JP2005505595A (enExample) |
| CN (1) | CN1599734A (enExample) |
| CA (1) | CA2462862A1 (enExample) |
| MX (1) | MXPA04003439A (enExample) |
| WO (1) | WO2003031440A1 (enExample) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7132445B2 (en) | 2001-04-16 | 2006-11-07 | Schering Corporation | 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands |
| US20040106794A1 (en) | 2001-04-16 | 2004-06-03 | Schering Corporation | 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands |
| JP2005505595A (ja) | 2001-10-12 | 2005-02-24 | シェーリング コーポレイション | Cxc−ケモカインレセプターアンタゴニストとしての3,4−二置換マレイミド化合物 |
| NZ535314A (en) * | 2002-03-18 | 2007-08-31 | Schering Corp | Combination treatments for chemokine-mediated diseases |
| CN100355423C (zh) | 2002-06-28 | 2007-12-19 | 诺瓦提斯公司 | 用于治疗肿瘤的包含血管抑制化合物和烷化剂的组合 |
| EP1551818B1 (en) * | 2002-10-09 | 2009-02-04 | Schering Corporation | Thiadiazoledioxides and thiadiazoleoxides as cxc- and cc-chemokine receptor ligands |
| EP2256106B1 (en) | 2003-07-22 | 2015-05-06 | Astex Therapeutics Limited | 3,4-disubstituted 1H-pyrazole compounds and their use as cyclin dependent kinases (CDK) and glycogen synthase kinase-3 (GSK-3) modulators |
| US7338968B2 (en) * | 2003-12-19 | 2008-03-04 | Schering Corporation | Thiadiazoles AS CXC- and CC- chemokine receptor ligands |
| WO2005068460A1 (en) * | 2003-12-22 | 2005-07-28 | Schering Corporation | Isothiazole dioxides as cxc- and cc- chemokine receptor ligands |
| WO2005103711A2 (en) * | 2004-04-20 | 2005-11-03 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with cxc chemokine receptor 1 (cxcr1) |
| CN1984899B (zh) * | 2004-05-12 | 2011-07-27 | 先灵公司 | Cxcr1和cxcr2趋化因子拮抗剂 |
| SE0500055D0 (sv) | 2005-01-10 | 2005-01-10 | Astrazeneca Ab | Therapeutic agents 3 |
| SE0500058D0 (sv) * | 2005-01-10 | 2005-01-10 | Astrazeneca Ab | Therapeutic agents 5 |
| MX2007008370A (es) | 2005-01-10 | 2007-08-21 | Astrazeneca Ab | Derivados de 1,1-dioxidos de isotiazol-3 (2h) -ona como moduladores del receptor del higado x. |
| US8440217B1 (en) | 2005-06-15 | 2013-05-14 | Mawaheb M. EL-Naggar | Method and system with contact lens product for treating and preventing adverse eye conditions |
| WO2007002764A2 (en) | 2005-06-29 | 2007-01-04 | Schering Corporation | Di-substituted oxadiazoles as cxc-chemokine receptor ligands |
| ATE486078T1 (de) | 2005-06-29 | 2010-11-15 | Schering Corp | 5,6-disubstituierte oxadiazolopyrazine und thiadiazolopyrazine als liganden des cxc- chemokinrezeptors |
| JP5374157B2 (ja) * | 2005-11-24 | 2013-12-25 | ドムペ・ファ.ル.マ・ソチエタ・ペル・アツィオーニ | (r)−アリールアルキルアミノ誘導体類と、それらを含有する薬剤組成物 |
| JP2009542700A (ja) * | 2006-07-07 | 2009-12-03 | シェーリング コーポレイション | Cxcケモカイン受容体リガンドとしての3,4−ジ置換シクロブテン−1,2−ジオン |
| FR2927075A1 (fr) * | 2008-02-04 | 2009-08-07 | Centre Nat Rech Scient | Molecules comprenant un squelette bis-(heteroaryl)maleimide, et leur utilisation dans l'inhibition d'enzymes |
| US7943527B2 (en) * | 2008-05-30 | 2011-05-17 | The Board Of Trustees Of The University Of Illinois | Surface preparation for thin film growth by enhanced nucleation |
| JP2013526542A (ja) | 2010-05-12 | 2013-06-24 | アッヴィ・インコーポレイテッド | キナーゼのインダゾール阻害薬 |
| CN104302640A (zh) | 2012-03-16 | 2015-01-21 | 埃克希金医药品有限公司 | 3,5-二氨基吡唑激酶抑制剂 |
| US8889730B2 (en) | 2012-04-10 | 2014-11-18 | Pfizer Inc. | Indole and indazole compounds that activate AMPK |
| KR101556276B1 (ko) * | 2012-12-28 | 2015-09-30 | 제일모직 주식회사 | 하드마스크 조성물용 모노머, 상기 모노머를 포함하는 하드마스크 조성물 및 상기 하드마스크 조성물을 사용하는 패턴형성방법 |
| JP6064062B2 (ja) | 2013-03-15 | 2017-01-18 | ファイザー・インク | Ampkを活性化させるインダゾール化合物 |
| NZ631142A (en) | 2013-09-18 | 2016-03-31 | Axikin Pharmaceuticals Inc | Pharmaceutically acceptable salts of 3,5-diaminopyrazole kinase inhibitors |
| MY191736A (en) | 2014-12-23 | 2022-07-13 | Axikin Pharmaceuticals Inc | 3,5-diaminopyrazole kinase inhibitors |
| CA3045944A1 (en) | 2016-12-07 | 2018-06-14 | Progenity, Inc. | Gastrointestinal tract detection methods, devices and systems |
| CA3045310A1 (en) | 2016-12-14 | 2018-06-21 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with a chemokine/chemokine receptor inhibitor |
| WO2019044739A1 (ja) * | 2017-08-31 | 2019-03-07 | 国立大学法人京都工芸繊維大学 | 蛍光体及びその利用 |
| CN113348011B (zh) | 2018-11-19 | 2023-04-18 | 比奥拉治疗股份有限公司 | 用生物治疗剂治疗疾病的方法和装置 |
| CN121197633A (zh) | 2019-12-13 | 2025-12-26 | 比特比德科有限责任公司 | 用于将治疗剂递送至胃肠道的可摄取装置 |
| WO2022193187A1 (en) * | 2021-03-17 | 2022-09-22 | Biofront Ltd. (Cayman) | Modulators of fpr1 and methods of using same |
| JP2024025430A (ja) * | 2022-08-12 | 2024-02-26 | 富士フイルム株式会社 | 化合物又はその塩、タンパク質間相互作用阻害剤、医薬組成物、及び抗腫瘍剤 |
| CN115433115A (zh) * | 2022-10-17 | 2022-12-06 | 聊城大学 | 一种3,4-二取代马来酰亚胺类化合物及其合成方法 |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1669798A1 (de) | 1966-07-28 | 1971-08-26 | Huels Chemische Werke Ag | Verfahren zum Stabilisieren markomolekularer Polyacetale |
| CS214745B2 (en) | 1976-08-28 | 1982-05-28 | Huels Chemische Werke Ag | Shaped and non-shaped products from plastic materials |
| FI832519L (fi) | 1982-07-12 | 1984-01-13 | Bristol Myers Co | Farmaceutiska foerfaranden och sammansaettningar |
| DE3309655A1 (de) | 1983-03-17 | 1984-09-20 | Bayer Ag, 5090 Leverkusen | 1,2,5-thiadiazol-1-oxide und 1,1-dioxide, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| JPS60255756A (ja) | 1984-06-01 | 1985-12-17 | Ikeda Mohandou:Kk | アミノアルキルフエノキシ誘導体 |
| HU198696B (en) | 1987-01-20 | 1989-11-28 | Nissan Chemical Ind Ltd | Process for producing 3/2h/-pyridazinon derivatives and pharmaceutical compositions containing them as active components |
| JPH02256668A (ja) | 1988-12-20 | 1990-10-17 | Nissan Chem Ind Ltd | ピリダジノン誘導体 |
| US5206252A (en) | 1992-05-08 | 1993-04-27 | American Home Products Corporation | Thiadiazolyl-amino derivatives of benzopyrans and indanes |
| GB9312210D0 (en) | 1993-06-14 | 1993-07-28 | Smithkline Beecham Plc | Chemical compounds |
| US5506252A (en) | 1993-11-17 | 1996-04-09 | American Home Products Corporation | Substituted N-heteroaryl and N-aryl-1,2-diaminocyclobutene-3,4-diones |
| US5354763A (en) | 1993-11-17 | 1994-10-11 | American Home Products Corporation | Substituted N-heteroaryl and N-aryl-1,2-diaminocyclobutene-3,4-diones |
| US5466712A (en) | 1994-11-04 | 1995-11-14 | American Home Products Corporation | Substituted n-aryl-1,2-diaminocyclobutene-3,4-diones |
| EP0796243B1 (en) | 1994-11-16 | 1999-01-27 | American Home Products Corporation | Diaminocyclobutene-3,4-diones |
| CN1217660C (zh) | 1997-01-23 | 2005-09-07 | 史密丝克莱恩比彻姆公司 | Il-8受体拮抗剂 |
| AU6250298A (en) | 1997-01-30 | 1998-08-25 | American Home Products Corporation | Substituted hydroxy-anilino derivatives of cyclobutene-3,4-diones |
| US5840764A (en) | 1997-01-30 | 1998-11-24 | American Home Products Corporation | Substituted hydroxy-anilino derivatives of cyclobutene-3,4-diones |
| AR015425A1 (es) | 1997-09-05 | 2001-05-02 | Smithkline Beecham Corp | Compuestos de benzotiazol, composicion farmaceutica que los contiene, su uso en la manufactura de un medicamento, procedimiento para su preparacion,compuestos intermediarios y procedimiento para su preparacion |
| AU5727899A (en) | 1998-10-02 | 2000-04-26 | Neurosearch A/S | Diaminocyclobutene-3,4-dione derivatives, their preparation and use |
| JP2002527419A (ja) | 1998-10-08 | 2002-08-27 | スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー | Gsk−3阻害物質としてのピロール−2,5−ジオン類 |
| US6376555B1 (en) | 1998-12-04 | 2002-04-23 | American Home Products Corporation | 4-substituted-3-substituted-amino-cyclobut-3-ene-1,2-diones and analogs thereof as novel potassium channel openers |
| JP2002532457A (ja) | 1998-12-14 | 2002-10-02 | アメリカン・ホーム・プロダクツ・コーポレイション | Vla−4により仲介される白血球接着を阻害する3,4−ジアミノ−3−シクロブテン−1,2−ジオン誘導体 |
| CN1334801A (zh) | 1998-12-16 | 2002-02-06 | 拜尔公司 | 作为整联蛋白拮抗剂的新的联苯基和类似联苯基的化合物 |
| US6420396B1 (en) | 1998-12-16 | 2002-07-16 | Beiersdorf Ag | Biphenyl and biphenyl-analogous compounds as integrin antagonists |
| US6518283B1 (en) | 1999-05-28 | 2003-02-11 | Celltech R&D Limited | Squaric acid derivatives |
| US6586446B1 (en) | 1999-10-15 | 2003-07-01 | Bristol-Myers Squibb Company | Bicyclic and tricyclic amines as modulators of chemokine receptor activity |
| AU2001243351A1 (en) | 2000-03-01 | 2001-09-12 | Smith Kline Beecham Corporation | Il-8 receptor antagonists |
| AR033803A1 (es) * | 2000-03-01 | 2004-01-07 | Smithkline Beecham Corp | Compuestos de dianilino escuarano, composiciones farmaceuticas que los comprenden, y el uso de los mismos en la fabricacion de medicamentos para tratar enfermedades mediadas por quimioquinas |
| EP1274415A4 (en) | 2000-03-14 | 2005-09-07 | Smithkline Beecham Corp | IL-8 RECEPTOR ANTAGONISTS |
| WO2001092202A1 (en) | 2000-05-30 | 2001-12-06 | Smithkline Beecham Corporation | Il-8 receptor antagonists |
| DE60230722D1 (de) | 2001-01-16 | 2009-02-26 | Smithkline Beecham Corp | Il-8-rezeptor-antagonisten |
| US20040048897A1 (en) | 2001-01-16 | 2004-03-11 | Mccleland Brent | Il-8 receptor antagonists |
| US20030204085A1 (en) | 2001-02-02 | 2003-10-30 | Taveras Arthur G. | 3, 4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor antagonists |
| EP1355875A1 (en) | 2001-02-02 | 2003-10-29 | Schering Corporation | 3,4-di-substituted cyclobutene-1, 2-diones as cxc chemokine receptor antagonists |
| KR20100008794A (ko) | 2001-04-16 | 2010-01-26 | 쉐링 코포레이션 | Cxc-케모카인 수용체 리간드로서의 3,4-이치환된 사이클로부텐-1,2-디온 |
| JP2005505595A (ja) | 2001-10-12 | 2005-02-24 | シェーリング コーポレイション | Cxc−ケモカインレセプターアンタゴニストとしての3,4−二置換マレイミド化合物 |
| US6878709B2 (en) | 2002-01-04 | 2005-04-12 | Schering Corporation | 3,4-di-substituted pyridazinediones as CXC chemokine receptor antagonists |
| NZ535314A (en) | 2002-03-18 | 2007-08-31 | Schering Corp | Combination treatments for chemokine-mediated diseases |
-
2002
- 2002-10-11 JP JP2003534423A patent/JP2005505595A/ja active Pending
- 2002-10-11 CA CA002462862A patent/CA2462862A1/en not_active Abandoned
- 2002-10-11 MX MXPA04003439A patent/MXPA04003439A/es unknown
- 2002-10-11 EP EP02786395A patent/EP1434775A1/en not_active Withdrawn
- 2002-10-11 WO PCT/US2002/032628 patent/WO2003031440A1/en not_active Ceased
- 2002-10-11 CN CNA028240529A patent/CN1599734A/zh active Pending
- 2002-10-11 US US10/269,775 patent/US6903131B2/en not_active Expired - Fee Related
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