JP2012511563A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2012511563A5 JP2012511563A5 JP2011540218A JP2011540218A JP2012511563A5 JP 2012511563 A5 JP2012511563 A5 JP 2012511563A5 JP 2011540218 A JP2011540218 A JP 2011540218A JP 2011540218 A JP2011540218 A JP 2011540218A JP 2012511563 A5 JP2012511563 A5 JP 2012511563A5
- Authority
- JP
- Japan
- Prior art keywords
- ureido
- tolyl
- butyl
- tert
- pyrazol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- -1 4- (4- (3- (3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl) ureido) naphthalen-1-yloxy) pyridin-2-yl Chemical group 0.000 claims 37
- 125000000217 alkyl group Chemical group 0.000 claims 23
- 150000001875 compounds Chemical class 0.000 claims 18
- 125000005842 heteroatom Chemical group 0.000 claims 9
- 125000000623 heterocyclic group Chemical group 0.000 claims 9
- 125000001951 carbamoylamino group Chemical group C(N)(=O)N* 0.000 claims 8
- 229910052717 sulfur Inorganic materials 0.000 claims 8
- 229910052757 nitrogen Inorganic materials 0.000 claims 7
- 229910052760 oxygen Inorganic materials 0.000 claims 7
- 150000003839 salts Chemical class 0.000 claims 7
- 125000003545 alkoxy group Chemical group 0.000 claims 6
- 125000004663 dialkyl amino group Chemical group 0.000 claims 6
- 229910052736 halogen Inorganic materials 0.000 claims 6
- 150000002367 halogens Chemical class 0.000 claims 6
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 6
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 5
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims 5
- 239000012453 solvate Substances 0.000 claims 5
- DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 claims 4
- 229910052799 carbon Inorganic materials 0.000 claims 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 3
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 3
- 239000004202 carbamide Substances 0.000 claims 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Natural products CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 230000000155 isotopic effect Effects 0.000 claims 2
- 125000001624 naphthyl group Chemical group 0.000 claims 2
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 2
- 229920006395 saturated elastomer Polymers 0.000 claims 2
- XZYOKLDOGCKXFU-AREMUKBSSA-N (3r)-n-[4-[4-[[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]carbamoylamino]naphthalen-1-yl]oxypyridin-2-yl]-3-(dimethylamino)pyrrolidine-1-carboxamide Chemical compound C1[C@H](N(C)C)CCN1C(=O)NC1=CC(OC=2C3=CC=CC=C3C(NC(=O)NC=3N(N=C(C=3)C(C)(C)C)C=3C=CC(C)=CC=3)=CC=2)=CC=N1 XZYOKLDOGCKXFU-AREMUKBSSA-N 0.000 claims 1
- 125000006716 (C1-C6) heteroalkyl group Chemical group 0.000 claims 1
- 125000006545 (C1-C9) alkyl group Chemical group 0.000 claims 1
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 1
- RHPOFSSHQSUXCH-UHFFFAOYSA-N 1-(2-methoxyethyl)-3-pyridin-2-ylurea Chemical compound COCCNC(=O)NC1=CC=CC=N1 RHPOFSSHQSUXCH-UHFFFAOYSA-N 0.000 claims 1
- JDSCOPALPVVAMI-UHFFFAOYSA-N 1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-[2-(carbamoylamino)pyridin-4-yl]oxynaphthalen-1-yl]urea Chemical compound C1=CC(C)=CC=C1N1C(NC(=O)NC=2C3=CC=CC=C3C(OC=3C=C(NC(N)=O)N=CC=3)=CC=2)=CC(C(C)(C)C)=N1 JDSCOPALPVVAMI-UHFFFAOYSA-N 0.000 claims 1
- YTTNMTQRALUGRX-UHFFFAOYSA-N 1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-[2-(carbamoylamino)pyrimidin-4-yl]oxynaphthalen-1-yl]urea Chemical compound C1=CC(C)=CC=C1N1C(NC(=O)NC=2C3=CC=CC=C3C(OC=3N=C(NC(N)=O)N=CC=3)=CC=2)=CC(C(C)(C)C)=N1 YTTNMTQRALUGRX-UHFFFAOYSA-N 0.000 claims 1
- BVFKRRNCUURTOI-UHFFFAOYSA-N 1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-[2-(cyclopropylcarbamoylamino)pyridin-4-yl]oxynaphthalen-1-yl]urea Chemical compound C1=CC(C)=CC=C1N1C(NC(=O)NC=2C3=CC=CC=C3C(OC=3C=C(NC(=O)NC4CC4)N=CC=3)=CC=2)=CC(C(C)(C)C)=N1 BVFKRRNCUURTOI-UHFFFAOYSA-N 0.000 claims 1
- DXLIDCWBUAERSC-UHFFFAOYSA-N 1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-[2-(cyclopropylcarbamoylamino)pyrimidin-4-yl]oxynaphthalen-1-yl]urea Chemical compound C1=CC(C)=CC=C1N1C(NC(=O)NC=2C3=CC=CC=C3C(OC=3N=C(NC(=O)NC4CC4)N=CC=3)=CC=2)=CC(C(C)(C)C)=N1 DXLIDCWBUAERSC-UHFFFAOYSA-N 0.000 claims 1
- HOWYJHYHNQTBNF-UHFFFAOYSA-N 1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-[2-(methylcarbamoylamino)pyrimidin-4-yl]oxynaphthalen-1-yl]urea Chemical compound CNC(=O)NC1=NC=CC(OC=2C3=CC=CC=C3C(NC(=O)NC=3N(N=C(C=3)C(C)(C)C)C=3C=CC(C)=CC=3)=CC=2)=N1 HOWYJHYHNQTBNF-UHFFFAOYSA-N 0.000 claims 1
- XLHTULSCPXKFHD-UHFFFAOYSA-N 1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-[2-(phenylcarbamoylamino)pyridin-4-yl]oxynaphthalen-1-yl]urea Chemical compound C1=CC(C)=CC=C1N1C(NC(=O)NC=2C3=CC=CC=C3C(OC=3C=C(NC(=O)NC=4C=CC=CC=4)N=CC=3)=CC=2)=CC(C(C)(C)C)=N1 XLHTULSCPXKFHD-UHFFFAOYSA-N 0.000 claims 1
- WUXMHKROVSEUIG-UHFFFAOYSA-N 1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-[2-(piperidin-4-ylcarbamoylamino)pyridin-4-yl]oxynaphthalen-1-yl]urea Chemical compound C1=CC(C)=CC=C1N1C(NC(=O)NC=2C3=CC=CC=C3C(OC=3C=C(NC(=O)NC4CCNCC4)N=CC=3)=CC=2)=CC(C(C)(C)C)=N1 WUXMHKROVSEUIG-UHFFFAOYSA-N 0.000 claims 1
- HQCCANAXHHBLJQ-UHFFFAOYSA-N 1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-[2-[(1-methylsulfonylpiperidin-4-yl)carbamoylamino]pyridin-4-yl]oxynaphthalen-1-yl]urea Chemical compound C1=CC(C)=CC=C1N1C(NC(=O)NC=2C3=CC=CC=C3C(OC=3C=C(NC(=O)NC4CCN(CC4)S(C)(=O)=O)N=CC=3)=CC=2)=CC(C(C)(C)C)=N1 HQCCANAXHHBLJQ-UHFFFAOYSA-N 0.000 claims 1
- GKLBOQXVLALWMH-UHFFFAOYSA-N 1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-[2-[(2-morpholin-4-yl-2-oxoethyl)carbamoylamino]pyridin-4-yl]oxynaphthalen-1-yl]urea Chemical compound C1=CC(C)=CC=C1N1C(NC(=O)NC=2C3=CC=CC=C3C(OC=3C=C(NC(=O)NCC(=O)N4CCOCC4)N=CC=3)=CC=2)=CC(C(C)(C)C)=N1 GKLBOQXVLALWMH-UHFFFAOYSA-N 0.000 claims 1
- MDOLZJKXHAXTEF-UHFFFAOYSA-N 1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-[2-[(2-oxo-2-pyrrolidin-1-ylethyl)carbamoylamino]pyridin-4-yl]oxynaphthalen-1-yl]urea Chemical compound C1=CC(C)=CC=C1N1C(NC(=O)NC=2C3=CC=CC=C3C(OC=3C=C(NC(=O)NCC(=O)N4CCCC4)N=CC=3)=CC=2)=CC(C(C)(C)C)=N1 MDOLZJKXHAXTEF-UHFFFAOYSA-N 0.000 claims 1
- DAJMQZIBLSBHAE-UHFFFAOYSA-N 1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-[2-[[2-(4-methylpiperazin-1-yl)-2-oxoethyl]carbamoylamino]pyridin-4-yl]oxynaphthalen-1-yl]urea Chemical compound C1CN(C)CCN1C(=O)CNC(=O)NC1=CC(OC=2C3=CC=CC=C3C(NC(=O)NC=3N(N=C(C=3)C(C)(C)C)C=3C=CC(C)=CC=3)=CC=2)=CC=N1 DAJMQZIBLSBHAE-UHFFFAOYSA-N 0.000 claims 1
- XQQKILZJJJNJBN-UHFFFAOYSA-N 1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-[6-(carbamoylamino)pyrimidin-4-yl]oxynaphthalen-1-yl]urea Chemical compound C1=CC(C)=CC=C1N1C(NC(=O)NC=2C3=CC=CC=C3C(OC=3N=CN=C(NC(N)=O)C=3)=CC=2)=CC(C(C)(C)C)=N1 XQQKILZJJJNJBN-UHFFFAOYSA-N 0.000 claims 1
- RHSMFYIHIIADSH-UHFFFAOYSA-N 1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-naphthalen-1-ylurea Chemical compound C1=CC(C)=CC=C1N1C(NC(=O)NC=2C3=CC=CC=C3C=CC=2)=CC(C(C)(C)C)=N1 RHSMFYIHIIADSH-UHFFFAOYSA-N 0.000 claims 1
- DPNYEFODFDMYDL-UHFFFAOYSA-N 1-benzyl-3-[4-[4-[[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]carbamoylamino]naphthalen-1-yl]oxypyridin-2-yl]urea Chemical compound C1=CC(C)=CC=C1N1C(NC(=O)NC=2C3=CC=CC=C3C(OC=3C=C(NC(=O)NCC=4C=CC=CC=4)N=CC=3)=CC=2)=CC(C(C)(C)C)=N1 DPNYEFODFDMYDL-UHFFFAOYSA-N 0.000 claims 1
- 125000001637 1-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C(*)=C([H])C([H])=C([H])C2=C1[H] 0.000 claims 1
- SGHDEYQIMDEDSS-UHFFFAOYSA-N 2-[[4-[4-[[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]carbamoylamino]naphthalen-1-yl]oxypyridin-2-yl]carbamoylamino]-n-methylacetamide Chemical compound C1=NC(NC(=O)NCC(=O)NC)=CC(OC=2C3=CC=CC=C3C(NC(=O)NC=3N(N=C(C=3)C(C)(C)C)C=3C=CC(C)=CC=3)=CC=2)=C1 SGHDEYQIMDEDSS-UHFFFAOYSA-N 0.000 claims 1
- HGYVVJZWXGWXPT-UHFFFAOYSA-N 2-methoxy-n-[4-[4-[[2-(4-methylphenyl)-5-propan-2-ylpyrazol-3-yl]carbamoylamino]naphthalen-1-yl]oxypyridin-2-yl]acetamide Chemical compound C1=NC(NC(=O)COC)=CC(OC=2C3=CC=CC=C3C(NC(=O)NC=3N(N=C(C=3)C(C)C)C=3C=CC(C)=CC=3)=CC=2)=C1 HGYVVJZWXGWXPT-UHFFFAOYSA-N 0.000 claims 1
- OKEWJDJWTSMGKA-UHFFFAOYSA-N 3-[4-[4-[[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]carbamoylamino]naphthalen-1-yl]oxypyridin-2-yl]-1,1-dimethylurea Chemical compound C1=NC(NC(=O)N(C)C)=CC(OC=2C3=CC=CC=C3C(NC(=O)NC=3N(N=C(C=3)C(C)(C)C)C=3C=CC(C)=CC=3)=CC=2)=C1 OKEWJDJWTSMGKA-UHFFFAOYSA-N 0.000 claims 1
- SZVBINLROMAAJO-UHFFFAOYSA-N 3-[4-[4-[[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]carbamoylamino]naphthalen-1-yl]oxypyrimidin-2-yl]-1,1-dimethylurea Chemical compound CN(C)C(=O)NC1=NC=CC(OC=2C3=CC=CC=C3C(NC(=O)NC=3N(N=C(C=3)C(C)(C)C)C=3C=CC(C)=CC=3)=CC=2)=N1 SZVBINLROMAAJO-UHFFFAOYSA-N 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010006458 Bronchitis chronic Diseases 0.000 claims 1
- 206010006895 Cachexia Diseases 0.000 claims 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 206010010741 Conjunctivitis Diseases 0.000 claims 1
- 206010010744 Conjunctivitis allergic Diseases 0.000 claims 1
- 201000003883 Cystic fibrosis Diseases 0.000 claims 1
- 206010012434 Dermatitis allergic Diseases 0.000 claims 1
- 206010012442 Dermatitis contact Diseases 0.000 claims 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 claims 1
- 206010014561 Emphysema Diseases 0.000 claims 1
- 201000009794 Idiopathic Pulmonary Fibrosis Diseases 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 206010027476 Metastases Diseases 0.000 claims 1
- 125000003047 N-acetyl group Chemical group 0.000 claims 1
- 206010033645 Pancreatitis Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical group C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 claims 1
- 206010039085 Rhinitis allergic Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
- 208000002205 allergic conjunctivitis Diseases 0.000 claims 1
- 201000010105 allergic rhinitis Diseases 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 208000024998 atopic conjunctivitis Diseases 0.000 claims 1
- 201000008937 atopic dermatitis Diseases 0.000 claims 1
- 208000010668 atopic eczema Diseases 0.000 claims 1
- 206010006451 bronchitis Diseases 0.000 claims 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 208000029771 childhood onset asthma Diseases 0.000 claims 1
- 208000007451 chronic bronchitis Diseases 0.000 claims 1
- 208000010247 contact dermatitis Diseases 0.000 claims 1
- 208000035250 cutaneous malignant susceptibility to 1 melanoma Diseases 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 125000004404 heteroalkyl group Chemical group 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 208000036971 interstitial lung disease 2 Diseases 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 230000009401 metastasis Effects 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- DMUQGBCYZATOMY-UHFFFAOYSA-N n-[2-[[4-[4-[[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]carbamoylamino]naphthalen-1-yl]oxypyridin-2-yl]amino]-2-oxoethyl]-3-morpholin-4-ylpropanamide Chemical compound C1=CC(C)=CC=C1N1C(NC(=O)NC=2C3=CC=CC=C3C(OC=3C=C(NC(=O)CNC(=O)CCN4CCOCC4)N=CC=3)=CC=2)=CC(C(C)(C)C)=N1 DMUQGBCYZATOMY-UHFFFAOYSA-N 0.000 claims 1
- CRTSPNMFWCENOV-UHFFFAOYSA-N n-[2-[[4-[4-[[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]carbamoylamino]naphthalen-1-yl]oxypyridin-2-yl]amino]-2-oxoethyl]morpholine-4-carboxamide Chemical compound C1=CC(C)=CC=C1N1C(NC(=O)NC=2C3=CC=CC=C3C(OC=3C=C(NC(=O)CNC(=O)N4CCOCC4)N=CC=3)=CC=2)=CC(C(C)(C)C)=N1 CRTSPNMFWCENOV-UHFFFAOYSA-N 0.000 claims 1
- UPBBOCRQZZBDGZ-UHFFFAOYSA-N n-[2-[[4-[4-[[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]carbamoylamino]naphthalen-1-yl]oxypyridin-2-yl]amino]-2-oxoethyl]oxane-4-carboxamide Chemical compound C1=CC(C)=CC=C1N1C(NC(=O)NC=2C3=CC=CC=C3C(OC=3C=C(NC(=O)CNC(=O)C4CCOCC4)N=CC=3)=CC=2)=CC(C(C)(C)C)=N1 UPBBOCRQZZBDGZ-UHFFFAOYSA-N 0.000 claims 1
- QBTIJQJNAFHVLA-UHFFFAOYSA-N n-[2-[[4-[4-[[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]carbamoylamino]naphthalen-1-yl]oxypyridin-2-yl]amino]-2-oxoethyl]pyridine-4-carboxamide Chemical compound C1=CC(C)=CC=C1N1C(NC(=O)NC=2C3=CC=CC=C3C(OC=3C=C(NC(=O)CNC(=O)C=4C=CN=CC=4)N=CC=3)=CC=2)=CC(C(C)(C)C)=N1 QBTIJQJNAFHVLA-UHFFFAOYSA-N 0.000 claims 1
- QGSYDPHSISRRKJ-UHFFFAOYSA-N n-[4-[4-[[5-(1-hydroxy-2-methylpropan-2-yl)-2-(4-methylphenyl)pyrazol-3-yl]carbamoylamino]naphthalen-1-yl]oxypyridin-2-yl]-2-methoxyacetamide Chemical compound C1=NC(NC(=O)COC)=CC(OC=2C3=CC=CC=C3C(NC(=O)NC=3N(N=C(C=3)C(C)(C)CO)C=3C=CC(C)=CC=3)=CC=2)=C1 QGSYDPHSISRRKJ-UHFFFAOYSA-N 0.000 claims 1
- SEXCAXGEWGCFFE-UHFFFAOYSA-N n-[4-[4-[[5-ethyl-2-(4-methylphenyl)pyrazol-3-yl]carbamoylamino]naphthalen-1-yl]oxypyridin-2-yl]-2-methoxyacetamide Chemical compound C=1C=C(C)C=CC=1N1N=C(CC)C=C1NC(=O)NC(C1=CC=CC=C11)=CC=C1OC1=CC=NC(NC(=O)COC)=C1 SEXCAXGEWGCFFE-UHFFFAOYSA-N 0.000 claims 1
- AVUUHIYJPTWYNX-UHFFFAOYSA-N n-[4-[4-[[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]carbamoylamino]naphthalen-1-yl]oxypyridin-2-yl]-2-methoxyacetamide Chemical compound C1=NC(NC(=O)COC)=CC(OC=2C3=CC=CC=C3C(NC(=O)NC=3N(N=C(C=3)C(C)(C)C)C=3C=CC(C)=CC=3)=CC=2)=C1 AVUUHIYJPTWYNX-UHFFFAOYSA-N 0.000 claims 1
- OFVXXPNLFUKQTB-UHFFFAOYSA-N n-[4-[4-[[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]carbamoylamino]naphthalen-1-yl]oxypyridin-2-yl]-4-methylpiperazine-1-carboxamide Chemical compound C1CN(C)CCN1C(=O)NC1=CC(OC=2C3=CC=CC=C3C(NC(=O)NC=3N(N=C(C=3)C(C)(C)C)C=3C=CC(C)=CC=3)=CC=2)=CC=N1 OFVXXPNLFUKQTB-UHFFFAOYSA-N 0.000 claims 1
- PFGPXCHWPKIYPY-UHFFFAOYSA-N n-[4-[4-[[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]carbamoylamino]naphthalen-1-yl]oxypyridin-2-yl]morpholine-4-carboxamide Chemical compound C1=CC(C)=CC=C1N1C(NC(=O)NC=2C3=CC=CC=C3C(OC=3C=C(NC(=O)N4CCOCC4)N=CC=3)=CC=2)=CC(C(C)(C)C)=N1 PFGPXCHWPKIYPY-UHFFFAOYSA-N 0.000 claims 1
- HPVNUUMLMRFDNP-UHFFFAOYSA-N n-[4-[4-[[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]carbamoylamino]naphthalen-1-yl]oxypyridin-2-yl]oxane-4-carboxamide Chemical compound C1=CC(C)=CC=C1N1C(NC(=O)NC=2C3=CC=CC=C3C(OC=3C=C(NC(=O)C4CCOCC4)N=CC=3)=CC=2)=CC(C(C)(C)C)=N1 HPVNUUMLMRFDNP-UHFFFAOYSA-N 0.000 claims 1
- INZJHXPSKMNVOB-UHFFFAOYSA-N n-[4-[4-[[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]carbamoylamino]naphthalen-1-yl]oxypyridin-2-yl]piperidine-1-carboxamide Chemical compound C1=CC(C)=CC=C1N1C(NC(=O)NC=2C3=CC=CC=C3C(OC=3C=C(NC(=O)N4CCCCC4)N=CC=3)=CC=2)=CC(C(C)(C)C)=N1 INZJHXPSKMNVOB-UHFFFAOYSA-N 0.000 claims 1
- JOPZSFGHCVMVBH-UHFFFAOYSA-N n-[4-[4-[[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]carbamoylamino]naphthalen-1-yl]oxypyridin-2-yl]pyrrolidine-1-carboxamide Chemical compound C1=CC(C)=CC=C1N1C(NC(=O)NC=2C3=CC=CC=C3C(OC=3C=C(NC(=O)N4CCCC4)N=CC=3)=CC=2)=CC(C(C)(C)C)=N1 JOPZSFGHCVMVBH-UHFFFAOYSA-N 0.000 claims 1
- NXEJIGOGROPCLK-UHFFFAOYSA-N n-[4-[4-[[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]carbamoylamino]naphthalen-1-yl]oxypyrimidin-2-yl]-2-methoxyacetamide Chemical compound COCC(=O)NC1=NC=CC(OC=2C3=CC=CC=C3C(NC(=O)NC=3N(N=C(C=3)C(C)(C)C)C=3C=CC(C)=CC=3)=CC=2)=N1 NXEJIGOGROPCLK-UHFFFAOYSA-N 0.000 claims 1
- UJDRMMPUXFYCMR-UHFFFAOYSA-N n-[4-[4-[[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]carbamoylamino]naphthalen-1-yl]oxypyrimidin-2-yl]morpholine-4-carboxamide Chemical compound C1=CC(C)=CC=C1N1C(NC(=O)NC=2C3=CC=CC=C3C(OC=3N=C(NC(=O)N4CCOCC4)N=CC=3)=CC=2)=CC(C(C)(C)C)=N1 UJDRMMPUXFYCMR-UHFFFAOYSA-N 0.000 claims 1
- BMKVKXCWBWUXAN-UHFFFAOYSA-N n-[4-[4-[[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]carbamoylamino]phenoxy]pyridin-2-yl]-2-methoxyacetamide Chemical compound C1=NC(NC(=O)COC)=CC(OC=2C=CC(NC(=O)NC=3N(N=C(C=3)C(C)(C)C)C=3C=CC(C)=CC=3)=CC=2)=C1 BMKVKXCWBWUXAN-UHFFFAOYSA-N 0.000 claims 1
- UFSCPCUZCQBBOT-UHFFFAOYSA-N n-[6-[4-[[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]carbamoylamino]phenoxy]pyrimidin-4-yl]-2-methoxyacetamide Chemical compound C1=NC(NC(=O)COC)=CC(OC=2C=CC(NC(=O)NC=3N(N=C(C=3)C(C)(C)C)C=3C=CC(C)=CC=3)=CC=2)=N1 UFSCPCUZCQBBOT-UHFFFAOYSA-N 0.000 claims 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- 125000004043 oxo group Chemical group O=* 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- MQDVUDAZJMZQMF-UHFFFAOYSA-N pyridin-2-ylurea Chemical compound NC(=O)NC1=CC=CC=N1 MQDVUDAZJMZQMF-UHFFFAOYSA-N 0.000 claims 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 1
- 206010039083 rhinitis Diseases 0.000 claims 1
- 201000000306 sarcoidosis Diseases 0.000 claims 1
- 201000009890 sinusitis Diseases 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 125000004434 sulfur atom Chemical group 0.000 claims 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- 230000004614 tumor growth Effects 0.000 claims 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 1
- 0 *CC(N(*)c1nccc(O[Al]NC(Nc2cc(*)n[n]2-c2ccccc2)=O)c1)=O Chemical compound *CC(N(*)c1nccc(O[Al]NC(Nc2cc(*)n[n]2-c2ccccc2)=O)c1)=O 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0822609.4 | 2008-12-11 | ||
| GB0822609A GB0822609D0 (en) | 2008-12-11 | 2008-12-11 | Novel compounds |
| US16659409P | 2009-04-03 | 2009-04-03 | |
| US61/166,594 | 2009-04-03 | ||
| GB0912470.2 | 2009-07-17 | ||
| GB0912470A GB0912470D0 (en) | 2009-07-17 | 2009-07-17 | Novel compounds |
| PCT/GB2009/051702 WO2010067130A1 (en) | 2008-12-11 | 2009-12-11 | P38 map kinase inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014187591A Division JP5959587B2 (ja) | 2008-12-11 | 2014-09-16 | ｐ３８ＭＡＰキナーゼ阻害剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012511563A JP2012511563A (ja) | 2012-05-24 |
| JP2012511563A5 true JP2012511563A5 (enExample) | 2013-01-17 |
Family
ID=42242379
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011540219A Active JP5670912B2 (ja) | 2008-12-11 | 2009-12-11 | ｐ３８ＭＡＰキナーゼ阻害剤 |
| JP2011540218A Pending JP2012511563A (ja) | 2008-12-11 | 2009-12-11 | ｐ３８ＭＡＰキナーゼ阻害剤 |
| JP2014187591A Active JP5959587B2 (ja) | 2008-12-11 | 2014-09-16 | ｐ３８ＭＡＰキナーゼ阻害剤 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011540219A Active JP5670912B2 (ja) | 2008-12-11 | 2009-12-11 | ｐ３８ＭＡＰキナーゼ阻害剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014187591A Active JP5959587B2 (ja) | 2008-12-11 | 2014-09-16 | ｐ３８ＭＡＰキナーゼ阻害剤 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US8299073B2 (enExample) |
| EP (2) | EP2370428B1 (enExample) |
| JP (3) | JP5670912B2 (enExample) |
| KR (2) | KR20110094130A (enExample) |
| CN (2) | CN102341384B (enExample) |
| AU (2) | AU2009326149B2 (enExample) |
| BR (1) | BRPI0922962A2 (enExample) |
| CA (2) | CA2746354A1 (enExample) |
| MX (2) | MX2011006220A (enExample) |
| NZ (1) | NZ593104A (enExample) |
| WO (2) | WO2010067131A1 (enExample) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2229391B1 (en) | 2007-12-19 | 2014-08-06 | Cancer Research Technology Limited | Pyrido[2,3-b]pyrazine-8-substituted compounds and their use |
| GB0818033D0 (en) * | 2008-10-02 | 2008-11-05 | Respivert Ltd | Novel compound |
| US8293748B2 (en) | 2008-10-02 | 2012-10-23 | Respivert Ltd. | p38 MAP kinase inhibitors |
| JP5670912B2 (ja) * | 2008-12-11 | 2015-02-18 | レスピバート・リミテツド | ｐ３８ＭＡＰキナーゼ阻害剤 |
| GB0905955D0 (en) | 2009-04-06 | 2009-05-20 | Respivert Ltd | Novel compounds |
| GB0921731D0 (en) * | 2009-12-11 | 2010-01-27 | Respivert Ltd | Theraputic uses |
| GB0921730D0 (en) * | 2009-12-11 | 2010-01-27 | Respivert Ltd | Method of treatment |
| CA2786834C (en) | 2010-02-01 | 2018-10-16 | Cancer Research Technology Limited | 1-(5-tert-butyl-2-phenyl-2h-pyrazol-3-yl)-3-[2-fluoro-4-(1-methyl-2-oxo-2,3-dihydro-1h-imidazo[4,5-b]pyridin-7-yloxy)-phenyl]-urea and related compounds and their use in therapy |
| GB201005589D0 (en) | 2010-04-01 | 2010-05-19 | Respivert Ltd | Novel compounds |
| WO2011124923A2 (en) | 2010-04-08 | 2011-10-13 | Respivert Limited | Novel compounds |
| WO2011124930A1 (en) * | 2010-04-08 | 2011-10-13 | Respivert Limited | P38 map kinase inhibitors |
| GB201009731D0 (en) * | 2010-06-10 | 2010-07-21 | Pulmagen Therapeutics Inflamma | Kinase inhibitors |
| US8933228B2 (en) | 2010-06-17 | 2015-01-13 | Respivert, Ltd. | Respiratory formulations and compounds for use therein |
| GB201010196D0 (en) | 2010-06-17 | 2010-07-21 | Respivert Ltd | Methods |
| GB201010193D0 (en) * | 2010-06-17 | 2010-07-21 | Respivert Ltd | Medicinal use |
| PH12014500547A1 (en) * | 2011-10-03 | 2014-04-21 | Respivert Ltd | 1-pyrazolyl-3-(-4-((2-anilinopyrimidin-4-yl)oxy)napththalen-1-yl)ureas as p38 map kinase inhibitors |
| EP2578582A1 (en) | 2011-10-03 | 2013-04-10 | Respivert Limited | 1-Pyrazolyl-3-(4-((2-anilinopyrimidin-4-yl)oxy)napththalen-1-yl)ureas as p38 MAP kinase inhibitors |
| MY170656A (en) * | 2011-12-09 | 2019-08-24 | Chiesi Farm Spa | Kinase inhibitors |
| GB201214750D0 (en) * | 2012-08-17 | 2012-10-03 | Respivert Ltd | Compounds |
| WO2014033449A1 (en) | 2012-08-29 | 2014-03-06 | Respivert Limited | Kinase inhibitors |
| EP2890695A2 (en) | 2012-08-29 | 2015-07-08 | Respivert Limited | Kinase inhibitors |
| GB201215357D0 (en) * | 2012-08-29 | 2012-10-10 | Respivert Ltd | Compounds |
| US20150210722A1 (en) | 2012-08-29 | 2015-07-30 | Respivert Limited | Kinase inhibitors |
| US11052202B2 (en) * | 2012-11-07 | 2021-07-06 | Chiesi Farmaceutici S.P.A. | Drug delivery device for the treatment of patients with respiratory diseases |
| WO2014076484A1 (en) | 2012-11-16 | 2014-05-22 | Respivert Limited | Kinase inhibitors |
| WO2014140582A1 (en) * | 2013-03-14 | 2014-09-18 | Respivert Limited | Kinase inhibitors |
| ES2856902T3 (es) | 2013-04-02 | 2021-09-28 | Oxular Acquisitions Ltd | Derivados de urea útiles como inhibidores de quinasa |
| EP2981534B1 (en) | 2013-04-02 | 2017-07-19 | Topivert Pharma Limited | Kinase inhibitors based upon n-alkyl pyrazoles |
| GB201320729D0 (en) | 2013-11-25 | 2014-01-08 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
| GB201320732D0 (en) | 2013-11-25 | 2014-01-08 | Cancer Rec Tech Ltd | Methods of chemical synthesis |
| CN113717162A (zh) | 2013-12-20 | 2021-11-30 | 奥苏拉收购有限公司 | 用作激酶抑制剂的脲衍生物 |
| JP6586098B2 (ja) * | 2014-02-14 | 2019-10-02 | レスピバート・リミテツド | キナーゼ阻害剤としてのピラゾリル尿素 |
| MA40774A (fr) | 2014-10-01 | 2017-08-08 | Respivert Ltd | Dérivés de diaryle-urée en tant qu'inhibiteurs de kinase p38 |
| CN108367012B (zh) * | 2015-09-21 | 2021-12-24 | 深圳埃格林医药有限公司 | 自体免疫性和自身炎症性疾病的治疗 |
| MA44607A (fr) | 2016-04-06 | 2021-05-19 | Oxular Acquisitions Ltd | Inhibiteurs de kinase |
| US12018000B2 (en) | 2017-03-27 | 2024-06-25 | HYDRO-QUéBEC | Lithium salts of cyano-substituted imidazole for lithium ion batteries |
| WO2019232275A1 (en) | 2018-05-30 | 2019-12-05 | Washington University | Mitogen-activated protein kinase inhibitors, methods of making, and methods of use thereof |
| US20230089368A1 (en) | 2019-07-19 | 2023-03-23 | Anagenesis Biotechnologies S.A.S. | Polyaromatic urea derivatives and their use in the treatment of muscle diseases |
| EP4029501A1 (en) | 2021-01-19 | 2022-07-20 | Anagenesis Biotechnologies | Combination of polyaromatic urea derivatives and glucocorticoid or hdac inhibitor for the treatment of diseases or conditions associated with muscle cells and/or satellite cells |
Family Cites Families (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2308428A1 (en) | 1997-11-03 | 1999-05-14 | Boehringer Ingelheim Pharmaceuticals, Inc. | Aromatic heterocyclic compounds as anti-inflammatory agents |
| TR200100917T2 (tr) | 1997-12-22 | 2001-07-23 | Bayer Corporation | Aril ve heteroaril sübstitüentli heteroksiklik üreler kullanılarak RAF kinazın inhibe edilmesi |
| ATE346600T1 (de) * | 1997-12-22 | 2006-12-15 | Bayer Pharmaceuticals Corp | Inhibierung der p38 kinase-aktivität durch die verwendung von aryl- und heteroarylsubstituierten harnstoffen |
| US20080300281A1 (en) | 1997-12-22 | 2008-12-04 | Jacques Dumas | Inhibition of p38 Kinase Activity Using Aryl and Heteroaryl Substituted Heterocyclic Ureas |
| TR200002618T2 (tr) * | 1997-12-22 | 2001-04-20 | Bayer Corporation | Sübstitüe edilmiş heterosiklik üreler kullanılarak raf kinazın inhibe edilmesi |
| CA2315720A1 (en) * | 1997-12-22 | 1999-07-01 | Bayer Corporation | Inhibition of p38 kinase activity using substituted heterocyclic ureas |
| US7329670B1 (en) | 1997-12-22 | 2008-02-12 | Bayer Pharmaceuticals Corporation | Inhibition of RAF kinase using aryl and heteroaryl substituted heterocyclic ureas |
| CA2319493A1 (en) | 1998-03-18 | 1999-09-23 | Regine Bohacek | Heterocyclic signal transduction inhibitors, compositions containing them |
| UA73492C2 (en) | 1999-01-19 | 2005-08-15 | Aromatic heterocyclic compounds as antiinflammatory agents | |
| WO2001004115A2 (en) | 1999-07-09 | 2001-01-18 | Boehringer Ingelheim Pharmaceuticals, Inc. | Novel process for synthesis of heteroaryl-substituted urea compounds |
| US6525046B1 (en) * | 2000-01-18 | 2003-02-25 | Boehringer Ingelheim Pharmaceuticals, Inc. | Aromatic heterocyclic compounds as antiinflammatory agents |
| US6492529B1 (en) * | 2000-01-18 | 2002-12-10 | Boehringer Ingelheim Pharmaceuticals, Inc. | Bis pyrazole-1H-pyrazole intermediates and their synthesis |
| MXPA03006749A (es) | 2001-02-15 | 2004-05-31 | Boehringer Ingelheim Pharma | Proceso para la sintesis de compuestos de urea sustituidos con heteroarilo, utiles como agentes antiinflamatorios. |
| EP1392661A1 (en) | 2001-05-16 | 2004-03-03 | Boehringer Ingelheim Pharmaceuticals Inc. | Diarylurea derivatives useful as anti-inflammatory agents |
| CA2453147A1 (en) | 2001-07-11 | 2003-01-23 | Boehringer Ingelheim Pharmaceuticals, Inc. | Methods of treating cytokine mediated diseases |
| AU2003210969A1 (en) * | 2002-02-11 | 2003-09-04 | Bayer Corporation | Aryl ureas with raf kinase and angiogenesis inhibiting activity |
| DK1478358T3 (da) | 2002-02-11 | 2013-10-07 | Bayer Healthcare Llc | Sorafenibtosylat til behandling af sygdomme kendetegnet ved unormal angiogenese |
| AU2003213806A1 (en) * | 2002-02-25 | 2003-09-09 | Boehringer Ingelheim Pharmaceuticals, Inc. | 1,4-disubstituted benzofused cycloalkyl urea compounds useful in treating cytokine mediated diseases |
| AU2003224025A1 (en) | 2002-04-05 | 2003-10-20 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | p38 kinase inhibitors for treating mucus hypersecretion |
| US20060063782A1 (en) * | 2002-07-03 | 2006-03-23 | Murray Christopher W | 3-Hetero arylmethoxy ! pyridines and their analogues as p38 map kinase inhibitors |
| US20040110755A1 (en) | 2002-08-13 | 2004-06-10 | Boehringer Ingelheim Pharmaceuticals, Inc. | Combination therapy with p38 MAP kinase inhibitors and their pharmaceutical compositions |
| JP2006503025A (ja) | 2002-09-05 | 2006-01-26 | サイオス インク． | ｐ３８ＭＡＰキナーゼの抑制による疼痛治療 |
| US7144911B2 (en) * | 2002-12-31 | 2006-12-05 | Deciphera Pharmaceuticals Llc | Anti-inflammatory medicaments |
| CN1756747A (zh) * | 2002-12-31 | 2006-04-05 | 迪赛孚尔药品研制有限公司 | 抗炎症药物 |
| US7202257B2 (en) | 2003-12-24 | 2007-04-10 | Deciphera Pharmaceuticals, Llc | Anti-inflammatory medicaments |
| ES2357288T3 (es) | 2003-02-28 | 2011-04-25 | Bayer Healthcare Llc | Derivados de 2-oxo-1,3,5-perhidrotriazapina útiles en el tratamiento de angiogénesis hiperproliferativa y trastornos inflamatorios. |
| JP4617299B2 (ja) | 2003-03-03 | 2011-01-19 | アレイ バイオファーマ、インコーポレイテッド | ｐ３８阻害剤及びその使用法 |
| GB0308511D0 (en) * | 2003-04-14 | 2003-05-21 | Astex Technology Ltd | Pharmaceutical compounds |
| GB0320244D0 (en) * | 2003-05-06 | 2003-10-01 | Aventis Pharma Inc | Pyrazoles as inhibitors of tumour necrosis factor |
| US20070010529A1 (en) | 2003-05-19 | 2007-01-11 | Kanji Takahashi | Nitrogenous heterocyclic compounds and medical use thereof |
| WO2005002673A1 (en) * | 2003-07-03 | 2005-01-13 | Astex Therapeutics Limited | Raf kinase inhibitors |
| BRPI0413757A (pt) | 2003-08-22 | 2006-10-31 | Boehringer Ingelheim Pharma | métodos para o tratamento de copd e da hipertensão pulmonar |
| CA2545711A1 (en) | 2003-11-13 | 2005-06-02 | Ambit Biosciences Corporation | Urea derivatives as kinase modulators |
| EP1755607A2 (en) | 2004-04-29 | 2007-02-28 | Pharmix Corporation | Compositions and treatments for inhibiting kinase and/or hmg-coa reductase |
| US7838524B2 (en) | 2004-04-30 | 2010-11-23 | Bayer Healthcare Llc | Substituted pyrazolyl urea derivatives useful in the treatment of cancer |
| JP2008500284A (ja) | 2004-05-12 | 2008-01-10 | ブリストル−マイヤーズ スクイブ カンパニー | 血栓症の治療に有用なｐ２ｙ１レセプターのウレアアンタゴニスト |
| PT1761520E (pt) | 2004-06-23 | 2008-09-15 | Lilly Co Eli | Inibidores de quinase |
| US20060035893A1 (en) | 2004-08-07 | 2006-02-16 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders |
| GB0423554D0 (en) | 2004-10-22 | 2004-11-24 | Cancer Rec Tech Ltd | Therapeutic compounds |
| EP1824843A2 (en) | 2004-12-07 | 2007-08-29 | Locus Pharmaceuticals, Inc. | Inhibitors of protein kinases |
| US20080081833A1 (en) | 2004-12-20 | 2008-04-03 | Astrazeneca Ab | Novel Pyrazole Derivatives And Their Use As Modulators Of Nicotinic Acetylcholine Receptors |
| JP2008525502A (ja) | 2004-12-23 | 2008-07-17 | デシファラ ファーマスーティカルズ， エルエルシー | 抗炎症薬 |
| US20070078121A1 (en) * | 2004-12-23 | 2007-04-05 | Flynn Daniel L | Enzyme modulators and treatments |
| GB0500435D0 (en) * | 2005-01-10 | 2005-02-16 | Novartis Ag | Organic compounds |
| DE102005015253A1 (de) * | 2005-04-04 | 2006-10-05 | Merck Patent Gmbh | Pyrazolderivate |
| WO2006136562A1 (en) | 2005-06-20 | 2006-12-28 | Tibotec Pharmaceuticals Ltd | Heterocyclylaminoalkyl substituted benzimidazoles |
| WO2007002635A2 (en) | 2005-06-27 | 2007-01-04 | Bristol-Myers Squibb Company | C-linked cyclic antagonists of p2y1 receptor useful in the treatment of thrombotic conditions |
| DE102005037499A1 (de) | 2005-08-09 | 2007-02-15 | Merck Patent Gmbh | Pyrazolderivate |
| KR100950737B1 (ko) | 2005-08-24 | 2010-03-31 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 신규 피리딘 유도체 및 피리미딘 유도체(3) |
| WO2007038425A2 (en) | 2005-09-27 | 2007-04-05 | Regents Of The University Of Minnesota | Anti-viral compouinds |
| ES2364901T3 (es) | 2005-11-15 | 2011-09-16 | Array Biopharma, Inc. | Procesos e intermedios para la preparación de derivados de n4-fenil-quinazolin-4-amina. |
| WO2007059202A2 (en) * | 2005-11-15 | 2007-05-24 | Bayer Healthcare Ag | Pyrazolyl urea derivatives useful in the treatment of cancer |
| MX2008006979A (es) * | 2005-12-01 | 2009-01-14 | Bayer Healthcare Llc | Compuestos de urea utiles en el tratamiento contra el cancer. |
| ATE539748T1 (de) | 2006-01-27 | 2012-01-15 | Array Biopharma Inc | Glucokinaseaktivatoren |
| KR20080081359A (ko) | 2006-01-30 | 2008-09-09 | 아이알엠 엘엘씨 | Ｐｐａｒ 조절제로서의 스피로 이미다졸 유도체 |
| WO2007096764A2 (en) | 2006-02-27 | 2007-08-30 | Glenmark Pharmaceuticals S.A. | Bicyclic heteroaryl derivatives as cannabinoid receptor modulators |
| TW200817409A (en) | 2006-08-04 | 2008-04-16 | Takeda Pharmaceutical | Fused heterocyclic derivative and use thereof |
| CN102112901B (zh) * | 2008-07-31 | 2014-08-06 | 惠普开发有限公司 | 用于放大、调制和检测光信号的纳米线光学块设备 |
| US8293748B2 (en) * | 2008-10-02 | 2012-10-23 | Respivert Ltd. | p38 MAP kinase inhibitors |
| GB0818033D0 (en) | 2008-10-02 | 2008-11-05 | Respivert Ltd | Novel compound |
| JP5670912B2 (ja) * | 2008-12-11 | 2015-02-18 | レスピバート・リミテツド | ｐ３８ＭＡＰキナーゼ阻害剤 |
| GB0905955D0 (en) * | 2009-04-06 | 2009-05-20 | Respivert Ltd | Novel compounds |
-
2009
- 2009-12-11 JP JP2011540219A patent/JP5670912B2/ja active Active
- 2009-12-11 WO PCT/GB2009/051703 patent/WO2010067131A1/en not_active Ceased
- 2009-12-11 BR BRPI0922962A patent/BRPI0922962A2/pt not_active IP Right Cessation
- 2009-12-11 MX MX2011006220A patent/MX2011006220A/es active IP Right Grant
- 2009-12-11 JP JP2011540218A patent/JP2012511563A/ja active Pending
- 2009-12-11 KR KR1020117015760A patent/KR20110094130A/ko not_active Ceased
- 2009-12-11 AU AU2009326149A patent/AU2009326149B2/en not_active Ceased
- 2009-12-11 WO PCT/GB2009/051702 patent/WO2010067130A1/en not_active Ceased
- 2009-12-11 US US13/133,998 patent/US8299073B2/en active Active
- 2009-12-11 CA CA2746354A patent/CA2746354A1/en not_active Abandoned
- 2009-12-11 AU AU2009326148A patent/AU2009326148B2/en not_active Ceased
- 2009-12-11 NZ NZ593104A patent/NZ593104A/xx not_active IP Right Cessation
- 2009-12-11 EP EP09768546.5A patent/EP2370428B1/en active Active
- 2009-12-11 CN CN200980156757.7A patent/CN102341384B/zh not_active Expired - Fee Related
- 2009-12-11 EP EP09771766.4A patent/EP2370429B1/en active Active
- 2009-12-11 KR KR1020117015734A patent/KR20110094127A/ko not_active Withdrawn
- 2009-12-11 US US13/139,010 patent/US8299074B2/en active Active
- 2009-12-11 CN CN200980156810.3A patent/CN102333770B/zh not_active Expired - Fee Related
- 2009-12-11 CA CA2746357A patent/CA2746357A1/en not_active Abandoned
- 2009-12-11 MX MX2011006219A patent/MX2011006219A/es not_active Application Discontinuation
-
2014
- 2014-09-16 JP JP2014187591A patent/JP5959587B2/ja active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2012511563A5 (enExample) | ||
| JP2012511564A5 (enExample) | ||
| JP4035559B1 (ja) | 酸分泌抑制薬としての１−ヘテロシクリルスルホニル、２−アミノメチル、５−（ヘテロ−）アリール置換１−ｈ−ピロール誘導体 | |
| EP2114917B1 (en) | Pyrrole compounds | |
| KR100802368B1 (ko) | 세포 증식의 억제제로서의 이미다졸로-5-일-2-아닐리노-피리미딘 | |
| JP5670912B2 (ja) | ｐ３８ＭＡＰキナーゼ阻害剤 | |
| JP2008517926A5 (enExample) | ||
| JP2011515462A5 (enExample) | ||
| JP2007524696A5 (enExample) | ||
| JP2013510876A5 (enExample) | ||
| RU2015143191A (ru) | Дигидропирролопиридиновые ингибиторы бромодоменов | |
| NZ591427A (en) | P38 map kinase inhibitors | |
| JP2013530179A (ja) | 呼吸器合胞体ウイルス（ｒｓｖ）感染の処置に使用するためのウレイド−ピラゾール誘導体 | |
| PT2727918T (pt) | Compostos e composições como inibidores de proteína quinase | |
| JP2013519733A5 (enExample) | ||
| RU2017135541A (ru) | Гетероциклические амины и их применения | |
| JP2013531055A5 (enExample) | ||
| PT2358698E (pt) | Antagonistas da via hedgehog de piridazina tetrasubstituída | |
| KR100642231B1 (ko) | 2-티오-치환 이미다졸 유도체류 및 제약에서의 그 용도 | |
| WO2007058482A1 (en) | Novel inhibitors of protein kinase | |
| ES2351308T3 (es) | Derivados de imidazol 2-sulfinil- y 2-sulfonil-sustituidos y su uso como inhibidores de citocina. | |
| ES2214150B1 (es) | "nuevos derivados de pirazolopiridinas". | |
| ES2214976B1 (es) | "nuevos derivados de pirazolopiridinas". | |
| HK1085214B (en) | Pyrazolopyridine derivates |