JP2005504797A5 - - Google Patents
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- JP2005504797A5 JP2005504797A5 JP2003528517A JP2003528517A JP2005504797A5 JP 2005504797 A5 JP2005504797 A5 JP 2005504797A5 JP 2003528517 A JP2003528517 A JP 2003528517A JP 2003528517 A JP2003528517 A JP 2003528517A JP 2005504797 A5 JP2005504797 A5 JP 2005504797A5
- Authority
- JP
- Japan
- Prior art keywords
- formulation
- active agent
- polyol
- polymer
- polylactide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000003077 polyols Chemical group 0.000 claims description 5
- 229920000642 polymer Polymers 0.000 claims description 4
- 229920001577 copolymer Polymers 0.000 claims description 3
- 239000011859 microparticle Substances 0.000 claims description 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 2
- 239000008103 glucose Substances 0.000 claims description 2
- -1 glycolide ester Chemical class 0.000 claims description 2
- 238000009472 formulation Methods 0.000 claims 13
- 239000000203 mixture Substances 0.000 claims 13
- 239000013543 active substance Substances 0.000 claims 6
- 229920005862 polyol Polymers 0.000 claims 4
- 238000002347 injection Methods 0.000 claims 2
- 239000007924 injection Substances 0.000 claims 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 1
- 229930195725 Mannitol Natural products 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- XSCHRSMBECNVNS-UHFFFAOYSA-N benzopyrazine Natural products N1=CC=NC2=CC=CC=C21 XSCHRSMBECNVNS-UHFFFAOYSA-N 0.000 claims 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims 1
- 229920000249 biocompatible polymer Polymers 0.000 claims 1
- 239000003405 delayed action preparation Substances 0.000 claims 1
- HKSZLNNOFSGOKW-UHFFFAOYSA-N ent-staurosporine Natural products C12=C3N4C5=CC=CC=C5C3=C3CNC(=O)C3=C2C2=CC=CC=C2N1C1CC(NC)C(OC)C4(C)O1 HKSZLNNOFSGOKW-UHFFFAOYSA-N 0.000 claims 1
- 208000030533 eye disease Diseases 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 239000012669 liquid formulation Substances 0.000 claims 1
- 239000000594 mannitol Substances 0.000 claims 1
- 235000010355 mannitol Nutrition 0.000 claims 1
- LFSXCDWNBUNEEM-UHFFFAOYSA-N phthalazine Chemical compound C1=NN=CC2=CC=CC=C21 LFSXCDWNBUNEEM-UHFFFAOYSA-N 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- HKSZLNNOFSGOKW-FYTWVXJKSA-N staurosporine Chemical compound C12=C3N4C5=CC=CC=C5C3=C3CNC(=O)C3=C2C2=CC=CC=C2N1[C@H]1C[C@@H](NC)[C@@H](OC)[C@]4(C)O1 HKSZLNNOFSGOKW-FYTWVXJKSA-N 0.000 claims 1
- CGPUWJWCVCFERF-UHFFFAOYSA-N staurosporine Natural products C12=C3N4C5=CC=CC=C5C3=C3CNC(=O)C3=C2C2=CC=CC=C2N1C1CC(NC)C(OC)C4(OC)O1 CGPUWJWCVCFERF-UHFFFAOYSA-N 0.000 claims 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 150000002905 orthoesters Chemical class 0.000 description 3
- TZCPCKNHXULUIY-RGULYWFUSA-N 1,2-distearoyl-sn-glycero-3-phosphoserine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCCCCCCCCCCCCCC TZCPCKNHXULUIY-RGULYWFUSA-N 0.000 description 2
- JZNWSCPGTDBMEW-UHFFFAOYSA-N Glycerophosphorylethanolamin Natural products NCCOP(O)(=O)OCC(O)CO JZNWSCPGTDBMEW-UHFFFAOYSA-N 0.000 description 2
- ZWZWYGMENQVNFU-UHFFFAOYSA-N Glycerophosphorylserin Natural products OC(=O)C(N)COP(O)(=O)OCC(O)CO ZWZWYGMENQVNFU-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 150000001408 amides Chemical class 0.000 description 2
- 150000008064 anhydrides Chemical class 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 150000002170 ethers Chemical class 0.000 description 2
- 150000002632 lipids Chemical class 0.000 description 2
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 description 2
- 150000008104 phosphatidylethanolamines Chemical class 0.000 description 2
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 1
- 229920000954 Polyglycolide Polymers 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 229930183167 cerebroside Natural products 0.000 description 1
- 150000001784 cerebrosides Chemical class 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 239000008393 encapsulating agent Substances 0.000 description 1
- 150000002270 gangliosides Chemical class 0.000 description 1
- 150000002334 glycols Chemical class 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 150000002895 organic esters Chemical class 0.000 description 1
- 125000001095 phosphatidyl group Chemical group 0.000 description 1
- 229920000747 poly(lactic acid) Polymers 0.000 description 1
- 229920001281 polyalkylene Polymers 0.000 description 1
- 229920001515 polyalkylene glycol Polymers 0.000 description 1
- 229920001610 polycaprolactone Polymers 0.000 description 1
- 239000004632 polycaprolactone Substances 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 239000004633 polyglycolic acid Substances 0.000 description 1
- 239000004626 polylactic acid Substances 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 150000003408 sphingolipids Chemical class 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0122318.9A GB0122318D0 (en) | 2001-09-14 | 2001-09-14 | Organic compounds |
| PCT/EP2002/010314 WO2003024420A1 (en) | 2001-09-14 | 2002-09-13 | Ophthalmic depot formulations for periocular or subconjunctival administration |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010224231A Division JP2011026338A (ja) | 2001-09-14 | 2010-10-01 | 眼周囲または結膜下投与のための眼用デポー製剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005504797A JP2005504797A (ja) | 2005-02-17 |
| JP2005504797A5 true JP2005504797A5 (enExample) | 2006-01-05 |
Family
ID=9922147
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003528517A Withdrawn JP2005504797A (ja) | 2001-09-14 | 2002-09-13 | 眼周囲または結膜下投与のための眼用デポー製剤 |
| JP2010224231A Withdrawn JP2011026338A (ja) | 2001-09-14 | 2010-10-01 | 眼周囲または結膜下投与のための眼用デポー製剤 |
| JP2013099024A Pending JP2013147516A (ja) | 2001-09-14 | 2013-05-09 | 眼周囲または結膜下投与のための眼用デポー製剤 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010224231A Withdrawn JP2011026338A (ja) | 2001-09-14 | 2010-10-01 | 眼周囲または結膜下投与のための眼用デポー製剤 |
| JP2013099024A Pending JP2013147516A (ja) | 2001-09-14 | 2013-05-09 | 眼周囲または結膜下投与のための眼用デポー製剤 |
Country Status (24)
| Country | Link |
|---|---|
| US (4) | US20040234611A1 (enExample) |
| EP (1) | EP1429725B1 (enExample) |
| JP (3) | JP2005504797A (enExample) |
| KR (1) | KR20040030869A (enExample) |
| CN (2) | CN102008428A (enExample) |
| AT (1) | ATE389385T1 (enExample) |
| AU (1) | AU2002342694B2 (enExample) |
| BR (1) | BR0212475A (enExample) |
| CA (1) | CA2455680C (enExample) |
| CO (1) | CO5560548A2 (enExample) |
| DE (1) | DE60225701T2 (enExample) |
| EC (1) | ECSP044967A (enExample) |
| ES (1) | ES2302849T3 (enExample) |
| GB (1) | GB0122318D0 (enExample) |
| HU (1) | HU229453B1 (enExample) |
| IL (2) | IL160027A0 (enExample) |
| MX (1) | MXPA04002421A (enExample) |
| NO (1) | NO333825B1 (enExample) |
| NZ (1) | NZ531481A (enExample) |
| PL (1) | PL203949B1 (enExample) |
| PT (1) | PT1429725E (enExample) |
| RU (1) | RU2316315C2 (enExample) |
| WO (1) | WO2003024420A1 (enExample) |
| ZA (1) | ZA200400524B (enExample) |
Families Citing this family (97)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8202979B2 (en) | 2002-02-20 | 2012-06-19 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid |
| US20060177416A1 (en) | 2003-10-14 | 2006-08-10 | Medivas, Llc | Polymer particle delivery compositions and methods of use |
| US7517864B2 (en) | 2001-05-18 | 2009-04-14 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA) |
| US20050148530A1 (en) | 2002-02-20 | 2005-07-07 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA) |
| US9994853B2 (en) | 2001-05-18 | 2018-06-12 | Sirna Therapeutics, Inc. | Chemically modified multifunctional short interfering nucleic acid molecules that mediate RNA interference |
| US20030119812A1 (en) * | 2001-11-08 | 2003-06-26 | Brazzell Romulus Kimbro | Method for decreasing capillary permeability in the retina |
| US9181551B2 (en) | 2002-02-20 | 2015-11-10 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) |
| US9657294B2 (en) | 2002-02-20 | 2017-05-23 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) |
| JP2006511475A (ja) * | 2002-09-18 | 2006-04-06 | トラスティーズ オブ ザ ユニバーシティ オブ ペンシルベニア | 脈絡膜新生血管症の抑制方法 |
| US9216106B2 (en) | 2003-04-09 | 2015-12-22 | Directcontact Llc | Device and method for the delivery of drugs for the treatment of posterior segment disease |
| US20050009910A1 (en) * | 2003-07-10 | 2005-01-13 | Allergan, Inc. | Delivery of an active drug to the posterior part of the eye via subconjunctival or periocular delivery of a prodrug |
| KR101160702B1 (ko) * | 2003-08-20 | 2012-06-28 | 산텐 세이야꾸 가부시키가이샤 | 미립자 테논낭하 투여 약물 전달 시스템 |
| WO2005027906A1 (en) | 2003-09-18 | 2005-03-31 | Macusight, Inc. | Transscleral delivery |
| WO2005072701A1 (en) * | 2004-01-20 | 2005-08-11 | Allergan, Inc. | Compositions for localized therapy of the eye, comprising preferably triamcinolone acetonide and hyaluronic acid |
| US9498457B2 (en) | 2004-04-30 | 2016-11-22 | Allergan, Inc. | Hypotensive prostamide-containing biodegradable intraocular implants and related implants |
| US8673341B2 (en) | 2004-04-30 | 2014-03-18 | Allergan, Inc. | Intraocular pressure reduction with intracameral bimatoprost implants |
| US8722097B2 (en) | 2004-04-30 | 2014-05-13 | Allergan, Inc. | Oil-in-water method for making polymeric implants containing a hypotensive lipid |
| US7771742B2 (en) | 2004-04-30 | 2010-08-10 | Allergan, Inc. | Sustained release intraocular implants containing tyrosine kinase inhibitors and related methods |
| US7993634B2 (en) | 2004-04-30 | 2011-08-09 | Allergan, Inc. | Oil-in-oil emulsified polymeric implants containing a hypotensive lipid and related methods |
| AU2011213904B2 (en) * | 2004-04-30 | 2014-06-05 | Allergan, Inc. | Sustained release intraocular implants comprising a beta adrenergic receptor antagonist and methods for treating ocular neuropathies |
| US20060182781A1 (en) * | 2004-04-30 | 2006-08-17 | Allergan, Inc. | Methods for treating ocular conditions with cyclic lipid contraining microparticles |
| US7799336B2 (en) | 2004-04-30 | 2010-09-21 | Allergan, Inc. | Hypotensive lipid-containing biodegradable intraocular implants and related methods |
| US20050244458A1 (en) * | 2004-04-30 | 2005-11-03 | Allergan, Inc. | Sustained release intraocular implants and methods for treating ocular neuropathies |
| US10508277B2 (en) | 2004-05-24 | 2019-12-17 | Sirna Therapeutics, Inc. | Chemically modified multifunctional short interfering nucleic acid molecules that mediate RNA interference |
| GB2438544A (en) | 2005-02-09 | 2007-11-28 | Cooper Internat Corp | Liquid formulations for treatment of diseases or conditions |
| US8663639B2 (en) | 2005-02-09 | 2014-03-04 | Santen Pharmaceutical Co., Ltd. | Formulations for treating ocular diseases and conditions |
| JP2006257080A (ja) * | 2005-02-18 | 2006-09-28 | Santen Pharmaceut Co Ltd | ステロイド化合物の副作用軽減または回避方法 |
| US8440217B1 (en) * | 2005-06-15 | 2013-05-14 | Mawaheb M. EL-Naggar | Method and system with contact lens product for treating and preventing adverse eye conditions |
| US9877921B2 (en) | 2005-09-09 | 2018-01-30 | Nova Southeastern University | Epinephrine nanoparticles, methods of fabrication thereof, and methods for use thereof for treatment of conditions responsive to epinephrine |
| US20160045457A1 (en) | 2005-09-09 | 2016-02-18 | Ousama Rachid | Epinephrine fine particles and methods for use thereof for treatment of conditions responsive to epinephrine |
| EP1926780B1 (en) | 2005-09-22 | 2013-08-14 | Medivas, LLC | Bis-( -amino)-diol-diester-containing poly(ester amide) and poly(ester urethane) compositions and methods of use |
| US8652504B2 (en) | 2005-09-22 | 2014-02-18 | Medivas, Llc | Solid polymer delivery compositions and methods for use thereof |
| CA2635797C (en) | 2006-02-09 | 2015-03-31 | Macusight, Inc. | Stable formulations, and methods of their preparation and use |
| CN101443004B (zh) | 2006-03-23 | 2013-03-06 | 参天制药株式会社 | 用于与血管通透性有关的疾病或病症的制剂 |
| US20070292476A1 (en) * | 2006-05-02 | 2007-12-20 | Medivas, Llc | Delivery of ophthalmologic agents to the exterior or interior of the eye |
| US8969415B2 (en) | 2006-12-01 | 2015-03-03 | Allergan, Inc. | Intraocular drug delivery systems |
| US8492334B2 (en) * | 2007-06-21 | 2013-07-23 | Yale University | Sustained intraocular delivery of drugs from biodegradable polymeric microparticles |
| US20110206773A1 (en) * | 2008-05-20 | 2011-08-25 | Yale University | Sustained delivery of drugs from biodegradable polymeric microparticles |
| KR102337046B1 (ko) | 2010-01-22 | 2021-12-08 | 알러간, 인코포레이티드 | 전방내 서방성 치료제 이식물 |
| WO2011106702A2 (en) | 2010-02-25 | 2011-09-01 | The Johns Hopkins University | Sustained delivery of therapeutic agents to an eye compartment |
| US20120322884A1 (en) | 2010-03-01 | 2012-12-20 | University Of Manitoba | Epinephrine nanoparticles, methods of fabrication thereof, and methods for use thereof for treatment of conditions responsive to epinephrine |
| WO2012039979A2 (en) | 2010-09-10 | 2012-03-29 | The Johns Hopkins University | Rapid diffusion of large polymeric nanoparticles in the mammalian brain |
| US9260471B2 (en) | 2010-10-29 | 2016-02-16 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using short interfering nucleic acids (siNA) |
| WO2012109363A2 (en) | 2011-02-08 | 2012-08-16 | The Johns Hopkins University | Mucus penetrating gene carriers |
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| US9873765B2 (en) | 2011-06-23 | 2018-01-23 | Dsm Ip Assets, B.V. | Biodegradable polyesteramide copolymers for drug delivery |
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| EP2753321B1 (en) | 2011-10-21 | 2021-12-15 | Nova Southeastern University | Epinephrine nanoparticles, methods of fabrication thereof, and methods for use thereof for treatment of conditions responsive to epinephrine |
| KR101811917B1 (ko) | 2012-01-19 | 2017-12-22 | 더 존스 홉킨스 유니버시티 | 점액 침투 강화를 나타내는 나노 입자 제형 |
| JP6282231B2 (ja) * | 2012-01-23 | 2018-02-21 | アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ | 固化するデポー形成の注入可能な薬物製剤に懸濁される持続放出された生分解性または生体侵食性微小球または微小粒子 |
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| US11596599B2 (en) | 2012-05-03 | 2023-03-07 | The Johns Hopkins University | Compositions and methods for ophthalmic and/or other applications |
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| US10568975B2 (en) | 2013-02-05 | 2020-02-25 | The Johns Hopkins University | Nanoparticles for magnetic resonance imaging tracking and methods of making and using thereof |
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| US11395853B2 (en) | 2016-06-23 | 2022-07-26 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Biomimetic drug delivery of an immunomodulatory agent for the treatment of ocular conditions |
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- 2002-09-13 AT AT02779354T patent/ATE389385T1/de active
- 2002-09-13 IL IL16002702A patent/IL160027A0/xx unknown
- 2002-09-13 ES ES02779354T patent/ES2302849T3/es not_active Expired - Lifetime
- 2002-09-13 RU RU2004111596/15A patent/RU2316315C2/ru not_active IP Right Cessation
- 2002-09-13 CA CA2455680A patent/CA2455680C/en not_active Expired - Fee Related
- 2002-09-13 WO PCT/EP2002/010314 patent/WO2003024420A1/en not_active Ceased
- 2002-09-13 AU AU2002342694A patent/AU2002342694B2/en not_active Ceased
- 2002-09-13 JP JP2003528517A patent/JP2005504797A/ja not_active Withdrawn
- 2002-09-13 CN CN2010105534172A patent/CN102008428A/zh active Pending
- 2002-09-13 US US10/489,752 patent/US20040234611A1/en not_active Abandoned
- 2002-09-13 EP EP02779354A patent/EP1429725B1/en not_active Expired - Lifetime
- 2002-09-13 MX MXPA04002421A patent/MXPA04002421A/es active IP Right Grant
- 2002-09-13 HU HU0401568A patent/HU229453B1/hu not_active IP Right Cessation
- 2002-09-13 CN CNA028155742A patent/CN1538835A/zh active Pending
- 2002-09-13 BR BR0212475-0A patent/BR0212475A/pt not_active IP Right Cessation
- 2002-09-13 PT PT02779354T patent/PT1429725E/pt unknown
- 2002-09-13 DE DE60225701T patent/DE60225701T2/de not_active Expired - Lifetime
- 2002-09-13 PL PL368128A patent/PL203949B1/pl not_active IP Right Cessation
- 2002-09-13 NZ NZ531481A patent/NZ531481A/en not_active IP Right Cessation
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- 2004-01-22 IL IL160027A patent/IL160027A/en not_active IP Right Cessation
- 2004-01-23 ZA ZA200400524A patent/ZA200400524B/en unknown
- 2004-02-02 EC EC2004004967A patent/ECSP044967A/es unknown
- 2004-02-18 CO CO04013821A patent/CO5560548A2/es not_active Application Discontinuation
- 2004-03-02 NO NO20040917A patent/NO333825B1/no not_active IP Right Cessation
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2008
- 2008-08-20 US US12/194,617 patent/US20080305172A1/en not_active Abandoned
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- 2010-10-01 JP JP2010224231A patent/JP2011026338A/ja not_active Withdrawn
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2012
- 2012-06-14 US US13/523,537 patent/US20120269894A1/en not_active Abandoned
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2013
- 2013-01-07 US US13/735,076 patent/US20130122064A1/en not_active Abandoned
- 2013-05-09 JP JP2013099024A patent/JP2013147516A/ja active Pending
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