IL160027A0 - Ophthalmic depot formulations for periocular or subconjunctival administration - Google Patents

Ophthalmic depot formulations for periocular or subconjunctival administration

Info

Publication number
IL160027A0
IL160027A0 IL16002702A IL16002702A IL160027A0 IL 160027 A0 IL160027 A0 IL 160027A0 IL 16002702 A IL16002702 A IL 16002702A IL 16002702 A IL16002702 A IL 16002702A IL 160027 A0 IL160027 A0 IL 160027A0
Authority
IL
Israel
Prior art keywords
periocular
depot formulations
subconjunctival administration
ophthalmic depot
ophthalmic
Prior art date
Application number
IL16002702A
Other languages
English (en)
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of IL160027A0 publication Critical patent/IL160027A0/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A61K9/0051—Ocular inserts, ocular implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
IL16002702A 2001-09-14 2002-09-13 Ophthalmic depot formulations for periocular or subconjunctival administration IL160027A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0122318.9A GB0122318D0 (en) 2001-09-14 2001-09-14 Organic compounds
PCT/EP2002/010314 WO2003024420A1 (en) 2001-09-14 2002-09-13 Ophthalmic depot formulations for periocular or subconjunctival administration

Publications (1)

Publication Number Publication Date
IL160027A0 true IL160027A0 (en) 2004-06-20

Family

ID=9922147

Family Applications (2)

Application Number Title Priority Date Filing Date
IL16002702A IL160027A0 (en) 2001-09-14 2002-09-13 Ophthalmic depot formulations for periocular or subconjunctival administration
IL160027A IL160027A (en) 2001-09-14 2004-01-22 Ophthalmic depot formulations for periocular or subconjunctival administration and use thereof in the manufacture of medicaments for treating ocular diseases

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL160027A IL160027A (en) 2001-09-14 2004-01-22 Ophthalmic depot formulations for periocular or subconjunctival administration and use thereof in the manufacture of medicaments for treating ocular diseases

Country Status (25)

Country Link
US (4) US20040234611A1 (xx)
EP (1) EP1429725B1 (xx)
JP (3) JP2005504797A (xx)
KR (1) KR20040030869A (xx)
CN (2) CN102008428A (xx)
AT (1) ATE389385T1 (xx)
AU (1) AU2002342694B2 (xx)
BR (1) BR0212475A (xx)
CA (1) CA2455680C (xx)
CO (1) CO5560548A2 (xx)
DE (1) DE60225701T2 (xx)
EC (1) ECSP044967A (xx)
ES (1) ES2302849T3 (xx)
GB (1) GB0122318D0 (xx)
HK (1) HK1066733A1 (xx)
HU (1) HU229453B1 (xx)
IL (2) IL160027A0 (xx)
MX (1) MXPA04002421A (xx)
NO (1) NO333825B1 (xx)
NZ (1) NZ531481A (xx)
PL (1) PL203949B1 (xx)
PT (1) PT1429725E (xx)
RU (1) RU2316315C2 (xx)
WO (1) WO2003024420A1 (xx)
ZA (1) ZA200400524B (xx)

Families Citing this family (84)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8202979B2 (en) 2002-02-20 2012-06-19 Sirna Therapeutics, Inc. RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid
US20060177416A1 (en) 2003-10-14 2006-08-10 Medivas, Llc Polymer particle delivery compositions and methods of use
US9994853B2 (en) 2001-05-18 2018-06-12 Sirna Therapeutics, Inc. Chemically modified multifunctional short interfering nucleic acid molecules that mediate RNA interference
US20030119812A1 (en) * 2001-11-08 2003-06-26 Brazzell Romulus Kimbro Method for decreasing capillary permeability in the retina
US9657294B2 (en) 2002-02-20 2017-05-23 Sirna Therapeutics, Inc. RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
US9181551B2 (en) 2002-02-20 2015-11-10 Sirna Therapeutics, Inc. RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
SI1539157T1 (sl) * 2002-09-18 2013-11-29 Trustees Of The University Of Pennsylvania Rapamicin za uporabo pri inhibiciji ali preprečevanju horoidalne neovaskularizacije
US9216106B2 (en) 2003-04-09 2015-12-22 Directcontact Llc Device and method for the delivery of drugs for the treatment of posterior segment disease
US20050009910A1 (en) * 2003-07-10 2005-01-13 Allergan, Inc. Delivery of an active drug to the posterior part of the eye via subconjunctival or periocular delivery of a prodrug
WO2005018608A1 (ja) * 2003-08-20 2005-03-03 Santen Pharmaceutical Co., Ltd. 微粒子テノン嚢下投与ドラッグデリバリーシステム
BRPI0506983A (pt) * 2004-01-20 2007-07-03 Allergan Inc composições para terapia localizada dos olhos, compreendendo preferencialmente acetonida de triancinolona e ácido hialurÈnico
US7993634B2 (en) 2004-04-30 2011-08-09 Allergan, Inc. Oil-in-oil emulsified polymeric implants containing a hypotensive lipid and related methods
US20060182781A1 (en) * 2004-04-30 2006-08-17 Allergan, Inc. Methods for treating ocular conditions with cyclic lipid contraining microparticles
US8673341B2 (en) * 2004-04-30 2014-03-18 Allergan, Inc. Intraocular pressure reduction with intracameral bimatoprost implants
US7771742B2 (en) 2004-04-30 2010-08-10 Allergan, Inc. Sustained release intraocular implants containing tyrosine kinase inhibitors and related methods
US7799336B2 (en) * 2004-04-30 2010-09-21 Allergan, Inc. Hypotensive lipid-containing biodegradable intraocular implants and related methods
US20050244458A1 (en) * 2004-04-30 2005-11-03 Allergan, Inc. Sustained release intraocular implants and methods for treating ocular neuropathies
US9498457B2 (en) 2004-04-30 2016-11-22 Allergan, Inc. Hypotensive prostamide-containing biodegradable intraocular implants and related implants
US8722097B2 (en) 2004-04-30 2014-05-13 Allergan, Inc. Oil-in-water method for making polymeric implants containing a hypotensive lipid
AU2011213904B2 (en) * 2004-04-30 2014-06-05 Allergan, Inc. Sustained release intraocular implants comprising a beta adrenergic receptor antagonist and methods for treating ocular neuropathies
US10508277B2 (en) 2004-05-24 2019-12-17 Sirna Therapeutics, Inc. Chemically modified multifunctional short interfering nucleic acid molecules that mediate RNA interference
GB2438544A (en) 2005-02-09 2007-11-28 Cooper Internat Corp Liquid formulations for treatment of diseases or conditions
US8663639B2 (en) 2005-02-09 2014-03-04 Santen Pharmaceutical Co., Ltd. Formulations for treating ocular diseases and conditions
JP2006257080A (ja) * 2005-02-18 2006-09-28 Santen Pharmaceut Co Ltd ステロイド化合物の副作用軽減または回避方法
US8440217B1 (en) * 2005-06-15 2013-05-14 Mawaheb M. EL-Naggar Method and system with contact lens product for treating and preventing adverse eye conditions
US20160045457A1 (en) 2005-09-09 2016-02-18 Ousama Rachid Epinephrine fine particles and methods for use thereof for treatment of conditions responsive to epinephrine
WO2013059629A1 (en) 2011-10-21 2013-04-25 Nova Southeastern University Epinephrine nanoparticles, methods of fabrication thereof, and methods for use thereof for treatment of conditions responsive to epinephrine
US9877921B2 (en) 2005-09-09 2018-01-30 Nova Southeastern University Epinephrine nanoparticles, methods of fabrication thereof, and methods for use thereof for treatment of conditions responsive to epinephrine
CA2623198C (en) 2005-09-22 2014-08-05 Medivas, Llc Bis-(a-amino)-diol-diester-containing poly(ester amide) and poly(ester urethane) compositions and methods of use
US8652504B2 (en) 2005-09-22 2014-02-18 Medivas, Llc Solid polymer delivery compositions and methods for use thereof
KR20140093764A (ko) 2006-02-09 2014-07-28 산텐 세이야꾸 가부시키가이샤 안정한 제제와 그 제조 및 사용 방법
WO2007112052A2 (en) 2006-03-23 2007-10-04 Macusight, Inc. Formulations and methods for vascular permeability-related diseases or conditions
WO2007130477A2 (en) * 2006-05-02 2007-11-15 Medivas, Llc Delivery of ophthalmologic agents to the exterior or interior of the eye
US8969415B2 (en) 2006-12-01 2015-03-03 Allergan, Inc. Intraocular drug delivery systems
US8492334B2 (en) * 2007-06-21 2013-07-23 Yale University Sustained intraocular delivery of drugs from biodegradable polymeric microparticles
US20110206773A1 (en) * 2008-05-20 2011-08-25 Yale University Sustained delivery of drugs from biodegradable polymeric microparticles
CA2787514C (en) 2010-01-22 2019-03-12 Allergan, Inc. Intracameral sustained release therapeutic agent implants
WO2011106702A2 (en) 2010-02-25 2011-09-01 The Johns Hopkins University Sustained delivery of therapeutic agents to an eye compartment
US20120322884A1 (en) 2010-03-01 2012-12-20 University Of Manitoba Epinephrine nanoparticles, methods of fabrication thereof, and methods for use thereof for treatment of conditions responsive to epinephrine
WO2012039979A2 (en) 2010-09-10 2012-03-29 The Johns Hopkins University Rapid diffusion of large polymeric nanoparticles in the mammalian brain
WO2012058210A1 (en) 2010-10-29 2012-05-03 Merck Sharp & Dohme Corp. RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACIDS (siNA)
WO2012109363A2 (en) 2011-02-08 2012-08-16 The Johns Hopkins University Mucus penetrating gene carriers
RU2456979C1 (ru) * 2011-04-11 2012-07-27 Общество с ограниченной ответственностью "ЭкоБиоФармДубна" Индометацин на основе фосфолипидных наночастиц для применения в офтальмологии
EP2723800B1 (en) 2011-06-23 2015-10-07 DSM IP Assets B.V. Micro- or nanoparticles comprising a biodegradable polyesteramide copolymer for use in the delivery of bioactive agents
US9873765B2 (en) 2011-06-23 2018-01-23 Dsm Ip Assets, B.V. Biodegradable polyesteramide copolymers for drug delivery
CN104936620B (zh) 2012-01-19 2019-08-09 约翰霍普金斯大学 增强粘膜渗透的纳米粒子调配物
KR20230104761A (ko) * 2012-01-23 2023-07-10 알러간, 인코포레이티드 고화 디포-형성 주사가능 약물 제형에 현탁된 서방형생분해성 또는 생체흡수성 미소구체 또는 미립자
CN104363924B (zh) 2012-03-16 2018-04-17 约翰霍普金斯大学 用于递送hif‑1抑制剂的控制释放调配物
JP6138904B2 (ja) 2012-03-16 2017-05-31 ザ・ジョンズ・ホプキンス・ユニバーシティー 活性剤の送達のための非線状マルチブロックコポリマー薬物コンジュゲート
KR102140989B1 (ko) 2012-05-03 2020-08-04 칼라 파마슈티컬스, 인크. 개선된 점막 수송을 나타내는 제약 나노입자
CA2871745C (en) 2012-05-03 2023-01-24 Kala Pharmaceuticals, Inc. Pharmaceutical nanoparticles showing improved mucosal transport
US11596599B2 (en) 2012-05-03 2023-03-07 The Johns Hopkins University Compositions and methods for ophthalmic and/or other applications
US9827191B2 (en) 2012-05-03 2017-11-28 The Johns Hopkins University Compositions and methods for ophthalmic and/or other applications
JP6392209B2 (ja) 2012-05-04 2018-09-19 ザ・ジョンズ・ホプキンス・ユニバーシティー 粘液内層を通過する迅速な透過のための脂質ベース薬物キャリア
CA3169368A1 (en) 2012-06-15 2014-01-09 Nova Southeastern University Epinephrine nanoparticles, methods of fabrication thereof, and methods for use thereof for treatment of conditions responsive to epinephrine
US10568975B2 (en) 2013-02-05 2020-02-25 The Johns Hopkins University Nanoparticles for magnetic resonance imaging tracking and methods of making and using thereof
PT2976072T (pt) * 2013-03-22 2021-08-12 Univ Nova Southeastern Partículas finas de epinefrina e métodos de utilização das mesmas para o tratamento de afeções que reagem à epinefrina
US9504653B2 (en) 2013-04-01 2016-11-29 Allergan, Inc. Microsphere drug delivery system for sustained intraocular release
HUE050902T2 (hu) 2013-10-31 2021-01-28 Allergan Inc Prosztamidot tartalmazó intraokuláris implantátumok és azok alkalmazási módszerei
WO2015127368A1 (en) 2014-02-23 2015-08-27 The Johns Hopkins University Hypotonic microbicidal formulations and methods of use
MY196111A (en) 2014-07-18 2023-03-15 Allergan Inc Suspension Compositions of Cyclosporin a for Subconjunctival and Periocular Injection
RU2616258C2 (ru) * 2014-11-10 2017-04-13 федеральное государственное автономное образовательное учреждение высшего образования "Московский физико-технический институт (государственный университет)" Способ получения полимерных наночастиц низкосиалированного эритропоэтина с высокой степенью сорбции для лечения неврологических заболеваний
WO2016100392A1 (en) 2014-12-15 2016-06-23 The Johns Hopkins University Sunitinib formulations and methods for use thereof in treatment of ocular disorders
EP3233067B1 (en) 2014-12-18 2019-11-06 DSM IP Assets B.V. Drug delivery system for delivery of acid sensitive drugs
JP6846351B2 (ja) 2015-01-27 2021-03-24 ザ・ジョンズ・ホプキンス・ユニバーシティー 粘膜表面における活性薬剤の増強された輸送のための低張ヒドロゲル製剤
AR106018A1 (es) 2015-08-26 2017-12-06 Achillion Pharmaceuticals Inc Compuestos de arilo, heteroarilo y heterocíclicos para el tratamiento de trastornos médicos
EP3340982B1 (en) 2015-08-26 2021-12-15 Achillion Pharmaceuticals, Inc. Compounds for treatment of immune and inflammatory disorders
MX2018005932A (es) 2015-11-12 2019-05-20 Graybug Vision Inc Microparticulas aglomerantes para terapia medica.
EP3454856A4 (en) 2016-05-10 2019-12-25 C4 Therapeutics, Inc. HETEROCYCLIC DEGRONIMERS FOR TARGET PROTEIN REDUCTION
WO2017197046A1 (en) 2016-05-10 2017-11-16 C4 Therapeutics, Inc. C3-carbon linked glutarimide degronimers for target protein degradation
EP3454862A4 (en) 2016-05-10 2020-02-12 C4 Therapeutics, Inc. SPIROCYCLIC DEGRONIMERS FOR TARGET PROTEIN REDUCTION
US11395853B2 (en) * 2016-06-23 2022-07-26 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Biomimetic drug delivery of an immunomodulatory agent for the treatment of ocular conditions
JP7057290B2 (ja) 2016-06-27 2022-04-19 アキリオン ファーマシューティカルズ，インコーポレーテッド 医学的障害を治療するためのキナゾリン及びインドール化合物
MX2019000200A (es) 2016-07-01 2019-09-26 G1 Therapeutics Inc Agentes antiproliferativos basados en pirimidina.
CN107397745A (zh) * 2016-08-24 2017-11-28 上海毕傲图生物科技有限公司 唑类化合物眼用制剂
CA3056923A1 (en) 2017-03-23 2018-09-27 Graybug Vision, Inc. Drugs and compositions for the treatment of ocular disorders
AU2018265415A1 (en) 2017-05-10 2019-10-31 Graybug Vision, Inc. Extended release microparticles and suspensions thereof for medical therapy
JP2021519337A (ja) 2018-03-26 2021-08-10 シー４ セラピューティクス， インコーポレイテッド Ｉｋａｒｏｓの分解のためのセレブロン結合剤
CA3104468A1 (en) * 2018-06-19 2019-12-26 Cella Therapeutics, Llc Sustained-release drug delivery systems comprising an intraocular pressure lowering agent, a c-type natriuretic peptide compound, an natriuretic peptide receptor-b compound, a tie-2 agonist, or neurotrophic agent for use for treating glaucoma or ocular hypertension
JP2021535112A (ja) 2018-08-20 2021-12-16 アキリオン ファーマシューティカルズ，インコーポレーテッド 補体ｄ因子の医学的障害の治療のための医薬化合物
JP7504088B2 (ja) 2018-10-16 2024-06-21 ジョージア ステイト ユニバーシティー リサーチ ファウンデーション インコーポレイテッド 医学的障害の治療のための一酸化炭素プロドラッグ
AU2020373065A1 (en) 2019-10-30 2022-05-26 Perfuse Therapeutics, Inc. Treatment of ocular diseases using endothelin receptor antagonists
AU2021217358A1 (en) 2020-02-06 2022-09-08 Perfuse Therapeutics, Inc. Compositions for treatment of ocular diseases
KR20240004643A (ko) 2021-04-30 2024-01-11 퍼퓨즈 세라퓨틱스, 인크. 안구 질환의 치료를 위한 제약 조성물 및 유리체내 약물 전달 시스템

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) * 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US3960150A (en) * 1971-09-09 1976-06-01 Alza Corporation Bioerodible ocular device
BE788575A (fr) * 1971-09-09 1973-01-02 Alza Corp Dispositif oculaire pour l'administration d'un
GB1425550A (en) * 1973-04-25 1976-02-18 Alza Corp Device for releasing active agent and process for producing the same
US4177256A (en) * 1973-04-25 1979-12-04 Alza Corporation Osmotic bursting drug delivery device
US3914402A (en) * 1973-06-14 1975-10-21 Alza Corp Ophthalmic dosage form, for releasing medication over time
CH656884A5 (de) * 1983-08-26 1986-07-31 Sandoz Ag Polyolester, deren herstellung und verwendung.
DE3722837A1 (de) * 1987-07-10 1989-01-19 Ruetgerswerke Ag Ophthalmisches depotpraeparat
US4853224A (en) * 1987-12-22 1989-08-01 Visionex Biodegradable ocular implants
US4997652A (en) * 1987-12-22 1991-03-05 Visionex Biodegradable ocular implants
US4865846A (en) * 1988-06-03 1989-09-12 Kaufman Herbert E Drug delivery system
US5538739A (en) * 1989-07-07 1996-07-23 Sandoz Ltd. Sustained release formulations of water soluble peptides
PH30995A (en) * 1989-07-07 1997-12-23 Novartis Inc Sustained release formulations of water soluble peptides.
US5164188A (en) * 1989-11-22 1992-11-17 Visionex, Inc. Biodegradable ocular implants
WO1991016869A1 (en) * 1990-04-27 1991-11-14 Allergan, Inc. Polymeric drug delivery system
WO1995003009A1 (en) * 1993-07-22 1995-02-02 Oculex Pharmaceuticals, Inc. Method of treatment of macular degeneration
US5443505A (en) * 1993-11-15 1995-08-22 Oculex Pharmaceuticals, Inc. Biocompatible ocular implants
US5801146A (en) * 1996-05-03 1998-09-01 Abbott Laboratories Compound and method for inhibiting angiogenesis
CA2275525C (en) * 1996-12-20 2011-02-08 Kevin J. Brodbeck Gel composition and methods
DK1105136T3 (da) * 1998-08-13 2007-10-15 Novartis Ag Fremgangsmåde til behandling af okulære neovaskulære sygdomme
DE69912304T2 (de) * 1998-11-23 2004-07-22 Novartis Ag Verwendung von staurosporine derivaten zur behandlung von okularen neovaskularen erkrankungen
US20010039438A1 (en) * 2000-03-24 2001-11-08 Brazzell Romulus Kimbro Method for treating neovascularization
EP1322308A2 (en) * 2000-10-06 2003-07-02 Durect Corporation Devices and methods for management of inflammation
US6673802B2 (en) * 2000-12-01 2004-01-06 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A3 receptor and uses thereof
US8425929B2 (en) * 2004-04-30 2013-04-23 Allergan, Inc. Sustained release intraocular implants and methods for preventing retinal dysfunction

Also Published As

Publication number Publication date
DE60225701D1 (de) 2008-04-30
RU2316315C2 (ru) 2008-02-10
JP2011026338A (ja) 2011-02-10
JP2013147516A (ja) 2013-08-01
NO20040917L (no) 2004-03-02
PT1429725E (pt) 2008-06-18
CA2455680A1 (en) 2003-03-27
HUP0401568A3 (en) 2008-04-28
US20120269894A1 (en) 2012-10-25
EP1429725A1 (en) 2004-06-23
ZA200400524B (en) 2004-11-17
KR20040030869A (ko) 2004-04-09
WO2003024420A1 (en) 2003-03-27
NO333825B1 (no) 2013-09-23
HK1066733A1 (en) 2005-04-01
PL368128A1 (en) 2005-03-21
HU229453B1 (en) 2013-12-30
MXPA04002421A (es) 2004-05-31
HUP0401568A2 (hu) 2004-11-29
GB0122318D0 (en) 2001-11-07
US20040234611A1 (en) 2004-11-25
CN1538835A (zh) 2004-10-20
RU2004111596A (ru) 2005-04-20
BR0212475A (pt) 2004-08-24
JP2005504797A (ja) 2005-02-17
IL160027A (en) 2009-11-18
EP1429725B1 (en) 2008-03-19
ES2302849T3 (es) 2008-08-01
CA2455680C (en) 2010-07-20
CN102008428A (zh) 2011-04-13
AU2002342694B2 (en) 2006-08-24
ATE389385T1 (de) 2008-04-15
PL203949B1 (pl) 2009-11-30
US20080305172A1 (en) 2008-12-11
DE60225701T2 (de) 2009-04-30
CO5560548A2 (es) 2005-09-30
NZ531481A (en) 2005-12-23
ECSP044967A (es) 2004-03-23
US20130122064A1 (en) 2013-05-16

Similar Documents

Publication Publication Date Title
IL160027A0 (en) Ophthalmic depot formulations for periocular or subconjunctival administration
WO2000040203A3 (en) Polymeric delivery agents and delivery agent compounds
WO2000041681A3 (de) ARZNEIFORMULIERUNGEN ENTHALTEND EIN OPIOID UND EINEN α-AGONISTEN
WO2004064769A3 (en) Methods for making and using topical delivery agents
WO2003079972A3 (en) Active agent delivery systems and methods for protecting and administering active agents
PT1401501E (pt) Composicoes farmaceuticas orais com libertacao modificada do ingrediente activo
IL153297A0 (en) Compounds and compositions for delivering active agents
WO2002100437A3 (en) Ophthalmic compositions comprising hyaluronic acid
CA2396152A1 (en) Osmotic device within an osmotic device
AU2274201A (en) Compounds and compositions for delivering active agents
WO2002024184A3 (de) Mechanisch stabile darreichungsformen, enthaltend ubichinone
WO2000007979A3 (en) Compounds and compositions for delivering active agents
MXPA03008401A (es) Combinacion de brimonidina y timolol para uso oftalmico, topico.
MXPA01008611A (es) Compuestos y composiciones para suministrar agentes activos.
WO2001060335A3 (en) Delivery systems using preformed biodegradable polymer compositions and methods
AU2001236744A1 (en) Delivery system for topical skin care agents
WO2003045306A3 (en) Phenoxy amine compounds and compositions for delivering active agents
AU2003238221A1 (en) Ibuprofen suspension
PT1121127E (pt) Composicoes farmaceuticas orais contendo buprenorfina
EP2308479A3 (en) Compounds and compositions for delivering active agents
WO2002015959A3 (en) Compounds and compositions for delivering active agents
WO2001007049A3 (en) Ophthalmic composition comprising ketotifen
YU46503A (sh) Farmaceutski oblik dronedarona za parenteralnu upotrebu
ZA200403803B (en) Selective targeting of apoptotic cells.
WO2003041656A3 (en) Soluble drug extended release system