HU229453B1 - Ophthalmic depot formulations for periocular or subconjunctival administration - Google Patents

Ophthalmic depot formulations for periocular or subconjunctival administration

Info

Publication number
HU229453B1
HU229453B1 HU0401568A HUP0401568A HU229453B1 HU 229453 B1 HU229453 B1 HU 229453B1 HU 0401568 A HU0401568 A HU 0401568A HU P0401568 A HUP0401568 A HU P0401568A HU 229453 B1 HU229453 B1 HU 229453B1
Authority
HU
Hungary
Prior art keywords
periocular
depot formulations
subconjunctival administration
ophthalmic depot
ophthalmic
Prior art date
Application number
HU0401568A
Other languages
English (en)
Inventor
Markus Ahlheim
Michael Ausborn
David Bodmer
Christian Schoch
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of HUP0401568A2 publication Critical patent/HUP0401568A2/hu
Publication of HUP0401568A3 publication Critical patent/HUP0401568A3/hu
Publication of HU229453B1 publication Critical patent/HU229453B1/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A61K9/0051—Ocular inserts, ocular implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HU0401568A 2001-09-14 2002-09-13 Ophthalmic depot formulations for periocular or subconjunctival administration HU229453B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0122318.9A GB0122318D0 (en) 2001-09-14 2001-09-14 Organic compounds
PCT/EP2002/010314 WO2003024420A1 (en) 2001-09-14 2002-09-13 Ophthalmic depot formulations for periocular or subconjunctival administration

Publications (3)

Publication Number Publication Date
HUP0401568A2 HUP0401568A2 (hu) 2004-11-29
HUP0401568A3 HUP0401568A3 (en) 2008-04-28
HU229453B1 true HU229453B1 (en) 2013-12-30

Family

ID=9922147

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0401568A HU229453B1 (en) 2001-09-14 2002-09-13 Ophthalmic depot formulations for periocular or subconjunctival administration

Country Status (25)

Country Link
US (4) US20040234611A1 (hu)
EP (1) EP1429725B1 (hu)
JP (3) JP2005504797A (hu)
KR (1) KR20040030869A (hu)
CN (2) CN1538835A (hu)
AT (1) ATE389385T1 (hu)
AU (1) AU2002342694B2 (hu)
BR (1) BR0212475A (hu)
CA (1) CA2455680C (hu)
CO (1) CO5560548A2 (hu)
DE (1) DE60225701T2 (hu)
EC (1) ECSP044967A (hu)
ES (1) ES2302849T3 (hu)
GB (1) GB0122318D0 (hu)
HK (1) HK1066733A1 (hu)
HU (1) HU229453B1 (hu)
IL (2) IL160027A0 (hu)
MX (1) MXPA04002421A (hu)
NO (1) NO333825B1 (hu)
NZ (1) NZ531481A (hu)
PL (1) PL203949B1 (hu)
PT (1) PT1429725E (hu)
RU (1) RU2316315C2 (hu)
WO (1) WO2003024420A1 (hu)
ZA (1) ZA200400524B (hu)

Families Citing this family (84)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8202979B2 (en) 2002-02-20 2012-06-19 Sirna Therapeutics, Inc. RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid
US20060177416A1 (en) 2003-10-14 2006-08-10 Medivas, Llc Polymer particle delivery compositions and methods of use
US9994853B2 (en) 2001-05-18 2018-06-12 Sirna Therapeutics, Inc. Chemically modified multifunctional short interfering nucleic acid molecules that mediate RNA interference
US20030119812A1 (en) * 2001-11-08 2003-06-26 Brazzell Romulus Kimbro Method for decreasing capillary permeability in the retina
US9657294B2 (en) 2002-02-20 2017-05-23 Sirna Therapeutics, Inc. RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
US9181551B2 (en) 2002-02-20 2015-11-10 Sirna Therapeutics, Inc. RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
PT1539157E (pt) * 2002-09-18 2013-10-04 Univ Pennsylvania Rapamicina para utilização na inibição ou prevenção de neovascularização coroidal
US9216106B2 (en) 2003-04-09 2015-12-22 Directcontact Llc Device and method for the delivery of drugs for the treatment of posterior segment disease
US20050009910A1 (en) * 2003-07-10 2005-01-13 Allergan, Inc. Delivery of an active drug to the posterior part of the eye via subconjunctival or periocular delivery of a prodrug
EP1666025A4 (en) * 2003-08-20 2011-08-31 Santen Pharmaceutical Co Ltd DRUG DELIVERY SYSTEM FOR THE SUBTENOIN DELIVERY OF FINE GRAINS
AU2005209201B2 (en) * 2004-01-20 2010-06-03 Allergan, Inc. Compositions for localized therapy of the eye, comprising preferably triamcinolone acetonide and hyaluronic acid
US20050244458A1 (en) * 2004-04-30 2005-11-03 Allergan, Inc. Sustained release intraocular implants and methods for treating ocular neuropathies
US8722097B2 (en) 2004-04-30 2014-05-13 Allergan, Inc. Oil-in-water method for making polymeric implants containing a hypotensive lipid
US7799336B2 (en) * 2004-04-30 2010-09-21 Allergan, Inc. Hypotensive lipid-containing biodegradable intraocular implants and related methods
US7993634B2 (en) 2004-04-30 2011-08-09 Allergan, Inc. Oil-in-oil emulsified polymeric implants containing a hypotensive lipid and related methods
US20060182781A1 (en) * 2004-04-30 2006-08-17 Allergan, Inc. Methods for treating ocular conditions with cyclic lipid contraining microparticles
US7771742B2 (en) 2004-04-30 2010-08-10 Allergan, Inc. Sustained release intraocular implants containing tyrosine kinase inhibitors and related methods
US8673341B2 (en) * 2004-04-30 2014-03-18 Allergan, Inc. Intraocular pressure reduction with intracameral bimatoprost implants
US9498457B2 (en) 2004-04-30 2016-11-22 Allergan, Inc. Hypotensive prostamide-containing biodegradable intraocular implants and related implants
AU2011213904B2 (en) * 2004-04-30 2014-06-05 Allergan, Inc. Sustained release intraocular implants comprising a beta adrenergic receptor antagonist and methods for treating ocular neuropathies
US10508277B2 (en) 2004-05-24 2019-12-17 Sirna Therapeutics, Inc. Chemically modified multifunctional short interfering nucleic acid molecules that mediate RNA interference
US8663639B2 (en) 2005-02-09 2014-03-04 Santen Pharmaceutical Co., Ltd. Formulations for treating ocular diseases and conditions
EP1848431B1 (en) 2005-02-09 2016-02-03 Santen Pharmaceutical Co., Ltd. Liquid formulations for treatment of diseases or conditions
JP2006257080A (ja) * 2005-02-18 2006-09-28 Santen Pharmaceut Co Ltd ステロイド化合物の副作用軽減または回避方法
US8440217B1 (en) * 2005-06-15 2013-05-14 Mawaheb M. EL-Naggar Method and system with contact lens product for treating and preventing adverse eye conditions
US20160045457A1 (en) 2005-09-09 2016-02-18 Ousama Rachid Epinephrine fine particles and methods for use thereof for treatment of conditions responsive to epinephrine
US9877921B2 (en) 2005-09-09 2018-01-30 Nova Southeastern University Epinephrine nanoparticles, methods of fabrication thereof, and methods for use thereof for treatment of conditions responsive to epinephrine
CA2623198C (en) 2005-09-22 2014-08-05 Medivas, Llc Bis-(a-amino)-diol-diester-containing poly(ester amide) and poly(ester urethane) compositions and methods of use
CA2623239C (en) 2005-09-22 2016-07-12 Medivas, Llc Solid polymer delivery compositions and methods for use thereof
WO2007092620A2 (en) 2006-02-09 2007-08-16 Macusight, Inc. Stable formulations, and methods of their preparation and use
ES2563288T3 (es) 2006-03-23 2016-03-14 Santen Pharmaceutical Co., Ltd Rapamicina en dosis bajas para el tratamiento de enfermedades relacionadas con la permeabilidad vascular
EP2019645A4 (en) * 2006-05-02 2013-03-06 Medivas Llc RELEASE OF OPHTHALMOLOGICAL ACTIVITIES OUTSIDE OR WITHIN THE EYE
US8969415B2 (en) 2006-12-01 2015-03-03 Allergan, Inc. Intraocular drug delivery systems
WO2008157614A2 (en) * 2007-06-21 2008-12-24 Yale University Sustained intraocular delivery of drugs from biodegradable polymeric microparticles
US20110206773A1 (en) * 2008-05-20 2011-08-25 Yale University Sustained delivery of drugs from biodegradable polymeric microparticles
KR101911960B1 (ko) 2010-01-22 2018-10-25 알러간, 인코포레이티드 전방내 서방성 치료제 이식물
WO2011106702A2 (en) 2010-02-25 2011-09-01 The Johns Hopkins University Sustained delivery of therapeutic agents to an eye compartment
US20120322884A1 (en) 2010-03-01 2012-12-20 University Of Manitoba Epinephrine nanoparticles, methods of fabrication thereof, and methods for use thereof for treatment of conditions responsive to epinephrine
US10307372B2 (en) 2010-09-10 2019-06-04 The Johns Hopkins University Rapid diffusion of large polymeric nanoparticles in the mammalian brain
ES2663009T3 (es) 2010-10-29 2018-04-10 Sirna Therapeutics, Inc. Inhibición de la expresión génica mediada por interferencia por ARN utilizando ácidos nucleicos de interferencia cortos (ANic)
WO2012109363A2 (en) 2011-02-08 2012-08-16 The Johns Hopkins University Mucus penetrating gene carriers
RU2456979C1 (ru) * 2011-04-11 2012-07-27 Общество с ограниченной ответственностью "ЭкоБиоФармДубна" Индометацин на основе фосфолипидных наночастиц для применения в офтальмологии
US9873765B2 (en) 2011-06-23 2018-01-23 Dsm Ip Assets, B.V. Biodegradable polyesteramide copolymers for drug delivery
EP2723800B1 (en) 2011-06-23 2015-10-07 DSM IP Assets B.V. Micro- or nanoparticles comprising a biodegradable polyesteramide copolymer for use in the delivery of bioactive agents
US20140242177A1 (en) 2011-10-21 2014-08-28 Nova Southeastern University Epinephrine nanoparticles, methods of fabrication thereof, and methods for use thereof for treatment of conditions responsive to epinephrine
EP2804632B1 (en) 2012-01-19 2019-09-18 The Johns Hopkins University Nanoparticle formulations with enhanced mucosal penetration
RU2672596C2 (ru) * 2012-01-23 2018-11-16 Аллерган, Инк. Биологически разлагаемые или биологически разрушаемые микросферы или микрочастицы длительного высвобождения, суспендированные в затвердевающем депообразующем инъекцируемом лекарственном составе
CA2867381C (en) 2012-03-16 2016-09-20 The Johns Hopkins University Controlled release formulations for the delivery of hif-1 inhibitors
US10159743B2 (en) 2012-03-16 2018-12-25 The Johns Hopkins University Non-linear multiblock copolymer-drug conjugates for the delivery of active agents
US11596599B2 (en) 2012-05-03 2023-03-07 The Johns Hopkins University Compositions and methods for ophthalmic and/or other applications
US9827191B2 (en) 2012-05-03 2017-11-28 The Johns Hopkins University Compositions and methods for ophthalmic and/or other applications
CA2871778C (en) 2012-05-03 2022-09-13 Kala Pharmaceuticals, Inc. Pharmaceutical nanoparticles showing improved mucosal transport
EP2844227B1 (en) 2012-05-03 2020-11-18 Kala Pharmaceuticals, Inc. Pharmaceutical nanoparticles showing improved mucosal transport
WO2013166498A1 (en) 2012-05-04 2013-11-07 The Johns Hopkins University Lipid-based drug carriers for rapid penetration through mucus linings
CA2876883C (en) 2012-06-15 2022-11-01 Nova Southeastern University Epinephrine nanoparticles, methods of fabrication thereof, and methods for use thereof for treatment of conditions responsive to epinephrine
WO2014124006A1 (en) 2013-02-05 2014-08-14 The Johns Hopkins University Nanoparticles for magnetic resonance imaging tracking and methods of making and using thereof
PT2976072T (pt) * 2013-03-22 2021-08-12 Univ Nova Southeastern Partículas finas de epinefrina e métodos de utilização das mesmas para o tratamento de afeções que reagem à epinefrina
ES2834964T3 (es) 2013-04-01 2021-06-21 Allergan Inc Sistema de administración de fármacos mediante microesferas para liberación intraocular sostenida
ES2805880T3 (es) 2013-10-31 2021-02-15 Allergan Inc Implantes intraoculares que contienen prostamida y métodos de uso de éstos
WO2015127368A1 (en) 2014-02-23 2015-08-27 The Johns Hopkins University Hypotonic microbicidal formulations and methods of use
MX2017000855A (es) 2014-07-18 2017-05-01 Allergan Inc Composiciones en suspension de ciclosporina a para inyecciones subconjuntivales y perioculares.
RU2616258C2 (ru) * 2014-11-10 2017-04-13 федеральное государственное автономное образовательное учреждение высшего образования "Московский физико-технический институт (государственный университет)" Способ получения полимерных наночастиц низкосиалированного эритропоэтина с высокой степенью сорбции для лечения неврологических заболеваний
EA201791337A1 (ru) 2014-12-15 2017-11-30 Дзе Джонс Хопкинс Юниверсити Составы сунитиниба и способы их применения в лечении глазных нарушений
AU2015366355B2 (en) 2014-12-18 2020-05-28 Dsm Ip Assets B.V. Drug delivery system for delivery of acid sensitive drugs
JP6846351B2 (ja) 2015-01-27 2021-03-24 ザ・ジョンズ・ホプキンス・ユニバーシティー 粘膜表面における活性薬剤の増強された輸送のための低張ヒドロゲル製剤
WO2017035408A1 (en) 2015-08-26 2017-03-02 Achillion Pharmaceuticals, Inc. Compounds for treatment of immune and inflammatory disorders
AR106018A1 (es) 2015-08-26 2017-12-06 Achillion Pharmaceuticals Inc Compuestos de arilo, heteroarilo y heterocíclicos para el tratamiento de trastornos médicos
BR112018009644A2 (pt) 2015-11-12 2018-11-06 Graybug Vision Inc micropartículas agregantes sólidas modificadas na superfície, material injetável, processo para preparação de micropartículas agregantes sólidas modificadas na superfície, método para tratamento de um distúrbio ocular, e, uso de micropartículas agregantes sólidas modificadas na superfície
WO2017197055A1 (en) 2016-05-10 2017-11-16 C4 Therapeutics, Inc. Heterocyclic degronimers for target protein degradation
EP3455218A4 (en) 2016-05-10 2019-12-18 C4 Therapeutics, Inc. C3 CARBON-BASED GLUTARIMIDE DEGRONIMERS FOR TARGET PROTEIN REDUCTION
CN109562113A (zh) 2016-05-10 2019-04-02 C4医药公司 用于靶蛋白降解的螺环降解决定子体
US11395853B2 (en) * 2016-06-23 2022-07-26 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Biomimetic drug delivery of an immunomodulatory agent for the treatment of ocular conditions
KR20190036520A (ko) 2016-06-27 2019-04-04 아칠리온 파르마세우티칼스 인코포레이티드 의학적 장애를 치료하기 위한 퀴나졸린 및 인돌 화합물
EP3858835A1 (en) 2016-07-01 2021-08-04 G1 Therapeutics, Inc. Pyrimidine-based antiproliferative agents
CN107397745A (zh) * 2016-08-24 2017-11-28 上海毕傲图生物科技有限公司 唑类化合物眼用制剂
AU2018240462C1 (en) 2017-03-23 2022-12-08 Graybug Vision, Inc. Drugs and compositions for the treatment of ocular disorders
WO2018209155A1 (en) 2017-05-10 2018-11-15 Graybug Vision, Inc. Extended release microparticles and suspensions thereof for medical therapy
CN111902141A (zh) 2018-03-26 2020-11-06 C4医药公司 用于ikaros降解的羟脑苷脂结合剂
CN112566622A (zh) * 2018-06-19 2021-03-26 细胞疗法有限责任公司 用于治疗青光眼或高眼压症的包含眼内压降低剂、cnp化合物、npr-b化合物、tie-2激动剂或神经营养剂的缓释药物递送系统
JP2021535112A (ja) 2018-08-20 2021-12-16 アキリオン ファーマシューティカルズ，インコーポレーテッド 補体ｄ因子の医学的障害の治療のための医薬化合物
JP7504088B2 (ja) 2018-10-16 2024-06-21 ジョージア ステイト ユニバーシティー リサーチ ファウンデーション インコーポレイテッド 医学的障害の治療のための一酸化炭素プロドラッグ
CN114786480B (zh) 2019-10-30 2024-03-29 珀弗斯治疗股份有限公司 使用内皮素受体拮抗剂治疗眼部疾病
WO2021158663A1 (en) 2020-02-06 2021-08-12 Perfuse Therapeutics, Inc. Compositions for treatment of ocular diseases
IL307997A (en) 2021-04-30 2023-12-01 Perfuse Therapeutics Inc Pharmaceutical preparations and intravitreal drug delivery systems for the treatment of eye diseases

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) * 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US3960150A (en) * 1971-09-09 1976-06-01 Alza Corporation Bioerodible ocular device
BE788575A (fr) * 1971-09-09 1973-01-02 Alza Corp Dispositif oculaire pour l'administration d'un
GB1425550A (en) * 1973-04-25 1976-02-18 Alza Corp Device for releasing active agent and process for producing the same
US4177256A (en) * 1973-04-25 1979-12-04 Alza Corporation Osmotic bursting drug delivery device
US3914402A (en) * 1973-06-14 1975-10-21 Alza Corp Ophthalmic dosage form, for releasing medication over time
CH656884A5 (de) * 1983-08-26 1986-07-31 Sandoz Ag Polyolester, deren herstellung und verwendung.
DE3722837A1 (de) * 1987-07-10 1989-01-19 Ruetgerswerke Ag Ophthalmisches depotpraeparat
US4997652A (en) * 1987-12-22 1991-03-05 Visionex Biodegradable ocular implants
US4853224A (en) * 1987-12-22 1989-08-01 Visionex Biodegradable ocular implants
US4865846A (en) * 1988-06-03 1989-09-12 Kaufman Herbert E Drug delivery system
PH30995A (en) * 1989-07-07 1997-12-23 Novartis Inc Sustained release formulations of water soluble peptides.
US5538739A (en) * 1989-07-07 1996-07-23 Sandoz Ltd. Sustained release formulations of water soluble peptides
US5164188A (en) * 1989-11-22 1992-11-17 Visionex, Inc. Biodegradable ocular implants
DE69129696T2 (de) * 1990-04-27 1999-02-25 Allergan Inc Polymeres arzneimittelabgabesystem
WO1995003009A1 (en) * 1993-07-22 1995-02-02 Oculex Pharmaceuticals, Inc. Method of treatment of macular degeneration
US5443505A (en) * 1993-11-15 1995-08-22 Oculex Pharmaceuticals, Inc. Biocompatible ocular implants
US5801146A (en) * 1996-05-03 1998-09-01 Abbott Laboratories Compound and method for inhibiting angiogenesis
DK0959873T3 (da) * 1996-12-20 2006-07-03 Alza Corp Gelsammensætning og fremgangsmåder
ES2291041T3 (es) * 1998-08-13 2008-02-16 Novartis Ag Metodo para tratar enfermedades neovasculares oculares.
CN1172673C (zh) * 1998-11-23 2004-10-27 诺瓦提斯公司 星形孢菌素衍生物在制备治疗眼睛新血管生成性疾病的药物中的应用
IL151833A0 (en) * 2000-03-24 2003-04-10 Novartis Ag Improved treatment of neovascularization
WO2002028366A2 (en) * 2000-10-06 2002-04-11 Durect Corporation Devices and methods for management of inflammation
US6673802B2 (en) * 2000-12-01 2004-01-06 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A3 receptor and uses thereof
US8425929B2 (en) * 2004-04-30 2013-04-23 Allergan, Inc. Sustained release intraocular implants and methods for preventing retinal dysfunction

Also Published As

Publication number Publication date
US20120269894A1 (en) 2012-10-25
HUP0401568A3 (en) 2008-04-28
EP1429725A1 (en) 2004-06-23
CN102008428A (zh) 2011-04-13
ES2302849T3 (es) 2008-08-01
RU2004111596A (ru) 2005-04-20
EP1429725B1 (en) 2008-03-19
PT1429725E (pt) 2008-06-18
GB0122318D0 (en) 2001-11-07
JP2013147516A (ja) 2013-08-01
ZA200400524B (en) 2004-11-17
DE60225701D1 (de) 2008-04-30
BR0212475A (pt) 2004-08-24
NO20040917L (no) 2004-03-02
CA2455680C (en) 2010-07-20
MXPA04002421A (es) 2004-05-31
NZ531481A (en) 2005-12-23
NO333825B1 (no) 2013-09-23
HK1066733A1 (en) 2005-04-01
CA2455680A1 (en) 2003-03-27
JP2011026338A (ja) 2011-02-10
KR20040030869A (ko) 2004-04-09
DE60225701T2 (de) 2009-04-30
PL368128A1 (en) 2005-03-21
HUP0401568A2 (hu) 2004-11-29
RU2316315C2 (ru) 2008-02-10
ATE389385T1 (de) 2008-04-15
WO2003024420A1 (en) 2003-03-27
CN1538835A (zh) 2004-10-20
US20040234611A1 (en) 2004-11-25
AU2002342694B2 (en) 2006-08-24
PL203949B1 (pl) 2009-11-30
IL160027A (en) 2009-11-18
JP2005504797A (ja) 2005-02-17
CO5560548A2 (es) 2005-09-30
IL160027A0 (en) 2004-06-20
US20080305172A1 (en) 2008-12-11
ECSP044967A (es) 2004-03-23
US20130122064A1 (en) 2013-05-16

Similar Documents

Publication Publication Date Title
HU229453B1 (en) Ophthalmic depot formulations for periocular or subconjunctival administration
WO2000040203A3 (en) Polymeric delivery agents and delivery agent compounds
WO2000041681A3 (de) ARZNEIFORMULIERUNGEN ENTHALTEND EIN OPIOID UND EINEN α-AGONISTEN
WO2004064769A3 (en) Methods for making and using topical delivery agents
PT1401501E (pt) Composicoes farmaceuticas orais com libertacao modificada do ingrediente activo
HK1054918A1 (en) Compounds and compositions for delivering active agents
CA2396152A1 (en) Osmotic device within an osmotic device
WO2002024184A3 (de) Mechanisch stabile darreichungsformen, enthaltend ubichinone
WO2000007979A3 (en) Compounds and compositions for delivering active agents
MXPA03008401A (es) Combinacion de brimonidina y timolol para uso oftalmico, topico.
MXPA01008611A (es) Compuestos y composiciones para suministrar agentes activos.
WO2001060335A3 (en) Delivery systems using preformed biodegradable polymer compositions and methods
AU2001236744A1 (en) Delivery system for topical skin care agents
WO2003045306A3 (en) Phenoxy amine compounds and compositions for delivering active agents
AU2003238221A1 (en) Ibuprofen suspension
PT1121127E (pt) Composicoes farmaceuticas orais contendo buprenorfina
EP2308479A3 (en) Compounds and compositions for delivering active agents
WO2002015959A3 (en) Compounds and compositions for delivering active agents
WO2001007049A3 (en) Ophthalmic composition comprising ketotifen
WO2004066983A3 (en) Controlled release of highly soluble agents
YU46503A (sh) Farmaceutski oblik dronedarona za parenteralnu upotrebu
ZA200403803B (en) Selective targeting of apoptotic cells.
WO2003041656A3 (en) Soluble drug extended release system
AU2001230195A1 (en) Pharmaceutical compositions comprising terbinafine
EP1273301A3 (en) Pharmaceutical preparations based on active ingredients susceptible to illict administration

Legal Events

Date Code Title Description
MM4A Lapse of definitive patent protection due to non-payment of fees