JP2005504055A5 - - Google Patents
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- Publication number
- JP2005504055A5 JP2005504055A5 JP2003522585A JP2003522585A JP2005504055A5 JP 2005504055 A5 JP2005504055 A5 JP 2005504055A5 JP 2003522585 A JP2003522585 A JP 2003522585A JP 2003522585 A JP2003522585 A JP 2003522585A JP 2005504055 A5 JP2005504055 A5 JP 2005504055A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- hydrogen
- heterocycle
- compound
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 77
- 150000001875 compounds Chemical class 0.000 claims 41
- 229910052739 hydrogen Inorganic materials 0.000 claims 41
- 239000001257 hydrogen Substances 0.000 claims 41
- 125000000623 heterocyclic group Chemical group 0.000 claims 36
- -1 cyano, carboxy Chemical group 0.000 claims 35
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 21
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 20
- 125000004414 alkyl thio group Chemical group 0.000 claims 18
- 125000003118 aryl group Chemical group 0.000 claims 18
- 125000001072 heteroaryl group Chemical group 0.000 claims 18
- 150000002431 hydrogen Chemical class 0.000 claims 18
- 125000001153 fluoro group Chemical group F* 0.000 claims 12
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 11
- 125000003545 alkoxy group Chemical group 0.000 claims 9
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 9
- 125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 claims 9
- 239000000203 mixture Substances 0.000 claims 9
- 125000000753 cycloalkyl group Chemical group 0.000 claims 7
- 208000037259 Amyloid Plaque Diseases 0.000 claims 6
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 5
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- 125000004769 (C1-C4) alkylsulfonyl group Chemical group 0.000 claims 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 4
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 3
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 3
- 125000004184 methoxymethyl group Chemical group [H]C([H])([H])OC([H])([H])* 0.000 claims 3
- 229910052760 oxygen Inorganic materials 0.000 claims 3
- 229910052717 sulfur Inorganic materials 0.000 claims 3
- 241000124008 Mammalia Species 0.000 claims 2
- 238000004220 aggregation Methods 0.000 claims 2
- 230000002776 aggregation Effects 0.000 claims 2
- 125000003282 alkyl amino group Chemical group 0.000 claims 2
- 125000003784 fluoroethyl group Chemical group [H]C([H])(F)C([H])([H])* 0.000 claims 2
- 125000004216 fluoromethyl group Chemical group [H]C([H])(F)* 0.000 claims 2
- 125000005816 fluoropropyl group Chemical group [H]C([H])(F)C([H])([H])C([H])([H])* 0.000 claims 2
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- 238000003384 imaging method Methods 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000006239 protecting group Chemical group 0.000 claims 1
- 0 CNCC(*)(*)* Chemical compound CNCC(*)(*)* 0.000 description 2
- PJANXHGTPQOBST-UHFFFAOYSA-N C(c1ccccc1)=C/c1ccccc1 Chemical compound C(c1ccccc1)=C/c1ccccc1 PJANXHGTPQOBST-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31465801P | 2001-08-27 | 2001-08-27 | |
| PCT/US2002/027201 WO2003018070A1 (en) | 2001-08-27 | 2002-08-27 | Stilbene derivatives and their use for binding and imaging amyloid plaques |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009140609A Division JP2009197037A (ja) | 2001-08-27 | 2009-06-11 | スチルベン誘導体、およびアミロイド斑の結合および画像化のためのその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005504055A JP2005504055A (ja) | 2005-02-10 |
| JP2005504055A5 true JP2005504055A5 (https=) | 2006-01-05 |
| JP4436928B2 JP4436928B2 (ja) | 2010-03-24 |
Family
ID=23220888
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003522585A Expired - Fee Related JP4436928B2 (ja) | 2001-08-27 | 2002-08-27 | スチルベン誘導体、およびアミロイド斑の結合および画像化のためのその使用 |
| JP2009140609A Pending JP2009197037A (ja) | 2001-08-27 | 2009-06-11 | スチルベン誘導体、およびアミロイド斑の結合および画像化のためのその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009140609A Pending JP2009197037A (ja) | 2001-08-27 | 2009-06-11 | スチルベン誘導体、およびアミロイド斑の結合および画像化のためのその使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US7250525B2 (https=) |
| EP (1) | EP1432453B1 (https=) |
| JP (2) | JP4436928B2 (https=) |
| KR (1) | KR100947913B1 (https=) |
| CN (2) | CN1299777C (https=) |
| AU (2) | AU2002323417B2 (https=) |
| CA (1) | CA2456411C (https=) |
| DK (1) | DK1432453T3 (https=) |
| ES (1) | ES2435070T3 (https=) |
| TW (1) | TWI267381B (https=) |
| WO (1) | WO2003018070A1 (https=) |
Families Citing this family (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1299777C (zh) * | 2001-08-27 | 2007-02-14 | 宾夕法尼亚州大学理事会 | 茋衍生物及其用于结合和成像淀粉样蛋白斑的用途 |
| CA2500358A1 (en) * | 2003-08-13 | 2005-02-24 | Bf Research Institute, Inc. | Probes for diseases in which amyloid accumulates, agents for staining amyloid, drugs for treatment and prophylaxis of diseases with accumulated amyloid, and probes for diagnosis of neurofibrillary tangles and agents for staining neurofibrillary tangles |
| US20050049487A1 (en) * | 2003-08-26 | 2005-03-03 | Johnson Bruce Fletcher | Compounds and kits for preparing imaging agents and methods of imaging |
| EP1732864B1 (en) * | 2004-03-18 | 2013-12-25 | Suntory Holdings Limited | Radiolabeled 3-[3- (benzoyl-amido) benzyloxy]aspartic acid derivative and method of producing the same |
| JP2007084526A (ja) * | 2004-11-26 | 2007-04-05 | Nagasaki Univ | アミロイド関連疾患診断用組成物 |
| EP2213652B1 (en) * | 2004-12-17 | 2014-10-22 | The Trustees of The University of Pennsylvania | Stilbene derivatives and their use for binding and imaging amyloid plaques |
| US7858072B2 (en) * | 2004-12-17 | 2010-12-28 | The Trustees Of The University Of Pennsylvania | Stilbene derivatives and their use for binding and imaging amyloid plaques |
| CN101123995B (zh) * | 2004-12-17 | 2011-11-16 | 宾夕法尼亚大学理事会 | 茋衍生物及其用于结合和成像淀粉样蛋白斑的用途 |
| JP2008546804A (ja) * | 2005-06-24 | 2008-12-25 | ザ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・ペンシルバニア | 造影剤として用いるためのリガンドの放射性標識ペグ化 |
| KR100778888B1 (ko) * | 2005-11-29 | 2007-11-28 | 재단법인서울대학교산학협력재단 | 베타아밀로이드 펩타이드 플라크의 영상화를 위한벤질리덴아닐린 계열의 유도체 및 그의 방사성 동위원소표지화합물 |
| PL1999109T3 (pl) * | 2006-03-30 | 2012-05-31 | Univ Pennsylvania | Pochodne styrylopirydyny i ich zastosowanie do wiązania i obrazowania blaszek amyloidowych |
| US20130178536A1 (en) * | 2006-04-25 | 2013-07-11 | Stc.Unm | Substituted cis- and trans-stilbenes as therapeutic agents |
| TW200803903A (en) * | 2006-04-28 | 2008-01-16 | Nihon Mediphysics Co Ltd | Novel compound having affinity to amyloid |
| WO2008118122A2 (en) * | 2006-05-08 | 2008-10-02 | Molecular Neuroimaging, Llc | Compounds and amyloid probes thereof for therapeutic and imaging uses |
| US8303935B2 (en) | 2006-05-19 | 2012-11-06 | Nihon Medi-Physics Co., Ltd. | Alkoxy substituted imidazo[1,2-a]pyridines having affinity for amyloid |
| WO2007148755A1 (ja) | 2006-06-21 | 2007-12-27 | Nihon Medi-Physics Co., Ltd. | 新規アミロイド親和性化合物 |
| KR100836753B1 (ko) * | 2006-09-08 | 2008-06-10 | 한국과학기술연구원 | 베타 아밀로이드 피브릴 형성 억제 화합물, 이의 제조 방법 및 이를 포함하는 약학 조성물 |
| CA2670436A1 (en) | 2006-11-30 | 2008-06-05 | Nihon Medi-Physics Co., Ltd. | Novel compound having affinity for amyloid |
| WO2008078424A1 (ja) * | 2006-12-25 | 2008-07-03 | Tohoku University | ベンゾキサゾール誘導体 |
| JP5190893B2 (ja) * | 2006-12-25 | 2013-04-24 | 国立大学法人東北大学 | ベンゾキサゾール誘導体 |
| JP5258583B2 (ja) | 2007-02-13 | 2013-08-07 | 日本メジフィジックス株式会社 | 放射性画像診断剤の製造方法 |
| EP2144916A4 (en) * | 2007-04-10 | 2012-01-04 | Univ Pennsylvania | PHEN-NAPHTHALENE AND PHEN-CHINOLINE DERIVATIVES AND THEIR USE FOR THE BINDING AND PICTURE OF AMYLOIDER PLAQUE |
| US20080253967A1 (en) * | 2007-04-13 | 2008-10-16 | Kung Hank F | Halo-Stilbene Derivatives And Their Use For Binding And Imaging Of Amyloid Plaques |
| EP2198040B1 (en) * | 2007-08-31 | 2018-08-15 | Case Western Reserve University | In vivo imaging of myelin |
| KR20100091965A (ko) | 2007-10-24 | 2010-08-19 | 니혼 메디피직스 가부시키가이샤 | 신규 아밀로이드 친화성 화합물 |
| AU2008314871A1 (en) | 2007-10-26 | 2009-04-30 | Nihon Medi-Physics Co., Ltd. | Novel compound having affinity for amyloid |
| KR20100101577A (ko) | 2007-10-30 | 2010-09-17 | 니혼 메디피직스 가부시키가이샤 | 신규 아밀로이드 친화성 화합물의 사용 및 제조 방법 |
| CA2704168A1 (en) * | 2007-10-30 | 2009-05-07 | Nihon Medi-Physics Co., Ltd. | Use of novel compound having affinity for amyloid, and process for production of the same |
| EP2072494B1 (en) * | 2007-12-21 | 2010-12-01 | Johnson & Johnson Consumer France SAS | Cosmetic and pharmaceutical compositions |
| EP2247558B2 (en) * | 2008-02-14 | 2024-07-03 | Eli Lilly and Company | Novel imaging agents for detecting neurological dysfunction |
| US8932557B2 (en) | 2008-02-14 | 2015-01-13 | Eli Lilly And Company | Imaging agents for detecting neurological dysfunction |
| EP2247944A1 (en) * | 2008-02-27 | 2010-11-10 | Avid Radiopharmaceuticals, Inc. | Gamma probe detection of amyloid plaque using radiolabeled a-beta binding compounds |
| JP5603855B2 (ja) * | 2008-04-04 | 2014-10-08 | アビッド レディオファーマシューティカルズ、インク． | 神経変成疾患の放射性薬剤による画像化 |
| JP2011529086A (ja) * | 2008-07-24 | 2011-12-01 | シーメンス メディカル ソリューションズ ユーエスエー インコーポレイテッド | Ａｄ病変を同定するために有用な造影剤 |
| JP4623166B2 (ja) * | 2008-08-25 | 2011-02-02 | ソニー株式会社 | 標識化合物及びこれを用いた検出方法 |
| US9987379B2 (en) | 2008-09-30 | 2018-06-05 | Case Western Reserve University | Molecular probes for imaging of myelin |
| WO2010046898A1 (en) * | 2008-10-23 | 2010-04-29 | Bromine Compounds Ltd. | A process for the preparation of halogenated aryl phosphonates |
| JP2012508889A (ja) * | 2008-11-13 | 2012-04-12 | アビッド レディオファーマシューティカルズ、インク． | 神経変性疾患の検出と診断のためのヒストグラムに基づいた分析方法 |
| US8691187B2 (en) * | 2009-03-23 | 2014-04-08 | Eli Lilly And Company | Imaging agents for detecting neurological disorders |
| JP2012521988A (ja) * | 2009-03-23 | 2012-09-20 | シーメンス メディカル ソリューションズ ユーエスエー インコーポレイテッド | 神経学的障害を検知するためのイメージング剤 |
| CU23844B1 (es) | 2009-04-17 | 2012-10-15 | Ct De Neurociencias De Cuba | Procedimiento de obtención de nuevos derivados de naftaleno para el diagnóstico in vivo de la enfermedad de alzheimer |
| US8658129B2 (en) * | 2009-06-04 | 2014-02-25 | General Electric Company | Agents and methods for the imaging of myelin basic protein |
| MX336896B (es) * | 2009-12-23 | 2016-02-05 | Piramal Imaging Sa | Formulaciones adecuadas para la generacion de imagenes pet con agentes pet hidrofobicos. |
| WO2011141515A1 (en) * | 2010-05-14 | 2011-11-17 | Bayer Pharma Aktiengesellschaft | Diagnostic agents for amyloid beta imaging |
| EP2627361B1 (en) | 2010-10-12 | 2017-09-20 | Mayo Foundation For Medical Education And Research | Imaging of meningiomas using phenylbenzothiazole, stilbene, or biphenylalkyne derivatives |
| JP5310702B2 (ja) * | 2010-11-01 | 2013-10-09 | ソニー株式会社 | 標識化合物及びこれを用いた検出方法 |
| CN110015962B (zh) | 2011-01-28 | 2022-03-15 | 肯塔基大学研究基金会 | 茋类似物和治疗癌症的方法 |
| AU2012259929B2 (en) | 2011-05-20 | 2016-08-04 | Nihon Medi-Physics Co., Ltd. | Novel compound having affinity for amyloid |
| BR112013032610B1 (pt) | 2011-06-21 | 2022-05-31 | Life Molecular Imaging Sa | Formulações de estilbeno fluorado adequadas para imagiologia pet, e seus métodos de preparação, obtenção e filtração estéril |
| CA2839199C (en) | 2011-06-24 | 2018-11-06 | Nihon Medi-Physics Co., Ltd. | Novel compound with amyloid affinity |
| WO2013082508A1 (en) * | 2011-12-02 | 2013-06-06 | The Regents Of The University Of Michigan | Compositions and methods for the treatment and analysis of neurological disorders |
| CN105030750B (zh) * | 2011-12-23 | 2018-08-28 | 中国医学科学院医药生物技术研究所 | 一组木豆素结构类似化合物在抗丙肝病毒和抗艾滋病毒的应用 |
| WO2014004664A2 (en) | 2012-06-27 | 2014-01-03 | Mayo Foundation For Medical Education And Research | Treatment of meningiomas using phenylbenzothiazole, stilbene, biphenylalkyne, or pyridine derivatives |
| CN103709050A (zh) * | 2012-09-28 | 2014-04-09 | 中山大学 | 白藜芦醇衍生物及其在制备抗阿尔茨海默病药物中的应用 |
| CU20130027A7 (es) | 2013-02-28 | 2014-10-30 | Ct De Neurociencias De Cuba | Chaperoninas químicas como nuevos moduladores moleculares de la beta agregación proteica presente en las enfermedades conformacionales |
| RU2015147450A (ru) | 2013-04-29 | 2017-06-05 | Ф. Хоффманн-Ля Рош Аг | ПРОИЗВОДНЫЕ 2-ФЕНИЛ ИЛИ 2-ГЕТЕРОАРИЛ ИМИДАЗОЛ[1,2-a]ПИРИДИНА |
| CA2920068A1 (en) | 2013-09-26 | 2015-04-02 | F. Hoffmann-La Roche Ag | Imidazo[1,2-a]pyridin-7-amines as imaging tools |
| WO2017156303A1 (en) * | 2016-03-09 | 2017-09-14 | Case Western Reserve University | Radioligands for myelin |
| CN106117076B (zh) * | 2016-07-07 | 2018-11-06 | 北京理工大学 | 一种新型二苯乙烯类衍生物及其制备方法 |
| JP6765518B2 (ja) | 2016-09-29 | 2020-10-07 | コリア アトミック エナジー リサーチ インスティテュートＫｏｒｅａ Ａｔｏｍｉｃ Ｅｎｅｒｇｙ Ｒｅｓｅａｒｃｈ Ｉｎｓｔｉｔｕｔｅ | クルクミン誘導体、その製造方法、及びそれを含むベータ−アミロイドプラーク検出用光音響イメージング剤 |
| KR102240400B1 (ko) * | 2020-11-19 | 2021-04-15 | 한국원자력연구원 | 베타-아밀로이드 검출용 수용성 화합물 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4001229A (en) * | 1974-04-04 | 1977-01-04 | Mead Johnson & Company | Alkanesulfonamido triphenylethylenes |
| US4622217A (en) * | 1984-04-27 | 1986-11-11 | The Regents Of The University Of Michigan | I-4-amino-3-iodobenzylguanidine as imaging and therapeutic agent |
| DE4225870A1 (de) * | 1992-08-05 | 1994-02-10 | Basf Ag | Verfahren zur Herstellung von Glycerincarbonat |
| JPH0797362A (ja) * | 1993-06-30 | 1995-04-11 | Nippon Mejifuijitsukusu Kk | 新規なキレート形成性化合物とその用途 |
| JPH0797361A (ja) * | 1993-06-30 | 1995-04-11 | Nippon Mejifuijitsukusu Kk | 新規なキレート形成性化合物とその用途 |
| US5690904A (en) * | 1993-07-12 | 1997-11-25 | Amersham International Plc | Diagnostic radiopharmaceutical compounds (That) |
| JPH0748366A (ja) * | 1993-07-30 | 1995-02-21 | Kanebo Ltd | 共役二重結合鎖を有するスルホン化ジアリールエテン系化合物 |
| TW325458B (en) * | 1993-09-08 | 1998-01-21 | Ajinomoto Kk | Stilbene derivatives and pharmaceutical compositions comprising the same for anti-cancer |
| JPH07330762A (ja) * | 1994-06-08 | 1995-12-19 | Kanebo Ltd | キノリル基を有するジアリールエテン系化合物 |
| US5601801A (en) * | 1994-08-02 | 1997-02-11 | Merck Frosst Canada, Inc. | Radiolabelled angiotensin converting enzyme inhibitors |
| JP2000219674A (ja) * | 1999-01-29 | 2000-08-08 | Daiichi Radioisotope Labs Ltd | 新規アラルキルグアニジン化合物 |
| CN1299777C (zh) * | 2001-08-27 | 2007-02-14 | 宾夕法尼亚州大学理事会 | 茋衍生物及其用于结合和成像淀粉样蛋白斑的用途 |
| EP2213652B1 (en) * | 2004-12-17 | 2014-10-22 | The Trustees of The University of Pennsylvania | Stilbene derivatives and their use for binding and imaging amyloid plaques |
| US7858072B2 (en) * | 2004-12-17 | 2010-12-28 | The Trustees Of The University Of Pennsylvania | Stilbene derivatives and their use for binding and imaging amyloid plaques |
-
2002
- 2002-08-27 CN CNB028168291A patent/CN1299777C/zh not_active Expired - Fee Related
- 2002-08-27 AU AU2002323417A patent/AU2002323417B2/en not_active Ceased
- 2002-08-27 CN CN2007100789205A patent/CN101003526B/zh not_active Expired - Fee Related
- 2002-08-27 WO PCT/US2002/027201 patent/WO2003018070A1/en not_active Ceased
- 2002-08-27 DK DK02757398.9T patent/DK1432453T3/da active
- 2002-08-27 KR KR1020047002943A patent/KR100947913B1/ko not_active Expired - Fee Related
- 2002-08-27 EP EP02757398.9A patent/EP1432453B1/en not_active Expired - Lifetime
- 2002-08-27 TW TW091119424A patent/TWI267381B/zh not_active IP Right Cessation
- 2002-08-27 JP JP2003522585A patent/JP4436928B2/ja not_active Expired - Fee Related
- 2002-08-27 CA CA2456411A patent/CA2456411C/en not_active Expired - Fee Related
- 2002-08-27 ES ES02757398T patent/ES2435070T3/es not_active Expired - Lifetime
- 2002-08-27 US US10/228,275 patent/US7250525B2/en not_active Expired - Fee Related
-
2005
- 2005-09-06 US US11/218,587 patent/US7297820B2/en not_active Expired - Fee Related
-
2007
- 2007-10-29 US US11/926,319 patent/US7759502B2/en not_active Expired - Fee Related
-
2008
- 2008-08-13 AU AU2008203856A patent/AU2008203856B8/en not_active Ceased
-
2009
- 2009-06-11 JP JP2009140609A patent/JP2009197037A/ja active Pending
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