JP2005501881A5 - - Google Patents
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- Publication number
- JP2005501881A5 JP2005501881A5 JP2003524523A JP2003524523A JP2005501881A5 JP 2005501881 A5 JP2005501881 A5 JP 2005501881A5 JP 2003524523 A JP2003524523 A JP 2003524523A JP 2003524523 A JP2003524523 A JP 2003524523A JP 2005501881 A5 JP2005501881 A5 JP 2005501881A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- group
- linear
- branched
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31583201P | 2001-08-29 | 2001-08-29 | |
| PCT/US2002/026990 WO2003020209A2 (en) | 2001-08-29 | 2002-08-23 | Processes for the production of alpha-difluoromethyl ornithine (dfmo) |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005501881A JP2005501881A (ja) | 2005-01-20 |
| JP2005501881A5 true JP2005501881A5 (https=) | 2005-12-22 |
Family
ID=23226251
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003524523A Pending JP2005501881A (ja) | 2001-08-29 | 2002-08-23 | α−ジフルオロメチルオルニチン（ＤＦＭＯ）の製造方法 |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US6730809B2 (https=) |
| EP (1) | EP1421058B1 (https=) |
| JP (1) | JP2005501881A (https=) |
| KR (1) | KR100668473B1 (https=) |
| CN (2) | CN1279019C (https=) |
| AR (1) | AR038450A1 (https=) |
| AT (1) | ATE466836T1 (https=) |
| AU (1) | AU2002331714B2 (https=) |
| BR (1) | BR0212153A (https=) |
| CA (1) | CA2457854C (https=) |
| DE (1) | DE60236295D1 (https=) |
| IL (2) | IL160314A0 (https=) |
| MX (1) | MXPA04001837A (https=) |
| NZ (1) | NZ531331A (https=) |
| RU (1) | RU2004108856A (https=) |
| WO (1) | WO2003020209A2 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7261878B2 (en) | 2001-08-10 | 2007-08-28 | The Gillette Company | Reduction of hair growth |
| US6730809B2 (en) * | 2001-08-29 | 2004-05-04 | Women First Healthcare, Inc. | Processes for the production of α-difluoromethyl ornithine (DFMO) |
| US7015349B2 (en) | 2003-03-26 | 2006-03-21 | The Gillette Company | Reduction of hair growth |
| US20100120727A1 (en) * | 2008-11-12 | 2010-05-13 | Kyphia Pharmaceuticals, Inc. | Eflornithine Prodrugs, Conjugates and Salts, and Methods of Use Thereof |
| US20130197088A1 (en) * | 2010-03-12 | 2013-08-01 | Robert A. Casero, JR. | Compositions and Methods for Combinations of Oligoamines with 2-Difluoromethylornithine (DFMO) |
| JP2012116776A (ja) * | 2010-11-30 | 2012-06-21 | Kyoto Univ | ホスホン酸ジエステル誘導体の製造法 |
| CN103724218B (zh) * | 2014-01-22 | 2015-08-12 | 呼伦贝尔东北阜丰生物科技有限公司 | 一种赖氨酸盐酸盐结晶新工艺 |
| CN105017244A (zh) * | 2014-04-16 | 2015-11-04 | 上海药明康德新药开发有限公司 | 顺反叔丁基-4-氧六氢化-1H-吡咯[3,4-c]吡啶-2(3H)-羧酸叔丁酯的合成方法 |
| CA2976106A1 (en) * | 2015-02-12 | 2016-08-18 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Methods for treating neuroblastoma |
| CN105660637B (zh) * | 2016-01-07 | 2018-04-24 | 南京中医药大学 | 防治当归早薹的药物及其应用 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4201788A (en) | 1976-10-20 | 1980-05-06 | University Patents, Inc. | Process for alleviating proliferative skin diseases |
| US4413141A (en) | 1977-07-11 | 1983-11-01 | Merrell Toraude Et Compagnie | 2-(Difluoromethyl)-2,5-diaminopentanoic acid |
| US4309442A (en) | 1977-07-11 | 1982-01-05 | Merrell Toraude Et Compagnie | Method for controlling fertility in mammals |
| US4421768A (en) | 1982-08-11 | 1983-12-20 | Merrell Toraude Et Compagnie | Fluorinated diamino-heptene and-heptyne derivatives |
| US4720489A (en) | 1984-10-15 | 1988-01-19 | Douglas Shander | Hair growth modification with ornithine decarboxylase inhibitors |
| CH672124A5 (en) | 1987-07-03 | 1989-10-31 | Lonza Ag | 2-di:fluoromethyl-2-cyanoethyl malonic acid lower alkyl ester(s) - obtd. by reacting di:alkyl-malonate with acrylonitrile, then with chloro:fluoromethane in presence of alkali, etc |
| US5096911A (en) | 1990-06-25 | 1992-03-17 | Ahluwalia Gurpreet S | Alteration of rate and character of hair growth |
| DE69128034T2 (de) | 1990-08-14 | 1998-04-16 | Handelman Joseph H | Enzymatische änderung des haarwuchses |
| US5095007A (en) | 1990-10-24 | 1992-03-10 | Ahluwalia Gurpreet S | Alteration of rate and character of hair growth |
| US5648394A (en) | 1993-05-27 | 1997-07-15 | Boxall; Brian Alfred | Topical composition for inhibiting hair growth |
| US5851537A (en) | 1996-02-02 | 1998-12-22 | Cancer Technologies, Inc. | Topical application of α-DFMO for preventing skin cancer |
| AU5526898A (en) | 1996-12-13 | 1998-07-03 | Ilex Oncology, Inc. | Isomeric pharmaceutical formulation containing dfmo for the treatment of cancer |
| US6730809B2 (en) * | 2001-08-29 | 2004-05-04 | Women First Healthcare, Inc. | Processes for the production of α-difluoromethyl ornithine (DFMO) |
-
2002
- 2002-08-19 US US10/224,890 patent/US6730809B2/en not_active Expired - Lifetime
- 2002-08-23 KR KR1020047002674A patent/KR100668473B1/ko not_active Expired - Fee Related
- 2002-08-23 IL IL16031402A patent/IL160314A0/xx unknown
- 2002-08-23 DE DE60236295T patent/DE60236295D1/de not_active Expired - Lifetime
- 2002-08-23 BR BR0212153-0A patent/BR0212153A/pt not_active IP Right Cessation
- 2002-08-23 AU AU2002331714A patent/AU2002331714B2/en not_active Ceased
- 2002-08-23 JP JP2003524523A patent/JP2005501881A/ja active Pending
- 2002-08-23 WO PCT/US2002/026990 patent/WO2003020209A2/en not_active Ceased
- 2002-08-23 RU RU2004108856/04A patent/RU2004108856A/ru not_active Application Discontinuation
- 2002-08-23 EP EP02768695A patent/EP1421058B1/en not_active Expired - Lifetime
- 2002-08-23 CN CNB028196414A patent/CN1279019C/zh not_active Expired - Fee Related
- 2002-08-23 CA CA002457854A patent/CA2457854C/en not_active Expired - Fee Related
- 2002-08-23 NZ NZ531331A patent/NZ531331A/en not_active IP Right Cessation
- 2002-08-23 AT AT02768695T patent/ATE466836T1/de not_active IP Right Cessation
- 2002-08-23 CN CNB2005100709165A patent/CN100478329C/zh not_active Expired - Fee Related
- 2002-08-23 MX MXPA04001837A patent/MXPA04001837A/es unknown
- 2002-08-29 AR ARP020103242A patent/AR038450A1/es unknown
-
2004
- 2004-02-10 IL IL160314A patent/IL160314A/en not_active IP Right Cessation
- 2004-02-26 US US10/788,728 patent/US7012158B2/en not_active Expired - Lifetime
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