JP2005501881A - α−ジフルオロメチルオルニチン（ＤＦＭＯ）の製造方法 - Google Patents

α−ジフルオロメチルオルニチン（ＤＦＭＯ）の製造方法 Download PDF

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JP2005501881A
JP2005501881A JP2003524523A JP2003524523A JP2005501881A JP 2005501881 A JP2005501881 A JP 2005501881A JP 2003524523 A JP2003524523 A JP 2003524523A JP 2003524523 A JP2003524523 A JP 2003524523A JP 2005501881 A JP2005501881 A JP 2005501881A
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formula
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JP2005501881A5 (https=
Inventor
ジンヤン・ツー
スコット・ティ・チャドウィック
ベンジャミン・エー・プライス
シャノン・エックス・ツァオ
カリー・エー・カステロ
プルショタム・ヴェミシェッティ
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ウィメン・ファースト・ヘルスケアー・インコーポレーテッド
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Publication of JP2005501881A publication Critical patent/JP2005501881A/ja
Publication of JP2005501881A5 publication Critical patent/JP2005501881A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/26—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing carboxyl groups by reaction with HCN, or a salt thereof, and amines, or from aminonitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/24—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton
    • C07C255/29—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton containing cyano groups and acylated amino groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/04—Formation of amino groups in compounds containing carboxyl groups
    • C07C227/10—Formation of amino groups in compounds containing carboxyl groups with simultaneously increasing the number of carbon atoms in the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/22—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from lactams, cyclic ketones or cyclic oximes, e.g. by reactions involving Beckmann rearrangement
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/38—Separation; Purification; Stabilisation; Use of additives
    • C07C227/40—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/38—Separation; Purification; Stabilisation; Use of additives
    • C07C227/40—Separation; Purification
    • C07C227/42—Crystallisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/24—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton
    • C07C255/28—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton containing cyano groups, amino groups and carboxyl groups, other than cyano groups, bound to the carbon skeleton

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Hydrogenated Pyridines (AREA)
JP2003524523A 2001-08-29 2002-08-23 α−ジフルオロメチルオルニチン（ＤＦＭＯ）の製造方法 Pending JP2005501881A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US31583201P 2001-08-29 2001-08-29
PCT/US2002/026990 WO2003020209A2 (en) 2001-08-29 2002-08-23 Processes for the production of alpha-difluoromethyl ornithine (dfmo)

Publications (2)

Publication Number Publication Date
JP2005501881A true JP2005501881A (ja) 2005-01-20
JP2005501881A5 JP2005501881A5 (https=) 2005-12-22

Family

ID=23226251

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2003524523A Pending JP2005501881A (ja) 2001-08-29 2002-08-23 α−ジフルオロメチルオルニチン（ＤＦＭＯ）の製造方法

Country Status (16)

Country Link
US (2) US6730809B2 (https=)
EP (1) EP1421058B1 (https=)
JP (1) JP2005501881A (https=)
KR (1) KR100668473B1 (https=)
CN (2) CN1279019C (https=)
AR (1) AR038450A1 (https=)
AT (1) ATE466836T1 (https=)
AU (1) AU2002331714B2 (https=)
BR (1) BR0212153A (https=)
CA (1) CA2457854C (https=)
DE (1) DE60236295D1 (https=)
IL (2) IL160314A0 (https=)
MX (1) MXPA04001837A (https=)
NZ (1) NZ531331A (https=)
RU (1) RU2004108856A (https=)
WO (1) WO2003020209A2 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012116776A (ja) * 2010-11-30 2012-06-21 Kyoto Univ ホスホン酸ジエステル誘導体の製造法
JP2018507910A (ja) * 2015-02-12 2018-03-22 ジ・アリゾナ・ボード・オブ・リージェンツ・オン・ビハーフ・オブ・ジ・ユニバーシティ・オブ・アリゾナ 神経芽細胞腫を治療する方法

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7261878B2 (en) 2001-08-10 2007-08-28 The Gillette Company Reduction of hair growth
US6730809B2 (en) * 2001-08-29 2004-05-04 Women First Healthcare, Inc. Processes for the production of α-difluoromethyl ornithine (DFMO)
US7015349B2 (en) 2003-03-26 2006-03-21 The Gillette Company Reduction of hair growth
US20100120727A1 (en) * 2008-11-12 2010-05-13 Kyphia Pharmaceuticals, Inc. Eflornithine Prodrugs, Conjugates and Salts, and Methods of Use Thereof
US20130197088A1 (en) * 2010-03-12 2013-08-01 Robert A. Casero, JR. Compositions and Methods for Combinations of Oligoamines with 2-Difluoromethylornithine (DFMO)
CN103724218B (zh) * 2014-01-22 2015-08-12 呼伦贝尔东北阜丰生物科技有限公司 一种赖氨酸盐酸盐结晶新工艺
CN105017244A (zh) * 2014-04-16 2015-11-04 上海药明康德新药开发有限公司 顺反叔丁基-4-氧六氢化-1H-吡咯[3,4-c]吡啶-2(3H)-羧酸叔丁酯的合成方法
CN105660637B (zh) * 2016-01-07 2018-04-24 南京中医药大学 防治当归早薹的药物及其应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4201788A (en) 1976-10-20 1980-05-06 University Patents, Inc. Process for alleviating proliferative skin diseases
US4413141A (en) 1977-07-11 1983-11-01 Merrell Toraude Et Compagnie 2-(Difluoromethyl)-2,5-diaminopentanoic acid
US4309442A (en) 1977-07-11 1982-01-05 Merrell Toraude Et Compagnie Method for controlling fertility in mammals
US4421768A (en) 1982-08-11 1983-12-20 Merrell Toraude Et Compagnie Fluorinated diamino-heptene and-heptyne derivatives
US4720489A (en) 1984-10-15 1988-01-19 Douglas Shander Hair growth modification with ornithine decarboxylase inhibitors
CH672124A5 (en) 1987-07-03 1989-10-31 Lonza Ag 2-di:fluoromethyl-2-cyanoethyl malonic acid lower alkyl ester(s) - obtd. by reacting di:alkyl-malonate with acrylonitrile, then with chloro:fluoromethane in presence of alkali, etc
US5096911A (en) 1990-06-25 1992-03-17 Ahluwalia Gurpreet S Alteration of rate and character of hair growth
DE69128034T2 (de) 1990-08-14 1998-04-16 Handelman Joseph H Enzymatische änderung des haarwuchses
US5095007A (en) 1990-10-24 1992-03-10 Ahluwalia Gurpreet S Alteration of rate and character of hair growth
US5648394A (en) 1993-05-27 1997-07-15 Boxall; Brian Alfred Topical composition for inhibiting hair growth
US5851537A (en) 1996-02-02 1998-12-22 Cancer Technologies, Inc. Topical application of α-DFMO for preventing skin cancer
AU5526898A (en) 1996-12-13 1998-07-03 Ilex Oncology, Inc. Isomeric pharmaceutical formulation containing dfmo for the treatment of cancer
US6730809B2 (en) * 2001-08-29 2004-05-04 Women First Healthcare, Inc. Processes for the production of α-difluoromethyl ornithine (DFMO)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012116776A (ja) * 2010-11-30 2012-06-21 Kyoto Univ ホスホン酸ジエステル誘導体の製造法
JP2018507910A (ja) * 2015-02-12 2018-03-22 ジ・アリゾナ・ボード・オブ・リージェンツ・オン・ビハーフ・オブ・ジ・ユニバーシティ・オブ・アリゾナ 神経芽細胞腫を治療する方法
US12582625B2 (en) 2015-02-12 2026-03-24 Uswm, Llc Methods for treating neuroblastoma

Also Published As

Publication number Publication date
RU2004108856A (ru) 2005-09-20
EP1421058B1 (en) 2010-05-05
AU2002331714B2 (en) 2007-11-01
WO2003020209A3 (en) 2004-03-04
IL160314A0 (en) 2004-07-25
CN1564806A (zh) 2005-01-12
CA2457854A1 (en) 2003-03-13
EP1421058A4 (en) 2006-02-08
CN1680293A (zh) 2005-10-12
US20040171876A1 (en) 2004-09-02
AR038450A1 (es) 2005-01-19
CN100478329C (zh) 2009-04-15
CA2457854C (en) 2006-10-31
IL160314A (en) 2009-11-18
US6730809B2 (en) 2004-05-04
US7012158B2 (en) 2006-03-14
HK1083213A1 (zh) 2006-06-30
US20030083384A1 (en) 2003-05-01
CN1279019C (zh) 2006-10-11
EP1421058A2 (en) 2004-05-26
DE60236295D1 (de) 2010-06-17
WO2003020209A2 (en) 2003-03-13
KR20040064258A (ko) 2004-07-16
ATE466836T1 (de) 2010-05-15
BR0212153A (pt) 2004-07-13
NZ531331A (en) 2004-06-25
MXPA04001837A (es) 2005-04-19
KR100668473B1 (ko) 2007-01-12

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