IL160314A0 - Processes for the production of alpha-difluoromethyl ornithine (dfmo) - Google Patents

Processes for the production of alpha-difluoromethyl ornithine (dfmo)

Info

Publication number
IL160314A0
IL160314A0 IL16031402A IL16031402A IL160314A0 IL 160314 A0 IL160314 A0 IL 160314A0 IL 16031402 A IL16031402 A IL 16031402A IL 16031402 A IL16031402 A IL 16031402A IL 160314 A0 IL160314 A0 IL 160314A0
Authority
IL
Israel
Prior art keywords
dfmo
alpha
processes
production
difluoromethyl ornithine
Prior art date
Application number
IL16031402A
Other languages
English (en)
Original Assignee
Women First Healthcare Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Women First Healthcare Inc filed Critical Women First Healthcare Inc
Publication of IL160314A0 publication Critical patent/IL160314A0/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/26Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing carboxyl groups by reaction with HCN, or a salt thereof, and amines, or from aminonitriles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00Carboxylic acid nitriles
    • C07C255/01Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/24Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton
    • C07C255/29Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton containing cyano groups and acylated amino groups bound to the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/04Formation of amino groups in compounds containing carboxyl groups
    • C07C227/10Formation of amino groups in compounds containing carboxyl groups with simultaneously increasing the number of carbon atoms in the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/16Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/22Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from lactams, cyclic ketones or cyclic oximes, e.g. by reactions involving Beckmann rearrangement
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/38Separation; Purification; Stabilisation; Use of additives
    • C07C227/40Separation; Purification
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/38Separation; Purification; Stabilisation; Use of additives
    • C07C227/40Separation; Purification
    • C07C227/42Crystallisation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00Preparation of carboxylic acid nitriles
    • C07C253/30Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00Carboxylic acid nitriles
    • C07C255/01Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/24Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton
    • C07C255/28Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton containing cyano groups, amino groups and carboxyl groups, other than cyano groups, bound to the carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Hydrogenated Pyridines (AREA)
IL16031402A 2001-08-29 2002-08-23 Processes for the production of alpha-difluoromethyl ornithine (dfmo) IL160314A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US31583201P 2001-08-29 2001-08-29
PCT/US2002/026990 WO2003020209A2 (en) 2001-08-29 2002-08-23 Processes for the production of alpha-difluoromethyl ornithine (dfmo)

Publications (1)

Publication Number Publication Date
IL160314A0 true IL160314A0 (en) 2004-07-25

Family

ID=23226251

Family Applications (2)

Application Number Title Priority Date Filing Date
IL16031402A IL160314A0 (en) 2001-08-29 2002-08-23 Processes for the production of alpha-difluoromethyl ornithine (dfmo)
IL160314A IL160314A (en) 2001-08-29 2004-02-10 Processes for the production of alpha-difluoromethyl ornithine (dfmo) and novel intermediates thereof

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL160314A IL160314A (en) 2001-08-29 2004-02-10 Processes for the production of alpha-difluoromethyl ornithine (dfmo) and novel intermediates thereof

Country Status (17)

Country Link
US (2) US6730809B2 (xx)
EP (1) EP1421058B1 (xx)
JP (1) JP2005501881A (xx)
KR (1) KR100668473B1 (xx)
CN (2) CN100478329C (xx)
AR (1) AR038450A1 (xx)
AT (1) ATE466836T1 (xx)
AU (1) AU2002331714B2 (xx)
BR (1) BR0212153A (xx)
CA (1) CA2457854C (xx)
DE (1) DE60236295D1 (xx)
HK (1) HK1083213A1 (xx)
IL (2) IL160314A0 (xx)
MX (1) MXPA04001837A (xx)
NZ (1) NZ531331A (xx)
RU (1) RU2004108856A (xx)
WO (1) WO2003020209A2 (xx)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7261878B2 (en) 2001-08-10 2007-08-28 The Gillette Company Reduction of hair growth
US6730809B2 (en) * 2001-08-29 2004-05-04 Women First Healthcare, Inc. Processes for the production of α-difluoromethyl ornithine (DFMO)
US7015349B2 (en) * 2003-03-26 2006-03-21 The Gillette Company Reduction of hair growth
US20100120727A1 (en) * 2008-11-12 2010-05-13 Kyphia Pharmaceuticals, Inc. Eflornithine Prodrugs, Conjugates and Salts, and Methods of Use Thereof
WO2011113005A2 (en) * 2010-03-12 2011-09-15 The Johns Hopkins University Compositions and methods for combinations of oligoamines with 2-difluoromethylornithine (dfmo)
JP2012116776A (ja) * 2010-11-30 2012-06-21 Kyoto Univ ホスホン酸ジエステル誘導体の製造法
CN103724218B (zh) * 2014-01-22 2015-08-12 呼伦贝尔东北阜丰生物科技有限公司 一种赖氨酸盐酸盐结晶新工艺
CN105017244A (zh) * 2014-04-16 2015-11-04 上海药明康德新药开发有限公司 顺反叔丁基-4-氧六氢化-1H-吡咯[3,4-c]吡啶-2(3H)-羧酸叔丁酯的合成方法
JP2018507910A (ja) * 2015-02-12 2018-03-22 ジ・アリゾナ・ボード・オブ・リージェンツ・オン・ビハーフ・オブ・ジ・ユニバーシティ・オブ・アリゾナ 神経芽細胞腫を治療する方法
CN105660637B (zh) * 2016-01-07 2018-04-24 南京中医药大学 防治当归早薹的药物及其应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4201788A (en) 1976-10-20 1980-05-06 University Patents, Inc. Process for alleviating proliferative skin diseases
US4309442A (en) 1977-07-11 1982-01-05 Merrell Toraude Et Compagnie Method for controlling fertility in mammals
US4413141A (en) 1977-07-11 1983-11-01 Merrell Toraude Et Compagnie 2-(Difluoromethyl)-2,5-diaminopentanoic acid
US4421768A (en) 1982-08-11 1983-12-20 Merrell Toraude Et Compagnie Fluorinated diamino-heptene and-heptyne derivatives
US4720489A (en) 1984-10-15 1988-01-19 Douglas Shander Hair growth modification with ornithine decarboxylase inhibitors
CH672124A5 (en) 1987-07-03 1989-10-31 Lonza Ag 2-di:fluoromethyl-2-cyanoethyl malonic acid lower alkyl ester(s) - obtd. by reacting di:alkyl-malonate with acrylonitrile, then with chloro:fluoromethane in presence of alkali, etc
US5096911A (en) 1990-06-25 1992-03-17 Ahluwalia Gurpreet S Alteration of rate and character of hair growth
ES2109949T3 (es) 1990-08-14 1998-02-01 Joseph H Handelman Alteracion enzimatica del crecimiento del pelo.
US5095007A (en) 1990-10-24 1992-03-10 Ahluwalia Gurpreet S Alteration of rate and character of hair growth
US5648394A (en) 1993-05-27 1997-07-15 Boxall; Brian Alfred Topical composition for inhibiting hair growth
US5851537A (en) 1996-02-02 1998-12-22 Cancer Technologies, Inc. Topical application of α-DFMO for preventing skin cancer
AU5526898A (en) 1996-12-13 1998-07-03 Ilex Oncology, Inc. Isomeric pharmaceutical formulation containing dfmo for the treatment of cancer
US6730809B2 (en) * 2001-08-29 2004-05-04 Women First Healthcare, Inc. Processes for the production of α-difluoromethyl ornithine (DFMO)

Also Published As

Publication number Publication date
WO2003020209A2 (en) 2003-03-13
EP1421058A2 (en) 2004-05-26
AU2002331714B2 (en) 2007-11-01
HK1083213A1 (en) 2006-06-30
WO2003020209A3 (en) 2004-03-04
US7012158B2 (en) 2006-03-14
CN1680293A (zh) 2005-10-12
EP1421058A4 (en) 2006-02-08
CN100478329C (zh) 2009-04-15
US20030083384A1 (en) 2003-05-01
BR0212153A (pt) 2004-07-13
MXPA04001837A (es) 2005-04-19
ATE466836T1 (de) 2010-05-15
CN1564806A (zh) 2005-01-12
DE60236295D1 (de) 2010-06-17
AR038450A1 (es) 2005-01-19
NZ531331A (en) 2004-06-25
KR20040064258A (ko) 2004-07-16
US6730809B2 (en) 2004-05-04
JP2005501881A (ja) 2005-01-20
CA2457854A1 (en) 2003-03-13
IL160314A (en) 2009-11-18
EP1421058B1 (en) 2010-05-05
US20040171876A1 (en) 2004-09-02
KR100668473B1 (ko) 2007-01-12
CA2457854C (en) 2006-10-31
RU2004108856A (ru) 2005-09-20
CN1279019C (zh) 2006-10-11

Similar Documents

Publication Publication Date Title
IL157478A0 (en) Method for the synthesis of 2', 3'-didehydronucleosides
IL166710A0 (en) Process for the preparation of 4-ÄÄ4-ÄÄ-(2-cyanoethenyl)2,6-dimethylphenylÜaminoÜ-2-pyrimidinylÜaminoÜbenzonitrile
IL159030A0 (en) Process for the preparation of prostaglandins and analogues thereof
EP1432721A4 (en) PROCESS FOR THE PREPARATION OF REBECCAMYCIN AND ANALOGUE THEREOF
HUP0402027A3 (en) Process for the preparation of a xantophyll
EG22992A (en) Process for the preparation of urea
PL368600A1 (en) Process for the preparation of tolterodine
HK1083213A1 (en) Intermediates useful for the preparation of alpha-difluoromethyl ornithine (dfmo) and processes for preparation the same
IL143106A (en) Process for the preparation of diphenylmethylthioacetamide
SI1423360T1 (sl) Postopek za izdelavo cilastatina
SG120874A1 (en) Process for the preparation of peptides
IL157709A0 (en) Process for the preparation of 1,2-benzisoxazole-3-acetic acid
IL159836A0 (en) Process for obtaining n-monosubstituted amides
IL162059A0 (en) Process for the synthesis of -amino- chirally purealcohols
PL364554A1 (en) Process for the production of nylon 6
HUP0201837A3 (en) Process for preparation n-carboxy-anhydrides
PL370705A1 (en) Process for the preparation of imipenem
HUP0401577A3 (en) Process for the preparation of 2,4-didezoxyhexoses and 2,4,6-tridezoxyhexoses
HUP0303025A3 (en) Process for the preparation of arylethanoldiamines
IL162770A0 (en) Process for the preparation methylsteroids of 7
EP1295864A4 (en) PROCESS FOR THE PREPARATION OF 1,5-DIAMINONAPHTHALINES
MXPA03009210A (es) PROCEDIMIENTO PARA LA PREPARACIoN DE OXABISPIDINAS.
IL164788A0 (en) Process for the preparation of 3-isochromanone
PL368905A1 (en) Process for the preparation of beta-ionylideneacetaldehyde
GB0113667D0 (en) Process for the preparation of endo-5-norbornene-2-ol