JP2005501093A5 - - Google Patents
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- Publication number
- JP2005501093A5 JP2005501093A5 JP2003519076A JP2003519076A JP2005501093A5 JP 2005501093 A5 JP2005501093 A5 JP 2005501093A5 JP 2003519076 A JP2003519076 A JP 2003519076A JP 2003519076 A JP2003519076 A JP 2003519076A JP 2005501093 A5 JP2005501093 A5 JP 2005501093A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- alkyl
- hydrogen
- formula
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0119243.4A GB0119243D0 (en) | 2001-08-07 | 2001-08-07 | Antitumoral analogs of ET-743 |
| PCT/GB2002/003592 WO2003014127A1 (en) | 2001-08-07 | 2002-08-06 | Antitumoral analogs |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010209928A Division JP2011026331A (ja) | 2001-08-07 | 2010-09-17 | 抗腫瘍類似体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005501093A JP2005501093A (ja) | 2005-01-13 |
| JP2005501093A5 true JP2005501093A5 (https=) | 2010-11-18 |
| JP4684552B2 JP4684552B2 (ja) | 2011-05-18 |
Family
ID=9919954
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003519076A Expired - Lifetime JP4684552B2 (ja) | 2001-08-07 | 2002-08-06 | 抗腫瘍類似体 |
| JP2010209928A Pending JP2011026331A (ja) | 2001-08-07 | 2010-09-17 | 抗腫瘍類似体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010209928A Pending JP2011026331A (ja) | 2001-08-07 | 2010-09-17 | 抗腫瘍類似体 |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US7763615B2 (https=) |
| EP (3) | EP1806349A1 (https=) |
| JP (2) | JP4684552B2 (https=) |
| KR (1) | KR20040032150A (https=) |
| CN (1) | CN100334094C (https=) |
| AT (1) | ATE374777T1 (https=) |
| AU (1) | AU2002313540B2 (https=) |
| CA (1) | CA2455768C (https=) |
| CY (1) | CY1107830T1 (https=) |
| DE (1) | DE60222775T2 (https=) |
| DK (1) | DK1414828T3 (https=) |
| ES (1) | ES2294151T3 (https=) |
| GB (1) | GB0119243D0 (https=) |
| HU (1) | HU229779B1 (https=) |
| IL (2) | IL160051A0 (https=) |
| MX (1) | MXPA04001240A (https=) |
| NO (1) | NO337476B1 (https=) |
| NZ (1) | NZ530837A (https=) |
| PL (1) | PL218295B1 (https=) |
| PT (1) | PT1414828E (https=) |
| RU (1) | RU2283842C2 (https=) |
| WO (1) | WO2003014127A1 (https=) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0202544D0 (en) * | 2002-02-04 | 2002-03-20 | Pharma Mar Sa | The synthesis of naturally occuring ecteinascidins and related compounds |
| KR101614723B1 (ko) | 2008-01-11 | 2016-04-22 | 알바니 몰레큘라 리써치, 인크. | Ｍｃｈ 길항물질로서 (1-아지논)-치환된 피리도인돌 |
| US8618299B2 (en) * | 2009-07-01 | 2013-12-31 | Albany Molecular Research, Inc. | Azinone-substituted azapolycycle MCH-1 antagonists, methods of making, and use thereof |
| JP2012532144A (ja) * | 2009-07-01 | 2012-12-13 | アルバニー モレキュラー リサーチ， インコーポレイテッド | アジノン置換アゼピノ［ｂ］インドールおよびピリド−ピロロ−アゼピンｍｃｈ−１拮抗薬、ならびにその作製方法および使用 |
| WO2011003007A1 (en) * | 2009-07-01 | 2011-01-06 | Albany Molecular Research, Inc. | Azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine mch-1 antagonists, methods of making, and use thereof |
| US9073925B2 (en) * | 2009-07-01 | 2015-07-07 | Albany Molecular Research, Inc. | Azinone-substituted azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine MCH-1 antagonists, methods of making, and use thereof |
| CN103038240A (zh) * | 2010-05-25 | 2013-04-10 | 法马马有限公司 | 制备海鞘素化合物的合成方法 |
| RS54648B1 (sr) * | 2010-11-12 | 2016-08-31 | Pharma Mar S.A. | Kombinovana terapija sa antitumorskim alkaloidom |
| PL3057323T3 (pl) | 2010-11-26 | 2018-11-30 | Nec Corporation | Urządzenie do dekodowania wideo, sposób dekodowania wideo oraz program |
| US8993765B2 (en) | 2010-12-21 | 2015-03-31 | Albany Molecular Research, Inc. | Tetrahydro-azacarboline MCH-1 antagonists, methods of making, and uses thereof |
| US8697700B2 (en) | 2010-12-21 | 2014-04-15 | Albany Molecular Research, Inc. | Piperazinone-substituted tetrahydro-carboline MCH-1 antagonists, methods of making, and uses thereof |
| WO2017067670A1 (en) | 2015-10-23 | 2017-04-27 | Pharmathen S.A. | A novel process for the preparation of tryptamines and derivatives thereof |
| KR102491180B1 (ko) * | 2017-04-27 | 2023-01-20 | 파르마 마르 에스.에이. | 항종양 화합물 |
| TWI824043B (zh) * | 2018-10-25 | 2023-12-01 | 西班牙商瑪製藥股份有限公司 | 藥物抗體共軛物 |
| CA3148690A1 (en) | 2019-09-03 | 2021-03-11 | Ioannis METAXAS | Lurbinectedin in the treatment of malignant mesothelioma |
| CN112574234B (zh) * | 2019-09-27 | 2022-05-24 | 江苏恒瑞医药股份有限公司 | 一种海鞘素衍生物的制备方法 |
| PE20252386A1 (es) | 2019-11-21 | 2025-10-10 | Pharma Mar Sa | Metodo de tratamiento del cancer de pulmon de celulas pequenas con formulaciones de lurbinectedina |
| MA56827B2 (fr) * | 2019-11-21 | 2023-09-27 | Pharma Mar Sa | Procédés de traitement du cancer du poumon à petites cellules avec des formulations de lurbinectédine |
| WO2021228414A1 (en) | 2020-05-14 | 2021-11-18 | Pharma Mar, S.A. | Methods of treating small cell lung cancer with lurbinectedin formulations |
| CN115427081B (zh) | 2020-04-21 | 2025-12-09 | 法马马有限公司 | 药物抗体共轭物 |
| WO2021218896A1 (zh) * | 2020-04-26 | 2021-11-04 | 江苏恒瑞医药股份有限公司 | 海鞘素类衍生物及其制备方法与医药用途 |
| AU2020466790B2 (en) | 2020-09-04 | 2025-07-10 | Pharma Mar, S.A. | Combination of lurbinectedin and immune checkpoint inhibitor |
| WO2022101255A1 (en) | 2020-11-10 | 2022-05-19 | Pharma Mar, S.A. | Lurbinectedin and irinotecan combinations |
| IN202141039393A (https=) * | 2021-08-31 | 2023-03-03 | ||
| IL312263A (en) | 2021-11-08 | 2024-06-01 | Pharma Mar Sa | Lurbinectedin and atezolizumab combinations |
| CN115246846B (zh) * | 2021-11-19 | 2024-10-01 | 江苏慧聚药业股份有限公司 | 卢比替定新晶型及其制备 |
| CN118388507A (zh) | 2022-04-08 | 2024-07-26 | 上海皓元医药股份有限公司 | 一种卢比替定的晶型及其制备方法 |
| CN114940682A (zh) * | 2022-05-18 | 2022-08-26 | 博瑞制药(苏州)有限公司 | 芦比替定的晶型及其制备方法和用途 |
| WO2024186263A1 (en) * | 2023-03-07 | 2024-09-12 | Axcynsis Therapeutics Pte. Ltd. | Antibody-drug conjugates comprising trabectedin and lurbinectedin derivatives |
| WO2024188978A1 (en) | 2023-03-10 | 2024-09-19 | Pharma Mar, S.A. | Lurbinectedin as mcl-1 inhibitor and combinations thereof for use in treating cancer |
| WO2025059336A1 (en) * | 2023-09-13 | 2025-03-20 | Navinta, Llc | An improved process for preparation of lurbinectedin |
| WO2025077996A1 (en) | 2023-10-09 | 2025-04-17 | Pharma Mar, S.A. | Synthetic process for the manufacture of ecteinascidin compounds |
| EP4563149A1 (en) | 2023-11-30 | 2025-06-04 | Pharma Mar, S.A. | Lurbinectedin, ecubectedin and a related compound for use in the treatment of skin cancers |
| WO2025168075A1 (zh) * | 2024-02-08 | 2025-08-14 | 映恩生物科技(上海)有限公司 | 海鞘素类化合物及其应用 |
| WO2026022359A2 (en) | 2024-07-26 | 2026-01-29 | Pharma Mar, S.A. | Synthetic process for the manufacture of ecteinascidin compounds |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59225189A (ja) | 1983-06-03 | 1984-12-18 | Shionogi & Co Ltd | キノナミン誘導体およびその製造法 |
| JPS6084288A (ja) | 1983-10-13 | 1985-05-13 | Shionogi & Co Ltd | シアノキノナミンアセテ−ト類およびその製造法 |
| US5256663A (en) | 1986-06-09 | 1993-10-26 | The Board Of Trustees Of The University Of Illinois | Compositions comprising ecteinascidins and a method of treating herpes simplex virus infections therewith |
| US5149804A (en) * | 1990-11-30 | 1992-09-22 | The Board Of Trustees Of The University Of Illinois | Ecteinascidins 736 and 722 |
| US5089273A (en) | 1986-06-09 | 1992-02-18 | Board Of Trustees Of The University Of Illinois | Ecteinascidins 729, 743, 745, 759A, 759B and 770 |
| EP0309477B1 (en) | 1986-06-09 | 1991-11-06 | The Board Of Trustees Of The University Of Illinois | Ecteinascidins 729, 743, 745, 759a, 759b and 770 |
| US5478932A (en) | 1993-12-02 | 1995-12-26 | The Board Of Trustees Of The University Of Illinois | Ecteinascidins |
| US5721362A (en) | 1996-09-18 | 1998-02-24 | President And Fellows Of Harvard College | Process for producing ecteinascidin compounds |
| US5985876A (en) | 1997-04-15 | 1999-11-16 | Univ Illinois | Nucleophile substituted ecteinascidins and N-oxide ecteinascidins |
| BR9909488B1 (pt) | 1998-04-06 | 2011-02-08 | ecteinascidinas semi-sintéticas e composição farmacêutica. | |
| CA2331593C (en) | 1998-05-11 | 2008-08-05 | Pharma Mar, S.A. | Metabolites of ecteinascidin 743 |
| US6124292A (en) | 1998-09-30 | 2000-09-26 | President And Fellows Of Harvard College | Synthetic analogs of ecteinascidin-743 |
| AR035842A1 (es) | 1999-05-14 | 2004-07-21 | Pharma Mar Sa | Metodo de hemisintesis para la formacion de compuestos intermediarios y derivados y de estructuras relacionadas con la ecteinascidina y de tetrahidroisoquinolinfenoles y compuestos intermediarios de aplicacion en dicho metodo |
| CA2397597A1 (en) | 2000-01-19 | 2001-07-26 | The Trustees Of Columbia University In The City Of New York | Compounds of the saframycin-ecteinascidin series, uses, and synthesis thereof |
| WO2001077115A1 (en) | 2000-04-12 | 2001-10-18 | Pharma Mar, S.A. | Antitumoral ecteinascidin derivatives |
| MXPA02011319A (es) | 2000-05-15 | 2003-06-06 | Pharma Mar Sa | Analogos antitumorales de ecteinascidina 743. |
-
2001
- 2001-08-07 GB GBGB0119243.4A patent/GB0119243D0/en not_active Ceased
-
2002
- 2002-08-06 MX MXPA04001240A patent/MXPA04001240A/es active IP Right Grant
- 2002-08-06 KR KR10-2004-7001924A patent/KR20040032150A/ko not_active Ceased
- 2002-08-06 ES ES02753134T patent/ES2294151T3/es not_active Expired - Lifetime
- 2002-08-06 RU RU2004106617/04A patent/RU2283842C2/ru active
- 2002-08-06 PL PL367940A patent/PL218295B1/pl unknown
- 2002-08-06 DK DK02753134T patent/DK1414828T3/da active
- 2002-08-06 JP JP2003519076A patent/JP4684552B2/ja not_active Expired - Lifetime
- 2002-08-06 US US10/485,536 patent/US7763615B2/en active Active
- 2002-08-06 EP EP07001308A patent/EP1806349A1/en not_active Ceased
- 2002-08-06 AU AU2002313540A patent/AU2002313540B2/en active Active
- 2002-08-06 EP EP10180740A patent/EP2270018A1/en not_active Withdrawn
- 2002-08-06 AT AT02753134T patent/ATE374777T1/de active
- 2002-08-06 WO PCT/GB2002/003592 patent/WO2003014127A1/en not_active Ceased
- 2002-08-06 CN CNB028196511A patent/CN100334094C/zh not_active Expired - Lifetime
- 2002-08-06 IL IL16005102A patent/IL160051A0/xx unknown
- 2002-08-06 CA CA2455768A patent/CA2455768C/en not_active Expired - Lifetime
- 2002-08-06 NZ NZ530837A patent/NZ530837A/en not_active IP Right Cessation
- 2002-08-06 PT PT02753134T patent/PT1414828E/pt unknown
- 2002-08-06 EP EP02753134A patent/EP1414828B9/en not_active Expired - Lifetime
- 2002-08-06 HU HU0401174A patent/HU229779B1/hu unknown
- 2002-08-06 DE DE60222775T patent/DE60222775T2/de not_active Expired - Lifetime
-
2004
- 2004-01-26 IL IL160051A patent/IL160051A/en active IP Right Grant
- 2004-03-05 NO NO20040961A patent/NO337476B1/no not_active IP Right Cessation
-
2007
- 2007-12-12 CY CY20071101576T patent/CY1107830T1/el unknown
-
2010
- 2010-09-17 JP JP2010209928A patent/JP2011026331A/ja active Pending
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