JP2004536580A5 - - Google Patents
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- Publication number
- JP2004536580A5 JP2004536580A5 JP2002582193A JP2002582193A JP2004536580A5 JP 2004536580 A5 JP2004536580 A5 JP 2004536580A5 JP 2002582193 A JP2002582193 A JP 2002582193A JP 2002582193 A JP2002582193 A JP 2002582193A JP 2004536580 A5 JP2004536580 A5 JP 2004536580A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- domain
- amino acid
- residues
- isolated nucleic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000005557 antagonist Substances 0.000 claims 20
- 238000000034 method Methods 0.000 claims 17
- 125000000539 amino acid group Chemical group 0.000 claims 16
- 210000004027 cell Anatomy 0.000 claims 15
- 108020004707 nucleic acids Proteins 0.000 claims 14
- 102000039446 nucleic acids Human genes 0.000 claims 14
- 150000007523 nucleic acids Chemical class 0.000 claims 14
- 108091026890 Coding region Proteins 0.000 claims 12
- 239000003112 inhibitor Substances 0.000 claims 12
- 150000001413 amino acids Chemical class 0.000 claims 11
- 108010055795 Integrin alpha1beta1 Proteins 0.000 claims 8
- 108010044426 integrins Proteins 0.000 claims 8
- 102000006495 integrins Human genes 0.000 claims 8
- 102100025323 Integrin alpha-1 Human genes 0.000 claims 7
- 108010041341 Integrin alpha1 Proteins 0.000 claims 7
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 4
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 4
- 238000013500 data storage Methods 0.000 claims 4
- 210000004408 hybridoma Anatomy 0.000 claims 4
- 229920001184 polypeptide Polymers 0.000 claims 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims 4
- 102000004196 processed proteins & peptides Human genes 0.000 claims 4
- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims 3
- 239000013078 crystal Substances 0.000 claims 3
- 230000002194 synthesizing effect Effects 0.000 claims 3
- 230000013595 glycosylation Effects 0.000 claims 2
- 238000006206 glycosylation reaction Methods 0.000 claims 2
- 230000035772 mutation Effects 0.000 claims 2
- 230000003936 working memory Effects 0.000 claims 2
- 150000005829 chemical entities Chemical class 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000012636 effector Substances 0.000 claims 1
- 230000006870 function Effects 0.000 claims 1
- 230000002068 genetic effect Effects 0.000 claims 1
- 208000026278 immune system disease Diseases 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- -1 residues Glu192 Chemical class 0.000 claims 1
- 239000011232 storage material Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28379401P | 2001-04-13 | 2001-04-13 | |
| US30368901P | 2001-07-06 | 2001-07-06 | |
| PCT/US2002/011521 WO2002083854A2 (en) | 2001-04-13 | 2002-04-12 | Antibodies to vla-1 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008231431A Division JP2009079047A (ja) | 2001-04-13 | 2008-09-09 | Ｖｌａ−１に対する抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004536580A JP2004536580A (ja) | 2004-12-09 |
| JP2004536580A5 true JP2004536580A5 (enExample) | 2005-12-22 |
| JP4303475B2 JP4303475B2 (ja) | 2009-07-29 |
Family
ID=26962254
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002582193A Expired - Fee Related JP4303475B2 (ja) | 2001-04-13 | 2002-04-12 | Ｖｌａ−１に対する抗体 |
| JP2008231431A Withdrawn JP2009079047A (ja) | 2001-04-13 | 2008-09-09 | Ｖｌａ−１に対する抗体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008231431A Withdrawn JP2009079047A (ja) | 2001-04-13 | 2008-09-09 | Ｖｌａ−１に対する抗体 |
Country Status (29)
| Country | Link |
|---|---|
| US (7) | US7358054B2 (enExample) |
| EP (1) | EP1423431B1 (enExample) |
| JP (2) | JP4303475B2 (enExample) |
| KR (1) | KR100927670B1 (enExample) |
| CN (1) | CN1561345B (enExample) |
| AR (1) | AR036330A1 (enExample) |
| AT (1) | ATE471344T1 (enExample) |
| AU (1) | AU2002258778C1 (enExample) |
| BG (1) | BG66334B1 (enExample) |
| BR (1) | BRPI0209792B8 (enExample) |
| CA (1) | CA2443903C (enExample) |
| CZ (1) | CZ303450B6 (enExample) |
| DE (1) | DE60236735D1 (enExample) |
| EA (1) | EA006705B1 (enExample) |
| EE (1) | EE200300509A (enExample) |
| ES (1) | ES2347532T3 (enExample) |
| GE (1) | GEP20074252B (enExample) |
| HU (1) | HUP0402250A3 (enExample) |
| IL (3) | IL158376A0 (enExample) |
| IS (1) | IS6982A (enExample) |
| MX (1) | MXPA03009390A (enExample) |
| MY (1) | MY138286A (enExample) |
| NO (1) | NO20034554L (enExample) |
| NZ (1) | NZ529494A (enExample) |
| PL (1) | PL367324A1 (enExample) |
| SK (1) | SK288124B6 (enExample) |
| UA (1) | UA83791C2 (enExample) |
| WO (1) | WO2002083854A2 (enExample) |
| YU (1) | YU80903A (enExample) |
Families Citing this family (64)
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| AU2006232287B2 (en) | 2005-03-31 | 2011-10-06 | Chugai Seiyaku Kabushiki Kaisha | Methods for producing polypeptides by regulating polypeptide association |
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| CN102875681A (zh) | 2005-07-08 | 2013-01-16 | 拜奥根Idec马萨诸塞公司 | 抗-αvβ6抗体及其用途 |
| ES2568436T3 (es) * | 2006-03-31 | 2016-04-29 | Chugai Seiyaku Kabushiki Kaisha | Procedimiento para controlar la farmacocinética en sangre de anticuerpos |
| US9670269B2 (en) | 2006-03-31 | 2017-06-06 | Chugai Seiyaku Kabushiki Kaisha | Methods of modifying antibodies for purification of bispecific antibodies |
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| AU2013204572B2 (en) * | 2006-05-25 | 2015-06-18 | Biogen Ma Inc. | Methods of Treating Stroke |
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| MA40764A (fr) | 2014-09-26 | 2017-08-01 | Chugai Pharmaceutical Co Ltd | Agent thérapeutique induisant une cytotoxicité |
| EP3233921B1 (en) | 2014-12-19 | 2021-09-29 | Chugai Seiyaku Kabushiki Kaisha | Anti-c5 antibodies and methods of use |
| EP4600372A3 (en) | 2014-12-19 | 2025-11-19 | Chugai Seiyaku Kabushiki Kaisha | Anti-myostatin antibodies, polypeptides containing variant fc regions, and methods of use |
| KR102605798B1 (ko) | 2015-02-05 | 2023-11-23 | 추가이 세이야쿠 가부시키가이샤 | 이온 농도 의존적 항원 결합 도메인을 포함하는 항체, Fc 영역 개변체, IL-8에 결합하는 항체, 및 그들의 사용 |
| TWI805046B (zh) | 2015-02-27 | 2023-06-11 | 日商中外製藥股份有限公司 | Il-6受體抗體用於製備醫藥組成物的用途 |
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