JP2004533409A - ブロックコポリマを含む薬物送達構成体及び医療器具 - Google Patents

ブロックコポリマを含む薬物送達構成体及び医療器具 Download PDF

Info

Publication number
JP2004533409A
JP2004533409A JP2002549300A JP2002549300A JP2004533409A JP 2004533409 A JP2004533409 A JP 2004533409A JP 2002549300 A JP2002549300 A JP 2002549300A JP 2002549300 A JP2002549300 A JP 2002549300A JP 2004533409 A JP2004533409 A JP 2004533409A
Authority
JP
Japan
Prior art keywords
medical device
block
copolymer
block copolymer
therapeutic agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2002549300A
Other languages
English (en)
Japanese (ja)
Other versions
JP2004533409A5 (enExample
Inventor
ピンチャック、レオナルド
ノット、セピデ
シュワルツ、マーリーン
カマス、カルパナ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boston Scientific Ltd Barbados
Original Assignee
Boston Scientific Ltd Barbados
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boston Scientific Ltd Barbados filed Critical Boston Scientific Ltd Barbados
Publication of JP2004533409A publication Critical patent/JP2004533409A/ja
Publication of JP2004533409A5 publication Critical patent/JP2004533409A5/ja
Withdrawn legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L53/00—Compositions of block copolymers containing at least one sequence of a polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds; Compositions of derivatives of such polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/16—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/048—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/10—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F293/00—Macromolecular compounds obtained by polymerisation on to a macromolecule having groups capable of inducing the formation of new polymer chains bound exclusively at one or both ends of the starting macromolecule
    • C08F293/005—Macromolecular compounds obtained by polymerisation on to a macromolecule having groups capable of inducing the formation of new polymer chains bound exclusively at one or both ends of the starting macromolecule using free radical "living" or "controlled" polymerisation, e.g. using a complexing agent
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F297/00—Macromolecular compounds obtained by successively polymerising different monomer systems using a catalyst of the ionic or coordination type without deactivating the intermediate polymer
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F297/00—Macromolecular compounds obtained by successively polymerising different monomer systems using a catalyst of the ionic or coordination type without deactivating the intermediate polymer
    • C08F297/02—Macromolecular compounds obtained by successively polymerising different monomer systems using a catalyst of the ionic or coordination type without deactivating the intermediate polymer using a catalyst of the anionic type
    • C08F297/04—Macromolecular compounds obtained by successively polymerising different monomer systems using a catalyst of the ionic or coordination type without deactivating the intermediate polymer using a catalyst of the anionic type polymerising vinyl aromatic monomers and conjugated dienes
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L53/00—Compositions of block copolymers containing at least one sequence of a polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds; Compositions of derivatives of such polymers
    • C08L53/02—Compositions of block copolymers containing at least one sequence of a polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds; Compositions of derivatives of such polymers of vinyl-aromatic monomers and conjugated dienes
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D153/00—Coating compositions based on block copolymers containing at least one sequence of a polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds; Coating compositions based on derivatives of such polymers
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D153/00—Coating compositions based on block copolymers containing at least one sequence of a polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds; Coating compositions based on derivatives of such polymers
    • C09D153/02—Vinyl aromatic monomers and conjugated dienes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/416—Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/602—Type of release, e.g. controlled, sustained, slow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/606—Coatings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Polymers & Plastics (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Vascular Medicine (AREA)
  • Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Inorganic Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Materials Engineering (AREA)
  • Dermatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2002549300A 2000-12-12 2001-12-12 ブロックコポリマを含む薬物送達構成体及び医療器具 Withdrawn JP2004533409A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/734,639 US6545097B2 (en) 2000-12-12 2000-12-12 Drug delivery compositions and medical devices containing block copolymer
PCT/US2001/048380 WO2002047731A2 (en) 2000-12-12 2001-12-12 Drug delivery compositions and coated medical devices

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2010136238A Division JP5270617B2 (ja) 2000-12-12 2010-06-15 ブロックコポリマを含む薬物送達構成体及び医療器具

Publications (2)

Publication Number Publication Date
JP2004533409A true JP2004533409A (ja) 2004-11-04
JP2004533409A5 JP2004533409A5 (enExample) 2005-05-26

Family

ID=24952503

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2002549300A Withdrawn JP2004533409A (ja) 2000-12-12 2001-12-12 ブロックコポリマを含む薬物送達構成体及び医療器具
JP2010136238A Expired - Fee Related JP5270617B2 (ja) 2000-12-12 2010-06-15 ブロックコポリマを含む薬物送達構成体及び医療器具

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2010136238A Expired - Fee Related JP5270617B2 (ja) 2000-12-12 2010-06-15 ブロックコポリマを含む薬物送達構成体及び医療器具

Country Status (7)

Country Link
US (4) US6545097B2 (enExample)
EP (1) EP1341565B1 (enExample)
JP (2) JP2004533409A (enExample)
AU (2) AU3085102A (enExample)
CA (1) CA2447900A1 (enExample)
DE (1) DE60121992T2 (enExample)
WO (1) WO2002047731A2 (enExample)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008528121A (ja) * 2005-01-25 2008-07-31 ボストン サイエンティフィック リミティッド 非共有結合型ポリマー含有の薬剤放出領域をもつ医療器具
WO2009041691A1 (ja) 2007-09-28 2009-04-02 Terumo Kabushiki Kaisha 生体内留置物
JP2009530023A (ja) * 2006-03-22 2009-08-27 ボストン サイエンティフィック リミテッド 生分解性ポリマー領域を有する医療デバイス
JP2009538704A (ja) * 2006-06-01 2009-11-12 ボストン サイエンティフィック リミテッド 向上した性能を有する医療用デバイス
JP2013528673A (ja) * 2010-04-16 2013-07-11 ランクセス・インク． ガラス転移温度の高い芯を有する樹木状重合体及びその製造方法

Families Citing this family (475)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8728143B2 (en) 1996-06-06 2014-05-20 Biosensors International Group, Ltd. Endoprosthesis deployment system for treating vascular bifurcations
US7238197B2 (en) 2000-05-30 2007-07-03 Devax, Inc. Endoprosthesis deployment system for treating vascular bifurcations
US7686846B2 (en) 1996-06-06 2010-03-30 Devax, Inc. Bifurcation stent and method of positioning in a body lumen
US7282220B1 (en) * 1996-11-05 2007-10-16 Hsing-Wen Sung Genipin-crosslinked gelatin microspheres as drug carrier
US6273913B1 (en) 1997-04-18 2001-08-14 Cordis Corporation Modified stent useful for delivery of drugs along stent strut
US6776792B1 (en) 1997-04-24 2004-08-17 Advanced Cardiovascular Systems Inc. Coated endovascular stent
US6306166B1 (en) * 1997-08-13 2001-10-23 Scimed Life Systems, Inc. Loading and release of water-insoluble drugs
US20030129215A1 (en) * 1998-09-24 2003-07-10 T-Ram, Inc. Medical devices containing rapamycin analogs
US6890546B2 (en) 1998-09-24 2005-05-10 Abbott Laboratories Medical devices containing rapamycin analogs
JP4612186B2 (ja) * 1998-02-24 2011-01-12 ナビリスト メディカル， インコーポレイテッド 高流速透析カテーテルおよび関連方法
US7208011B2 (en) * 2001-08-20 2007-04-24 Conor Medsystems, Inc. Implantable medical device with drug filled holes
US6241762B1 (en) 1998-03-30 2001-06-05 Conor Medsystems, Inc. Expandable medical device with ductile hinges
US7208010B2 (en) * 2000-10-16 2007-04-24 Conor Medsystems, Inc. Expandable medical device for delivery of beneficial agent
US7713297B2 (en) 1998-04-11 2010-05-11 Boston Scientific Scimed, Inc. Drug-releasing stent with ceramic-containing layer
US20020099438A1 (en) * 1998-04-15 2002-07-25 Furst Joseph G. Irradiated stent coating
US20030040790A1 (en) * 1998-04-15 2003-02-27 Furst Joseph G. Stent coating
US8029561B1 (en) * 2000-05-12 2011-10-04 Cordis Corporation Drug combination useful for prevention of restenosis
ATE466603T1 (de) * 1998-04-27 2010-05-15 Surmodics Inc Bioaktive wirkstoffe freisetzende beschichtungen
US20020188037A1 (en) * 1999-04-15 2002-12-12 Chudzik Stephen J. Method and system for providing bioactive agent release coating
US8070796B2 (en) 1998-07-27 2011-12-06 Icon Interventional Systems, Inc. Thrombosis inhibiting graft
US7967855B2 (en) * 1998-07-27 2011-06-28 Icon Interventional Systems, Inc. Coated medical device
WO2000015273A1 (de) * 1998-09-11 2000-03-23 Gerhard Schmidmaier Biologisch aktive implantate
US7220276B1 (en) * 2000-03-06 2007-05-22 Surmodics, Inc. Endovascular graft coatings
US9522217B2 (en) 2000-03-15 2016-12-20 Orbusneich Medical, Inc. Medical device with coating for capturing genetically-altered cells and methods for using same
US8088060B2 (en) 2000-03-15 2012-01-03 Orbusneich Medical, Inc. Progenitor endothelial cell capturing with a drug eluting implantable medical device
US20050002986A1 (en) * 2000-05-12 2005-01-06 Robert Falotico Drug/drug delivery systems for the prevention and treatment of vascular disease
US7300662B2 (en) 2000-05-12 2007-11-27 Cordis Corporation Drug/drug delivery systems for the prevention and treatment of vascular disease
US8236048B2 (en) * 2000-05-12 2012-08-07 Cordis Corporation Drug/drug delivery systems for the prevention and treatment of vascular disease
AU9486901A (en) 2000-09-29 2002-04-08 Cordis Corp Coated medical devices
EP1582180B1 (en) 2000-10-16 2008-02-27 Conor Medsystems, Inc. Expandable medical device for delivery of beneficial agent
US6783793B1 (en) 2000-10-26 2004-08-31 Advanced Cardiovascular Systems, Inc. Selective coating of medical devices
US6545097B2 (en) * 2000-12-12 2003-04-08 Scimed Life Systems, Inc. Drug delivery compositions and medical devices containing block copolymer
US6887857B2 (en) * 2001-04-27 2005-05-03 Scimed Life Systems, Inc. Microparticle protection of therapeutic agents
US20040225326A1 (en) * 2001-05-07 2004-11-11 Weiner Mike L. Apparatus for the detection of restenosis
US7175873B1 (en) 2001-06-27 2007-02-13 Advanced Cardiovascular Systems, Inc. Rate limiting barriers for implantable devices and methods for fabrication thereof
WO2003002243A2 (en) 2001-06-27 2003-01-09 Remon Medical Technologies Ltd. Method and device for electrochemical formation of therapeutic species in vivo
US8741378B1 (en) 2001-06-27 2014-06-03 Advanced Cardiovascular Systems, Inc. Methods of coating an implantable device
US7247313B2 (en) 2001-06-27 2007-07-24 Advanced Cardiovascular Systems, Inc. Polyacrylates coatings for implantable medical devices
US6565659B1 (en) 2001-06-28 2003-05-20 Advanced Cardiovascular Systems, Inc. Stent mounting assembly and a method of using the same to coat a stent
US6656216B1 (en) 2001-06-29 2003-12-02 Advanced Cardiovascular Systems, Inc. Composite stent with regioselective material
US7056338B2 (en) * 2003-03-28 2006-06-06 Conor Medsystems, Inc. Therapeutic agent delivery device with controlled therapeutic agent release rates
US20040137066A1 (en) * 2001-11-26 2004-07-15 Swaminathan Jayaraman Rationally designed therapeutic intravascular implant coating
US20030073961A1 (en) * 2001-09-28 2003-04-17 Happ Dorrie M. Medical device containing light-protected therapeutic agent and a method for fabricating thereof
US20030077310A1 (en) 2001-10-22 2003-04-24 Chandrashekhar Pathak Stent coatings containing HMG-CoA reductase inhibitors
US8740973B2 (en) * 2001-10-26 2014-06-03 Icon Medical Corp. Polymer biodegradable medical device
US20030216758A1 (en) * 2001-12-28 2003-11-20 Angiotech Pharmaceuticals, Inc. Coated surgical patches
US8133501B2 (en) 2002-02-08 2012-03-13 Boston Scientific Scimed, Inc. Implantable or insertable medical devices for controlled drug delivery
US6887270B2 (en) 2002-02-08 2005-05-03 Boston Scientific Scimed, Inc. Implantable or insertable medical device resistant to microbial growth and biofilm formation
US8685427B2 (en) 2002-07-31 2014-04-01 Boston Scientific Scimed, Inc. Controlled drug delivery
US7993390B2 (en) 2002-02-08 2011-08-09 Boston Scientific Scimed, Inc. Implantable or insertable medical device resistant to microbial growth and biofilm formation
US20060100408A1 (en) * 2002-03-11 2006-05-11 Powell P M Method for forming contact lenses comprising therapeutic agents
US6846892B2 (en) * 2002-03-11 2005-01-25 Johnson & Johnson Vision Care, Inc. Low polydispersity poly-HEMA compositions
US7131997B2 (en) * 2002-03-29 2006-11-07 Scimed Life Systems, Inc. Tissue treatment
US7462366B2 (en) 2002-03-29 2008-12-09 Boston Scientific Scimed, Inc. Drug delivery particle
US7094369B2 (en) * 2002-03-29 2006-08-22 Scimed Life Systems, Inc. Processes for manufacturing polymeric microspheres
US20030195610A1 (en) * 2002-04-04 2003-10-16 Herrmann Robert A. Processes for producing polymer coatings through surface polymerization
US7053134B2 (en) * 2002-04-04 2006-05-30 Scimed Life Systems, Inc. Forming a chemically cross-linked particle of a desired shape and diameter
US20030203000A1 (en) * 2002-04-24 2003-10-30 Schwarz Marlene C. Modulation of therapeutic agent release from a polymeric carrier using solvent-based techniques
US20040127895A1 (en) * 2002-05-20 2004-07-01 Flock Stephen T. Electromagnetic treatment of tissues and cells
US20040043052A1 (en) * 2002-05-24 2004-03-04 Angiotech Pharmaceuticals, Inc. Compositions and methods for coating medical implants
US6835387B2 (en) * 2002-06-11 2004-12-28 Scimed Life Systems, Inc. Sustained release of superoxide dismutase mimics from implantable or insertable medical devices
US20030232087A1 (en) * 2002-06-18 2003-12-18 Lawin Laurie R. Bioactive agent release coating with aromatic poly(meth)acrylates
US7097850B2 (en) * 2002-06-18 2006-08-29 Surmodics, Inc. Bioactive agent release coating and controlled humidity method
US7939094B2 (en) * 2002-06-19 2011-05-10 Boston Scientific Scimed, Inc. Multiphase polymeric drug release region
US8211455B2 (en) 2002-06-19 2012-07-03 Boston Scientific Scimed, Inc. Implantable or insertable medical devices for controlled delivery of a therapeutic agent
US7105175B2 (en) * 2002-06-19 2006-09-12 Boston Scientific Scimed, Inc. Implantable or insertable medical devices for controlled delivery of a therapeutic agent
US20030236513A1 (en) * 2002-06-19 2003-12-25 Scimed Life Systems, Inc. Implantable or insertable medical devices for controlled delivery of a therapeutic agent
US7005137B1 (en) * 2002-06-21 2006-02-28 Advanceed Cardiovascular Systems, Inc. Coating for implantable medical devices
US7217426B1 (en) 2002-06-21 2007-05-15 Advanced Cardiovascular Systems, Inc. Coatings containing polycationic peptides for cardiovascular therapy
US7396539B1 (en) * 2002-06-21 2008-07-08 Advanced Cardiovascular Systems, Inc. Stent coatings with engineered drug release rate
AU2003243755A1 (en) * 2002-06-24 2004-01-06 William R. Noyes Fillers and methods for displacing tissues to improve radiological outcomes
JP2005537822A (ja) * 2002-06-28 2005-12-15 ノバルティス アクチエンゲゼルシャフト 有機化合物の使用
WO2004002548A1 (en) * 2002-06-28 2004-01-08 Novartis Ag Use of organic compounds
US7622146B2 (en) 2002-07-18 2009-11-24 Advanced Cardiovascular Systems, Inc. Rate limiting barriers for implantable devices and methods for fabrication thereof
WO2004009664A2 (en) * 2002-07-19 2004-01-29 Omeros Corporation Biodegradable triblock copolymers, synthesis methods therefor, and hydrogels and biomaterials made there from
US7491233B1 (en) 2002-07-19 2009-02-17 Advanced Cardiovascular Systems Inc. Purified polymers for coatings of implantable medical devices
US8920826B2 (en) * 2002-07-31 2014-12-30 Boston Scientific Scimed, Inc. Medical imaging reference devices
US8016881B2 (en) * 2002-07-31 2011-09-13 Icon Interventional Systems, Inc. Sutures and surgical staples for anastamoses, wound closures, and surgical closures
US7842377B2 (en) * 2003-08-08 2010-11-30 Boston Scientific Scimed, Inc. Porous polymeric particle comprising polyvinyl alcohol and having interior to surface porosity-gradient
US7449236B2 (en) * 2002-08-09 2008-11-11 Boston Scientific Scimed, Inc. Porous polymeric particle comprising polyvinyl alcohol and having interior to surface porosity-gradient
US8012454B2 (en) * 2002-08-30 2011-09-06 Boston Scientific Scimed, Inc. Embolization
US20040063805A1 (en) * 2002-09-19 2004-04-01 Pacetti Stephen D. Coatings for implantable medical devices and methods for fabrication thereof
HK1077730A1 (zh) * 2002-09-26 2006-02-24 Endovascular Devices, Inc. 有关通过洗脱生物适应可移植的医疗装置输送丝裂霉素的设备及方法
AU2003301669B2 (en) * 2002-10-22 2009-04-30 Biomerix Corporation Method and system for intravesicular delivery of the therapeutic agents
US7883490B2 (en) * 2002-10-23 2011-02-08 Boston Scientific Scimed, Inc. Mixing and delivery of therapeutic compositions
US7588825B2 (en) * 2002-10-23 2009-09-15 Boston Scientific Scimed, Inc. Embolic compositions
AU2002356575B2 (en) 2002-11-08 2009-07-16 Jean-Claude Laborde Endoprosthesis for vascular bifurcation
CA2505576A1 (en) * 2002-11-08 2004-05-27 Conor Medsystems, Inc. Expandable medical device and method for treating chronic total occlusions with local delivery of an angiogenic factor
US7169178B1 (en) 2002-11-12 2007-01-30 Advanced Cardiovascular Systems, Inc. Stent with drug coating
US7491234B2 (en) 2002-12-03 2009-02-17 Boston Scientific Scimed, Inc. Medical devices for delivery of therapeutic agents
US20040106952A1 (en) * 2002-12-03 2004-06-03 Lafontaine Daniel M. Treating arrhythmias by altering properties of tissue
US20040111144A1 (en) * 2002-12-06 2004-06-10 Lawin Laurie R. Barriers for polymeric coatings
KR20050091040A (ko) * 2002-12-30 2005-09-14 안지오테크 인터내셔날 아게 실크 함유 스텐트 이식편
US20050043585A1 (en) * 2003-01-03 2005-02-24 Arindam Datta Reticulated elastomeric matrices, their manufacture and use in implantable devices
NZ540771A (en) * 2003-01-10 2009-05-31 Ablynx Nv Recombinant VHH single domain antibody from camelidae against von willebrand factor (vWF) or against collagen
US8318235B2 (en) 2003-01-22 2012-11-27 Cordis Corporation Method for applying drug coating to a medical device in surgeon room
US6919100B2 (en) * 2003-01-22 2005-07-19 Cordis Corporation Method for coating medical devices
US7144419B2 (en) * 2003-01-24 2006-12-05 Medtronic Vascular, Inc. Drug-polymer coated stent with blended phenoxy and styrenic block copolymers
EP1610752B1 (en) 2003-01-31 2013-01-02 Boston Scientific Limited Localized drug delivery using drug-loaded nanocapsules and implantable device coated with the same
EP2865385B1 (en) * 2003-02-04 2016-11-16 Cornell Research Foundation, Inc. Uses of aromatic-cationic peptide
US7816337B2 (en) * 2003-02-18 2010-10-19 Roche Madison Inc. Reversible attachment of a membrane active polymer to a polynucleotide
PL1603603T3 (pl) * 2003-02-28 2015-07-31 Biointeractions Ltd System sieci polimerowych dla urządzeń medycznych oraz sposoby zastosowania
US8313759B2 (en) * 2003-03-06 2012-11-20 Boston Scientific Scimed, Inc. Implantable or insertable medical devices containing miscible polymer blends for controlled delivery of a therapeutic agent
WO2004087214A1 (en) * 2003-03-28 2004-10-14 Conor Medsystems, Inc. Implantable medical device with beneficial agent concentration gradient
US20040202692A1 (en) * 2003-03-28 2004-10-14 Conor Medsystems, Inc. Implantable medical device and method for in situ selective modulation of agent delivery
US7241455B2 (en) * 2003-04-08 2007-07-10 Boston Scientific Scimed, Inc. Implantable or insertable medical devices containing radiation-crosslinked polymer for controlled delivery of a therapeutic agent
US20080215137A1 (en) * 2003-04-30 2008-09-04 Boston Scientific Scimed, Inc. Therapeutic driving layer for a medical device
US20060105018A1 (en) * 2004-11-17 2006-05-18 Epstein Samuel J Therapeutic driving layer for a medical device
US7563454B1 (en) 2003-05-01 2009-07-21 Advanced Cardiovascular Systems, Inc. Coatings for implantable medical devices
US8791171B2 (en) * 2003-05-01 2014-07-29 Abbott Cardiovascular Systems Inc. Biodegradable coatings for implantable medical devices
US8246974B2 (en) 2003-05-02 2012-08-21 Surmodics, Inc. Medical devices and methods for producing the same
AU2004237774B2 (en) 2003-05-02 2009-09-10 Surmodics, Inc. Implantable controlled release bioactive agent delivery device
CA2525792C (en) * 2003-05-15 2015-10-13 Biomerix Corporation Reticulated elastomeric matrices, their manufacture and use in implantable devices
FR2855521B1 (fr) * 2003-05-28 2005-08-05 Flamel Tech Sa Polyaminoacides fonctionnalises par au moins un groupement h ydrophobe et leurs applications notamment therapeutiques.
US20040253281A1 (en) * 2003-06-12 2004-12-16 Atrium Medical Corp. Therapeutic markings applied to tissue
CA2529420A1 (en) 2003-06-20 2004-12-29 Rudolf Faust End-capped polymer chains and products thereof
US7169404B2 (en) 2003-07-30 2007-01-30 Advanced Cardiovasular Systems, Inc. Biologically absorbable coatings for implantable devices and methods for fabricating the same
US7914805B2 (en) 2003-07-31 2011-03-29 Boston Scientific Scimed, Inc. Implantable or insertable medical devices containing radiation-treated polymer for improved delivery of therapeutic agent
US9114199B2 (en) * 2003-07-31 2015-08-25 Boston Scientific Scimed, Inc. Implantable or insertable medical devices containing acrylic copolymer for controlled delivery of therapeutic agent
US8870814B2 (en) * 2003-07-31 2014-10-28 Boston Scientific Scimed, Inc. Implantable or insertable medical devices containing silicone copolymer for controlled delivery of therapeutic agent
US7357940B2 (en) * 2003-07-31 2008-04-15 Boston Scientific Scimed, Inc. Implantable or insertable medical devices containing graft copolymer for controlled delivery of therapeutic agents
US20050064011A1 (en) * 2003-08-11 2005-03-24 Young-Ho Song Implantable or insertable medical devices containing phenolic compound for inhibition of restenosis
US20050037047A1 (en) * 2003-08-11 2005-02-17 Young-Ho Song Medical devices comprising spray dried microparticles
US20050037048A1 (en) * 2003-08-11 2005-02-17 Young-Ho Song Medical devices containing antioxidant and therapeutic agent
US7364585B2 (en) * 2003-08-11 2008-04-29 Boston Scientific Scimed, Inc. Medical devices comprising drug-loaded capsules for localized drug delivery
US7976823B2 (en) 2003-08-29 2011-07-12 Boston Scientific Scimed, Inc. Ferromagnetic particles and methods
US7488343B2 (en) * 2003-09-16 2009-02-10 Boston Scientific Scimed, Inc. Medical devices
US7198675B2 (en) 2003-09-30 2007-04-03 Advanced Cardiovascular Systems Stent mandrel fixture and method for selectively coating surfaces of a stent
US7901770B2 (en) 2003-11-04 2011-03-08 Boston Scientific Scimed, Inc. Embolic compositions
US20050100577A1 (en) * 2003-11-10 2005-05-12 Parker Theodore L. Expandable medical device with beneficial agent matrix formed by a multi solvent system
EP1689457A2 (en) * 2003-11-10 2006-08-16 Angiotech International Ag Intravascular devices and fibrosis-inducing agents
US9066912B2 (en) * 2003-11-17 2015-06-30 Ethicon, Inc. Drug-enhanced adhesion prevention
US20050106230A1 (en) * 2003-11-17 2005-05-19 Young Janel E. Drug-enhanced adhesion prevention
US7807722B2 (en) 2003-11-26 2010-10-05 Advanced Cardiovascular Systems, Inc. Biobeneficial coating compositions and methods of making and using thereof
ES2449496T3 (es) * 2003-12-05 2014-03-20 Innfocus, Inc. Dispositivo mejorado de implante para glaucoma
EP1696831B1 (en) * 2003-12-05 2014-01-15 Innolene LLC Method of producing a refractive ocular lens
US20050137568A1 (en) * 2003-12-17 2005-06-23 Jones Donald K. Activatable bioactive implantable medical device and method of use
US7763077B2 (en) 2003-12-24 2010-07-27 Biomerix Corporation Repair of spinal annular defects and annulo-nucleoplasty regeneration
US7563324B1 (en) 2003-12-29 2009-07-21 Advanced Cardiovascular Systems Inc. System and method for coating an implantable medical device
US7303758B2 (en) * 2004-01-20 2007-12-04 Cordis Corporation Local vascular delivery of mycophenolic acid in combination with rapamycin to prevent restenosis following vascular injury
US7211108B2 (en) * 2004-01-23 2007-05-01 Icon Medical Corp. Vascular grafts with amphiphilic block copolymer coatings
US20050165480A1 (en) * 2004-01-23 2005-07-28 Maybelle Jordan Endovascular treatment devices and methods
US7803178B2 (en) 2004-01-30 2010-09-28 Trivascular, Inc. Inflatable porous implants and methods for drug delivery
US7056985B2 (en) 2004-02-11 2006-06-06 University Of Massachusetts Lowell End-capped polymer chains and products thereof
US7226979B2 (en) 2004-02-11 2007-06-05 University Of Massachusetts Lowell Copolymers comprising olefin and protected or unprotected hydroxystyrene units
US7537781B2 (en) * 2004-02-12 2009-05-26 Boston Scientific Scimed, Inc. Polymer-filler composites for controlled delivery of therapeutic agents from medical articles
US20050181015A1 (en) * 2004-02-12 2005-08-18 Sheng-Ping (Samuel) Zhong Layered silicate nanoparticles for controlled delivery of therapeutic agents from medical articles
US7744619B2 (en) * 2004-02-24 2010-06-29 Boston Scientific Scimed, Inc. Rotatable catheter assembly
US7922740B2 (en) 2004-02-24 2011-04-12 Boston Scientific Scimed, Inc. Rotatable catheter assembly
CA2557524A1 (en) * 2004-02-25 2005-09-01 Collgard Biopharmaceuticals Ltd. Biocompatible polymeric delivery systems for sustained release of quinazolinones
US8137397B2 (en) * 2004-02-26 2012-03-20 Boston Scientific Scimed, Inc. Medical devices
US7736671B2 (en) 2004-03-02 2010-06-15 Boston Scientific Scimed, Inc. Embolization
US7761138B2 (en) * 2004-03-12 2010-07-20 Boston Scientific Scimed, Inc. MRI and X-ray visualization
US20050202079A1 (en) * 2004-03-15 2005-09-15 Mylan Pharmaceuticals Inc. Novel orally administrable formulation of nitrofurantoin and a method for preparing said formulation
US20050205691A1 (en) * 2004-03-16 2005-09-22 Todd Robida Double acting pneumatic three-way valve for handling coating solution
US20050228433A1 (en) * 2004-03-16 2005-10-13 Weenna Bucay-Couto In situ implant and method of forming same
US20050208107A1 (en) * 2004-03-16 2005-09-22 Helmus Michael N Dry spun styrene-isobutylene copolymers
EP1727583A1 (en) * 2004-03-23 2006-12-06 Boston Scientific Limited Agent eluting stent and catheter
US20050220835A1 (en) 2004-03-30 2005-10-06 Jayaraman Ramesh B Agent eluting bioimplantable devices and polymer systems for their preparation
US8173176B2 (en) 2004-03-30 2012-05-08 Boston Scientific Scimed, Inc. Embolization
US7883491B2 (en) * 2004-04-01 2011-02-08 Shah Tilak M Extrusion laminate polymeric film article and gastric occlusive device comprising same
US20050220853A1 (en) * 2004-04-02 2005-10-06 Kinh-Luan Dao Controlled delivery of therapeutic agents from medical articles
US20060083772A1 (en) * 2004-04-06 2006-04-20 Dewitt David M Coating compositions for bioactive agents
US7541048B2 (en) * 2004-04-06 2009-06-02 Surmodics, Inc. Coating compositions for bioactive agents
US20050238870A1 (en) * 2004-04-22 2005-10-27 Marcia Buiser Embolization
US9498563B2 (en) * 2004-04-23 2016-11-22 Boston Scientific Scimed, Inc. Medical articles having therapeutic-agent-containing regions formed from coalesced polymer particles
US7767220B2 (en) * 2004-04-23 2010-08-03 Boston Scientific Scimed, Inc. Implantable or insertable medical articles having covalently modified, biocompatible surfaces
US7553377B1 (en) 2004-04-27 2009-06-30 Advanced Cardiovascular Systems, Inc. Apparatus and method for electrostatic coating of an abluminal stent surface
US7311861B2 (en) * 2004-06-01 2007-12-25 Boston Scientific Scimed, Inc. Embolization
US20050271700A1 (en) * 2004-06-03 2005-12-08 Desnoyer Jessica R Poly(ester amide) coating composition for implantable devices
US20050283226A1 (en) * 2004-06-18 2005-12-22 Scimed Life Systems, Inc. Medical devices
US8709469B2 (en) 2004-06-30 2014-04-29 Abbott Cardiovascular Systems Inc. Anti-proliferative and anti-inflammatory agent combination for treatment of vascular disorders with an implantable medical device
US8697119B2 (en) * 2004-07-19 2014-04-15 Boston Scientific Scimed, Inc. Medical devices and materials containing isobutylene copolymer
US20060013853A1 (en) * 2004-07-19 2006-01-19 Richard Robert E Medical devices having conductive substrate and covalently bonded coating layer
US7771740B2 (en) * 2004-07-19 2010-08-10 Boston Scientific Scimed, Inc. Medical devices containing copolymers with graft copolymer endblocks for drug delivery
US7713539B2 (en) * 2004-07-19 2010-05-11 Boston Scientific Scimed, Inc. Medical devices containing radiation resistant block copolymer
EP2594259A1 (en) * 2004-08-04 2013-05-22 Brookwood Pharmaceuticals, Inc. Methods for manufacturing delivery devices and devices thereof
US8980300B2 (en) 2004-08-05 2015-03-17 Advanced Cardiovascular Systems, Inc. Plasticizers for coating compositions
US8158151B2 (en) * 2004-08-10 2012-04-17 Boston Scientific Scimed, Inc. Solvent-assisted loading of therapeutic agents
US7244443B2 (en) 2004-08-31 2007-07-17 Advanced Cardiovascular Systems, Inc. Polymers of fluorinated monomers and hydrophilic monomers
US7862835B2 (en) * 2004-10-27 2011-01-04 Boston Scientific Scimed, Inc. Method of manufacturing a medical device having a porous coating thereon
US8388677B2 (en) * 2004-10-29 2013-03-05 Boston Scientific Scimed, Inc. Anti-thrombogenic and anti-restenotic vascular medical devices
US20060116713A1 (en) * 2004-11-26 2006-06-01 Ivan Sepetka Aneurysm treatment devices and methods
US8771294B2 (en) * 2004-11-26 2014-07-08 Biomerix Corporation Aneurysm treatment devices and methods
US8425550B2 (en) 2004-12-01 2013-04-23 Boston Scientific Scimed, Inc. Embolic coils
US20070118065A1 (en) * 2004-12-03 2007-05-24 Leonard Pinchuk Glaucoma Implant Device
US20070141116A1 (en) * 2004-12-03 2007-06-21 Leonard Pinchuk Glaucoma Implant Device
US7837644B2 (en) * 2004-12-03 2010-11-23 Innfocus, Llc Glaucoma implant device
US7594899B2 (en) * 2004-12-03 2009-09-29 Innfocus, Llc Glaucoma implant device
US7964209B2 (en) * 2004-12-07 2011-06-21 Boston Scientific Scimed, Inc. Orienting polymer domains for controlled drug delivery
US7632307B2 (en) 2004-12-16 2009-12-15 Advanced Cardiovascular Systems, Inc. Abluminal, multilayer coating constructs for drug-delivery stents
US7559952B2 (en) * 2004-12-17 2009-07-14 Innovia, Llc Elastomeric polymer filament cosmetic implant
US20060136042A1 (en) * 2004-12-22 2006-06-22 Scimed Life Systems, Inc. Vulnerable plaque stent
US7988987B2 (en) * 2005-01-25 2011-08-02 Boston Scientific Scimed, Inc. Medical devices containing crazed polymeric release regions for drug delivery
US8535702B2 (en) 2005-02-01 2013-09-17 Boston Scientific Scimed, Inc. Medical devices having porous polymeric regions for controlled drug delivery and regulated biocompatibility
US8075906B2 (en) * 2005-02-01 2011-12-13 Boston Scientific Scimed, Inc. Medical devices having polymeric regions with copolymers containing hydrocarbon and heteroatom-containing monomeric species
US9050393B2 (en) * 2005-02-08 2015-06-09 Bruce N. Saffran Medical devices and methods for modulation of physiology using device-based surface chemistry
US8048028B2 (en) 2005-02-17 2011-11-01 Boston Scientific Scimed, Inc. Reinforced medical balloon
US7727555B2 (en) * 2005-03-02 2010-06-01 Boston Scientific Scimed, Inc. Particles
US7858183B2 (en) * 2005-03-02 2010-12-28 Boston Scientific Scimed, Inc. Particles
US20060201601A1 (en) * 2005-03-03 2006-09-14 Icon Interventional Systems, Inc. Flexible markers
US20060200048A1 (en) * 2005-03-03 2006-09-07 Icon Medical Corp. Removable sheath for device protection
US20060264914A1 (en) * 2005-03-03 2006-11-23 Icon Medical Corp. Metal alloys for medical devices
US9107899B2 (en) 2005-03-03 2015-08-18 Icon Medical Corporation Metal alloys for medical devices
WO2006110197A2 (en) * 2005-03-03 2006-10-19 Icon Medical Corp. Polymer biodegradable medical device
ES2986867T3 (es) * 2005-03-03 2024-11-12 Mirus Llc Aleaciones metálicas mejoradas para dispositivos médicos
US7540995B2 (en) 2005-03-03 2009-06-02 Icon Medical Corp. Process for forming an improved metal alloy stent
US8323333B2 (en) * 2005-03-03 2012-12-04 Icon Medical Corp. Fragile structure protective coating
US8067026B2 (en) * 2005-03-14 2011-11-29 Boston Scientific Scimed, Inc. Drug release regions for medical devices, which include polycyclic-structure-containing polymers
US9125968B2 (en) * 2005-03-30 2015-09-08 Boston Scientific Scimed, Inc. Polymeric/ceramic composite materials for use in medical devices
US7517914B2 (en) * 2005-04-04 2009-04-14 Boston Scientificscimed, Inc. Controlled degradation materials for therapeutic agent delivery
US7963287B2 (en) 2005-04-28 2011-06-21 Boston Scientific Scimed, Inc. Tissue-treatment methods
US20070004973A1 (en) * 2005-06-15 2007-01-04 Tan Sharon M L Tissue treatment methods
US20060286071A1 (en) * 2005-06-21 2006-12-21 Epstein Samuel J Therapeutic pastes for medical device coating
US9463426B2 (en) 2005-06-24 2016-10-11 Boston Scientific Scimed, Inc. Methods and systems for coating particles
US7778684B2 (en) * 2005-08-08 2010-08-17 Boston Scientific Scimed, Inc. MRI resonator system with stent implant
WO2007024500A1 (en) * 2005-08-25 2007-03-01 Medtronic Vascular, Inc. Controlled radical polymerization-derived block copolymer compositions for medical device coatings
US7914809B2 (en) 2005-08-26 2011-03-29 Boston Scientific Scimed, Inc. Lubricious composites for medical devices
US20070067882A1 (en) * 2005-09-21 2007-03-22 Liliana Atanasoska Internal medical devices having polyelectrolyte-containing extruded regions
US8008395B2 (en) * 2005-09-27 2011-08-30 Boston Scientific Scimed, Inc. Organic-inorganic hybrid particle material and polymer compositions containing same
US8007509B2 (en) 2005-10-12 2011-08-30 Boston Scientific Scimed, Inc. Coil assemblies, components and methods
BRPI0617325B8 (pt) 2005-10-13 2021-06-22 Synthes Gmbh luva biologicamente compatível
US20070112300A1 (en) * 2005-11-14 2007-05-17 Roman Ricardo D Balloon folding design, apparatus and method of making the same
WO2007059144A1 (en) * 2005-11-15 2007-05-24 Surmodics, Inc. Ultrasonic nozzles for applying two-component coatings
WO2007062320A2 (en) * 2005-11-18 2007-05-31 Innovia, Llc Trileaflet heart valve
US8034874B2 (en) * 2005-11-23 2011-10-11 Boston Scientific Scimed, Inc. Medical devices having polymeric regions that contain fluorocarbon-containing block copolymers
US20070135751A1 (en) * 2005-12-09 2007-06-14 Dicarlo Paul D Medical devices
US8101197B2 (en) 2005-12-19 2012-01-24 Stryker Corporation Forming coils
US8152839B2 (en) 2005-12-19 2012-04-10 Boston Scientific Scimed, Inc. Embolic coils
US7947368B2 (en) * 2005-12-21 2011-05-24 Boston Scientific Scimed, Inc. Block copolymer particles
US7501179B2 (en) * 2005-12-21 2009-03-10 Boston Scientific Scimed, Inc. Block copolymer particles
US20070149916A1 (en) * 2005-12-22 2007-06-28 Alza Corporation Dry matrices as drug reservoirs in electrotransport applications
US20070148697A1 (en) * 2005-12-27 2007-06-28 Boston Scientific Scimed, Inc. Methods and system for high throughput screening of polymer materials for medical devices
US8834912B2 (en) * 2005-12-30 2014-09-16 Boston Scientific Scimed, Inc. Medical devices having multiple charged layers
US20070154466A1 (en) * 2005-12-30 2007-07-05 Jan Weber Internal medical devices containing peroxide-converting catalysts
EP1981560B1 (en) * 2006-01-05 2010-09-08 Med Institute, Inc. Zein coated medical device
US8840660B2 (en) 2006-01-05 2014-09-23 Boston Scientific Scimed, Inc. Bioerodible endoprostheses and methods of making the same
US20070160640A1 (en) * 2006-01-12 2007-07-12 Eun-Hyun Jang Halofuginone delivering vascular medical devices
WO2007083797A1 (ja) 2006-01-23 2007-07-26 Terumo Kabushiki Kaisha ステント
US8089029B2 (en) 2006-02-01 2012-01-03 Boston Scientific Scimed, Inc. Bioabsorbable metal medical device and method of manufacture
WO2007100881A2 (en) * 2006-02-28 2007-09-07 Tyco Healthcare Group Lp Antimicrobial medical devices
CA2638768A1 (en) * 2006-02-28 2007-09-07 Tyco Healthcare Group Lp Antimicrobial releasing polymers
US20070207182A1 (en) * 2006-03-06 2007-09-06 Jan Weber Medical devices having electrically aligned elongated particles
US20070239256A1 (en) * 2006-03-22 2007-10-11 Jan Weber Medical devices having electrical circuits with multilayer regions
US8545865B2 (en) * 2006-03-24 2013-10-01 Boston Scientific Scimed, Inc. Medical devices having polymer brushes
US20070224235A1 (en) 2006-03-24 2007-09-27 Barron Tenney Medical devices having nanoporous coatings for controlled therapeutic agent delivery
US8187620B2 (en) 2006-03-27 2012-05-29 Boston Scientific Scimed, Inc. Medical devices comprising a porous metal oxide or metal material and a polymer coating for delivering therapeutic agents
US7737060B2 (en) * 2006-03-31 2010-06-15 Boston Scientific Scimed, Inc. Medical devices containing multi-component fibers
US8048150B2 (en) 2006-04-12 2011-11-01 Boston Scientific Scimed, Inc. Endoprosthesis having a fiber meshwork disposed thereon
US7559949B2 (en) * 2006-04-28 2009-07-14 Leonard Pinchuk Injectable intraocular lens that minimizes posterior capsule opacification and methods and materials for realizing same
US20070254003A1 (en) * 2006-05-01 2007-11-01 Pu Zhou Non-sticky coatings with therapeutic agents for medical devices
US8092818B2 (en) 2006-05-17 2012-01-10 Boston Scientific Scimed, Inc. Medical devices having bioactive surfaces
US7727541B2 (en) * 2006-05-18 2010-06-01 Boston Scientific Scimed, Inc. Medical devices having polymeric regions based on vinyl ether block copolymers
US8048168B2 (en) * 2006-06-16 2011-11-01 Boston Scientific Scimed, Inc. Partially soluble implantable or insertable medical devices
US20070298067A1 (en) * 2006-06-22 2007-12-27 Boston Scientific Scimed, Inc. Control release drug coating for medical devices
US20070298069A1 (en) * 2006-06-26 2007-12-27 Boston Scientific Scimed, Inc. Medical devices for release of low solubility therapeutic agents
US8815275B2 (en) 2006-06-28 2014-08-26 Boston Scientific Scimed, Inc. Coatings for medical devices comprising a therapeutic agent and a metallic material
US8771343B2 (en) 2006-06-29 2014-07-08 Boston Scientific Scimed, Inc. Medical devices with selective titanium oxide coatings
US8956640B2 (en) * 2006-06-29 2015-02-17 Advanced Cardiovascular Systems, Inc. Block copolymers including a methoxyethyl methacrylate midblock
US9028859B2 (en) 2006-07-07 2015-05-12 Advanced Cardiovascular Systems, Inc. Phase-separated block copolymer coatings for implantable medical devices
WO2008008291A2 (en) * 2006-07-13 2008-01-17 Icon Medical Corp. Stent
US9375217B2 (en) 2006-07-18 2016-06-28 Boston Scientific Scimed, Inc. Catheterizing body lumens
US8052743B2 (en) * 2006-08-02 2011-11-08 Boston Scientific Scimed, Inc. Endoprosthesis with three-dimensional disintegration control
US8900619B2 (en) * 2006-08-24 2014-12-02 Boston Scientific Scimed, Inc. Medical devices for the release of therapeutic agents
US20080051702A1 (en) * 2006-08-24 2008-02-28 Herrmann Robert A Therapeutic agent delivery for the treatment of asthma via implantable and insertable medical devices
US20080051759A1 (en) * 2006-08-24 2008-02-28 Boston Scientific Scimed, Inc. Polycarbonate polyurethane venous access devices
US8092821B2 (en) * 2006-08-25 2012-01-10 Boston Scientific Scimed, Inc. Medical devices having polymeric regions with improved adhesion
WO2008030951A2 (en) * 2006-09-06 2008-03-13 Innfocus, Llc Glaucoma implant device
WO2008033199A1 (en) * 2006-09-12 2008-03-20 Boston Scientific Limited Liquid masking for selective coating of a stent
ATE508708T1 (de) 2006-09-14 2011-05-15 Boston Scient Ltd Medizinprodukte mit wirkstofffreisetzender beschichtung
EP2399616A1 (en) 2006-09-15 2011-12-28 Boston Scientific Scimed, Inc. Bioerodible endoprosthesis with biostable inorganic layers
CA2663271A1 (en) 2006-09-15 2008-03-20 Boston Scientific Limited Bioerodible endoprostheses and methods of making the same
CA2663220A1 (en) 2006-09-15 2008-03-20 Boston Scientific Limited Medical devices and methods of making the same
JP2010503489A (ja) 2006-09-15 2010-02-04 ボストン サイエンティフィック リミテッド 生体内分解性内部人工器官およびその製造方法
CA2663303A1 (en) * 2006-09-15 2008-03-20 Boston Scientific Limited Endoprosthesis with adjustable surface features
EP2068962B1 (en) 2006-09-18 2013-01-30 Boston Scientific Limited Endoprostheses
EP2076211A4 (en) * 2006-10-20 2015-07-22 Elixir Medical Corp LUMINOUS PROSTHESES AND METHODS OF COATING THEREOF
US8414927B2 (en) 2006-11-03 2013-04-09 Boston Scientific Scimed, Inc. Cross-linked polymer particles
US7691402B2 (en) * 2006-11-06 2010-04-06 Medtronic Vascular, Inc. Block biodegradable copolymers for medical devices
US7981150B2 (en) 2006-11-09 2011-07-19 Boston Scientific Scimed, Inc. Endoprosthesis with coatings
US7919137B2 (en) * 2006-11-13 2011-04-05 Boston Scientific Scimed, Inc. Medical devices having adherent polymeric layers with depth-dependent properties
US20080132991A1 (en) * 2006-11-30 2008-06-05 Leonard Pinchuk Method for Ionically Cross-Linking Gellan Gum for Thin Film Applications and Medical Devices Produced Therefrom
US8147539B2 (en) * 2006-12-20 2012-04-03 Boston Scientific Scimed, Inc. Stent with a coating for delivering a therapeutic agent
US8080055B2 (en) 2006-12-28 2011-12-20 Boston Scientific Scimed, Inc. Bioerodible endoprostheses and methods of making the same
US20080175881A1 (en) * 2007-01-18 2008-07-24 Boston Scientific Scimed, Inc. Blood-contacting medical devices for the release of nitric oxide and anti-restenotic agents
NZ588816A (en) 2007-01-21 2011-11-25 Hemoteq Ag Medical device for the treatment of stenoses of corporal lumina and for the prevention of impending restenoses
JP2010517638A (ja) * 2007-02-02 2010-05-27 トアニエ， インコーポレイテッド 腱および靱帯を修復するシステムおよび方法
US20100104880A1 (en) * 2007-02-13 2010-04-29 Cornova, Inc. Biocompatible polymers polymer, tie-coats-, methods of making and using the same, and products incorporating the polymers
US7887830B2 (en) * 2007-02-27 2011-02-15 Boston Scientific Scimed, Inc. Medical devices having polymeric regions based on styrene-isobutylene copolymers
US20080208325A1 (en) * 2007-02-27 2008-08-28 Boston Scientific Scimed, Inc. Medical articles for long term implantation
US8431149B2 (en) 2007-03-01 2013-04-30 Boston Scientific Scimed, Inc. Coated medical devices for abluminal drug delivery
US8070797B2 (en) 2007-03-01 2011-12-06 Boston Scientific Scimed, Inc. Medical device with a porous surface for delivery of a therapeutic agent
EP2131754B1 (en) 2007-03-05 2010-06-02 Boston Scientific Scimed, Inc. Deploying embolic coils
US7914807B2 (en) * 2007-03-05 2011-03-29 Boston Scientific Scimed, Inc. Medical devices having improved performance
EP2136854A2 (en) * 2007-03-20 2009-12-30 Boston Scientific Scimed, Inc. Urological medical devices for release of therapeutic agents
JP2010522023A (ja) * 2007-03-20 2010-07-01 ボストン サイエンティフィック サイムド，インコーポレイテッド 前立腺に対して有益な治療薬を放出するための泌尿器科学的医療機器
WO2008121702A2 (en) * 2007-03-28 2008-10-09 Boston Scientific Scimed, Inc. Medical devices having bioerodable layers for the release of therapeutic agents
US8067054B2 (en) 2007-04-05 2011-11-29 Boston Scientific Scimed, Inc. Stents with ceramic drug reservoir layer and methods of making and using the same
WO2008134478A2 (en) * 2007-04-27 2008-11-06 Medtronic, Inc. Increased drug loading capacity of polymeric material
US7767726B2 (en) * 2007-05-11 2010-08-03 Boston Scientific Scimed, Inc. Medical devices having crosslinked polymeric surfaces
US8168213B2 (en) * 2007-05-15 2012-05-01 Boston Scientific Scimed, Inc. Medical devices having coating with improved adhesion
US7976915B2 (en) 2007-05-23 2011-07-12 Boston Scientific Scimed, Inc. Endoprosthesis with select ceramic morphology
US8133553B2 (en) 2007-06-18 2012-03-13 Zimmer, Inc. Process for forming a ceramic layer
US8309521B2 (en) 2007-06-19 2012-11-13 Zimmer, Inc. Spacer with a coating thereon for use with an implant device
WO2009006538A2 (en) * 2007-07-02 2009-01-08 University Of Massachusetts Lowell Modified polymers and methods for making and using the same
US9192697B2 (en) 2007-07-03 2015-11-24 Hemoteq Ag Balloon catheter for treating stenosis of body passages and for preventing threatening restenosis
US20090018633A1 (en) * 2007-07-10 2009-01-15 Boston Scientific Scimed, Inc. Protector for an insertable or implantable medical device
US9216101B2 (en) * 2007-07-10 2015-12-22 Boston Scientific Scime, Inc. Dual taper stent protector
US20090018635A1 (en) * 2007-07-10 2009-01-15 Boston Scientific Scimed, Inc. Stent protector
US7942926B2 (en) * 2007-07-11 2011-05-17 Boston Scientific Scimed, Inc. Endoprosthesis coating
US8002823B2 (en) 2007-07-11 2011-08-23 Boston Scientific Scimed, Inc. Endoprosthesis coating
CA2696996C (en) * 2007-07-16 2016-03-22 The State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University Antimicrobial constructs
US9284409B2 (en) * 2007-07-19 2016-03-15 Boston Scientific Scimed, Inc. Endoprosthesis having a non-fouling surface
US8815273B2 (en) 2007-07-27 2014-08-26 Boston Scientific Scimed, Inc. Drug eluting medical devices having porous layers
US7931683B2 (en) 2007-07-27 2011-04-26 Boston Scientific Scimed, Inc. Articles having ceramic coated surfaces
US8221822B2 (en) 2007-07-31 2012-07-17 Boston Scientific Scimed, Inc. Medical device coating by laser cladding
EP2185103B1 (en) 2007-08-03 2014-02-12 Boston Scientific Scimed, Inc. Coating for medical device having increased surface area
EP2197508B1 (en) * 2007-09-06 2014-12-10 Boston Scientific Limited Medical devices containing silicate and carbon particles
US20090068244A1 (en) * 2007-09-12 2009-03-12 Boston Scientific Scimed, Inc. Polymeric/carbon composite materials for use in medical devices
US8052745B2 (en) 2007-09-13 2011-11-08 Boston Scientific Scimed, Inc. Endoprosthesis
US9248219B2 (en) * 2007-09-14 2016-02-02 Boston Scientific Scimed, Inc. Medical devices having bioerodable layers for the release of therapeutic agents
CA2698812A1 (en) 2007-09-14 2009-03-19 Nitto Denko Corporation Drug carriers
US9107828B2 (en) * 2007-10-05 2015-08-18 Boston Scientific Scimed, Inc. Multi-component particles for injection and processes for forming the same
US8608049B2 (en) * 2007-10-10 2013-12-17 Zimmer, Inc. Method for bonding a tantalum structure to a cobalt-alloy substrate
US20110230973A1 (en) * 2007-10-10 2011-09-22 Zimmer, Inc. Method for bonding a tantalum structure to a cobalt-alloy substrate
US8337451B2 (en) * 2007-10-19 2012-12-25 Angio Dynamics, Inc. Recirculation minimizing catheter
US8661630B2 (en) 2008-05-21 2014-03-04 Abbott Cardiovascular Systems Inc. Coating comprising an amorphous primer layer and a semi-crystalline reservoir layer
US7938855B2 (en) 2007-11-02 2011-05-10 Boston Scientific Scimed, Inc. Deformable underlayer for stent
US8029554B2 (en) 2007-11-02 2011-10-04 Boston Scientific Scimed, Inc. Stent with embedded material
US8216632B2 (en) 2007-11-02 2012-07-10 Boston Scientific Scimed, Inc. Endoprosthesis coating
US8765895B2 (en) 2007-11-08 2014-07-01 Innolene Llc Crosslinked polyolefins for biomedical applications and method of making same
EP2214747A2 (en) 2007-11-20 2010-08-11 Cook Incorporated Controlled drug delivery using a zein layer modified with levulinic acid
WO2009076272A2 (en) * 2007-12-07 2009-06-18 Boston Scientific Scimed, Inc. Drug coated stent with endosome-disrupting conjugate
US20090156772A1 (en) * 2007-12-12 2009-06-18 Boston Scientific Scimed, Inc. Melt processed materials for medical articles
US8551072B2 (en) * 2007-12-12 2013-10-08 Boston Scientific Scimed, Inc. Methods, devices and compositions for controlled drug delivery to injured myocardium
US8728528B2 (en) 2007-12-20 2014-05-20 Evonik Corporation Process for preparing microparticles having a low residual solvent volume
US20090169471A1 (en) * 2007-12-28 2009-07-02 Boston Scientific Scimed, Inc. Particles for injection and processes for forming the same
US20090187256A1 (en) * 2008-01-21 2009-07-23 Zimmer, Inc. Method for forming an integral porous region in a cast implant
US20090198286A1 (en) * 2008-02-05 2009-08-06 Zimmer, Inc. Bone fracture fixation system
CA2716671A1 (en) * 2008-02-27 2009-09-03 Thommen Medical Ag Implant and method for the manufacture thereof
US8252048B2 (en) * 2008-03-19 2012-08-28 Boston Scientific Scimed, Inc. Drug eluting stent and method of making the same
CA2719474C (en) 2008-03-27 2016-09-27 Boston Scientific Scimed, Inc. Ureteral stents for release of urologically beneficial agents
JP5581311B2 (ja) 2008-04-22 2014-08-27 ボストン サイエンティフィック サイムド，インコーポレイテッド 無機材料のコーティングを有する医療デバイス及びその製造方法
WO2009132176A2 (en) 2008-04-24 2009-10-29 Boston Scientific Scimed, Inc. Medical devices having inorganic particle layers
US7998192B2 (en) 2008-05-09 2011-08-16 Boston Scientific Scimed, Inc. Endoprostheses
US8771332B2 (en) * 2008-05-29 2014-07-08 Boston Scientific Scimed, Inc. Multi-layer balloon design for use in combination with catheter assemblies, and methods of making the same
US20090306769A1 (en) * 2008-06-06 2009-12-10 Boston Scientific Scimed, Inc. Medical balloon made with hybrid polymer-ceramic material and method of making and using the same
US8236046B2 (en) * 2008-06-10 2012-08-07 Boston Scientific Scimed, Inc. Bioerodible endoprosthesis
EP2303350A2 (en) 2008-06-18 2011-04-06 Boston Scientific Scimed, Inc. Endoprosthesis coating
EP2307067A2 (en) 2008-06-25 2011-04-13 Boston Scientific Scimed, Inc. Medical devices containing therapeutic agents
EP2307068A2 (en) * 2008-06-25 2011-04-13 Boston Scientific Scimed, Inc. Medical devices having surface coatings
EP2310065A2 (en) * 2008-06-26 2011-04-20 Boston Scientific Scimed, Inc. Medical device coatings containing charged materials
WO2009158485A2 (en) * 2008-06-26 2009-12-30 Boston Scientific Scimed, Inc. Medical devices having fluorocarbon polymer coatings
US20090326077A1 (en) * 2008-06-27 2009-12-31 Cardiac Pacemakers, Inc. Polyisobutylene urethane, urea and urethane/urea copolymers and medical devices containing the same
US7985252B2 (en) 2008-07-30 2011-07-26 Boston Scientific Scimed, Inc. Bioerodible endoprosthesis
WO2010027678A2 (en) * 2008-08-27 2010-03-11 Boston Scientific Scimed, Inc. Medical devices having inorganic coatings for therapeutic agent delivery
US8133199B2 (en) 2008-08-27 2012-03-13 Boston Scientific Scimed, Inc. Electroactive polymer activation system for a medical device
US8795704B2 (en) 2008-08-27 2014-08-05 Boston Scientific Scimed, Inc. Medical devices having fluorine-containing polymer coatings with improved adhesion
WO2010027679A2 (en) * 2008-08-27 2010-03-11 Boston Scientific Scimed, Inc. Medical devices having coatings for therapeutic agent delivery
US8628539B2 (en) * 2008-09-05 2014-01-14 Innovia, Llc Flexible disposable surgical port
US8128951B2 (en) 2008-09-15 2012-03-06 Cv Ingenuity Corp. Local delivery of water-soluble or water-insoluble therapeutic agents to the surface of body lumens
US8114429B2 (en) 2008-09-15 2012-02-14 Cv Ingenuity Corp. Local delivery of water-soluble or water-insoluble therapeutic agents to the surface of body lumens
US9198968B2 (en) * 2008-09-15 2015-12-01 The Spectranetics Corporation Local delivery of water-soluble or water-insoluble therapeutic agents to the surface of body lumens
US8257722B2 (en) 2008-09-15 2012-09-04 Cv Ingenuity Corp. Local delivery of water-soluble or water-insoluble therapeutic agents to the surface of body lumens
US9220811B2 (en) 2008-09-22 2015-12-29 Boston Scientific Scimed, Inc. Implantable or insertable medical devices
EP3257551B1 (en) 2008-09-22 2018-11-28 Cardiac Pacemakers, Inc. Implantable and insertable medical device comprising styrene-isobutylene copolymer-based insulating layers
US8226603B2 (en) 2008-09-25 2012-07-24 Abbott Cardiovascular Systems Inc. Expandable member having a covering formed of a fibrous matrix for intraluminal drug delivery
US8076529B2 (en) 2008-09-26 2011-12-13 Abbott Cardiovascular Systems, Inc. Expandable member formed of a fibrous matrix for intraluminal drug delivery
US8049061B2 (en) 2008-09-25 2011-11-01 Abbott Cardiovascular Systems, Inc. Expandable member formed of a fibrous matrix having hydrogel polymer for intraluminal drug delivery
US8382824B2 (en) 2008-10-03 2013-02-26 Boston Scientific Scimed, Inc. Medical implant having NANO-crystal grains with barrier layers of metal nitrides or fluorides
ES2440751T3 (es) * 2008-10-07 2014-01-30 Boston Scientific Scimed, Inc. Dispositivos médicos para administración de agentes terapéuticos a los lúmenes corporales
DE102008043724A1 (de) 2008-11-13 2010-05-20 Biotronik Vi Patent Ag Erhöhung der Effizienz pharmazeutische Wirkstoffe-freisetzender Medizinprodukte durch Kombination mit einem Inhibitor des Transportproteins P-Glycoprotein
US8231980B2 (en) 2008-12-03 2012-07-31 Boston Scientific Scimed, Inc. Medical implants including iridium oxide
CN102341134B (zh) 2008-12-31 2014-09-10 波士顿科学医学有限公司 具有聚异丁烯和可生物降解聚合物链段的共聚物
US9574043B2 (en) * 2009-01-12 2017-02-21 University Of Massachusetts Lowell Polyisobutylene-based polyurethanes
US8933145B2 (en) 2009-02-20 2015-01-13 The General Hospital Corporation High temperature melting
US8267992B2 (en) 2009-03-02 2012-09-18 Boston Scientific Scimed, Inc. Self-buffering medical implants
US8071156B2 (en) 2009-03-04 2011-12-06 Boston Scientific Scimed, Inc. Endoprostheses
US20100233227A1 (en) * 2009-03-10 2010-09-16 Boston Scientific Scimed, Inc. Medical devices having carbon drug releasing layers
US8765238B2 (en) 2009-03-18 2014-07-01 Boston Scientific Scimed, Inc. Polymeric/inorganic composite materials for use in medical devices
WO2010114633A1 (en) * 2009-04-03 2010-10-07 Biomerix Corporation At least partially resorbable reticulated elastomeric matrix elements and methods of making same
US9050176B2 (en) 2009-04-03 2015-06-09 Biomerix Corporation At least partially resorbable reticulated elastomeric matrix elements and methods of making same
US20100256546A1 (en) * 2009-04-03 2010-10-07 Davis Scott A Polycarbonate Polyurethane Venous Access Devices Having Enhanced Strength
US8287937B2 (en) 2009-04-24 2012-10-16 Boston Scientific Scimed, Inc. Endoprosthese
US20100285085A1 (en) * 2009-05-07 2010-11-11 Abbott Cardiovascular Systems Inc. Balloon coating with drug transfer control via coating thickness
US10369256B2 (en) 2009-07-10 2019-08-06 Boston Scientific Scimed, Inc. Use of nanocrystals for drug delivery from a balloon
EP2453938B1 (en) 2009-07-17 2015-08-19 Boston Scientific Scimed, Inc. Nucleation of drug delivery balloons to provide improved crystal size and density
EP2467174B1 (en) 2009-08-21 2018-09-26 Cardiac Pacemakers, Inc. Crosslinkable polyisobutylene-based polymers and medical devices containing the same
US8644952B2 (en) * 2009-09-02 2014-02-04 Cardiac Pacemakers, Inc. Medical devices including polyisobutylene based polymers and derivatives thereof
US8374704B2 (en) 2009-09-02 2013-02-12 Cardiac Pacemakers, Inc. Polyisobutylene urethane, urea and urethane/urea copolymers and medical leads containing the same
US20110071500A1 (en) * 2009-09-21 2011-03-24 Navilyst Medical, Inc. Branched catheter tip
RU2545865C2 (ru) * 2009-09-22 2015-04-10 Евоник Корпорейшн Имплантируемые устройства с различными вариантами загрузки биологически активного компонента
US20110144746A1 (en) * 2009-12-11 2011-06-16 Vanderbilt David P Intraocular Lens
EP3960215B1 (en) 2009-12-15 2024-10-16 Incept, LLC Implants and biodegradable fiducial markers
US8361140B2 (en) * 2009-12-29 2013-01-29 Boston Scientific Scimed, Inc. High strength low opening pressure stent design
US8328760B2 (en) * 2010-01-11 2012-12-11 Angiodynamics, Inc. Occlusion resistant catheter
US8398916B2 (en) 2010-03-04 2013-03-19 Icon Medical Corp. Method for forming a tubular medical device
WO2011119536A1 (en) 2010-03-22 2011-09-29 Abbott Cardiovascular Systems Inc. Stent delivery system having a fibrous matrix covering with improved stent retention
WO2011119573A1 (en) 2010-03-23 2011-09-29 Boston Scientific Scimed, Inc. Surface treated bioerodible metal endoprostheses
US8685433B2 (en) 2010-03-31 2014-04-01 Abbott Cardiovascular Systems Inc. Absorbable coating for implantable device
US8889211B2 (en) 2010-09-02 2014-11-18 Boston Scientific Scimed, Inc. Coating process for drug delivery balloons using heat-induced rewrap memory
US9828324B2 (en) 2010-10-20 2017-11-28 Sirrus, Inc. Methylene beta-diketone monomers, methods for making methylene beta-diketone monomers, polymerizable compositions and products formed therefrom
US10414839B2 (en) 2010-10-20 2019-09-17 Sirrus, Inc. Polymers including a methylene beta-ketoester and products formed therefrom
US9279022B1 (en) * 2014-09-08 2016-03-08 Sirrus, Inc. Solution polymers including one or more 1,1-disubstituted alkene compounds, solution polymerization methods, and polymer compositions
US9249265B1 (en) 2014-09-08 2016-02-02 Sirrus, Inc. Emulsion polymers including one or more 1,1-disubstituted alkene compounds, emulsion methods, and polymer compositions
WO2012087480A1 (en) 2010-12-20 2012-06-28 Cardiac Pacemakers, Inc. Lead having a conductive polymer conductor
US9050435B2 (en) 2011-03-22 2015-06-09 Angiodynamics, Inc. High flow catheters
US9999746B2 (en) 2011-03-22 2018-06-19 Angiodynamics, Inc. High flow catheters
WO2012158779A1 (en) 2011-05-17 2012-11-22 Reprotect, Inc. Reusable intravaginal delivery device, system, and method
US8669360B2 (en) 2011-08-05 2014-03-11 Boston Scientific Scimed, Inc. Methods of converting amorphous drug substance into crystalline form
WO2013028208A1 (en) 2011-08-25 2013-02-28 Boston Scientific Scimed, Inc. Medical device with crystalline drug coating
EP2768897B1 (en) 2011-10-19 2019-01-23 Sirrus, Inc. Methods for making methylene beta-diketone monomers
TWI590843B (zh) 2011-12-28 2017-07-11 信迪思有限公司 膜及其製造方法
US9101444B2 (en) 2012-01-12 2015-08-11 Innfocus, Inc. Method, surgical kit and device for treating glaucoma
US9707339B2 (en) 2012-03-28 2017-07-18 Angiodynamics, Inc. High flow rate dual reservoir port system
US9713704B2 (en) 2012-03-29 2017-07-25 Bradley D. Chartrand Port reservoir cleaning system and method
JP6345644B2 (ja) 2012-03-30 2018-06-20 シラス・インコーポレイテッド インク配合物およびコーティング配合物ならびにこれらを作製するための重合性の系
EP2831124B1 (en) 2012-03-30 2016-10-05 Sirrus, Inc. Composite and laminate articles and polymerizable systems for producing the same
US8858491B2 (en) * 2012-05-23 2014-10-14 Alcon Research, Ltd. Pre-biased membrane valve
WO2013176739A1 (en) * 2012-05-25 2013-11-28 Regents Of The University Of Minnesota Biomaterials with a sustainable surface
WO2013181600A2 (en) 2012-06-01 2013-12-05 Bioformix Inc. Optical material and articles formed therefrom
MX351261B (es) 2012-06-01 2017-10-06 Surmodics Inc Aparato y método para recubrir catéteres con globo.
US9827401B2 (en) 2012-06-01 2017-11-28 Surmodics, Inc. Apparatus and methods for coating medical devices
US9956385B2 (en) 2012-06-28 2018-05-01 The Spectranetics Corporation Post-processing of a medical device to control morphology and mechanical properties
US11090468B2 (en) 2012-10-25 2021-08-17 Surmodics, Inc. Apparatus and methods for coating medical devices
CN105008438B (zh) 2012-11-16 2019-10-22 拜奥福米克斯公司 塑料粘结体系及方法
US9205242B2 (en) 2012-11-19 2015-12-08 Angiodynamics, Inc. Port septum with integral valve
US20140141048A1 (en) 2012-11-21 2014-05-22 Boston Scientific Scimed, Inc. Ionic hydrophilic polymer coatings for use in medical devices
JP2015535538A (ja) 2012-11-21 2015-12-14 ユニバーシティー オブ マサチューセッツＵｎｉｖｅｒｓｉｔｙ ｏｆ Ｍａｓｓａｃｈｕｓｅｔｔｓ 高強度ポリイソブチレンポリウレタン
WO2014085570A1 (en) 2012-11-30 2014-06-05 Bioformix, Inc. Composite compositions for electronics applications
EP2943462B1 (en) 2013-01-11 2018-06-27 Sirrus, Inc. Method to obtain methylene malonate via bis(hydroxymethyl) malonate pathway
WO2014120587A1 (en) 2013-01-30 2014-08-07 Boston Scientific Scimed, Inc. Ureteral stent with drug-releasing structure
WO2014164753A1 (en) * 2013-03-11 2014-10-09 Emory University Methods and compositions for managing vascular conditions
KR102249720B1 (ko) 2013-06-21 2021-05-11 디퍼이 신테스 프로덕츠, 인코포레이티드 필름 및 제조 방법
US8952126B2 (en) * 2013-07-10 2015-02-10 Xerox Corporation Purification of functionalized triblock copolymers via methanol trituration
US9226851B2 (en) 2013-08-24 2016-01-05 Novartis Ag MEMS check valve chip and methods
EP3089768A1 (en) 2013-12-30 2016-11-09 Boston Scientific Scimed, Inc. Functionalized lubricious medical device coatings
US10166321B2 (en) 2014-01-09 2019-01-01 Angiodynamics, Inc. High-flow port and infusion needle systems
US10525171B2 (en) 2014-01-24 2020-01-07 The Spectranetics Corporation Coatings for medical devices
EP3160397A4 (en) 2014-06-24 2018-03-21 Icon Medical Corp. Improved metal alloys for medical devices
CN104072707A (zh) * 2014-07-08 2014-10-01 成都市绿科华通科技有限公司 一种星型嵌段共聚物多孔药物载体的制备方法
US9315597B2 (en) 2014-09-08 2016-04-19 Sirrus, Inc. Compositions containing 1,1-disubstituted alkene compounds for preparing polymers having enhanced glass transition temperatures
US9416091B1 (en) 2015-02-04 2016-08-16 Sirrus, Inc. Catalytic transesterification of ester compounds with groups reactive under transesterification conditions
EP3028719A1 (en) * 2014-12-01 2016-06-08 Lanxess Inc. Polymer-drug conjugate based on a polyisoolefin-based copolymer
US10501400B2 (en) 2015-02-04 2019-12-10 Sirrus, Inc. Heterogeneous catalytic transesterification of ester compounds with groups reactive under transesterification conditions
US9334430B1 (en) 2015-05-29 2016-05-10 Sirrus, Inc. Encapsulated polymerization initiators, polymerization systems and methods using the same
US9217098B1 (en) 2015-06-01 2015-12-22 Sirrus, Inc. Electroinitiated polymerization of compositions having a 1,1-disubstituted alkene compound
US20160346219A1 (en) 2015-06-01 2016-12-01 Autotelic Llc Phospholipid-coated therapeutic agent nanoparticles and related methods
US10335406B2 (en) 2015-10-01 2019-07-02 Elysium Therapeutics, Inc. Opioid compositions resistant to overdose and abuse
GB2556817B (en) 2015-10-01 2019-11-06 Elysium Therapeutics Inc Polysubunit opioid prodrugs resistant to overdose and abuse
EP3373990A1 (en) 2015-11-12 2018-09-19 The General Hospital Corporation Methods of making therapeutic polymeric material
US20190290474A1 (en) * 2016-01-04 2019-09-26 Jurox Pty Ltd Drug release device and use
EP3411422A1 (en) 2016-02-05 2018-12-12 The General Hospital Corporation Drug eluting polymer composed of biodegradable polymers applied to surface of medical device
US11766506B2 (en) 2016-03-04 2023-09-26 Mirus Llc Stent device for spinal fusion
EP3452119A1 (en) * 2016-05-02 2019-03-13 The General Hospital Corporation Implant surfaces for pain control
US9518001B1 (en) 2016-05-13 2016-12-13 Sirrus, Inc. High purity 1,1-dicarbonyl substituted-1-alkenes and methods for their preparation
US10428177B2 (en) 2016-06-03 2019-10-01 Sirrus, Inc. Water absorbing or water soluble polymers, intermediate compounds, and methods thereof
US9617377B1 (en) 2016-06-03 2017-04-11 Sirrus, Inc. Polyester macromers containing 1,1-dicarbonyl-substituted 1 alkenes
US9567475B1 (en) 2016-06-03 2017-02-14 Sirrus, Inc. Coatings containing polyester macromers containing 1,1-dicarbonyl-substituted 1 alkenes
US10196481B2 (en) 2016-06-03 2019-02-05 Sirrus, Inc. Polymer and other compounds functionalized with terminal 1,1-disubstituted alkene monomer(s) and methods thereof
US10526429B2 (en) 2017-03-07 2020-01-07 Cardiac Pacemakers, Inc. Hydroboration/oxidation of allyl-terminated polyisobutylene
EP3595663A4 (en) 2017-03-17 2021-01-13 Elysium Therapeutics, Inc. MULTI-UNIT OPIOID MEDICINES RESISTANT TO OVERDOSE AND ABUSE
WO2019014408A1 (en) 2017-07-13 2019-01-17 Boston Scientific Scimed, Inc. EMBOLIC MICROSPHERES
CN110997746B (zh) 2017-08-17 2021-12-28 心脏起搏器股份公司 用于增强的耐久性的光交联聚合物
EP3740253B1 (en) 2018-01-17 2023-08-16 Cardiac Pacemakers, Inc. End-capped polyisobutylene polyurethane
BR112020025239A2 (pt) * 2018-06-11 2021-03-09 DePuy Synthes Products, Inc. Lubrificante e preventivo contra corrosão biocompatíveis e estáveis ao calor e à radiação gama para dispositivos médicos
EP3824917B1 (en) 2018-07-17 2025-10-29 FUJIFILM Corporation Use of a composition for a laminated material used for a medical lubricating member, use of a laminated material used for a medical lubricating member, medical lubricating member, and medical device
US11628466B2 (en) 2018-11-29 2023-04-18 Surmodics, Inc. Apparatus and methods for coating medical devices
US11819590B2 (en) 2019-05-13 2023-11-21 Surmodics, Inc. Apparatus and methods for coating medical devices
US20230044613A1 (en) * 2019-12-17 2023-02-09 Nanyang Technological University Block copolymers with nitric oxide donor
US12011391B2 (en) 2020-02-27 2024-06-18 Innfocus, Inc. Ocular implant
JP7601891B2 (ja) 2020-03-18 2024-12-17 ボストン サイエンティフィック サイムド，インコーポレイテッド 腫瘍併用治療用の固体塞栓組成物
US20240199793A1 (en) * 2020-08-06 2024-06-20 Regents Of The University Of Minnesota Thermoplastic biodegradable elastomers and methods of use
US11970600B2 (en) 2021-03-31 2024-04-30 The General Hospital Corporation Di-cumyl peroxide crosslinking of UHMWPE
US12427061B2 (en) 2022-05-25 2025-09-30 R. Philip Doss Curved microtube for treating glaucoma

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4276394A (en) 1979-09-10 1981-06-30 The University Of Akron Novel telechelic polymers, block copolymers and processes for the preparation thereof
US4316973A (en) 1979-09-10 1982-02-23 The University Of Akron Novel telechelic polymers and processes for the preparation thereof
US4342849A (en) 1979-09-10 1982-08-03 The University Of Akron Novel telechelic polymers and processes for the preparation thereof
JPS593967B2 (ja) * 1979-12-11 1984-01-27 日東電工株式会社 湿布剤
US4481323A (en) * 1980-05-07 1984-11-06 Medical Research Associates, Ltd. #2 Hydrocarbon block copolymer with dispersed polysiloxane
US5122572A (en) 1985-06-20 1992-06-16 Kennedy Joseph P Living catalysts, complexes and polymers therefrom
US4910321A (en) 1985-06-20 1990-03-20 University Of Akron Living catalysts, complexes and polymers therefrom
US5066730A (en) 1986-08-25 1991-11-19 The University Of Akron Living polymerization of olefins to end-functionalized polymers
US4929683A (en) 1986-08-25 1990-05-29 University Of Akron Living polymerization of olefin to end-functionalized polymers
JPH0787841B2 (ja) 1989-02-10 1995-09-27 株式会社シーメツクス・ジヤパン 哺乳動物の授精適期検出装置
US5014710A (en) 1988-09-13 1991-05-14 Acuson Corporation Steered linear color doppler imaging
US4946899A (en) 1988-12-16 1990-08-07 The University Of Akron Thermoplastic elastomers of isobutylene and process of preparation
JPH02211135A (ja) 1989-02-10 1990-08-22 Hitachi Medical Corp 超音波診断装置
JPH07116023B2 (ja) * 1989-04-12 1995-12-13 積水化学工業株式会社 ポリウレタンフィルムを支持体とする貼付剤
IL90193A (en) * 1989-05-04 1993-02-21 Biomedical Polymers Int Polurethane-based polymeric materials and biomedical articles and pharmaceutical compositions utilizing the same
US5811447A (en) 1993-01-28 1998-09-22 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
JP3276188B2 (ja) * 1993-01-08 2002-04-22 積水化学工業株式会社 貼付剤及びその製造方法
EP0689465A1 (en) 1993-03-18 1996-01-03 Cedars-Sinai Medical Center Drug incorporating and releasing polymeric coating for bioprosthesis
US5994341A (en) 1993-07-19 1999-11-30 Angiogenesis Technologies, Inc. Anti-angiogenic Compositions and methods for the treatment of arthritis
AU7476894A (en) 1993-07-29 1995-02-28 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Method of treating atherosclerosis or restenosis using microtubule stabilizing agent
US5630844A (en) * 1995-06-07 1997-05-20 Novamed Medical Products Manufacturing, Inc. Biocompatible hydrophobic laminate with thermoplastic elastomer layer
CA2199890C (en) 1996-03-26 2002-02-05 Leonard Pinchuk Stents and stent-grafts having enhanced hoop strength and methods of making the same
US5741331A (en) 1996-07-29 1998-04-21 Corvita Corporation Biostable elastomeric polymers having quaternary carbons
US5980972A (en) 1996-12-20 1999-11-09 Schneider (Usa) Inc Method of applying drug-release coatings
US5879697A (en) 1997-04-30 1999-03-09 Schneider Usa Inc Drug-releasing coatings for medical devices
JP3618527B2 (ja) 1997-09-25 2005-02-09 株式会社クラレ ブロック共重合体とその製造方法及び樹脂組成物
JP2000157627A (ja) 1998-11-26 2000-06-13 Kuraray Co Ltd 医療用具およびその成形材料
US6147135A (en) * 1998-12-31 2000-11-14 Ethicon, Inc. Fabrication of biocompatible polymeric composites
US6368658B1 (en) * 1999-04-19 2002-04-09 Scimed Life Systems, Inc. Coating medical devices using air suspension
US6545097B2 (en) * 2000-12-12 2003-04-08 Scimed Life Systems, Inc. Drug delivery compositions and medical devices containing block copolymer

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008528121A (ja) * 2005-01-25 2008-07-31 ボストン サイエンティフィック リミティッド 非共有結合型ポリマー含有の薬剤放出領域をもつ医療器具
JP2009530023A (ja) * 2006-03-22 2009-08-27 ボストン サイエンティフィック リミテッド 生分解性ポリマー領域を有する医療デバイス
JP2009538704A (ja) * 2006-06-01 2009-11-12 ボストン サイエンティフィック リミテッド 向上した性能を有する医療用デバイス
WO2009041691A1 (ja) 2007-09-28 2009-04-02 Terumo Kabushiki Kaisha 生体内留置物
JP2013528673A (ja) * 2010-04-16 2013-07-11 ランクセス・インク． ガラス転移温度の高い芯を有する樹木状重合体及びその製造方法

Also Published As

Publication number Publication date
CA2447900A1 (en) 2002-06-20
DE60121992D1 (de) 2006-09-14
EP1341565A2 (en) 2003-09-10
US20020107330A1 (en) 2002-08-08
AU3085102A (en) 2002-06-24
US20030171496A1 (en) 2003-09-11
JP5270617B2 (ja) 2013-08-21
US20100092540A1 (en) 2010-04-15
US6545097B2 (en) 2003-04-08
US7923509B2 (en) 2011-04-12
EP1341565B1 (en) 2006-08-02
WO2002047731A3 (en) 2003-01-23
AU2002230851B2 (en) 2006-07-27
DE60121992T2 (de) 2007-04-05
WO2002047731A2 (en) 2002-06-20
US7622530B2 (en) 2009-11-24
US20050215722A1 (en) 2005-09-29
JP2010194355A (ja) 2010-09-09
US6855770B2 (en) 2005-02-15

Similar Documents

Publication Publication Date Title
JP5270617B2 (ja) ブロックコポリマを含む薬物送達構成体及び医療器具
JP5475950B2 (ja) 制御された薬物送達および調節された生体適合性のための多孔質高分子領域を有する医療機器
JP5013862B2 (ja) 治療薬を制御して送達する放射線架橋されたポリマーを含有する埋め込み可能又は挿入可能な医療装置
AU2002230851A1 (en) Drug delivery compositions and coated medical devices
JP4662556B2 (ja) 治療薬デリバリー制御に関する相溶性ポリマーブレンド含有埋め込み又は挿入可能医療器具
JP5134013B2 (ja) スチレンイソブチレン共重合体に基づくポリマー領域を有する医療デバイス
JP5313498B2 (ja) 薬物送達用グラフトコポリマー末端ブロックを有するコポリマーを含む医療器具
JP5001005B2 (ja) 治療薬デリバリー制御のためのグラフトコポリマー含有埋め込み可能又は挿入可能な医療器具
JP2008506502A (ja) 導電性基板および共有結合したコーティング層を有する医療器具
JP2007513643A5 (enExample)
JP2009530023A (ja) 生分解性ポリマー領域を有する医療デバイス
JP2008506504A (ja) 耐放射線ブロックコポリマーを含む医療用デバイス
JP5122281B2 (ja) イソブチレンコポリマーを含む医療器具及び材料

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20040701

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20041020

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20041213

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20080708

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20081008

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20081016

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20081110

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20081117

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20081208

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20081215

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20090108

RD02 Notification of acceptance of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7422

Effective date: 20090306

RD03 Notification of appointment of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7423

Effective date: 20090306

RD04 Notification of resignation of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7424

Effective date: 20090327

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20100215

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20100615

A761 Written withdrawal of application

Free format text: JAPANESE INTERMEDIATE CODE: A761

Effective date: 20100622