WO2009041691A1 - 生体内留置物 - Google Patents

生体内留置物 Download PDF

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Publication number
WO2009041691A1
WO2009041691A1 PCT/JP2008/067672 JP2008067672W WO2009041691A1 WO 2009041691 A1 WO2009041691 A1 WO 2009041691A1 JP 2008067672 W JP2008067672 W JP 2008067672W WO 2009041691 A1 WO2009041691 A1 WO 2009041691A1
Authority
WO
WIPO (PCT)
Prior art keywords
matter
vivo indwelling
stent
medicinal agent
main body
Prior art date
Application number
PCT/JP2008/067672
Other languages
English (en)
French (fr)
Inventor
Yuji Nakagawa
Kenichi Shimura
Original Assignee
Terumo Kabushiki Kaisha
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Terumo Kabushiki Kaisha filed Critical Terumo Kabushiki Kaisha
Priority to EP08833465.1A priority Critical patent/EP2191853B1/en
Priority to JP2009534457A priority patent/JP5356239B2/ja
Publication of WO2009041691A1 publication Critical patent/WO2009041691A1/ja
Priority to US12/732,616 priority patent/US20100233229A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/08—Materials for coatings
    • A61L29/10—Inorganic materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
    • A61L29/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/10—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L67/00—Compositions of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Compositions of derivatives of such polymers
    • C08L67/04—Polyesters derived from hydroxycarboxylic acids, e.g. lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/416—Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/426—Immunomodulating agents, i.e. cytokines, interleukins, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/80—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special chemical form
    • A61L2300/802—Additives, excipients, e.g. cyclodextrins, fatty acids, surfactants

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Vascular Medicine (AREA)
  • Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Transplantation (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Polymers & Plastics (AREA)
  • Materials For Medical Uses (AREA)
  • Media Introduction/Drainage Providing Device (AREA)

Abstract

　本発明は、生体内留置物、例えばステントの製造工程や輸送工程、更に臨床使用時におけるステント拡張時に、ステント表面に形成されたコーティング層が破壊される恐れが低く、安全性の高い生体内留置物を提供し、または、できるだけ早期に薬剤が消失することにより残存薬剤の副作用低減を期待でき、かつ、再狭窄を抑制することが可能な必要最少量の薬剤を担持可能な生体内留置物を提供する。 　本発明は、生体内留置物本体と、前記生体内留置物本体の表面の少なくとも一部に形成される中鎖脂肪酸トリグリセリドを含有する層とを有する、生体内の管腔に留置する生体内留置物により上記課題を解決する。
PCT/JP2008/067672 2007-09-28 2008-09-29 生体内留置物 WO2009041691A1 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP08833465.1A EP2191853B1 (en) 2007-09-28 2008-09-29 In-vivo indwelling matter
JP2009534457A JP5356239B2 (ja) 2007-09-28 2008-09-29 生体内留置物
US12/732,616 US20100233229A1 (en) 2007-09-28 2010-03-26 In-vivo indwelling device

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2007-254540 2007-09-28
JP2007254540 2007-09-28
JP2008-089451 2008-03-31
JP2008089451 2008-03-31

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/732,616 Continuation US20100233229A1 (en) 2007-09-28 2010-03-26 In-vivo indwelling device

Publications (1)

Publication Number Publication Date
WO2009041691A1 true WO2009041691A1 (ja) 2009-04-02

Family

ID=40511569

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/067672 WO2009041691A1 (ja) 2007-09-28 2008-09-29 生体内留置物

Country Status (4)

Country Link
US (1) US20100233229A1 (ja)
EP (1) EP2191853B1 (ja)
JP (2) JP5356239B2 (ja)
WO (1) WO2009041691A1 (ja)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012020812A1 (ja) * 2010-08-12 2012-02-16 株式会社オプトニクス精密 ステント
JP2020529231A (ja) * 2017-07-26 2020-10-08 鼎科医療技術（蘇州）有限公司 表面液化薬物コートバルーン

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9492587B2 (en) * 2009-04-13 2016-11-15 Abbott Cardiovascular Systems Inc. Stent made from an ultra high molecular weight bioabsorbable polymer with high fatigue and fracture resistance
US8114149B2 (en) * 2009-10-20 2012-02-14 Svelte Medical Systems, Inc. Hybrid stent with helical connectors
US11241322B2 (en) 2014-10-28 2022-02-08 Jimro Co., Ltd. Drug-eluting stent
CN107998458B (zh) * 2017-12-22 2021-02-19 鼎科医疗技术（苏州）有限公司 球囊药物涂层及药物球囊

Citations (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01124463A (ja) * 1987-11-09 1989-05-17 Terumo Corp 医療用軟質樹脂組成物および医療用具
JPH07529A (ja) 1993-04-23 1995-01-06 Schneider Europ Ag 膨張可能な不連続な壁部を有するステント及びステントにカバー層を取り付ける方法
JPH07500272A (ja) 1992-01-15 1995-01-12 クック・インコーポレーテッド 螺旋型ステント
JPH0833718A (ja) 1993-04-26 1996-02-06 Medtronic Inc 血管内ステント及び方法
JPH08502428A (ja) 1992-10-13 1996-03-19 ボストン・サイエンティフィック・コーポレイション 蠕動運動を示す体の管腔のためのステント
JPH09215753A (ja) 1996-02-08 1997-08-19 Schneider Usa Inc チタン合金製自己拡張型ステント
JPH11323113A (ja) * 1998-05-08 1999-11-26 Shimadzu Corp ポリ乳酸系組成物
JP2001512354A (ja) 1997-02-20 2001-08-21 クック インコーポレーティッド． 被覆された移植可能な医療器具
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JP2003526477A (ja) 2000-03-15 2003-09-09 オーバス メディカル テクノロジーズ インク． 内皮細胞接着を促進するコーティング
JP2004518458A (ja) 2000-09-29 2004-06-24 コーディス・コーポレイション 被覆医用器具
JP2004522559A (ja) 2000-10-31 2004-07-29 クック　インコーポレイティド 医療器具
JP2004524346A (ja) 2001-03-26 2004-08-12 シユペツク，ウルリヒ 再狭窄予防のための調製物
JP2004533409A (ja) 2000-12-12 2004-11-04 ボストン サイエンティフィック リミテッド ブロックコポリマを含む薬物送達構成体及び医療器具
JP2005516736A (ja) 2002-02-15 2005-06-09 シーブイ・セラピューティクス・インコーポレイテッド 医療器具用ポリマーコーティング
JP2007097706A (ja) 2005-09-30 2007-04-19 Terumo Corp ステント
JP2007144108A (ja) 2005-03-30 2007-06-14 Terumo Corp 生体内留置用ステント
JP2007254540A (ja) 2006-03-22 2007-10-04 Showa Denko Kk 高分子発光材料、有機エレクトロルミネッセンス素子および表示装置
JP2008089451A (ja) 2006-10-03 2008-04-17 Toshiba Corp 洗濯廃液の処理方法および処理装置
JP2008220811A (ja) * 2007-03-15 2008-09-25 Terumo Corp ステント

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CA2466432A1 (en) * 2001-11-08 2003-05-15 Atrium Medical Corporation Intraluminal device with a coating containing a therapeutic agent
US8518097B2 (en) * 2003-04-25 2013-08-27 Medtronic Vascular, Inc. Plasticized stent coatings
ES2632124T3 (es) * 2004-02-28 2017-09-11 Hemoteq Ag Revestimiento biocompatible, método y utilización de superficies médicas
WO2006036967A1 (en) * 2004-09-28 2006-04-06 Atrium Medical Corporation Solubilizing a drug for use in a coating
US20060083768A1 (en) * 2004-09-28 2006-04-20 Atrium Medical Corporation Method of thickening a coating using a drug
WO2007047781A2 (en) * 2005-10-15 2007-04-26 Atrium Medical Corporation Hydrophobic cross-linked gels for bioabsorbable drug carrier coatings
US8092819B2 (en) * 2006-01-27 2012-01-10 Cook Medical Technologies LLC. Implantable medical device coated with a bioactive agent

Patent Citations (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01124463A (ja) * 1987-11-09 1989-05-17 Terumo Corp 医療用軟質樹脂組成物および医療用具
JPH07500272A (ja) 1992-01-15 1995-01-12 クック・インコーポレーテッド 螺旋型ステント
JPH08502428A (ja) 1992-10-13 1996-03-19 ボストン・サイエンティフィック・コーポレイション 蠕動運動を示す体の管腔のためのステント
JPH07529A (ja) 1993-04-23 1995-01-06 Schneider Europ Ag 膨張可能な不連続な壁部を有するステント及びステントにカバー層を取り付ける方法
JP3673973B2 (ja) 1993-04-26 2005-07-20 メドトロニック・インコーポレーテッド 血管内ステントを製造する方法、及びこの方法で製造されたステント
JPH0833718A (ja) 1993-04-26 1996-02-06 Medtronic Inc 血管内ステント及び方法
JPH09215753A (ja) 1996-02-08 1997-08-19 Schneider Usa Inc チタン合金製自己拡張型ステント
JP2001512354A (ja) 1997-02-20 2001-08-21 クック インコーポレーティッド． 被覆された移植可能な医療器具
JPH11323113A (ja) * 1998-05-08 1999-11-26 Shimadzu Corp ポリ乳酸系組成物
JP2003526477A (ja) 2000-03-15 2003-09-09 オーバス メディカル テクノロジーズ インク． 内皮細胞接着を促進するコーティング
JP2004518458A (ja) 2000-09-29 2004-06-24 コーディス・コーポレイション 被覆医用器具
JP2004522559A (ja) 2000-10-31 2004-07-29 クック　インコーポレイティド 医療器具
JP2004533409A (ja) 2000-12-12 2004-11-04 ボストン サイエンティフィック リミテッド ブロックコポリマを含む薬物送達構成体及び医療器具
JP2004524346A (ja) 2001-03-26 2004-08-12 シユペツク，ウルリヒ 再狭窄予防のための調製物
JP2003147180A (ja) * 2001-11-15 2003-05-21 New Japan Chem Co Ltd 乳酸系ポリマー組成物及びその成形体
JP2005516736A (ja) 2002-02-15 2005-06-09 シーブイ・セラピューティクス・インコーポレイテッド 医療器具用ポリマーコーティング
JP2007144108A (ja) 2005-03-30 2007-06-14 Terumo Corp 生体内留置用ステント
JP2007097706A (ja) 2005-09-30 2007-04-19 Terumo Corp ステント
JP2007254540A (ja) 2006-03-22 2007-10-04 Showa Denko Kk 高分子発光材料、有機エレクトロルミネッセンス素子および表示装置
JP2008089451A (ja) 2006-10-03 2008-04-17 Toshiba Corp 洗濯廃液の処理方法および処理装置
JP2008220811A (ja) * 2007-03-15 2008-09-25 Terumo Corp ステント

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See also references of EP2191853A4 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012020812A1 (ja) * 2010-08-12 2012-02-16 株式会社オプトニクス精密 ステント
JP2012040050A (ja) * 2010-08-12 2012-03-01 Optnics Precision Co Ltd ステント
JP2020529231A (ja) * 2017-07-26 2020-10-08 鼎科医療技術（蘇州）有限公司 表面液化薬物コートバルーン
JP7005742B2 (ja) 2017-07-26 2022-01-24 鼎科医療技術（蘇州）有限公司 表面液化薬物コートバルーン

Also Published As

Publication number Publication date
EP2191853A1 (en) 2010-06-02
JP5684863B2 (ja) 2015-03-18
EP2191853B1 (en) 2015-07-29
US20100233229A1 (en) 2010-09-16
JPWO2009041691A1 (ja) 2011-01-27
EP2191853A4 (en) 2010-10-06
JP5356239B2 (ja) 2013-12-04
JP2013236940A (ja) 2013-11-28

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