JP2004533409A5 - - Google Patents

Info

Publication number

JP2004533409A5

JP2004533409A5 JP2002549300A JP2002549300A JP2004533409A5 JP 2004533409 A5 JP2004533409 A5 JP 2004533409A5 JP 2002549300 A JP2002549300 A JP 2002549300A JP 2002549300 A JP2002549300 A JP 2002549300A JP 2004533409 A5 JP2004533409 A5 JP 2004533409A5

Authority

JP

Japan

Prior art keywords

medical device

block

polyolefin

block copolymer

vinyl aromatic

Prior art date

2001-12-12

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Withdrawn

Links

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• 229920000098 polyolefin Polymers 0.000 claims description 30
• 229920001400 block copolymer Polymers 0.000 claims description 27
• 239000003814 drug Substances 0.000 claims description 27
• 239000000178 monomer Substances 0.000 claims description 21
• 229920000642 polymer Polymers 0.000 claims description 21
• 229920002554 vinyl polymer Polymers 0.000 claims description 21
• 229940124597 therapeutic agent Drugs 0.000 claims description 19
• PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 claims description 18
• 125000001931 aliphatic group Chemical group 0.000 claims description 16
• 239000000203 mixture Substances 0.000 claims description 14
• CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 claims description 12
• XYLMUPLGERFSHI-UHFFFAOYSA-N alpha-Methylstyrene Chemical compound CC(=C)C1=CC=CC=C1 XYLMUPLGERFSHI-UHFFFAOYSA-N 0.000 claims description 11
• 229920001169 thermoplastic Polymers 0.000 claims description 10
• 239000004416 thermosoftening plastic Substances 0.000 claims description 10
• 239000011248 coating agent Substances 0.000 claims description 8
• 238000000576 coating method Methods 0.000 claims description 8
• 125000004122 cyclic group Chemical group 0.000 claims description 8
• 230000002792 vascular Effects 0.000 claims description 6
• 229920000234 biocompatible block copolymer Polymers 0.000 claims description 5
• 229920001577 copolymer Polymers 0.000 claims description 5
• 229920006124 polyolefin elastomer Polymers 0.000 claims description 5
• 229920002818 (Hydroxyethyl)methacrylate Polymers 0.000 claims description 3
• WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 claims description 3
• VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 claims description 3
• 229920002367 Polyisobutene Polymers 0.000 claims description 3
• SUPCQIBBMFXVTL-UHFFFAOYSA-N ethyl 2-methylprop-2-enoate Chemical compound CCOC(=O)C(C)=C SUPCQIBBMFXVTL-UHFFFAOYSA-N 0.000 claims description 3
• CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 claims description 2
• 238000010276 construction Methods 0.000 claims description 2
• VQTUBCCKSQIDNK-UHFFFAOYSA-N Isobutene Chemical group CC(C)=C VQTUBCCKSQIDNK-UHFFFAOYSA-N 0.000 claims 8
• 229940079593 drug Drugs 0.000 claims 8
• 210000004204 blood vessel Anatomy 0.000 claims 7
• 108020004414 DNA Proteins 0.000 claims 6
• 239000003795 chemical substances by application Substances 0.000 claims 5
• 229930012538 Paclitaxel Natural products 0.000 claims 4
• 239000003146 anticoagulant agent Substances 0.000 claims 4
• HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 4
• 229960001592 paclitaxel Drugs 0.000 claims 4
• RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 4
• 210000004027 cell Anatomy 0.000 claims 3
• 230000010261 cell growth Effects 0.000 claims 3
• 108020005544 Antisense RNA Proteins 0.000 claims 2
• 102000008186 Collagen Human genes 0.000 claims 2
• 108010035532 Collagen Proteins 0.000 claims 2
• 108010037362 Extracellular Matrix Proteins Proteins 0.000 claims 2
• 102000010834 Extracellular Matrix Proteins Human genes 0.000 claims 2
• 239000004793 Polystyrene Substances 0.000 claims 2
• 229940035674 anesthetics Drugs 0.000 claims 2
• 239000002260 anti-inflammatory agent Substances 0.000 claims 2
• 230000002095 anti-migrative effect Effects 0.000 claims 2
• 230000001028 anti-proliverative effect Effects 0.000 claims 2
• 229940127219 anticoagulant drug Drugs 0.000 claims 2
• 239000002246 antineoplastic agent Substances 0.000 claims 2
• 230000015572 biosynthetic process Effects 0.000 claims 2
• 235000012000 cholesterol Nutrition 0.000 claims 2
• 229920001436 collagen Polymers 0.000 claims 2
• 239000003184 complementary RNA Substances 0.000 claims 2
• 239000000824 cytostatic agent Substances 0.000 claims 2
• 210000002744 extracellular matrix Anatomy 0.000 claims 2
• 239000003193 general anesthetic agent Substances 0.000 claims 2
• 239000003966 growth inhibitor Substances 0.000 claims 2
• 239000007952 growth promoter Substances 0.000 claims 2
• 230000008520 organization Effects 0.000 claims 2
• 229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 claims 2
• 229920000747 poly(lactic acid) Polymers 0.000 claims 2
• 229920001281 polyalkylene Polymers 0.000 claims 2
• 229920001610 polycaprolactone Polymers 0.000 claims 2
• 239000004632 polycaprolactone Substances 0.000 claims 2
• 239000004626 polylactic acid Substances 0.000 claims 2
• 229920002223 polystyrene Polymers 0.000 claims 2
• 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 2
• 239000001267 polyvinylpyrrolidone Substances 0.000 claims 2
• 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 2
• 210000005167 vascular cell Anatomy 0.000 claims 2
• 230000002227 vasoactive effect Effects 0.000 claims 2
• 229940124549 vasodilator Drugs 0.000 claims 2
• 239000003071 vasodilator agent Substances 0.000 claims 2
• KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 1
• 108020004491 Antisense DNA Proteins 0.000 claims 1
• 229940123587 Cell cycle inhibitor Drugs 0.000 claims 1
• 102000009123 Fibrin Human genes 0.000 claims 1
• 108010073385 Fibrin Proteins 0.000 claims 1
• BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 claims 1
• 108010010803 Gelatin Proteins 0.000 claims 1
• 229920002683 Glycosaminoglycan Polymers 0.000 claims 1
• 108700021154 Metallothionein 3 Proteins 0.000 claims 1
• 102100028708 Metallothionein-3 Human genes 0.000 claims 1
• 239000000020 Nitrocellulose Substances 0.000 claims 1
• 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 1
• 239000004952 Polyamide Substances 0.000 claims 1
• 239000004695 Polyether sulfone Substances 0.000 claims 1
• -1 Polyethylene terephthalate Polymers 0.000 claims 1
• 229920000954 Polyglycolide Polymers 0.000 claims 1
• 229920000331 Polyhydroxybutyrate Polymers 0.000 claims 1
• 229920001710 Polyorthoester Polymers 0.000 claims 1
• 239000004721 Polyphenylene oxide Substances 0.000 claims 1
• 239000004372 Polyvinyl alcohol Substances 0.000 claims 1
• 229920002125 Sokalan® Polymers 0.000 claims 1
• FJWGYAHXMCUOOM-QHOUIDNNSA-N [(2s,3r,4s,5r,6r)-2-[(2r,3r,4s,5r,6s)-4,5-dinitrooxy-2-(nitrooxymethyl)-6-[(2r,3r,4s,5r,6s)-4,5,6-trinitrooxy-2-(nitrooxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-3,5-dinitrooxy-6-(nitrooxymethyl)oxan-4-yl] nitrate Chemical compound O([C@@H]1O[C@@H]([C@H]([C@H](O[N+]([O-])=O)[C@H]1O[N+]([O-])=O)O[C@H]1[C@@H]([C@@H](O[N+]([O-])=O)[C@H](O[N+]([O-])=O)[C@@H](CO[N+]([O-])=O)O1)O[N+]([O-])=O)CO[N+](=O)[O-])[C@@H]1[C@@H](CO[N+]([O-])=O)O[C@@H](O[N+]([O-])=O)[C@H](O[N+]([O-])=O)[C@H]1O[N+]([O-])=O FJWGYAHXMCUOOM-QHOUIDNNSA-N 0.000 claims 1
• 239000002253 acid Substances 0.000 claims 1
• 230000000735 allogeneic effect Effects 0.000 claims 1
• 239000002870 angiogenesis inducing agent Substances 0.000 claims 1
• 229940121363 anti-inflammatory agent Drugs 0.000 claims 1
• 229940124599 anti-inflammatory drug Drugs 0.000 claims 1
• 229940034982 antineoplastic agent Drugs 0.000 claims 1
• 229940041181 antineoplastic drug Drugs 0.000 claims 1
• 239000003816 antisense DNA Substances 0.000 claims 1
• 229960004676 antithrombotic agent Drugs 0.000 claims 1
• 229940127217 antithrombotic drug Drugs 0.000 claims 1
• 210000000013 bile duct Anatomy 0.000 claims 1
• 210000001124 body fluid Anatomy 0.000 claims 1
• 239000010839 body fluid Substances 0.000 claims 1
• 210000004556 brain Anatomy 0.000 claims 1
• 229920002301 cellulose acetate Polymers 0.000 claims 1
• 239000003638 chemical reducing agent Substances 0.000 claims 1
• 210000001072 colon Anatomy 0.000 claims 1
• 230000001085 cytostatic effect Effects 0.000 claims 1
• KPUWHANPEXNPJT-UHFFFAOYSA-N disiloxane Chemical class [SiH3]O[SiH3] KPUWHANPEXNPJT-UHFFFAOYSA-N 0.000 claims 1
• 210000003238 esophagus Anatomy 0.000 claims 1
• 239000005038 ethylene vinyl acetate Substances 0.000 claims 1
• 229950003499 fibrin Drugs 0.000 claims 1
• 229920000159 gelatin Polymers 0.000 claims 1
• 239000008273 gelatin Substances 0.000 claims 1
• 235000019322 gelatine Nutrition 0.000 claims 1
• 235000011852 gelatine desserts Nutrition 0.000 claims 1
• 150000004676 glycans Chemical class 0.000 claims 1
• 229920002674 hyaluronan Polymers 0.000 claims 1
• 229960003160 hyaluronic acid Drugs 0.000 claims 1
• FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical compound O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 claims 1
• 238000000034 method Methods 0.000 claims 1
• 229920001220 nitrocellulos Polymers 0.000 claims 1
• 230000002188 osteogenic effect Effects 0.000 claims 1
• 230000002093 peripheral effect Effects 0.000 claims 1
• 239000005015 poly(hydroxybutyrate) Substances 0.000 claims 1
• 239000002745 poly(ortho ester) Substances 0.000 claims 1
• 229920002401 polyacrylamide Polymers 0.000 claims 1
• 239000004584 polyacrylic acid Substances 0.000 claims 1
• 229920002647 polyamide Polymers 0.000 claims 1
• 239000004417 polycarbonate Substances 0.000 claims 1
• 229920000515 polycarbonate Polymers 0.000 claims 1
• 229920000728 polyester Polymers 0.000 claims 1
• 229920000570 polyether Polymers 0.000 claims 1
• 229920006393 polyether sulfone Polymers 0.000 claims 1
• 229920000139 polyethylene terephthalate Polymers 0.000 claims 1
• 239000005020 polyethylene terephthalate Substances 0.000 claims 1
• 239000004633 polyglycolic acid Substances 0.000 claims 1
• 229920001184 polypeptide Polymers 0.000 claims 1
• 229920001282 polysaccharide Polymers 0.000 claims 1
• 239000005017 polysaccharide Substances 0.000 claims 1
• 229920001296 polysiloxane Polymers 0.000 claims 1
• 229920002635 polyurethane Polymers 0.000 claims 1
• 239000004814 polyurethane Substances 0.000 claims 1
• 229920002451 polyvinyl alcohol Polymers 0.000 claims 1
• 229920006216 polyvinyl aromatic Polymers 0.000 claims 1
• 229920001289 polyvinyl ether Polymers 0.000 claims 1
• 102000004196 processed proteins & peptides Human genes 0.000 claims 1
• 108090000765 processed proteins & peptides Proteins 0.000 claims 1
• 210000002307 prostate Anatomy 0.000 claims 1
• 108090000623 proteins and genes Proteins 0.000 claims 1
• 102000004169 proteins and genes Human genes 0.000 claims 1
• 238000002560 therapeutic procedure Methods 0.000 claims 1
• 210000001519 tissue Anatomy 0.000 claims 1
• 210000003437 trachea Anatomy 0.000 claims 1
• 210000003708 urethra Anatomy 0.000 claims 1